期刊
PEDIATRIC HEMATOLOGY AND ONCOLOGY
卷 26, 期 3, 页码 119-128出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/08880010902772208
关键词
children; graft-versus-host disease; haploidentical hematopoietic stem cell transplantation; leukemia
资金
- Beijing Medical Development Grants [2007-2033, 2006-2042]
In this report, the authors describe a protocol for haploidentical bone marrow transplantation in children who received G-CSF-mobilized bone marrow grafts without T-cell depletion from HLA-mismatched parents. Forty-two of 45 patients achieved complete donor hematopoietic engraftment; the medium time for neutrophil and platelet recovery was 17 and 19 days, respectively. Three died of early transplantation-associated complications; other causes of death included relapse (11 cases), fungal pneumonia (5), and acute graft-versus-host disease (2). The total disease-free survival rate longer than 2 years was 53.3%. These data suggest that haploidentical hematopoietic transplantation is an alterative strategy for children who lack immediate access to HLA-matched sources.
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