期刊
PEDIATRIC DIABETES
卷 12, 期 2, 页码 95-99出版社
WILEY
DOI: 10.1111/j.1399-5448.2010.00668.x
关键词
autoantibodies; diabetes mellitus; epidemiology; food; type 1; pregnancy
资金
- Academy of Finland [63672, 79685, 79686, 80846, 201988, 210632]
- Finnish Diabetes Research Foundation
- Juho Vainio Foundation
- Yrjo Jahnsson Foundation
- European Foundation for the Study of Diabetes
- Medical Research Funds, Turku, Oulu
- Tampere University Hospitals
- Juvenile Diabetes Research Foundation [197032, 4-1998-274, 4-1999-731, 4-2001-435]
- Novo Nordisk Foundation
- EU [BMH4-CT98-3314]
- Academy of Finland (AKA) [210632, 210632] Funding Source: Academy of Finland (AKA)
Background: Evidence for a putative role of maternal diet during pregnancy in the development of beta-cell autoimmunity in the child is scarce. The authors study the association of food consumption during pregnancy and the development of beta-cell autoimmunity in the offspring. Subjects and methods: A prospective Finnish birth cohort of 4297 infants with human leukocyte antigen (HLA)-DQB1-conferred susceptibility to type 1 diabetes and their mothers. Blood samples were collected from the children at 3-12 months intervals to measure type 1 diabetes-associated antibodies: antibodies against islet cells (ICA), insulin, glutamate dehydroxylase, and islet antigen 2. The mothers completed a validated food frequency questionnaire. The end-point was repeated positivity for ICA together with at least one of the other three antibodies. Piecewise-exponential survival models were used. The effective sample size was 3723, with 138 end-points. The median follow-up time was 4.4 years. Results: Maternal consumption of butter, low-fat margarines, berries, and coffee were inversely associated with the development of advanced beta-cell autoimmunity in the offspring, adjusted for genetic risk group and familial diabetes. These associations for low-fat margarines (use vs. non-use HR 0.60, 95% CI: 0.38-0.93, p = 0.02), berries (continuous variable HR 0.90, 95% CI: 0.83-0.98, p = 0.02) and coffee (highest quarter vs. lowest HR 0.62, 95% CI: 0.40-0.97, p = 0.04), remained significant when adjusting for potential confounding sociodemographic, perinatal, and other dietary factors. Conclusions: In this study assessing total food consumption of the mother during pregnancy, only few among the 27 food groups tested were weakly related to the development of advanced beta-cell autoimmunity in Finnish children.
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