期刊
PEDIATRIC HEMATOLOGY AND ONCOLOGY
卷 25, 期 6, 页码 528-540出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/08880010802237054
关键词
Burkitt; immunohistochemistry; lymphoma; pediatric; protein tyrosine phosphatase
资金
- American Cancer Society
- Swedish Childrens Cancer Foundation
- Alfred Osterlund Foundation
- Magnus Bergvall Foundation
- Medical Faculty of Lund
- Svenska Lakaresallskapet
- Siv-Inger
- Per-Erik Andersson Foundation
- Berta Kamprad Foundation
- Cancer Foundation at Malmo University Hospital
- Ellen Bachrach's Children's Cancer Foundation of Haematology
Although many pediatric B-cell lymphoma patients are being cured today, much is still unknown about the pathogenesis of this disease. Protein tyrosine phosphatases are involved in the control of survival, growth, and differentiation of cells. The authors have analyzed 26 pediatric B-cell lymphoma cases for the expression of a panel of phosphatases and report a statistically significant lower expression intensity of PTEN and HePTP and higher nuclear SHP2 expression in B-cell lymphoma cases compared to lymphoid tissue. Knowledge about the expression of key regulatory proteins in pediatric B-cell lymphomas is necessary for revealing the complex molecular background of this disease.
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