Article
Gastroenterology & Hepatology
Kimberly P. Newton, Laura A. Wilson, Nancy A. Crimmins, Mark H. Fishbein, Jean P. Molleston, Stavra A. Xanthakos, Cynthia Behling, Jeffrey B. Schwimmer
Summary: The study aimed to determine the incidence of type 2 diabetes (T2D) in children with nonalcoholic fatty liver disease (NAFLD) and identify associated risk factors. The results showed a high incidence rate of T2D in children with NAFLD, and being female, having a higher BMI z-score, and more severe liver histology were independent risk factors for T2D development.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Nutrition & Dietetics
Christine B. Christiansen, Per B. Jeppesen, Kjeld Hermansen, Soren Gregersen
Summary: This study compared the effects of fermented or non-fermented aronia pulp with placebo in subjects with T2DM. The results showed that aronia extracts had no significant impact except for a higher increase in GIP levels after FAE supplementation.
Review
Medicine, Research & Experimental
Simeon I. Taylor, Zhinous Shahidzadeh Yazdi, Amber L. Beitelshees
Summary: Diabetes mellitus is a significant public health issue, with pharmacotherapy aiming to prevent complications. Clinical trials have shown that intensive glycemic control can slow the progression of complications, with some drugs also demonstrating cardiovascular benefits and slowed progression of diabetic kidney disease.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Environmental Sciences
Zhaoyang Li, Tengfei Long, Ruixin Wang, Yue Feng, Hua Hu, Yali Xu, Yue Wei, Fei Wang, Huan Guo, Xiaomin Zhang, Meian He
Summary: Limited evidence suggests a link between plasma levels of multiple metals and incident cancer risk in patients with type 2 diabetes mellitus. Copper and lead were significantly associated with increased cancer risk, while zinc and chromium were associated with decreased cancer risk. Monitoring metal levels in diabetic patients is crucial for cancer prevention.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Review
Medicine, General & Internal
Ehtasham Ahmad, Soo Lim, Roberta Lamptey, David R. Webb, Melanie J. Davies
Summary: Type 2 diabetes accounts for nearly 90% of global diabetes cases, with an increasing number of affected individuals, particularly among young people. Early detection and proactive management are crucial for preventing complications and reducing mortality. Technology and precision medicine offer potential improvements to treatment outcomes but face significant barriers.
Article
Endocrinology & Metabolism
Laura M. Jacobsen, Kendra Vehik, Riitta Veijola, Katharina Warncke, Jorma Toppari, Andrea K. Steck, Patricia Gesualdo, Beena Akolkar, Markus Lundgren, William A. Hagopian, Jin-Xiong She, Marian Rewers, Anette-G Ziegler, Jeffrey P. Krischer, Helena Elding Larsson, Michael J. Haller
Summary: The TEDDY study examines age-specific differences associated with type 1 diabetes. Younger children with type 1 diabetes tend to have fewer autoantibodies and more symptoms at diagnosis. The incidence of DKA at onset in TEDDY is rare, especially among individuals with a family history of the disease.
Review
Endocrinology & Metabolism
Jie Liu, Xin Sun, Fu-Liang Zhang, Hang Jin, Xiu-Li Yan, Shuo Huang, Zhen-Ni Guo, Yi Yang
Summary: Type 2 diabetes (T2D) is a major global public health disease characterized by insulin resistance, insufficient pancreatic beta-cell mass, and chronic inflammation. Recent research has highlighted the critical role of extracellular vesicles (EVs) in the pathogenesis of T2D, which can be utilized for diagnosis and treatment.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Immunology
Amanda Rangert, Carin Oldin, Marie Golsater, Johnny Ludvigsson, Karin Akesson
Summary: The study found no association between rotavirus vaccination in children and the incidence or clinical manifestation of type 1 diabetes.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Silva A. Arslanian, Tamara Hannon, Philip Zeitler, Lily C. Chao, Claudia Boucher-Berry, Margarita Barrientos-Perez, Elise Bismuth, Sergio Dib, Jang Ik Cho, David Cox
Summary: In this 26-week trial, researchers found that once-weekly treatment with dulaglutide has significant efficacy in improving glycemic control among youths with type 2 diabetes.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Medicine, General & Internal
Silva A. Arslanian, Tamara Hannon, Philip Zeitler, Lily C. Chao, Claudia Boucher-Berry, Margarita Barrientos-Perez, Elise Bismuth, Sergio Dib, Jang Ik Cho, David Cox
Summary: The incidence of type 2 diabetes mellitus is increasing among youths. Treatment with dulaglutide at a once-weekly dose of 0.75 mg or 1.5 mg was superior to placebo in improving glycemic control through 26 weeks among youths with type 2 diabetes, without an effect on BMI.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Agnieszka Przezak, Weronika Bielka, Andrzej Pawlik
Summary: Hypertension and hyperglycemia often coexist and are strongly associated with diabetes and cardiovascular risk. It is crucial to find the missing link between the development of hypertension and diabetes, and to find drugs that can effectively treat both disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Kaitlyn M. Peper, Boyi Guo, D. Leann Long, George Howard, April P. Carson, Virginia J. Howard, Suzanne E. Judd, Neil A. Zakai, Andrea Cherrington, Mary Cushman, Timothy B. Plante
Summary: Black adults have a higher prevalence of type 2 diabetes and inflammatory markers, but the impact of inflammation on racial differences in diabetes is unclear. This study found that lower CRP levels are the main driver of excess burden of diabetes in Black adults.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Medicine, General & Internal
Brian H. Buck, Naveed Akhtar, Anas Alrohimi, Khurshid Khan, Ashfaq Shuaib
Summary: Stroke mimics account for a significant proportion of hospital admissions, and accurate diagnosis with multi-modal CT or MRI is essential to avoid unnecessary treatment and costs. Prompt resolution of symptoms can be achieved in neurological and medical mimics, while treatment of functional disorders may be challenging and incomplete.
ANNALS OF MEDICINE
(2021)
Article
Endocrinology & Metabolism
Lining Dong, Yanyun Hu, Lei Xu, Hui Zeng, Wenqi Shen, Patrick Esser, Helen Dawes, Fang Liu
Summary: It is believed that gait characteristics differ between diabetic neuropathic patients and non-diabetic individuals. However, the influence of abnormal foot sensation on gait during walking in type 2 diabetes is still unclear. In this study, gait features were compared among participants with normal glucose tolerance and diabetic individuals with or without peripheral neuropathy, in order to gain insight into the alterations of detailed gait parameters and identify important aspects in gait indexes affected by peripheral neuropathy in older type 2 diabetes patients.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Annika Vestergaard Kvist, Mohamad I. Nasser, Peter Vestergaard, Morten Frost, Andrea M. Burden
Summary: A study in Denmark from 1997 to 2017 found that the incidence rates of fractures were higher in patients with type 1 and type 2 diabetes compared to those without diabetes, except for foot fractures. The incidence of hip fractures decreased by 35.2%, 47.0%, and 23.4% in patients with type 1 diabetes, type 2 diabetes, and without diabetes, respectively, over the last 5 years. However, vertebral fractures increased by 14.8%, 18.5%, and 38.9% in the same groups. After age adjustment, patients with type 1 diabetes still had a higher risk of fractures compared to those without diabetes, while patients with type 2 diabetes had a risk similar to those without diabetes.
