Article
Microbiology
Yu P. Song, Man F. Tang, Agnes S. Y. Leung, Kin P. Tao, Oi M. Chan, Gary W. K. Wong, Paul K. S. Chan, Renee W. Y. Chan, Ting F. Leung
Summary: This case-control study investigated the interaction between CDHR3 genotypes and rhinovirus (RV) species on disease severity in Hong Kong children hospitalized for respiratory tract infection (RTI). There were synergistic effects between RV-C and CDHR3 SNPs for RTI severity, which was mainly driven by RV-C.
MICROBIOLOGY SPECTRUM
(2023)
Review
Nutrition & Dietetics
Chiara Nava, Anna Di Gallo, Andrea Biuso, Irene Daniele, Gianluca Lista, Pasquale Comberiati, Diego Peroni, Gian Vincenzo Zuccotti, Enza D'Auria
Summary: Preterm birth can have long-term consequences on respiratory health. The impact of early-life nutrition on the risk of respiratory morbidities in preterm infants remains uncertain due to conflicting evidence. Further well-designed studies are needed to clarify this relationship.
Article
Infectious Diseases
Zhilei Zhang, Li Tan, Miao Tan, Xiaolin Zhang, Wenji He, Ming Li, Juan He, Yue Pan, Bin Xu, Songtao Bin, Zhengyan Gan, Lingmei Yan, Yuxing Sun, Hongchao Jiang, Qiangming Sun, Zhen Zhang
Summary: This article reports the first case of HRV-A11-associated lower respiratory tract infection in China. The nucleotide and amino acid mutations in these clinical strains were analyzed, and mutations in the capsid protein region and specific epitopes were found. The study results may provide references for virological surveillance and vaccine development.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Immunology
Jonathan M. Mansbach, Ruth J. Geller, Kohei Hasegawa, Pedro A. Piedra, Vasanthi Avadhanula, James E. Gern, Yury A. Bochkov, Janice A. Espinola, Ashley F. Sullivan, Carlos A. Camargo
Summary: This study found that infants with respiratory syncytial virus (RSV) at hospitalization followed by a new rhinovirus (RV) infection had the highest risk of recurrent wheezing among severe bronchiolitis cases.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Nicole Maison, Jimmy Omony, Sophia Rinderknecht, Laura Kolberg, Melanie Meyer-Buehn, Erika von Mutius, Johannes Huebner, Ulrich von Both
Summary: Following COVID-19 lockdown measures, respiratory tract infections increased worldwide, specifically affecting children's hospitals. Changes in the epidemiological pattern of respiratory viral infections were observed, with a higher number of virus detections and a shift in the pattern of infections.
Review
Pediatrics
Etienne Bizot, Anais Bousquet, Maelle Charpie, Florence Coquelin, Servane Lefevre, Justin Le Lorier, Margaux Patin, Perrine See, Eytan Sarfati, Servane Walle, Benoit Visseaux, Romain Basmaci
Summary: Human rhinoviruses (HRVs) are a main cause of common colds in children and are increasingly involved in severe clinical infections. They can cause upper and lower respiratory tract infections, with HRV bronchiolitis posing a higher risk of asthma. Although HRVs can be detected in stools, blood, or cerebrospinal fluid, their high rate of asymptomatic carriage and prolonged excretion post-symptoms complicate interpretation.
FRONTIERS IN PEDIATRICS
(2021)
Article
Infectious Diseases
Ran Jia, Lijuan Lu, Shu Li, Pengcheng Liu, Menghua Xu, Lingfeng Cao, Liyun Su, Jin Xu
Summary: In 2020, there was a major prevalence of HRV among children, with HRV-As being more prone to cause severe lower respiratory tract infections and HRV-Cs closely associated with childhood wheezing. Predominant genotypes included A11, A28, A47, A82, A101, C40, and C43, with A21, A82, and A101 taking up larger proportions in severe cases.
BMC INFECTIOUS DISEASES
(2022)
Article
Immunology
Ville Forsstroem, Laura Toivonen, Kiara Homil, Matti Waris, Casper-Emil T. Pedersen, Klaus Bonnelykke, Tuomas Jartti, Ville Peltola
Summary: This study found that genetic predisposition to childhood asthma is associated with early respiratory tract infections, particularly in the 17q21 and CDHR3 genes. Multiple asthma risk alleles are also associated with viral respiratory infections and asthma. Therefore, non-wheezing and wheezing respiratory infections and asthma may share common genetic risk factors.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Immunology
Pekka Hurme, Miisa Komulainen, Marleena Tulkki, Annamari Leino, Beate Ruckert, Riitta Turunen, Tytti Vuorinen, Mubeccel Akdis, Cezmi A. Akdis, Tuomas Jartti
Summary: The cytokine profiles of Rhinovirus (RV) and respiratory syncytial virus (RSV)-induced first wheezing episode differ, with higher cytokine expression and longer hospitalization time in the RSV group. In the RV group, increased expression of I-309 (CCL1) and TARC is associated with fewer relapses.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Infectious Diseases
Sheila F. Lumley, Nicholas Richens, Emily Lees, Jack Cregan, Elizabeth Kalimeris, Sarah Oakley, Marcus Morgan, Shelley Segal, Moya Dawson, A. Sarah Walker, David W. Eyre, Derrick W. Crook, Sally Beer, Alex Novak, Nicole E. Stoesser, Philippa C. Matthews
Summary: The SARS-CoV-2 pandemic had a significant impact on the incidence of paediatric viral respiratory tract infection in Oxfordshire, UK. The findings have implications for clinical service demand, testing strategies, timing of palivizumab RSV prophylaxis, and the effectiveness of public health interventions in preventing respiratory virus infections.
JOURNAL OF INFECTION
(2022)
Article
Pediatrics
Lihua Yang, Guocheng Zhang, Lusheng Huang, Xiaoling Ren, Yanqi Su, Chengxiu Wang, Yuanbin Shi, Liao Li, Hui Shan, Jing Chen, Jianxin Xiong, Xue Xue, Shaofeng Song, Li Zhao, Shuhua An, Haiming Yu, Hong Cao, Lin Zhao, Ming Li, Xiaocui Sheng, Yajun Wang
Summary: The study found that early use of recombinant human interferon alpha 1b and breastfeeding in infants hospitalized with lower respiratory tract infections can prevent subsequent wheezing. Childhood history of allergy, no use of rhIFN alpha 1b, and living in crowded housing may be risk factors for wheezing. Breastfeeding and hospitalization at age <= 1 year old were identified as protective factors.
JORNAL DE PEDIATRIA
(2021)
Article
Medicine, General & Internal
Christopher C. Butler, F. D. Richard Hobbs, Oghenekome A. Gbinigie, Najib M. Rahman, Gail Hayward, Duncan B. Richards, Jienchi Dorward, David M. Lowe, Joseph F. Standing, Judith Breuer, Saye Khoo, Stavros Petrou, Kerenza Hood, Jonathan S. Nguyen-Van-Tam, Mahendra G. Patel, Benjamin R. Saville, Joe Marion, Emma Ogburn, Julie Allen, Heather Rutter, Nick Francis, Nicholas P. B. Thomas, Philip Evans, Melissa Dobson, Tracie-Ann Madden, Jane Holmes, Victoria Harris, May Ee Png, Mark Lown, Oliver van Hecke, Michelle A. Detry, Christina T. Saunders, Mark Fitzgerald, Nicholas S. Berry, Lazaro Mwandigha, Ushma Galal, Sam Mort, Bhautesh D. Jani, Nigel D. Hart, Haroon Ahmed, Daniel Butler, Micheal McKenna, Jem Chalk, Layla Lavallee, Elizabeth Hadley, Lucy Cureton, Magdalena Benysek, Monique Andersson, Maria Coates, Sarah Barrett, Clare Bateman, Jennifer C. Davies, Ivy Raymundo-Wood, Andrew Ustianowski, Andrew Carson-Stevens, Ly-Mee Yu, Paul Little
Summary: This study aimed to determine the safety, effectiveness, and cost-effectiveness of molnupiravir in vaccinated high-risk patients in the community. The results showed that molnupiravir did not reduce hospital admissions or deaths associated with COVID-19 compared to usual care in this population.
Article
Microbiology
Yu P. Song, Man F. Tang, Agnes S. Y. Leung, Kin P. Tao, Oi M. Chan, Gary W. K. Wong, Paul K. S. Chan, Renee W. Y. Chan, Ting F. Leung
Summary: This case-control study investigated the interaction between CDHR3 genotypes and rhinovirus (RV) species on disease severity in Hong Kong children hospitalized for respiratory tract infection (RTI). There were synergistic effects between RV-C and CDHR3 SNPs for RTI severity, which was mainly driven by RV-C. Specifically, rs6967330 and rs140154310 alone and their epistatic interaction were associated with RV-C-related and severe RTIs in our subjects. Therefore, genotyping of CDHR3 SNPs may help physicians formulate prediction models for severity of RV-associated RTIs.
MICROBIOLOGY SPECTRUM
(2023)
Article
Infectious Diseases
Mohammad Hussain Alqahtani, Mohammad Faraj Alqahtani, Mohammed Asiri, Saad Alghamdi, Ziyad Alshagawi, Saleh Alzahrani
Summary: The study aims to determine the clinical presentation, past medical history, hospitalization course, and prognosis in children below two years of age who have been hospitalized in the past five years. The results show a significant increase in the length of ICU and ventilator use among females compared to males. Furthermore, infants younger than 12 months account for the majority of ICU admissions.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Otorhinolaryngology
Young-Kyung Ko, Yu-Lian Zhang, Jee Hye Wee, Doo Hee Han, Hyun Jik Kim, Chae-Seo Rhee
Summary: This study found that the HRV infection rates were similar in patients with chronic rhinosinusitis, regardless of the presence of allergic rhinitis. HRV infection enhanced the Th2 environment by modulating PD-L1 and PD-L2 expression levels in allergic mucosa and by increasing the IL-4/IFN-gamma ratio in non-allergic mucosa.
CLINICAL AND EXPERIMENTAL OTORHINOLARYNGOLOGY
(2021)