Article
Chemistry, Multidisciplinary
Jae-Hong Lee, Seong-Nyum Jeong
Summary: The study found an association between chronic periodontitis and acute respiratory infections, particularly with acute upper and lower respiratory infections.
APPLIED SCIENCES-BASEL
(2021)
Review
Virology
Manika Suryadevara, Joseph B. Domachowske
Summary: RSV infections in young children are a major global health concern, with seasonal patterns of activity playing a crucial role in guiding resource allocation for treatment and prevention strategies. Surveillance data from developed countries have been instrumental in advancing public health initiatives, while surveillance in tropical regions still needs improvement.
Article
Virology
Fu-Lu Chu, Chen Li, Li Chen, Bo Dong, Yang Qiu, Yiqing Liu
Summary: This study investigated the prevalence of viruses and risk factors associated with pediatric intensive care unit (PICU) admission among patients hospitalized for acute lower respiratory tract infections (ALRI). The results showed that human rhinovirus (HRV) had the highest detection rate, the viral infection rate was highest in winter, and respiratory syncytial virus (RSV) infection and comorbidities were associated with the need for PICU admission.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Public, Environmental & Occupational Health
Rodrigo C. Menezes, Isabella B. B. Ferreira, Luciana Sobral, Stefania L. Garcia, Hugo N. Pustilnik, Mariana Araujo-Pereira, Bruno B. Andrade
Summary: This study aimed to identify the clinical features associated with viral pathogens responsible for severe lower respiratory tract infections (LRTI) in children. The study found that different viral agents have distinct associations with clinical features in children.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2024)
Article
Medicine, Research & Experimental
Yinghan Chan, Sin Wi Ng, Sachin Kumar Singh, Monica Gulati, Gaurav Gupta, Sushil Kumar Chaudhary, Goh Bey Hing, Trudi Collet, Ronan MacLoughlin, Raimar Lobenberg, Brian G. Oliver, Dinesh Kumar Chellappan, Kamal Dua
Summary: Viral respiratory tract infections have a significant impact on global health and socio-economic growth, with vaccination being the primary method of prevention. However, traditional vaccines have limitations, prompting the need for novel vaccine delivery vehicles to enhance immune responses. This review explores how polymer-based nanoparticles can be integrated with vaccine development to effectively combat viral respiratory tract infections.
Article
Infectious Diseases
Kanako Otani, Mayuko Saito, Michiko Okamoto, Raita Tamaki, Mariko Saito-Obata, Taro Kamigaki, Irene C. Lirio, Edelwisa Segubre-Mercado, Veronica Tallo, Socorro Lupisan, Hitoshi Oshitani
Summary: This study analyzed data from a birth cohort in the Philippines and found that the incidence rates and severity of lower respiratory tract infection (LRTI) varied for different viruses and age groups. In particular, the incidence rate of influenza virus was low in infants aged 0-5 months.
BMC INFECTIOUS DISEASES
(2022)
Article
Virology
Taoyu Li, Heping Fang, Xiangyu Liu, Yu Deng, Na Zang, Jun Xie, Xiaohong Xie, Zhengxiu Luo, Jian Luo, Yulin Liu, Zhou Fu, Luo Ren, Enmei Liu
Summary: Respiratory syncytial virus (RSV) is a common cause of lower respiratory tract infections (LRTI). This retrospective study analyzed RSV seasonality from June 2009 to May 2019 in Chongqing, China. The study found that RSV epidemic season typically occurs from October to March with a small peak in June, and infants born 1-2 months before the epidemic season were more susceptible to RSV infection. Additionally, RSV-A dominant years had an earlier, longer, and more severe epidemic compared to RSV-B dominant years.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Medicine, General & Internal
Abdullah I. Almojali, Musab S. Alshareef, Othman F. Aljadoa, Fahad F. Alotaibi, Emad M. Masuadi, Tahir K. Hameed
Summary: The study aimed to determine the prevalence and risk factors of serious bacterial infections (SBIs) in infants 90 days and younger with a confirmed respiratory tract infection (RTI). Results showed no cases of invasive bacterial infections in infants with PCR-proven viral RTIs, but there was a risk of concurrent urinary tract infection (UTI). Neonates had a higher risk of UTIs compared to older infants.
SAUDI MEDICAL JOURNAL
(2022)
Review
Nutrition & Dietetics
Hai Yun Shi, Xi Zhu, Wei Lin Li, Joyce W. Y. Mak, Sunny H. Wong, Sheng Tao Zhu, Shui Long Guo, Francis K. L. Chan, Shu Tian Zhang, Siew C. Ng
Summary: Probiotics have shown to have a positive impact on the prevention and treatment of viral respiratory tract infections by modulating gut microbiota to enhance host immunity, decrease viral load, and alleviate symptoms. Further research is needed on next generation probiotics specific to different viral types for the prevention and treatment of emerging viral RTIs.
EUROPEAN JOURNAL OF NUTRITION
(2021)
Review
Immunology
Coen Govers, Philip C. Calder, Huub F. J. Savelkoul, Ruud Albers, R. J. Joost van Neerven
Summary: Respiratory infections, especially in vulnerable groups, place a heavy burden on the health care system. Nutrition plays a role in optimizing immune responsiveness and preventing infections. Micronutrients act as regulators of immune cells' molecular responses, while undernutrition and specific micronutrient deficiencies impair immune response and increase susceptibility to respiratory and gastrointestinal infections. Dietary components such as proteins, pre-, pro- and synbiotics, as well as animal- and plant-derived bioactive components, can support the immune system. Both innate and adaptive defense systems contribute to respiratory tract immunity, and this review aims to describe the effects of different dietary components on these immune responses.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Infectious Diseases
Andre Almeida, Matteo Boattini, Eirini Christaki, Torcato Moreira Marques, Ines Moreira, Lourenco Cruz, Valentina Tosatto, Diogo Antao, Gabriele Bianco, Marco Iannaccone, Cristina Costa, Georgios Tsiolakkis, Elina Khattab, Diamanto Kasapi, Ana Teresa Ferreira, Rossana Cavallo, Rita Corte-Real
Summary: The study found that Influenza A H1N1 was independently associated with a higher risk of death and IMV, while RSV was associated with older age and more comorbidities.
Article
Multidisciplinary Sciences
Rute Maria Pinto, Siddharth Bakshi, Spyros Lytras, Mohammad Khalid Zakaria, Simon Swingler, Julie C. Worrell, Vanessa Herder, Kerrie E. Hargrave, Margus Varjak, Natalia Cameron-Ruiz, Mila Collados Rodriguez, Mariana Varela, Arthur Wickenhagen, Colin Loney, Yanlong Pei, Joseph Hughes, Elise Valette, Matthew L. Turnbull, Wilhelm Furnon, Quan Gu, Lauren Orr, Aislynn Taggart, Ola Diebold, Chris Davis, Chris Boutell, Finn Grey, Edward Hutchinson, Paul Digard, Isabella Monne, Sarah K. Wootton, Megan K. L. MacLeod, Sam J. Wilson, Massimo Palmarini
Summary: The human protein BTN3A3 has been identified as a potent inhibitor of avian influenza viruses but not human influenza viruses. However, some avian influenza viruses can evade this inhibition. Therefore, the sensitivity or resistance to BTN3A3 should be considered in the risk assessment of zoonotic potential of avian influenza viruses.
Article
Immunology
Cheng-Chun Tai, Cheng-Hsien Tsai, Yu-Han Huang, Chia-Lin Lee, Hsin-Pai Chen, Yu-Jiun Chan
Summary: Respiratory viruses, particularly NIRVs, were frequently detected in adults hospitalized with RTIs, showing distinctive seasonal variations. A substantial number of RVs were identified in lower RT specimens or from patients admitted to ICU, highlighting their important role in causing severe respiratory infections.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2021)
Article
Cardiac & Cardiovascular Systems
Rotem Lapidot, Jeffrey Vietri, Melody Shaff, Ahuva Averin, Alex Lonshteyn, Derek Weycker, Matt Wasserman, Ray Farkouh, Stephen Pelton
Summary: This study found that hospitalized community-acquired pneumonia (CAP) in infancy increases the risk of subsequent chronic respiratory disorders, especially when CAP occurs closer to pre-school age (i.e., age 2-5 years). These findings support the hypothesis that inflammation persists beyond the acute stage of pneumonia and plays a role in the development of chronic respiratory sequelae.
RESPIRATORY MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Abate Bekele Belachew, Aino K. Rantala, Maritta S. Jaakkola, Timo T. Hugg, Jouni J. K. Jaakkola
Summary: Using data from a population-based prospective study, we found that individuals with asthma are more susceptible to respiratory tract infections (RTIs). This susceptibility is evident from childhood to young adulthood, with increased risks of both upper and lower RTIs. Women with asthma are at a particularly high risk.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Critical Care Medicine
Tessa M. Kole, Elise Vanden Berghe, Monica Kraft, Judith M. Vonk, Martijn C. Nawijn, Salman Siddiqui, Kai Sun, Leonardo M. Fabbri, Klaus F. Rabe, Kian Fan Chung, Gabriele Nicolini, Alberto Papi, Chris Brightling, Dave Singh, Thys van der Molen, Sven-Erik Dahlen, Alvar Agusti, Rosa Faner, Jadwiga A. Wedzicha, Gavin C. Donaldson, Ian M. Adcock, Lies Lahousse, Huib A. M. Kerstjens, Maarten van den Berge
Summary: This post-hoc analysis investigates the determinants, clinical implications, and outcome of persistent airflow limitation (PAL) in patients with asthma. The study reveals that PAL is not only present in severe asthma, but also in a considerable proportion of patients with milder disease. In patients with mild asthma, PAL is associated with eosinophilic inflammation and a higher risk of exacerbations, suggesting the need for increased treatment intensity.
LANCET RESPIRATORY MEDICINE
(2023)
Article
Oncology
Fabio Girardi, Veronica Di Carlo, Charles Stiller, Gemma Gatta, Ryan R. Woods, Otto Visser, Brigitte Lacour, Thomas C. Tucker, Michel P. Coleman, Claudia Allemani
Summary: This study provides comprehensive data on global trends in population-based survival for childhood brain tumors. The researchers used a revised version of the International Classification of Childhood Cancer and estimated survival rates for different histology groups. The findings have important implications for public health.
Article
Pediatrics
Marc-Andrea Heinzelmann, Claudia E. Kuehni, Katharina Roser, Luzius Mader, Guido F. Laube
Summary: This study analyzed the health-related quality of life (HRQoL) of adults after pediatric kidney failure in Switzerland and identified socio-demographic and clinical factors associated with HRQoL. The findings showed that adults after pediatric kidney failure have lower physical HRQoL compared to the general population, but similar mental HRQoL. Lower education, unemployment, and being single were associated with lower HRQoL, while the type of kidney disease was also a significant factor.
PEDIATRIC NEPHROLOGY
(2023)
Article
Allergy
Carmen C. M. de Jong, Cristina Ardura-Garcia, Eva S. L. Pedersen, Maria Christina Mallet, Dominik Mueller-Suter, Anja Jochmann, Florian Singer, Carmen A. Casaulta, Nicolas Regamey, Alexander Moeller, Myrofora Goutaki, Claudia E. Kuehni
Summary: This study investigated the diagnostic labels and features used by pediatric pulmonologists to describe obstructive airway disease in children and aimed to reach consensus for standardized reporting. The results showed great heterogeneity and proposed recommendations to simplify communication among physicians and improve research quality based on electronic health records.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Article
Oncology
Isabelle M. Dudley, Ceren Sunguc, Emma J. Heymer, David L. Winter, Jop C. Teepen, Fabien N. Belle, Edit Bardi, Francesca Bagnasco, Thorgerdur Gudmundsdottir, Roderick Skinner, Gisela Michel, Julianne Byrne, Hilde Ofstaas, Momcilo Jankovic, Maja Cesen Mazic, Luzius Mader, Jaqueline Loonen, Stanislaw Garwicz, Thomas Wiebe, Daniela Alessi, Rodrigue S. Allodji, Nadia Haddy, Desiree Grabow, Peter Kaatsch, Melanie Kaiser, Milena M. Maule, Zsuzsanna Jakab, Maria Winther Gunnes, Monica Terenziani, Lorna Zadravec Zaletel, Claudia E. Kuehni, Riccardo Haupt, Florent de Vathaire, Leontien C. Kremer, Paivi M. Lahteenmaki, Jeanette F. Winther, Lars Hjorth, Michael M. Hawkins, Raoul C. Reulen
Summary: This study found that survivors of Hodgkin lymphoma (HL) are at an increased risk of developing non-Hodgkin lymphoma (NHL) after treatment. The researchers also identified other types of childhood cancer survivors who are at risk of developing NHL, including survivors of Wilms tumor, leukemia, and bone sarcoma. Treatment with chemotherapy increased the risk of NHL, while treatment with radiotherapy did not.
Article
Respiratory System
Nicole Beydon, Panayiotis Kouis, June K. Marthin, Philipp Latzin, Murielle Colas, Stephanie D. Davis, Eric Haarman, Amanda Lea Harris, Claire Hogg, Emma Kilbride, Claudia E. Kuehni, Diana Marangu, Kim G. Nielsen, Catherine Pendergrast, Phil Robinson, Nisreen Rumman, Matthew Rutter, Woolf T. Walker, Thomas Ferkol, Jane S. Lucas
Summary: Nasal nitric oxide (nNO) is an essential diagnostic marker for primary ciliary dyskinesia (PCD), but there is a lack of guidelines for measuring nNO in pre-school-age children. A European Respiratory Society Task Force has developed this technical standard to standardize the sampling, analysis, and reporting of nNO for PCD diagnosis in all age groups, including pre-schoolers. The task force considers both chemiluminescence and electrochemical analyzers and proposes future research priorities for improving the reliability of nNO measurement in young children.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Editorial Material
Respiratory System
Eva S. L. Pedersen, Claudia E. Kuehni
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Oncology
Raoul C. Reulen, David L. Winter, Ibrahim Diallo, Cristina Veres, Damien Llanas, Rodrigue S. Allodji, Francesca Bagnasco, Edit Bardi, Elizabeth A. M. Feijen, Daniela Alessi, Miranda M. Fidler-Benaoudia, Stine Hogsholt, Jop C. Teepen, Helena Linge, Nadia Haddy, Julianne Byrne, Ghazi Debiche, Desiree Grabow, Thorgerdur Gudmundsdottir, Romain Fauchery, Wael Zrafi, Gisela Michel, Hilde ofstaas, Peter Kaatsch, Giao Vu-Bezin, Helen Jenkinson, Melanie Kaiser, Roderick Skinner, Trevor Cole, Nicolas Waespe, Grit Sommer, Susanne Nordenfelt, Momcilo Jankovic, Tuomas Lahteenmaki Taalas, Milena M. Maule, Helena J. H. van der Pal, Cecile M. Ronckers, Flora E. van Leeuwen, Judith L. Kok, Monica Terenziani, Maria Winther Gunnes, Thomas Wiebe, Carlotta Sacerdote, Zsuzsanna Jakab, Riccardo Haupt, Paivi M. Lahteenmaki, Lorna Zadravec Zaletel, Claudia E. Kuehni, Jeanette Falck Winther, Leontien C. M. Kremer, Lars Hjorth, Florent de Vathaire, Michael M. Hawkins
Summary: Radiation and exposure to alkylating agents increase the risk of bone cancer among survivors of childhood cancer. This study demonstrates, for the first time, that the risk of bone cancer is increased 5-10 fold after exposure of bone tissue to cumulative radiation doses of 1-9 Gy. Alkylating agents exceeding 10,000 mg/m(2), particularly procarbazine, ifosfamide, and cyclophosphamide, increase the risk 7-8 fold. These findings should be used to develop/update clinical follow-up guidelines and survivorship care plans.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Pediatrics
Guido F. Laube, Marc-Andrea Heinzelmann, Katharina E. Roser, Claudia E. Kuehni, Luzius Mader
Summary: Little is known about the long-term social and professional outcomes in adults after pediatric kidney replacement therapy (KRT). In this study, adults who had kidney failure during childhood experienced adverse social and professional outcomes compared to the general population. Healthcare professionals should be more aware of this and provide additional psycho-social support to mitigate these risks.
PEDIATRIC NEPHROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yuehan Wang, Cecile M. Ronckers, Flora E. van Leeuwen, Chaya S. Moskowitz, Wendy Leisenring, Gregory T. Armstrong, Florent de Vathaire, Melissa M. Hudson, Claudia E. Kuehni, Michael A. Arnold, Charlotte Demoor-Goldschmidt, Daniel M. Green, Tara O. Henderson, Rebecca M. Howell, Matthew J. Ehrhardt, Joseph P. Neglia, Kevin C. Oeffinger, Helena J. H. van der Pal, Leslie L. Robison, Michael Schaapveld, Lucie M. Turcotte, Nicolas Waespe, Nadia Haddy, Ibrahima Diallo, K. Scott Baker, Amy Berrington de Gonzalez, Miriam R. Conces, Louis S. Constine, Mike Hawkins, Jacqueline J. Loonen, Marloes Louwerens, Geert O. Janssens, Lene Mellemkjaer, Raoul Reulen, Jeanette F. Winther, Leontien C. M. Kremer, Jop C. Teepen
Summary: In this study, the association between anthracycline-based chemotherapy and subsequent breast cancer risk in female childhood cancer survivors was investigated. The findings suggest that there is a dose-dependent increased risk of subsequent breast cancer associated with doxorubicin, with a more than twofold increased risk for survivors treated with a cumulative doxorubicin dose of 200 mg/m² or higher. Early initiation of breast cancer surveillance may be reasonable for these survivors.
Article
Pediatrics
Rahel Kasteler, Maria Otth, Florian S. Halbeisen, Luzius Mader, Florian Singer, Jochen Roessler, Nicolas X. von der Weid, Marc Ansari, Claudia E. Kuehni
Summary: Childhood cancer survivors exposed to lung-toxic treatments are at risk for pulmonary morbidity. This study investigated the lung function trajectories in these survivors over time and the association with lung-toxic treatments. The results showed that reduced pulmonary function was frequent but mainly of mild to moderate severity, and survivors treated with thoracic surgery had lower lung function compared to those without surgery.
PEDIATRIC PULMONOLOGY
(2023)
Article
Oncology
Angela Lopez-Cortes, Fabio Didone, Laura Botta, Lisa L. Hjalgrim, Zsuzsanna Jakab, Adela Canete Nieto, Charles Stiller, Bernward Zeller, Gemma Gatta, Kathy Pritchard-Jones
Summary: The BENCHISTA project aims to understand the variation in stage at diagnosis of childhood cancers across geographical regions and promote the use of Toronto Staging Guidelines by cancer registries. This project has established a large collaboration between registries and clinicians to collect and standardize data, enhancing the understanding of survival rate differences and improving child health plans.
FRONTIERS IN ONCOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Eva S. L. Pedersen, Leonie D. Schreck, Myrofora Goutaki, Sara Bellu, Fiona Copeland, Jane S. Lucas, Marcel Zwahlen, Claudia E. Kuehni, COVID PCD Patient Advisory Grp
Summary: This study investigates the incidence and severity of SARS-CoV-2 in people with primary ciliary dyskinesia (PCD) and identifies risk factors for infection. The results show that PCD patients do not have a higher incidence of SARS-CoV-2 infections or a higher risk of severe COVID-19 disease compared to the general population.
INTERNATIONAL JOURNAL OF PUBLIC HEALTH
(2023)
Article
Medicine, General & Internal
Maria Christina Mallet, Rebeca Mozun, Eva S. L. Pedersen, Cristina Ardura-Garcia, Erol A. Gaillard, Philipp Latzin, Alexander Moeller, Claudia E. Kuehni
Summary: Two population-based studies show that the prevalence estimates of cough in children vary depending on the questions asked, and there is only partial overlap between the responses to different questions. The prevalence of cough is also influenced by age, sex, presence of wheeze, and parental education.
SWISS MEDICAL WEEKLY
(2023)
Letter
Pediatrics
Marc-Alexander Oestreich, Robin Hanni, Florian Wyler, Anne-Christianne Kentgens, Sophie Yammine, Dominik Obrist, Philipp Latzin, Kathryn A. Ramsey
PEDIATRIC PULMONOLOGY
(2023)