Article
Biochemistry & Molecular Biology
Viktoria Rungelrath, Frank R. DeLeo
Summary: Staphylococcus aureus is a major cause of bacterial infections worldwide, with resistance to antibiotics and the ability to evade host defenses. Research has identified certain virulence molecules of S. aureus as therapeutic targets. Treatment options for methicillin-resistant S. aureus are limited, highlighting the need for further research to develop new therapies.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Review
Microbiology
Vanessa Silva, Sara Araujo, Andreia Monteiro, Jose Eira, Jose Eduardo Pereira, Luis Maltez, Gilberto Igrejas, Teresa Semedo Lemsaddek, Patricia Poeta
Summary: Animal production involves the use of antimicrobial agents to promote growth and treat diseases, but it also leads to the emergence of antibiotic-resistant strains such as methicillin-resistant Staphylococcus aureus (MRSA). MRSA poses a significant threat to public health and animal welfare. Livestock-associated MRSA (LA-MRSA) was initially restricted to a specific clonal complex (CC398), but its diversity has increased over time, accompanied by multidrug resistance. This review summarizes the main clonal lineages of MRSA associated with different animals, including swine, cattle, rabbits, and poultry, and highlights the multidrug resistance patterns.
Review
Infectious Diseases
Joshua. B. Parsons, Annette. C. Westgeest, Brian. P. B. Conlon, Vance. G. Fowler
Summary: Methicillin-resistant Staphylococcus aureus (MRSA) is a deadly pathogen that can persist in the bloodstream for days despite appropriate antibiotics. Persistent MRSA bacteremia is common and associated with poor clinical outcomes. This review explores the factors related to host-pathogen interaction and discusses the clinical relevance of each element. Treatment options and diagnostic approaches for managing persistent MRSA bacteremia are also discussed.
Article
Public, Environmental & Occupational Health
Sara Quero, Marina Serras-Pujol, Noemi Parraga-Nino, Carmen Torres, Marian Navarro, Anna Vilamala, Emma Puigoriol, Javier Diez de los Rios, Elisenda Arque, Judit Serra-Pladevall, Alba Romero, Daniel Molina, Roger Paredes, Maria Luisa Pedro-Botet, Esteban Reynaga
Summary: This study investigated the prevalence of methicillin-susceptible S. aureus (MSSA) and methicillin-resistant S. aureus (MRSA) among workers in the pork production chain. The results showed that the prevalence of MRSA was high among workers in contact with live animals, especially in pig farms, livestock transporters, and slaughterhouses.
Article
Immunology
Zhaotao Li, Pavani Beesetty, George Gerges, Maureen Kleinhenz, Melissa Moore-Clingenpeel, Ching Yang, Luul B. Ahmed, Josey Hensley, Lisa Steele, Anita S. Chong, Christopher P. Montgomery
Summary: The study found that S. aureus-specific antibody levels and T-cell responses increase with age, indicating a coordinated development of anti-staphylococcal immunity. Young infected children had higher levels of certain antibodies compared to healthy children, but these differences disappeared with age. Both global and S. aureus-specific T-cell function were impaired in children with invasive and noninvasive infections.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Review
Multidisciplinary Sciences
Kirsten A. Berry, Mackenzie T. A. Verhoef, Allison C. Leonard, Georgina Cox
Summary: Staphylococcus aureus is a pathobiont capable of colonizing and infecting most tissues within the human body, relying on a complex and diverse arsenal of adhesins. Therapeutics targeting the S. aureus host-pathogen interaction remain understudied, and alternative approaches are crucial due to the increasing global threat of antimicrobial resistance. Developing antivirulence agents to neutralize virulence factors could reduce bacterial pathogenicity and the burden of S. aureus infections.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Mark Hutchins, Richard A. Bovill, Peter J. Stephens, John A. Brazier, Helen M. I. Osborn
Summary: The increasing number of antibiotic-resistant bacteria poses a serious threat to global human health. This study examines the glycosylation of nadifloxacin to improve its solubility and finds that one glycoside derivative has the potential to be an effective antibacterial agent.
Article
Microbiology
N. Effelsberg, M. Stegger, L. Peitzmann, O. Altinok, G. W. Coombs, B. Pichon, A. Kearns, P. R. Randad, C. D. Heaney, S. Bletz, F. Schaumburg, A. Mellmann
Summary: Staphylococcus aureus ST45 is a major global MRSA lineage with significant strain diversity and clinical impact. A study analyzing a large collection of 451 diverse ST45 isolates from 6 continents and 26 countries found two distinct sublineages correlated with geographical origins, with Bayesian analysis predicting an origin in northwestern Europe around 500 years ago. Multiple acquisitions of virulence factors were observed throughout the evolution of the ST45 lineage.
JOURNAL OF CLINICAL MICROBIOLOGY
(2021)
Article
Infectious Diseases
Emily M. Meredith, Lauren T. Harven, Andrew D. Berti
Summary: This study compared the effects of different mechanisms of tolerance induction on the effectiveness of antibiotics against Staphylococcus aureus. It was found that each mechanism of tolerance rendered at least one antibiotic ineffective, and each antibiotic was rendered ineffective by at least one mechanism of tolerance. Further research is needed to evaluate additional antibiotics, combination therapy, and different tolerance inducers.
Article
Infectious Diseases
Mingbiao Ma, Minjun Chu, Lvyan Tao, Jue Li, Xiaojuan Li, Hailin Huang, Kexuan Qu, Haiping Wang, Li Li, Tingyi Du
Summary: The study revealed a high detection rate of OS-MRSA in children's hospital, with the dominant molecular typing being ST59-SCCmec IV. The automated antimicrobial susceptibility test system has limited ability to identify OS-MRSA, therefore a combination of phenotypic analysis and molecular detection is recommended for better identification.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Biochemistry & Molecular Biology
Thibaut Barbier, Alexia Barbry, Jeremy Magand, Cedric Badiou, Floriane Davy, Anne Baudouin, Yves Queneau, Oana Dumitrescu, Gerard Lina, Laurent Soulere
Summary: In this study, new series of compounds were synthesized by combining the benzo[b]thiophene nucleus and the acylhydrazone functional group for screening against Staphylococcus aureus. Among the compounds tested, (E)-6-chloro-N'-(pyridin-2-ylmethylene)benzo[b]thiophene-2-carbohydrazide (II.b) showed promising antimicrobial activity with a minimal inhibitory concentration of 4 μg/mL against S. aureus strains, including clinically isolated strains resistant to methicillin and daptomycin.
Article
Multidisciplinary Sciences
Erin E. Zwack, Ze Chen, Joseph C. Devlin, Zhi Li, Xuhui Zheng, Ada Weinstock, Keenan A. Lacey, Edward A. Fisher, David Fenyo, Kelly V. Ruggles, P'ng Loke, Victor J. Torres
Summary: Infection with Staphylococcus aureus weakens the transcriptional response and downregulates genes related to innate immune response and cytokine signaling, leading to impaired neutrophil recruitment. This transcriptional suppression is conserved across different S. aureus clones and is absent in blood exposed to heat-killed S. aureus or infected with less virulent Staphylococcus epidermidis. The master regulator S. aureus exoprotein expression and its regulated pore-forming toxins are key mediators of this transcriptional suppression.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Medicine, General & Internal
Ahmed Alsolami, Naif Saad ALGhasab, Mohammed S. M. Alharbi, Abdelhafiz I. Bashir, Mohd Saleem, Azharuddin Sajid Syed Khaja, Dakheel F. Aldakheel, Ehab Rakha, Jabar Aziz Alshammari, Taha E. Taha, Ziyad Melibari, Yaseer H. Alharbi, Ali A. Almutlag, Kamaleldin B. Said
Summary: MRSA lineages are a significant clinical and public health issue, and there is limited data on local lineage profiles. This study reports on the frequency of community-acquired and hospital-acquired MRSA cases. The majority of the isolates were community-acquired MRSA, with variations in infection types between males and females.
Article
Microbiology
Alexandra E. Chittams-Miles, Areej Malik, Erin B. Purcell, Claudia Muratori, Brian Conlon
Summary: Treatment with short electric pulses can enhance the effects of multiple antibiotics against methicillin-resistant Staphylococcus aureus (MRSA). This combination therapy reduces the necessary antibiotic dosage and improves the efficacy of treating S. aureus infections such as skin and soft-tissue infections (SSTIs). SSTIs are accessible to physical intervention, making electric pulse co-treatment a potential option for wound and abscess debridement.
MICROBIOLOGY SPECTRUM
(2023)
Article
Infectious Diseases
Kevin Simon, Wolfgang Pier, Alex Kruettgen, Hans-Peter Horz
Summary: The combination of Sb-1 phage and oxacillin showed enhanced antibacterial effects against most S. aureus isolates, with rare antagonism observed. This heterologous antimicrobial pair provides a robust approach for controlling MRSA.
