Article
Immunology
Chinh C. Ngo, Helen M. Massa, Brent A. McMonagle, Christopher F. Perry, Michael D. Nissen, Theo P. Sloots, Ruth B. Thornton, Allan W. Cripps
Summary: This study identified Streptococcus pneumoniae, non-typeable Haemophilus influenzae (NTHi), and rhinovirus as the predominant bacteria and viruses in the upper respiratory tract of children in South-East Queensland, Australia, with and without a clinical history of otitis media. The presence of bacterial otopathogens within the middle ear was found to be more predictive of concurrent upper respiratory tract infection than viruses. The study also confirmed the complex polymicrobial environment within adenoid tissues in children, regardless of otitis media history.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Medicine, General & Internal
Elena-Lia Spoiala, Iuliana Magdalena Starcea, Ileana Katerina Ioniuc, Romica Sebastian Cozma, Daniela Carmen Rusu, Laura Bozomitu, Vasile Valeriu Lupu, Codruta Olimpiada Iliescu Halitchi, Vasile Eduard Rosu, Solange Tamara Rosu, Cristina Gavrilovici
Summary: Acute otitis media (AOM) in children is a major reason for healthcare visits and antibiotic prescriptions globally. This study aimed to analyze antibiotic prescription patterns in uncomplicated AOM in children and assess the extent of the watchful-waiting approach. A systematic review was conducted, and 12 papers were included in the analysis. The study found variations in antibiotic prescription rates and discrepancies in watchful-waiting approach and choice of second or third-line antimicrobial agents.
MEDICINA-LITHUANIA
(2023)
Article
Immunology
Nader Shaikh, Alejandro Hoberman, Jack L. L. Paradise, Howard E. E. Rockette, Marcia Kurs-Lasky, Judith M. M. Martin
Summary: Through two separate clinical trials, we found that young children aged 6-23 months without nasopharyngeal colonization of either Streptococcus pneumoniae or Haemophilus influenzae may not need or can have a shortened duration of antibiotic treatment.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2023)
Article
Pharmacology & Pharmacy
Manar Magdy, Enas Elmowafy, Mona Elassal, Rania A. H. Ishak
Summary: This research aimed to design and optimize innovative nanovesicles called Glycerospanlastics for delivering triamcinolone acetonide (TA) for otitis media treatment. The optimized Glycerospanlastics showed good properties such as nanometer size, negative charges, high TA entrapment, and improved permeation across the tympanic membrane. They outperformed the marketed drug suspension in treating otitis media, as evidenced by the restoration of histopathological alterations and reduced levels of IL-1 beta and TNF-alpha.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Public, Environmental & Occupational Health
Michael Nieratschker, Markus Haas, Mateo Lucic, Franziska Pichler, Faris F. Brkic, Thomas Parzefall, Dominik Riss, David T. Liu
Summary: This study aimed to identify associations between extreme weather events and the immediate and delayed risks for acute otitis media (AOM)-related emergency department visits (EV). The results showed that prolonged extreme weather conditions, such as temperature, humidity, precipitation, wind speeds, and atmospheric pressure, significantly impacted the risk ratio (RR) for AOM-related EVs. These findings could improve healthcare resource allocation in similar climates and educate patients about the role of environmental factors in AOM.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Immunology
Daniel N. Frank, Jose Pedrito M. Magno, Karen Joyce S. Velasco, Tori C. Bootpetch, Jacob Ephraim D. Salud, Kevin Jer V. David, Aaron L. Miller, Eljohn C. Yee, Heather P. Dulnuan, Richard B. Pyles, Jan Alexeis C. Lacuata, Jeric L. Arbizo, Jennifer M. Kofonow, Beatrice Guce, Kevin Michael D. Mendoza, Charles E. Robertson, Gabriel Martin S. Ilustre, Alessandra Nadine E. Chiong, Shi-Long Lu, Erik A. Tongol, Nicole D. Sacayan, Talitha Karisse L. Yarza, Charlotte M. Chiong, Regie Lyn P. Santos-Cortez
Summary: This study analyzed the microbiota of cholesteatoma tissue compared to other middle ear tissues in patients with chronic otitis media. The findings revealed differences in bacterial profiles and abundance across different sample types and patient age quartiles. The study provides valuable insights for improving treatment protocols for cholesteatoma and chronic otitis media in settings with limited healthcare resources.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Microbiology
Jennifer Jorissen, Marianne F. L. van den Broek, Ilke De Boeck, Wannes Van Beeck, Stijn Wittouck, An Boudewyns, Paul Van de Heyning, Vedat Topsakal, Vincent Van Rompaey, Ine Wouters, Liesbet Van Heirstraeten, Pierre Van Damme, Surbi Malhotra-Kumar, Heidi Theeten, Olivier M. Vanderveken, Sarah Lebeer
Summary: This study found that besides Haemophilus influenzae, other microbes were commonly detected in the ear canal of chronic otitis media with effusion (OME) patients. Healthy controls had more Streptococci of the salivarius group and Acinetobacter lwoffii in their nasopharynx. Additionally, tested Streptococcus salivarius isolates showed potential to inhibit the growth of respiratory pathobionts in OME patients.
Article
Genetics & Heredity
Scott D. Hirsch, Christina L. Elling, Tori C. Bootpetch, Melissa A. Scholes, Lena Hafren, Sven-Olrik Streubel, Harold S. Pine, Todd M. Wine, Wasyl Szeremeta, Jeremy D. Prager, Elisabet Einarsdottir, Ayesha Yousaf, Erin E. Baschal, Sakina Rehman, Michael J. Bamshad, Deborah A. Nickerson, Saima Riazuddin, Suzanne M. Leal, Zubair M. Ahmed, Patricia J. Yoon, Juha Kere, Kenny H. Chan, Petri S. Mattila, Norman R. Friedman, Tasnee Chonmaitree, Daniel N. Frank, Allen F. Ryan, Regie Lyn P. Santos-Cortez
Summary: The study reveals the critical role of CDHR3 in susceptibility to otitis media, identifying novel CDHR3 variants associated with OM through exome sequencing, as well as pathogenic CDHR3 variants in US and Finnish families. The CDHR3 p.Cys529Tyr variant is linked to the absence of middle ear fluid and specific bacterial abundance.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Article
Pharmacology & Pharmacy
Manar Magdy, Enas Elmowafy, Mona I. A. El-Assal, Rania A. H. Ishak
Summary: This study explores the use of glycerosomes for delivering triamcinolone acetonide (TA) to the middle ear, improving the treatment of otitis media (OM). The optimized formulation of TA glycerosomes showed superior tolerability and efficacy compared to the marketed drug in ex vivo and in vivo experiments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Immunology
Isabella O. Conway, Marcia Kurs-Lasky, Nader Shaikh
Summary: In this study, we compared the distribution of organisms in the nasopharynx and middle ear fluid in episodes of acute otitis media in young children. We found that Moraxella catarrhalis is isolated from middle ear fluid in only 11% of cases with nasopharyngeal colonization by this organism, in contrast to Streptococcus pneumoniae and Haemophilus influenzae.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2023)
Article
Medicine, Research & Experimental
Thomas M. Kaffenberger, Michael A. Belsky, Nicholas R. Oberlies, Aarti Kumar, Joseph P. Donohue, Tiffany S. Yang, Amber D. Shaffer, David H. Chi
Summary: This study examined the impact of intraoperative middle ear effusion (MEE) types on outcomes of pediatric bilateral myringotomy and tympanostomy tube placement (BMT) surgeries. The results indicated that purulent effusions increased the odds of in-office suctioning in patients with recurrent acute otitis media (RAOM) compared to other types of MEE.
Article
Microbiology
Steven L. Taylor, Lito E. Papanicolas, Alyson Richards, Furdosa Ababor, Wan Xian Kang, Jocelyn M. Choo, Charmaine Woods, Steve L. Wesselingh, Eng H. Ooi, Patricia MacFarlane, Geraint B. Rogers
Summary: This study in a remote Aboriginal community in South Australia found a variety of OM conditions in children, with ear microbiota characteristics related to OM diagnosis and changing with disease course. Nasopharyngeal microbiota characteristics were consistent with the contribution of acute upper respiratory infection to OM aetiology.
Article
Health Care Sciences & Services
Michele Cavaliere, Antonella Miriam Di Lullo, Pasquale Capriglione, Gaetano Motta, Elena Cantone
Summary: Chronic otitis media (COM) is a persistent inflammation of the middle ear that often requires surgical management and significantly affects the quality of life of patients. This study evaluated the QoL of COM patients undergoing surgery using the Italian version of the COMOT-15 questionnaire. The results showed an overall improvement in QoL after surgery, with better ratings in ear symptoms and hearing in the whole analyzed group. However, different operation techniques produced varying effects, with closed techniques showing greater improvement in hearing and mental health, and age was found to be positively correlated with the COMOT-15 results.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Clinical Neurology
Zhi Yong Wong, Yoon Soo Park, Gagandeep Singh Mann
Summary: The objective of this study was to compare postoperative outcomes of tympanoplasty between active and inactive otitis media patients with tympanic membrane perforation. A total of 33 studies comprising 2,373 patients were included in the analysis. The findings showed that inactive otitis media patients have higher average postoperative mean hearing gain and graft uptake compared to active otitis media patients. The meta-analysis results indicated that there were no statistically significant differences in postoperative mean hearing gain and graft uptake between active and inactive otitis media patients undergoing tympanoplasty.
OTOLOGY & NEUROTOLOGY
(2023)
Article
Medicine, General & Internal
Shanila Ahmed, Syed Muhammad Mustahsan, Bushra Jamil, Faiza Ilyas
Summary: This article reports two cases of nasopharyngeal tuberculosis (NPTB) in Pakistan, which have not been reported before. NPTB is a rare disease even in high tuberculosis endemic areas, and its initial symptoms can easily be misdiagnosed.
JCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN
(2022)
Article
Infectious Diseases
Stephen I. Pelton, Kimberly M. Shea, Raymond A. Farkouh, David R. Strutton, Sebastian Braun, Christian Jacob, Rogier Klok, Elana S. Gruen, Derek Weycker
BMC INFECTIOUS DISEASES
(2015)
Article
Infectious Diseases
Qiuzhi Chang, Abbie E. Stevenson, Nicholas J. Croucher, Grace M. Lee, Stephen I. Pelton, Marc Lipsitch, Jonathan A. Finkelstein, William P. Hanage
BMC INFECTIOUS DISEASES
(2015)
Article
Immunology
Inci Yildirim, Kimberly M. Shea, Stephen I. Pelton
INFECTIOUS DISEASE CLINICS OF NORTH AMERICA
(2015)
Editorial Material
Medicine, General & Internal
Robyn T. Cohen, Stephen I. Pelton
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2015)
Article
Immunology
Pui-Ying Iroh Tam, Lawrence C. Madoff, Michael O'Connell, Stephen I. Pelton
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2015)
Article
Pediatrics
Inci Yildirim, Kimberly M. Shea, Brent A. Little, Amy L. Silverio, Stephen I. Pelton
Article
Multidisciplinary Sciences
Nicholas J. Croucher, Jonathan A. Finkelstein, Stephen I. Pelton, Julian Parkhill, Stephen D. Bentley, Marc Lipsitch, William P. Hanage
Article
Immunology
Stephen I. Pelton, Kimberly M. Shea, Derek Weycker, Raymond A. Farkouh, David R. Strutton, John Edelsberg
OPEN FORUM INFECTIOUS DISEASES
(2015)
Editorial Material
Immunology
Stephen I. Pelton
CLINICAL INFECTIOUS DISEASES
(2014)
Article
Immunology
Vishakha Sabharwal, Abbie Stevenson, Marisol Figueira, George Orthopoulos, Krzysztof Trzcinski, Stephen I. Pelton
MICROBES AND INFECTION
(2014)
Letter
Immunology
Pui-Ying Iroh Tam, Brandon Coombes, Lawrence Madoff, Stephen I. Pelton
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2014)
Article
Immunology
Anita M. Loughlin, Katherine Hsu, Amy L. Silverio, Colin D. Marchant, Stephen I. Pelton
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2014)
Article
Pediatrics
Pui-Ying Iroh Tam, Lawrence C. Madoff, Brandon Coombes, Stephen I. Pelton
Article
Multidisciplinary Sciences
Marisol Figueira, Monica Moschioni, Gabriella De Angelis, Michele Barocchi, Vishakha Sabharwal, Vega Masignani, Stephen I. Pelton
Article
Multidisciplinary Sciences
Lisa J. McGarry, Girishanthy Krishnarajah, Gregory Hill, Cristina Masseria, Michelle Skornicki, Narin Pruttivarasin, Bhakti Arondekar, Julie Roiz, Stephen I. Pelton, Milton C. Weinstein