Article
Biochemistry & Molecular Biology
Jeremy R. B. Newman, Patrick Concannon, Yan Ge
Summary: UBASH3A is a negative regulator of T cell activation and IL-2 production and its relationship with other T1D risk factors is largely unknown. This study reveals a physical interaction between UBASH3A and PTPN22 in T cells, independent of a T1D risk coding variant in PTPN22. Additionally, UBASH3A and PTPN22 transcripts cooperatively affect IL2 expression in human primary CD8(+) T cells, and two independent T1D risk variants in UBASH3A and PTPN22 have a statistical interaction, jointly influencing T1D risk.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Bum Chul Kwon, Peter Achenbach, Vibha Anand, Brigitte I. Frohnert, William Hagopian, Jianying Hu, Eileen Koski, Ake Lernmark, Olivia Lou, Frank Martin, Kenney Ng, Jorma Toppari, Riitta Veijola
Summary: Analyzing the levels of autoantibodies can better differentiate children who progress to type 1 diabetes from those who do not.
Review
Endocrinology & Metabolism
Michelle So, Cate Speake, Andrea K. Steck, Markus Lundgren, Peter G. Colman, Jerry P. Palmer, Kevan C. Herold, Carla J. Greenbaum
Summary: Islet autoantibodies are key markers for diagnosing type 1 diabetes and identifying at-risk individuals pre-symptomatically. Prediction of disease progression based on autoantibody count has been shown to be effective, but heterogeneous. Characteristics such as molecular specifics and sequence-dependent risk profiles have emerged as predictive features. Studying these features can improve trial design aimed at predicting and preventing disease.
Article
Immunology
Sulafa Elhassan, Fran Dong, Teresa Buckner, Randi K. Johnson, Jennifer A. Seifert, Patrick M. Carry, Lauren Vanderlinden, Kathleen Waugh, Marian Rewers, Jill M. Norris
Summary: Studies have shown that iron intake may be associated with the risk of developing type 1 diabetes. This study found that individuals with high iron intake had a lower risk of developing type 1 diabetes compared to those with moderate iron intake.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Medicine, General & Internal
Ake Lernmark, Beena Akolkar, William Hagopian, Jeffrey Krischer, Richard McIndoe, Marian Rewers, Jorma Toppari, Kendra Vehik, Anette-G. Ziegler, TEDDY Study Grp
Summary: The etiology of type 1 diabetes involves pancreatic islet beta-cell autoimmune pathogenesis that leads to the clinical onset of the disease. By testing autoantibodies against insulin, glutamic acid decarboxylase, islet antigen-2, and ZnT8 transporter, children can be monitored from birth until the appearance of the first islet autoantibody. The incidence rate of the first-appearing autoantibody follows two different patterns, and an innate immune reaction may precede the adaptive response.
JOURNAL OF INTERNAL MEDICINE
(2023)
Review
Medicine, General & Internal
Anna-Maria Lampousi, Sofia Carlsson, Josefin E. Lofvenborg
Summary: Breastfeeding and late introduction of gluten, fruit, and cow's milk may reduce the risk of T1D, while high childhood intake of cow's milk may increase it.
Article
Endocrinology & Metabolism
Randi K. Johnson, Roy Tamura, Nicole Frank, Ulla Uusitalo, Jimin Yang, Sari Niinisto, Carin Andren Aronsson, Anette-G. Ziegler, William Hagopian, Marian Rewers, Jorma Toppari, Beena Akolkar, Jeffrey Krischer, Suvi M. Virtanen, Jill M. Norris
Summary: The study found that maternal food consumption during late pregnancy was not significantly associated with offspring risk for IA or type 1 diabetes.
Review
Nutrition & Dietetics
Valdemar Brimnes Ingemann Johansen, Knud Josefsen, Julie Christine Antvorskov
Summary: This study systematically reviewed the association between maternal dietary factors during gestation and the risk of developing type 1 diabetes and/or islet autoimmunity (IA) in offspring. The most investigated dietary factors were gluten, dietary advanced glycosylated end products (dAGEs), vitamin D, fatty acids, and iron. The results showed that prenatal exposure to a gluten-free environment and certain fatty acids and vitamin D had protective effects against IA development, while in utero exposure to iron and fat correlated with increased risks of IA.
Review
Biochemistry & Molecular Biology
Eiji Kawasaki
Summary: Anti-islet autoantibodies are crucial markers for immune-mediated type 1 diabetes (T1D) and slowly progressive T1D (SPIDDM) or latent autoimmune diabetes in adults (LADA). They are used for diagnosis, pathological analysis, and prediction of T1D. Different autoantibodies serve different purposes, such as reflecting insulitis or pancreatic & beta-cell destruction. Combinatorial analysis of these autoantibodies helps diagnose immune-mediated T1D, while a lack of autoantibodies is associated with fulminant T1D. Evaluating the epitopes and subclasses of these autoantibodies aids in distinguishing diabetes-associated from non-diabetes-associated autoantibodies and predicting future insulin deficiency. New advancements in autoantibody assays can improve the accuracy of diagnosis and prediction of autoimmune disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Anita M. Nucci, Suvi M. Virtanen, David Cuthbertson, Johnny Ludvigsson, Ulle Einberg, Celine Huot, Luis Castano, Baerbel Aschemeier, Dorothy J. Becker, Mikael Knip, Jeffrey P. Krischer
Summary: In children at genetic risk of type 1 diabetes, being overweight at 2-10 years of age is associated with an increased risk of progression from multiple IA to type 1 diabetes and with the development of type 1 diabetes, but not with the development of IA. Future studies should assess the impact of weight management strategies on these outcomes.
Article
Endocrinology & Metabolism
Fabio Russo, Antonio Citro, Giorgia Squeri, Francesca Sanvito, Paolo Monti, Silvia Gregori, Maria Grazia Roncarolo, Andrea Annoni
Summary: The study demonstrated that a combination therapy using a lentiviral vector and a suboptimal dose of anti-CD3 monoclonal antibody could effectively control autoimmune diabetes and prevent recurrence of autoimmunity post-islet transplantation in NOD mice. Optimized therapeutic conditioning before alloislet transplantation resulted in normoglycemia and reduced insulitis in diabetic NOD mice, showing a potential for resolving autoimmune diabetes in the presence of residual endogenous beta-cell mass.
Review
Immunology
Susanna Esposito, Elena Mariotti Zani, Lisa Torelli, Sara Scavone, Maddalena Petraroli, Viviana Patianna, Barbara Predieri, Lorenzo Iughetti, Nicola Principi
Summary: Type 1 diabetes is the most common pediatric endocrine disease with an increased infection risk and lower immune response to vaccines; further research is needed to establish the most effective and safe vaccine use in this population.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Endocrinology & Metabolism
Kenney Ng, Harry Stavropoulos, Vibha Anand, Riitta Veijola, Jorma Toppari, Marlena Maziarz, Markus Lundgren, Kathy Waugh, Brigitte Frohnert, Frank Martin, William Hagopian, Peter Achenbach
Summary: This study defined islet autoantibody type-specific titer thresholds that significantly improved type 1 diabetes risk stratification in children.
Review
Multidisciplinary Sciences
Anneliese J. S. Flatt, Carla J. Greenbaum, James A. M. Shaw, Michael R. Rickels
Summary: Type 1 diabetes is characterized by loss and dysfunction of pancreatic islet beta cells, leading to insulin deficiency and hyperglycemia. Assessment of beta cell secretory capacity can detect the loss of beta cells during a presymptomatic phase of autoimmune attack. Islet transplantation can restore physiologic reserve capacity for insulin secretion.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2021)
Review
Endocrinology & Metabolism
Peter J. Thompson, Jasmine Pipella, Guy A. Rutter, Herbert Y. Gaisano, Pere Santamaria
Summary: Type 1 diabetes occurs when the body's immune system mistakenly attacks and destroys pancreatic beta cells. This review highlights recent advances in understanding how early life exposures and stress response pathways impact beta cells and contribute to the autoimmune process in type 1 diabetes. Progress in this area holds promise for developing targeted therapies that could be implemented in the early stages of the disease, potentially in combination with immunotherapies.
Article
Endocrinology & Metabolism
Christine von Toerne, Michael Laimighofer, Peter Achenbach, Andreas Beyerlein, Tonia de las Heras Gala, Jan Krumsiek, Fabian J. Theis, Anette G. Ziegler, Stefanie M. Hauck
Article
Endocrinology & Metabolism
Ezio Bonifacio, Chantal Mathieu, Gerald T. Nepom, Anette-G. Ziegler, Henry Anhalt, Michael J. Haller, Leonard C. Harrison, Matthias Hebrok, Jake A. Kushner, Jill M. Norris, Mark Peakman, Alvin C. Powers, John A. Todd, Mark A. Atkinson
Review
Endocrinology & Metabolism
Christina Yassouridis, Friedrich Leisch, Christiane Winkler, Anette-Gabriele Ziegler, Andreas Beyerlein
PEDIATRIC DIABETES
(2017)
Article
Endocrinology & Metabolism
Katharina Warncke, Ramona Lickert, Stephanie Eitel, Karl-Philipp Gloning, Ezio Bonifacio, Eva-Maria Sedlmeier, Petra Becker, Jan Knoop, Andreas Beyerlein, Anette-Gabriele Ziegler
HORMONE AND METABOLIC RESEARCH
(2017)
Article
Immunology
Andreas Beyerlein, Andreas N. Strobl, Christiane Winkler, Michaela Carpus, Annette Knopff, Ewan Donnachie, Donna P. Ankerst, Anette-G. Ziegler
Article
Nutrition & Dietetics
Stefanie Schoen, Sibille Jergens, Janett Barbaresko, Ute Noethlings, Mathilde Kersting, Thomas Remer, Marta Stelmach-Mardas, Anette-G. Ziegler, Sandra Hummel
Article
Multidisciplinary Sciences
Yannick F. Fuchs, Anne Eugster, Sevina Dietz, Christian Sebelefsky, Denise Kuehn, Carmen Wilhelm, Annett Lindner, Anita Gavrisan, Jan Knoop, Andreas Dahl, Anette-G. Ziegler, Ezio Bonifacio
SCIENTIFIC REPORTS
(2017)
Letter
Pediatrics
Andreas Beyerlein, Fabienne Wehweck, Anette-Gabriele Ziegler, Maren Pflueger
Article
Endocrinology & Metabolism
Meike Koehler, Andreas Beyerlein, Kendra Vehik, Sonja Greven, Nikolaus Umlauf, Ake Lernmark, William A. Hagopian, Marian Rewers, Jin-Xiong She, Jorma Toppari, Beena Akolkar, Jeffrey P. Krischer, Ezio Bonifacio, Anette-G. Ziegler
ACTA DIABETOLOGICA
(2017)
Article
Endocrinology & Metabolism
Maria Lonnrot, Kristian F. Lynch, Helena Elding Larsson, Ake Lernmark, Marian J. Rewers, Carina Torn, Brant R. Burkhardt, Thomas Briese, William A. Hagopian, Jin-Xiong She, Olli G. Simell, Jorma Toppari, Anette-G. Ziegler, Beena Akolkar, Jeffrey P. Krischer, Heikki Hyoty
Article
Cell Biology
Stefanie Kaelin, Maike Becker, Verena B. Ott, Isabelle Serr, Fabian Hosp, Mohammad M. H. Mollah, Susanne Keipert, Daniel Lamp, Francoise Rohner-Jeanrenaud, Victoria K. Flynn, Martin G. Scherm, Lucas F. R. Nascimento, Katharina Gerlach, Vanessa Popp, Sarah Dietzen, Tobias Bopp, Purna Krishnamurthy, Mark H. Kaplan, Manuel Serrano, Stephen C. Woods, Philipp Tripal, Ralf Palmisano, Martin Jastroch, Matthias Blueher, Christian Wolfrum, Benno Weigmann, Anette-Gabriele Ziegler, Matthias Mann, Matthias H. Tschoep, Carolin Daniel
Article
Endocrinology & Metabolism
Jeffrey P. Krischer, Kristian F. Lynch, Ake Lernmark, William A. Hagopian, Marian J. Rewers, Jin-Xiong She, Jorma Toppari, Anette-G. Ziegler, Beena Akolkar
Article
Pediatrics
Markus Lundgren, Leigh Johnson Steed, Roy Tamura, Berglind Jonsdottir, Patricia Gesualdo, Claire Crouch, Maija Sjoberg, Gertie Hansson, William A. Hagopian, Anette G. Ziegler, Marian J. Rewers, Ake Lernmark, Jorma Toppari, Jin-Xiong She, Beena Akolkar, Jeffrey P. Krischer, Michael J. Haller, Helena Elding Larsson
Article
Gastroenterology & Hepatology
Kaisa M. Kemppainen, Kristian F. Lynch, Edwin Liu, Maria Lonnrot, Ville Simell, Thomas Briese, Sibylle Koletzko, William Hagopian, Marian Rewers, Jin-Xiong She, Olli Simell, Jorma Toppari, Anette-G. Ziegler, Beena Akolkar, Jeffrey P. Krischer, Ake Lernmark, Heikki Hyoty, Eric W. Triplett, Daniel Agardh
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2017)
Article
Endocrinology & Metabolism
Sandra Hummel, Andreas Beyerlein, Roy Tamura, Ulla Uusitalo, Carin Andren Aronsson, Jimin Yang, Anne Riikonen, Ake Lernmark, Marian J. Rewers, William A. Hagopian, Jin-Xiong She, Olli G. Simell, Jorma Toppari, Anette-G. Ziegler, Beena Akolkar, Jeffrey P. Krischer, Suvi M. Virtanen, Jill M. Norris