Article
Oncology
Jiacheng Bi, Chen Huang, Xiaomeng Jin, Chaoyue Zheng, Yingying Huang, Xiaohu Zheng, Zhigang Tian, Haoyu Sun
Summary: By analyzing single-cell transcriptomics and using gene reporter mice, this study found that TIPE2 expression correlated with NK cell exhaustion in the tumor microenvironment (TME) in both humans and mice. Deletion of TIPE2 improved the antitumor activity of adoptively transferred mouse NK cells and human NK cells, either derived from peripheral blood or induced pluripotent stem cells (iPSCs). Additionally, TIPE2 deletion synergized with CISH deletion to further enhance antitumor activity in vivo.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Review
Oncology
Sainiteesh Maddineni, John L. Silberstein, John B. Sunwoo
Summary: This article reviews multiple approaches for allogeneic NK cell therapy and discusses the advantages and disadvantages of each method. In recent years, NK cells have become increasingly important players in the immune response against cancer.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Alvaro Haroun-Izquierdo, Marianna Vincenti, Herman Netskar, Hanna van Ooijen, Bin Zhang, Laura Bendzick, Minoru Kanaya, Pouria Momayyezi, Shuo Li, Merete Thune Wiiger, Hanna Julie Hoel, Silje Zandstra Krokeide, Veronika Kremer, Geir Tjonnfjord, Stephanie Berggren, Kristina Wikstroem, Pontus Blomberg, Evren Alici, Martin Felices, Bjoern oenfelt, Petter Hoeglund, Bahram Valamehr, Hans-Gustaf Ljunggren, Andreas Bjoerklund, Quirin Hammer, Lise Kveberg, Frank Cichocki, Jeffrey S. Miller, Karl-Johan Malmberg, Ebba Sohlberg
Summary: This study demonstrates the feasibility of off-the-shelf therapy with a non-engineered, yet highly specific, NK cell population for hematological malignancies. The expanded adaptive NK cells retained high cytotoxicity and efficiently killed leukemia cells from AML patients.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Ilias Christodoulou, Won Jin Ho, Andrew Marple, Jonas W. Ravich, Ada Tam, Ruyan Rahnama, Adam Fearnow, Cambrynne Rietberg, Sean Yanik, Elena E. Solomou, Ravi Varadhan, Michael A. Koldobskiy, Challice L. Bonifant
Summary: The study demonstrates that engineering NK cells to express CARs and IL-15 can enhance their anti-AML activity. However, this modification also comes with potential systemic toxicities.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Biochemistry & Molecular Biology
Naomi C. Bosch, Lena-Marie Martin, Caroline J. Voskens, Carola Berking, Barbara Seliger, Gerold Schuler, Niels Schaft, Jan Doerrie
Summary: NK cells play a crucial role in tumor cell rejection, and activating NK cells along with other immune cells can lead to a more comprehensive cellular response. Dendritic cells are capable of enhancing immune responses by activating NK cells and producing IL-12, while IL-15 serves as an important NK cell activator as well.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Alireza Shokouhifar, Gholamreza Anani Sarab, Mahboubeh Yazdanifar, Mohammad Fereidouni, Masoumeh Nouri, Marzieh Ebrahimi
Summary: NK cells differentiated from umbilical cord blood hematopoietic stem cells through manipulation of signaling pathways showed enhanced cytotoxicity against cancer cells, suggesting their potential application in cancer immunotherapy.
CANCER CELL INTERNATIONAL
(2021)
Article
Immunology
Samantha A. Barnes, Katherine M. Audsley, Hannah V. Newnes, Sonia Fernandez, Emma de Jong, Jason Waithman, Bree Foley
Summary: The study found that IFN alpha 14 and IFN beta are superior activators of NK cell effector function in vitro. It was also shown that NK cells pre-activated with IFN alpha 14 significantly prolonged survival in a preclinical model of leukaemia. These results suggest that further investigation into using IFN alpha 14 to modulate NK cells against leukaemia is promising.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Soo-Hyeon Lee, Yu-Jin Lim, Cheol-Jung Kim, Dohyeon Yu, Je-Jung Lee, Jeong Won Hong, Yeon-Ju Baek, Ji-Youn Jung, Dong-Jun Shin, Sang-Ki Kim
Summary: The study demonstrated that recombinant canine IL-15 (rcIL-15) injections in dogs promoted the selective proliferation and activation of anti-cancer effector cells without serious side effects, indicating the potential value of rcIL-15 in enhancing immunity against cancer in dogs.
Article
Oncology
Congcong Zhang, Jasmin Roeder, Anne Scherer, Malena Bodden, Jordi Pfeifer Serrahima, Anita Bhatti, Anja Waldmann, Nina Mueller, Pranav Oberoi, Winfried S. Wels
Summary: The study developed a bispecific antibody NKAB-ErbB2 that redirects NKG2D-expressing effector cells to ErbB2-positive tumor cells, synergizing with NKG2D-CAR cells and natural NK cell-mediated cytotoxicity. In mouse model, NKAR-NK-92 cells combined with NKAB-ErbB2 effectively suppressed tumor outgrowth and induced antitumor immunity and cures in most animals.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Stefanie Renken, Takahiro Nakajima, Isabelle Magalhaes, Jonas Mattsson, Andreas Lundqvist, Elias S. J. Arner, Rolf Kiessling, Stina Linnea Wickstrom
Summary: Auranofin can significantly reduce intracellular ROS accumulation in human cytotoxic lymphocytes ex vivo, preserving their antitumoral activity and increasing resistance to oxidative stress.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Chemistry, Multidisciplinary
Min Li, Di Xie, Xinfeng Tang, Chen Yang, Yanqiong Shen, Han Zhou, Wuxian Deng, Jiwei Liu, Shanbao Cai, Li Bai, Yucai Wang
Summary: The study demonstrates that the use of photothermal therapy can enhance the antitumor ability of adoptively transferred NKT cells, leading to excellent growth inhibition of local tumors and efficient rejection of distant tumors. It also triggers long-term immunological memory to prevent tumor recurrence, showing promising potential for cancer immunotherapy.
Review
Medicine, Research & Experimental
Gheorghita Isvoranu, Mihaela Surcel, Adriana Narcisa Munteanu, Ovidiu Gabriel Bratu, Florentina Ionita-Radu, Monica Teodora Neagu, Marioara Chiritoiu-Butnaru
Summary: IL-15 is a promising candidate for cancer immunotherapy, as it enhances antitumor responses by promoting the activation of T cells, B cells, and NK cells.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Medicine, Research & Experimental
Tatsiana V. Shman, Katsiaryna P. Vashkevich, Alexandr A. Migas, Mikhail A. Matveyenka, Yauheni A. Lasiukov, Nastassia S. Mukhametshyna, Katsiaryna I. Horbach, Olga V. Aleinikova
Summary: In this study, we characterized the expansion, phenotype, and functional activity of NK cells obtained for a clinical trial. We found that ex vivo expansion of NK cells resulted in a relatively undifferentiated phenotype and enhanced cytolytic activity against cancer cells.
CLINICAL AND EXPERIMENTAL MEDICINE
(2022)
Article
Oncology
Baoguo Xie, Leisheng Zhang, Jianhua Gao, Ti'er Wang, Min Liu, Xiaoming Feng, Xianghong Xu, Shixun Ma, Hui Cai, Tiankang Guo, Weibin Huang, Xiaoyan Tu, Shuling Wang, Hongju Yang, Yihu Fang, Feifei Li, Cunrong Chen
Summary: This study compared NK cells from different sources and found differences in cell numbers and gene expression. Furthermore, both UC and BM-derived NK cells exhibited effective tumor killing capacity, providing new insights for future cancer immunotherapy.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Article
Oncology
Hans Raskov, Adile Orhan, Ali Salanti, Shruti Gaggar, Ismail Gogenur
Summary: NK cells play a crucial role in cancer treatment by recognizing and killing transformed cells, potentially improving treatment outcomes. Current research focuses on the development of immunotherapeutic approaches, including immune checkpoint inhibitors and adoptive cell transfer using T cells with chimeric antigen receptors to enhance immune function.
Article
Immunology
Chun-Hao Lu, Chun-Ming Chen, Jason Ma, Cheng-Jang Wu, Li-Chen Chen, Ming-Ling Kuo
INTERNATIONAL IMMUNOPHARMACOLOGY
(2020)
Article
Toxicology
Yu-Wen Chen, Mei-Zi Huang, Chyi-Liang Chen, Chieh-Ying Kuo, Chia-Yu Yang, Chuan Chiang-Ni, Yi-Ywan M. Chen, Chia-Ming Hsieh, Hui-Yu Wu, Ming-Ling Kuo, Cheng-Hsun Chiu, Chih-Ho Lai
PARTICLE AND FIBRE TOXICOLOGY
(2020)
Article
Oncology
Jeng-Chang Chen, Liang-Shiou Ou, Ming-Ling Kuo, Li-Yun Tseng, Hsueh-Ling Chang
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2020)
Article
Biochemistry & Molecular Biology
Jeng-Chang Chen, Liang-Shiou Ou, Ming-Ling Kuo, Li-Yun Tseng, Hsueh-Ling Chang, Shiang-Chi Chen, Cheng-Hsun Chiu
Summary: Fetal exposure to microbial antigens or adoptive transfer of microbial antigen-loaded fetal macrophages can provide antigen-specific adaptive immunity, but protective immunity against lethal Salmonella challenge is only granted to those exposed to heat-killed Salmonella antigens.
Article
Allergy
Li-Chen Chen, Hsu-Min Tseng, Ming-Ling Kuo, Chih-Yung Chiu, Sui-Ling Liao, Kuan-Wen Su, Ming-Han Tsai, Man-Chin Hua, Shen-Hao Lai, Tsung-Chieh Yao, Kuo-Wei Yeh, Ai-Hsuan Wu, Hsiu-Yueh Yu, Jing-Long Huang, Shau-Ku Huang
Summary: The study found that exhaled 15-HETE can distinguish childhood asthma, while significantly increased levels of 15-HETE and decreased levels of TXB2 at convalescence play a significant role in monitoring therapeutic outcomes.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Jason Ma, Ming-Xun Liu, Li-Chen Chen, Jiann-Jong Shen, Ming-Ling Kuo
Summary: Ding Chuan Tang (DCT), a traditional Chinese herbal decoction, has the potential to alleviate asthma symptoms by regulating Th2 cells. Experimental findings demonstrate that DCT can reduce airway hyperresponsiveness and eosinophil accumulation while decreasing mucus production.
BIOMED RESEARCH INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Jeng-Chang Chen, Cheng-Chi Chan, Nai-Chun Ting, Ming-Ling Kuo
Summary: The study found that neonatal exposure to allergens can trigger asthma-related immune responses and exacerbate asthma symptoms in adulthood. Gender differences play a significant role in asthma development, with females being more susceptible to asthma-related stimuli.
Article
Biochemistry & Molecular Biology
Yung-An Huang, Jeng-Chang Chen, Chih-Ching Wu, Chia-Wei Hsu, Albert Min-Shan Ko, Li-Chen Chen, Ming-Ling Kuo
Summary: The study demonstrated that applying rAAV-CD39 to asthmatic mice can reduce lung eATP levels and alleviate asthma symptoms, including decreased airway hyperresponsiveness, eosinophilia, mucin deposition, and IL-5/IL-13 production. Additionally, the treatment led to reduced IL-5/IL-13 production and increased frequency of CD4(+)FoxP3(+) regulatory T cells in draining lymph nodes, indicating potential therapeutic benefits of rAAV-CD39 for asthma.
Article
Environmental Sciences
Ju Chang-Chien, Jing-Long Huang, Hui-Ju Tsai, Shih-Ling Wang, Ming-Ling Kuo, Tsung-Chieh Yao
Summary: Exposure to PM resulted in decreased cell viability, increased cellular uptake, shortening of telomere length, induction of G0/G1 phase arrest, and increased expression of senescence hallmarks in A549 cells. PM exposure induced upregulation of p21 and downregulation of PCNA and hTERT expression, leading to telomere shortening and the onset of cellular senescence in human lung epithelial cells. Overall, PM exposure may downregulate hTERT and PCNA through p53-independent induction of p21 expression.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Multidisciplinary Sciences
Chien-Ya Hsu, Yu-Shan Chueh, Ming-Ling Kuo, Pei-Tzu Lee, Hsiu-Shan Hsiao, Jing-Long Huang, Syh-Jae Lin
Summary: The research demonstrated numeric and functional deficiency of iNKT cells and their response to IL-15 in SLE patients differs from healthy controls, suggesting potential implications for adoptive iNKT cell therapy in autoimmune diseases.
Review
Immunology
Yi-Ru Lai, Yu-Fang Chang, Jason Ma, Cheng-Hsun Chiu, Ming-Ling Kuo, Chih-Ho Lai
Summary: Recent studies have shown that bacteria producing CDT target host DNA, potentially contributing to cancer development. Understanding the mechanisms of genotoxins causing DNA damage may help identify potential markers that drive cancer progression and discover new therapeutic strategies to prevent diseases caused by pathogens.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Li-Jie Hsu, Chao-Lin Liu, Ming-Ling Kuo, Chia-Ning Shen, Chia-Rui Shen
Summary: Cell therapy involves using cells selected, manipulated, and treated outside the body to treat or prevent human disease. iPSCs are ideal cell sources due to their unique characteristics. NK cells are effective tumor killers without causing GVHD, making them excellent candidates for cell therapy.
Article
Integrative & Complementary Medicine
Nai-Chun Ting, Yu-Hao Chen, Jeng-Chang Chen, Wen-Chung Huang, Chian-Jiun Liou, Li-Chen Chen, Sien-Hung Yang, Ming-Ling Kuo
Summary: The study found that Perilla fruit water extract can reduce lung inflammation and neutrophil infiltration, potentially through the MAPK/JNK-AP-1/c-Fos pathway.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Pei-Chuan Chiang, Jeng-Chang Chen, Li-Chen Chen, Ming-Ling Kuo
Summary: High levels of allergen exposure can increase the prevalence of asthma in developed countries. Traditional treatments for asthma cannot fully control the disease, so the development of novel approaches is still important. Based on the balance between Th1 and Th2 immune responses, enhancing Th1 response has the potential to alleviate Th2 response. In this study, researchers overexpressed single chain IL-12 through a viral vector and observed its efficacy in a mouse model of asthma. The results showed that the overexpression of IL-12 significantly suppressed cell infiltration, mucus secretion, and reduced specific IgE levels. It also modulated the expression of relevant genes.
HUMAN GENE THERAPY
(2022)
Article
Oncology
Matarr Khan, Yung-An Huang, Chieh-Ying Kuo, Tong Lin, Chun-Hao Lu, Li-Chen Chen, Ming-Ling Kuo
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2020)
