Review
Biochemistry & Molecular Biology
Josephine Yu, Preeti Sharma, Christian M. Girgis, Jenny E. Gunton
Summary: The prevalence of type 1 diabetes is rising steadily and vitamin D may contribute to this increase. This systematic review examined studies on vitamin D and type 1 diabetes, finding strong associations between low vitamin D levels and type 1 diabetes. Animal studies and human trials also suggest that vitamin D treatment or supplementation can be beneficial in reducing the risk of type 1 diabetes. Maintaining optimal circulating 25-hydroxyvitamin D levels may help to prevent or delay the development of type 1 diabetes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Multidisciplinary Sciences
Colin M. Dayan, Rachel E. J. Besser, Richard A. Oram, William Hagopian, Manu Vatish, Owen Bendor-Samuel, Matthew D. Snape, John A. Todd
Summary: Recent studies have shown that monitoring pancreatic islet autoantibodies and genetic risk assessment can identify most children who will develop T1D, with immunotherapy and primary prevention methods showing success in delaying disease progression. By shifting focus towards early diagnosis and b cell preservation, a future without daily insulin injections for children with T1D is anticipated.
Article
Medicine, General & Internal
Teresa Quattrin, Lucy D. Mastrandrea, Lucy S. K. Walker
Summary: Type 1 diabetes is a chronic disease caused by autoimmune destruction of pancreatic beta cells, and individuals with this disease rely on insulin for survival. Despite advancements, the burden of this disease remains high. Research shows that blocking the immune attack on beta cells holds promise in preserving endogenous insulin production.
Article
Genetics & Heredity
Watip Tangjittipokin, Pichakorn Umjai, Khwanhatai Khemaprasit, Parichat Charoentawornpanich, Chutima Chanprasert, Nipaporn Teerawattanapong, Tassanee Narkdontri, Jeerunda Santiprabhob
Summary: The study aimed to investigate genetic polymorphisms of vitamin D-related genes in children with T1D and their association with vitamin D and cytokine levels. Significant relationships were found between T1D and CYP2R1 polymorphism, as well as different VDR haplotypes between T1D patients and controls. Vitamin D gene-related variations were associated with vitamin D and circulating cytokine levels in children with T1D.
Article
Medicine, General & Internal
Despoina Manousaki, Adil Harroud, Ruth E. Mitchell, Stephanie Ross, Vince Forgetta, Nicholas J. Timpson, George Davey Smith, Constantin Polychronakos, J. Brent Richards
Summary: By applying a Mendelian randomization study design, researchers found no substantial impact of vitamin D levels on the risk of type 1 diabetes. The results suggest that previous epidemiological associations may be influenced by confounding factors, and do not support increasing vitamin D levels as a strategy to decrease the risk of type 1 diabetes.
Article
Pediatrics
Xiaofang Chen, Jia Fu, Ying Qian, Xiufang Zhi, Linjie Pu, Chunyu Gu, Jianbo Shu, Ling Lv, Chunquan Cai
Summary: Low vitamin D levels may be associated with susceptibility to type 1 diabetes, and genetic polymorphisms such as SNP may modulate the risk of the disease. This study found that Chinese children carrying the C allele of the CYP2R1 gene's rs1993116 SNP had a higher risk of developing T1D, and there was a significant interaction between rs1993116 and rs12794714 of CYP2R1.
FRONTIERS IN PEDIATRICS
(2022)
Article
Medicine, General & Internal
Quynh Thi Vu Huynh, Minh Thi Tuyet Trinh, Khang Kim Doan, Ban Tran Ho, Szu-Chuan Shen, Tung Huu Trinh, Thanh Hoa Vo, Nguyen Quoc Khanh Le, Ngan Thi Kim Nguyen
Summary: Asian children in Vietnam are being diagnosed with both type 1 and type 2 diabetes, and the presence of islet autoantibodies makes the diagnosis more complicated. A study found that the prevalence of islet cell autoantibodies (ICAs) and glutamic acid decarboxylase 65 autoantibodies (GADAs) in children with type 1 diabetes was not significantly different from those with type 2 diabetes. Older children with type 1 diabetes were more likely to have ICAs or ICAs and GADAs, while a small proportion of young children had GADAs. However, a significant number of older children with type 2 diabetes were positive for GADAs, and all of them were classified as overweight or obese. The study suggests that further investigation is needed to find better biomarkers or an appropriate time to confirm diabetes type.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Vibha Anand, Ying Li, Bin Liu, Mohamed Ghalwash, Eileen Koski, Kenney Ng, Jessica L. Dunne, Josefine Jonsson, Christiane Winkler, Mikael Knip, Jorma Toppari, Jorma Ilonen, Michael B. Killian, Brigitte I. Frohnert, Markus Lundgren, Anette-Gabriele Ziegler, William Hagopian, Riitta Veijola, Marian Rewers
Summary: The study shows that the number of islet autoantibodies at seroconversion can reliably predict the 15-year risk of type 1 diabetes. In children with a single autoantibody, HLA-DR-DQ genotypes can further refine the risk of progression. Additionally, the age at which multiple autoantibodies develop can impact the rate of progression to diabetes.
Article
Endocrinology & Metabolism
Anna Parkkola, Maaret Turtinen, Taina Harkonen, Jorma Ilonen, Mikael Knip
Summary: Family history of type 2 diabetes may impact the phenotype and genotype of children with type 1 diabetes, as children with a positive family history for type 2 diabetes tend to have features associated with type 2 diabetes at the time of type 1 diabetes diagnosis.
Article
Endocrinology & Metabolism
Nicholas J. Thomas, Helen C. Walkey, Akaal Kaur, Shivani Misra, Nick S. Oliver, Kevin Colclough, Michael N. Weedon, Desmond G. Johnston, Andrew T. Hattersley, Kashyap A. Patel
Summary: By assessing the genetic risk of type 1 diabetes in autoantibody-negative and -positive individuals, the study found that autoantibody-negative adults with clinician-diagnosed type 1 diabetes had a lower genetic risk compared to autoantibody-positive adults but higher risk compared to type 2 diabetes. The presence of non-autoimmune diabetes was identified as the likely explanation for the lower rate of autoantibody positivity in adult-onset type 1 diabetes.
Article
Medicine, General & Internal
Tomi Suomi, Inna Starskaia, Ubaid Ullah Kalim, Omid Rasool, Maria K. Jaakkola, Toni Gronroos, Tommi Valikangas, Caroline Brorsson, Gianluca Mazzoni, Sylvaine Bruggraber, Lut Overbergh, David Dunger, Mark Peakman, Piotr Chmura, Seren Brunak, Anke M. Schulte, Chantal Mathieu, Mikael Knip, Riitta Lahesmaa, Laura L. Elo
Summary: This study aimed to identify transcriptional changes associated with disease progression in patients with recent-onset type 1 diabetes. They found that genes and pathways related to innate immunity were downregulated during the first year after diagnosis. Associations between gene expression changes and ZnT8A autoantibody positivity were also observed. Additionally, changes in the expression of 16 genes were found to predict the decline in C-peptide at 24 months, and increased B cell levels and decreased neutrophil levels were associated with rapid progression, consistent with previous reports.
Review
Nutrition & Dietetics
Liana Najjar, Joshua Sutherland, Ang Zhou, Elina Hyppoenen
Summary: A systematic review and meta-analysis were conducted to assess the association between selected variants affecting 25-hydroxyvitamin D concentrations and T1D risk, revealing no significant correlation. Despite some heterogeneity in one of the genetic variants analyzed, overall results did not show any association with T1D susceptibility. Additionally, subgroup analysis for Caucasians also found no association with T1D.
Article
Endocrinology & Metabolism
Sian Louise Grace, Jack Bowden, Helen C. Walkey, Akaal Kaur, Shivani Misra, Beverley M. Shields, Trevelyan J. McKinley, Nick S. Oliver, Timothy McDonald, Desmond G. Johnston, Angus G. Jones, Kashyap A. Patel
Summary: This study aimed to assess the association between glutamate decarboxylase (GADA), islet antigen-2 (IA-2A), and zinc transporter 8 (ZnT8A) autoantibody levels with clinical and genetic characteristics at diagnosis of type 1 diabetes (T1D).
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
R. David Leslie, Carmella Evans-Molina, Jacquelyn Freund-Brown, Raffaella Buzzetti, Dana Dabelea, Kathleen M. Gillespie, Robin Goland, Angus G. Jones, Mark Kacher, Lawrence S. Phillips, Olov Rolandsson, Jana L. Wardian, Jessica L. Dunne
Summary: Recent epidemiological data indicates that over half of new cases of type 1 diabetes occur in adults. Key genetic, immune, and metabolic differences are present between adult-onset and childhood-onset type 1 diabetes, many of which remain poorly understood.
Review
Immunology
S. Alice Long, Jane H. Buckner
Summary: This review examines the current understanding of the etiology of Type 1 diabetes (T1D), focusing on the role of immune cells in the progression of the disease. It also highlights how this knowledge is driving the development of immunotherapies for the prevention and treatment of T1D.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Marisa Stahl, Qian Li, Kristian Lynch, Sibylle Koletzko, Pooja Mehta, Loren Gragert, Jill M. Norris, Carin Andren Aronsson, Katri Lindfors, Kalle Kurppa, Jorma Ilonen, Jeffrey Krischer, Beena Alkolkar, Anette-G Ziegler, Jorma Toppari, Marian J. Rewers, Daniel Agardh, William Hagopian, Edwin Liu, TEDDY Study Grp
Summary: The study examines regional differences in celiac disease (CD) development among children in Europe and the United States. The incidence of CD varied by region, with Swedish children having the highest incidence at 3%. In the United States, the incidence was highest in Colorado at 2.4%.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Nutrition & Dietetics
Leena Hakola, Anna-Leena Vuorinen, Hanna-Mari Takkinen, Sari Niinisto, Suvi Ahonen, Jenna Rautanen, Essi J. Peltonen, Jaakko Nevalainen, Jorma Ilonen, Jorma Toppari, Riitta Veijola, Mikael Knip, Suvi M. Virtanen
Summary: This study aimed to investigate the associations between dietary intake of fatty acids in childhood and the risk of islet autoimmunity and type 1 diabetes (T1D). The results showed that higher intake of monounsaturated fatty acids, arachidonic acid, total n-3 fatty acids, and long-chain n-3 fatty acids was associated with a decreased risk of islet autoimmunity. Higher intake of total fat and saturated fatty acids was associated with a decreased risk of T1D only when energy adjusted.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Endocrinology & Metabolism
Mari-Anne Pulkkinen, Tero J. Varimo, Elina T. Hakonen, Minna H. Harsunen, Mervi E. Hyvonen, Joakim N. Janer, Sanne M. Kiiveri, Hanne M. Laakkonen, Saila M. Laakso, Karoliina Wehkalampi, Matti T. Hero, Paivi J. Miettinen, Anna-Kaisa Tuomaala
Summary: The safety and impact of the advanced hybrid closed-loop (AHCL) system on glycemic outcome in 2- to 6-year-old children with type 1 diabetes and the diabetes distress of caregivers were evaluated. The study found that after 12 weeks of using the AHCL system, glycemic control in children improved and diabetes distress in caregivers decreased.
DIABETES TECHNOLOGY & THERAPEUTICS
(2023)
Article
Endocrinology & Metabolism
Minna Harsunen, Jarno L. T. Kettunen, Taina Harkonen, Om Dwivedi, Mikko Lehtovirta, Paula Vahasalo, Riitta Veijola, Jorma Ilonen, Paivi J. Miettinen, Mikael Knip, Tiinamaija Tuomi
Summary: More than 10% of AAB-negative children with diabetes were found to have monogenic diabetes through genetic testing. Genetic diagnosis can lead to major changes in treatment, therefore, it is recommended to refer all AAB-negative pediatric diabetes patients for genetic testing.
Article
Multidisciplinary Sciences
Astrid Oras, Henna Kallionpa, Tomi Suomi, Satu Koskinen, Asta Laiho, Laura L. Elo, Mikael Knip, Riitta Lahesmaa, Alar Aints, Raivo Uibo
Summary: A study on the gene expression in B-cells from children developing CoD early in life revealed gene expression changes associated with CoD development, indicating the important role of B-cells in CoD development.
Article
Pediatrics
Mira Kallio, Anna Tornivuori, Paeivi Miettinen, Kaija-Leena Kolho, Evelyn Culnane, Susan Sawyer, Silja Kosola
Summary: This study examines disease control, psychiatric comorbidity, and substance use in adolescents with chronic medical conditions before transitioning to adult healthcare. Findings indicate that adolescents with concomitant psychiatric diagnoses experience poorer disease control and higher rates of hazardous substance use compared to those with only a medical condition.
BMJ PAEDIATRICS OPEN
(2023)
Article
Nutrition & Dietetics
Tuuli E. I. Salo, Sari Niinisto, Tuuli E. Korhonen, Helena Pastell, Heli Reinivuo, Hanna-Mari Takkinen, Jorma Ilonen, Jorma Toppari, Mikael Knip, Riitta Veijola, Suvi M. Virtanen
Summary: This study investigated the intake and sources of dietary fibre among Finnish children using new CODEX-compliant values. The intake of fibre was associated with age, sex, and breastfeeding status. Cereal products, fruits, and vegetables were identified as major sources of dietary fibre.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Endocrinology & Metabolism
Iiro Kostiainen, Susanna Majala, Jukka Schildt, Helka Parviainen, Saila Kauhanen, Hanna Seppanen, Paivi J. Miettinen, Niina Matikainen, Eeva M. Ryhanen, Camilla Schalin-Jantti
Summary: SSTR PET/CT demonstrates high accuracy in the detection of panNETs and alters the clinical management in nearly half of the MEN1-patients.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Immunology
Anna-Mari Schroderus, Josh Poorbaugh, Samantha McElyea, Stephanie Beasley, Lin Zhang, Kirsti Nanto-Salonen, Reeta Rintamaki, Jussi Pihlajamaki, Mikael Knip, Riitta Veijola, Jorma Toppari, Jorma Ilonen, Robert J. Benschop, Tuure Kinnunen
Summary: This study aimed to examine plasma IL-21 levels in individuals at different stages of type 1 diabetes progression. The results showed that adults with established type 1 diabetes had higher plasma IL-21 levels compared to healthy controls, but no significant correlation was found with clinical variables. In children, plasma IL-21 levels were almost ten times higher, but no significant differences were detected between different groups.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Microbiology
Joachim Johansen, Koji Atarashi, Yasumichi Arai, Nobuyoshi Hirose, Soren J. Sorensen, Tommi Vatanen, Mikael Knip, Kenya Honda, Ramnik J. Xavier, Simon Rasmussen, Damian R. Plichta
Summary: Distinct gut virome composition in centenarians, with higher diversity and lytic activity compared to younger and older individuals, suggests a potential role in healthy aging. Furthermore, phage-encoded sulfate metabolism genes in the centenarian gut microbiome may contribute to mucosal integrity and resistance to pathogens.
NATURE MICROBIOLOGY
(2023)
Article
Immunology
Sirpa Pahkuri, Ilse Ekman, Celine Vandamme, Kirsti Nanto-Salonen, Jorma Toppari, Riitta Veijola, Mikael Knip, Tuure Kinnunen, Jorma Ilonen, Johanna Lempainen
Summary: This study investigates the effect of four known SNP markers associated with T1D susceptibility on the methylation of their proximal promoters in three genes. The results show that one SNP in the INS gene is associated with methylation at multiple CpG sites in the promoter region. Another SNP is associated with methylation in the IL2RA gene in B cells. Additionally, there are significant differences in methylation levels between T1D patients and controls at certain CpG sites in specific gene and cell types.
Review
Immunology
Meghan A. Berryman, Jorma Ilonen, Eric W. Triplett, Johnny Ludvigsson
Summary: Human leukocyte antigen (HLA) genes are associated with a wide range of diseases, particularly autoimmune disorders. Despite differing causes, many autoimmune diseases share the same HLA genes. Studies have found a connection between gut microbial composition and autoimmune diseases, as autoimmune conditions are often associated with gut dysbiosis. Autoimmune-risk-associated HLA genes are connected to gut dysbiosis long before the onset of autoimmunity.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Endocrinology & Metabolism
Santosh Lamichhane, Partho Sen, Alex M. Dickens, Matilda Krakstrom, Jorma Ilonen, Johanna Lempainen, Heikki Hyoty, Riitta Lahesmaa, Riitta Veijola, Jorma Toppari, Tuulia Hyotylainen, Mikael Knip, Matej Oresic
Summary: Distinct metabolic patterns can differentiate rapid progressors (RP) from slow progressors (SP) in the development of type 1 diabetes. Metabolites mediated by gut microbiome play a key role in distinguishing RP from SP. Identification of specific metabolites and pathways may have implications for delaying the development of type 1 diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Mikael Knip, Anna Parviainen, Maaret Turtinen, Anna But, Taina Harkonen, Jussi Hepojoki, Tarja Sironen, Rommel Iheozor-Ejiofor, Hasan Ugurlu, Kalle Saksela, Johanna Lempainen, Jorma Ilonen, Olli Vapalahti
Summary: An observational cohort study in Finland found that the incidence of type 1 diabetes among children under 15 years old significantly increased during the COVID-19 pandemic. This increase may be attributed to the effects of lockdown and physical distancing, rather than a direct effect of SARS-CoV-2 infection.
LANCET DIABETES & ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
M. Karoliina Hirvonen, Niina Lietzen, Robert Moulder, Santosh D. Bhosale, Jaakko Koskenniemi, Mari Vaha-Makila, Mirja Nurmio, Matej Oresic, Jorma Ilonen, Jorma Toppari, Riitta Veijola, Heikki Hyoty, Harri Lahdesmaki, Mikael Knip, Lu Cheng, Riitta Lahesmaa
Summary: By analyzing samples from children with type 1 diabetes, researchers identified the relationship between protein levels and disease progression, which can improve prediction and monitoring of the disease.
SCIENTIFIC REPORTS
(2023)