Article
Immunology
Sheila Lorente-Pozo, Paula Navarrete, Maria Jose Garzon, Inmaculada Lara-Canton, Jesus Beltran-Garcia, Rebeca Osca-Verdegal, Salvador Mena-Molla, Eva Garcia-Lopez, Maximo Vento, Federico Pallardo, Jose Luis Garcia-Gimenez
Summary: Neonatal sepsis is a systemic condition affecting preterm infants, with epigenetics potentially playing a role in impaired immune response. DNA methylation marks can serve as a biomarker for neonatal sepsis, aiding in diagnosis and differentiation between early and late onset sepsis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Georgia Anna Sofouli, Asimina Tsintoni, Sotirios Fouzas, Aggeliki Vervenioti, Despoina Gkentzi, Gabriel Dimitriou
Summary: This study assessed the value of clinical and laboratory parameters in predicting septicemia in the Neonatal Intensive Care Unit (NICU). The identified parameters were combined into a sepsis prediction score (SPS) that can assist in predicting septicemia in the NICU.
Article
Infectious Diseases
Marcello Mariani, Alessandro Parodi, Diego Minghetti, Luca A. Ramenghi, Candida Palmero, Elisabetta Ugolotti, Chiara Medici, Carolina Saffioti, Elio Castagnola
Summary: This study retrospectively analyzed the etiology and antibiotic resistance profiles of bacteria in blood or cerebrospinal fluid cultures to evaluate the appropriateness of initial empirical therapy for neonatal sepsis. The results showed that early onset sepsis (EOS) was mainly caused by Gram-positive bacteria, while late onset sepsis (LOS) was predominantly due to Coagulase Negative Staphylococci (CoNS).
Article
Medicine, General & Internal
Yi-Hsuan Tang, Mei-Jy Jeng, Hsin-Hui Wang, Pei-Chen Tsao, Wei-Yu Chen, Yu-Sheng Lee
Summary: Detecting and predicting bacteremic sepsis in preterm and term neonates is challenging. This study identified different risk factors and predictive markers for early-onset and late-onset neonatal sepsis. PCT and PLT count were accurate diagnostic serum markers for early-onset sepsis, while WBC count was useful for late-onset sepsis.
JOURNAL OF THE CHINESE MEDICAL ASSOCIATION
(2022)
Article
Infectious Diseases
Cecilia Herbozo, Irene Julca, Fiorella Flores, Roger Hernandez, Jaime Zegarra
Summary: This study aimed to determine the incidence of late onset sepsis and the most frequent causative microorganisms in the neonatal unit at Hospital Cayetano Heredia in Lima, Peru. The results showed that late onset sepsis was more prevalent in low birth weight infants, with gram-negative bacteria being the main causative microorganism in very low birth weight infants.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Review
Medicine, General & Internal
Steven Kwasi Korang, Sanam Safi, Chiara Nava, Gorm Greisen, Munish Gupta, Ulrik Lausten-Thomsen, Janus C. Jakobsen
Summary: The study summarized the effects of different antibiotic regimens for late-onset neonatal sepsis, and concluded that current evidence is insufficient to support the superiority of any regimen. More randomized controlled trials with low risk of bias are warranted.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Article
Immunology
Alyssa Varghese, Anne J. Blaschke, Ernest. Kent Korgenski, Hillary Crandall
Summary: In this study, the clinical and microbiologic features of 10 cases of early-onset sepsis caused by Haemophilus influenzae in newborns in Utah were presented.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2023)
Article
Immunology
Amadu E. Juliana, Natanael Holband, Neirude P. A. Lissone, Rens Zonneveld, Niels Evers, Frans B. Plotz, Niek B. Achten
Summary: This study aimed to describe the incidence and outcome of neonatal sepsis in a middle-income country in South America. The findings indicate comparable incidence and outcomes of early onset neonatal sepsis (EONS) to high-income settings, while late onset neonatal sepsis (LONS) is a more prevalent and significant challenge with a predominance of gram-negative bacteria and high mortality.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2022)
Article
Immunology
Natascha Koestlin-Gille, Christoph Haertel, Clara Haug, Wolfgang Goepel, Michael Zemlin, Andreas Mueller, Christian F. Poets, Egbert Herting, Christian Gille
Summary: A study in Germany analyzed data from 14,926 preterm infants with birth weight <1500 g and found the rates of early-onset sepsis to be 1.1% and late-onset sepsis to be 11.9%. Multidisciplinary approaches are needed to reduce the burden of sepsis in VLBW infants.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2021)
Article
Pediatrics
Daniel O'Reilly, Claire Anne Murphy, Carmel Maria Moore, Fionnuala Ni Ainle, Isobel Claire Gormley, Craig N. Morrell, Anna Curley, Naomi Mc Callion, Patricia Maguire
Summary: This study aims to prospectively identify late onset neonatal sepsis through platelet/endothelial associated plasma proteins. This is particularly important for preterm infants who are at high risk for sepsis.
PEDIATRIC RESEARCH
(2023)
Article
Pediatrics
Sagori Mukhopadhyay, Sara M. Briker, Dustin D. Flannery, Miren B. Dhudasia, Sarah A. Coggins, Emily Woodford, Eileen M. Walsh, Sherian Li, Karen M. Puopolo, Michael W. Kuzniewicz
Summary: Blood cultures from infants with late-onset bacteremia are usually positive within 36 hours, therefore empiric antibiotic therapy can be stopped at this time, except when dealing with coagulase-negative staphylococci with lower sensitivity.
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2022)
Article
Medicine, General & Internal
Deepshikha Rana, Himadri Hazarika, Aditi Agarwal, Richa Gupta, Mrinalini Kotru
Summary: This study finds that there is a significant correlation between neonatal sepsis and neutrophil to lymphocyte ratio (NLR). NLR is an important predictor for neonatal sepsis.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Infectious Diseases
Panpan Fang, Kaijie Gao, Junmei Yang, Tiewei Li, Weihua Gong, Qianqian Sun, Yingyuan Wang
Summary: This study retrospectively analyzed the epidemiology, antibiotic resistance profiles, and prevalence of multidrug-resistant (MDR) bacteria in neonatal sepsis. The results showed a high prevalence of MDR strains in neonatal sepsis, emphasizing the need for effective prevention and treatment measures.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Infectious Diseases
I Marr, K. Swe, A. Henderson, J. A. Lacey, G. P. Carter, J. K. Ferguson
Summary: The study evaluated the sensitivity of CoNS isolated in an Australian neonatal ICU to cefazolin, finding that CoNS had significantly lower MIC values for cefazolin compared to other antibiotics. Whole genome sequencing revealed the presence of isolates closely related to a global clone. The study suggests that CoNS may exhibit specificity for cefazolin.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Infectious Diseases
Nati Friedman, Sivan Yochpaz, Semyon Zirkin, Jacky Herzlich, Ronella Marom
Summary: The NEOSC has higher specificity than CRP in diagnosing neonatal EOS, enabling safe avoidance of multiple blood tests and antibiotics for suspected neonates who are not infected. Although there is a significant correlation between NEOSC risk and CRP values, the relationship is not strong.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2021)
Article
Pediatrics
Rebecca R. Seltzer, Simone Thompson
PEDIATRIC CLINICS OF NORTH AMERICA
(2024)
Article
Pediatrics
Kimberly E. Sawyer, Douglas J. Opel
PEDIATRIC CLINICS OF NORTH AMERICA
(2024)
Article
Pediatrics
Micah Hester, Skye A. Miner
Summary: The process of soliciting a minor's assent has moral importance, even if it is not always required by regulations. It allows the child's opinion to be heard and respects their development and involvement in research. The extent of the child's involvement depends on their age, experience, and maturity.
PEDIATRIC CLINICS OF NORTH AMERICA
(2024)
Article
Pediatrics
Nicholas A. Jabre, Margaret R. Moon
PEDIATRIC CLINICS OF NORTH AMERICA
(2024)
Article
Pediatrics
Carrie M. Henderson, Renee D. Boss
Summary: An increasing number of children with serious/complex illness are living with long-term prognostic uncertainty, intensive interactions with medical systems, functional limitations, and the use of chronic medical technologies that affect their quality of life. These families often face multiple medical decision points and rely on intentional and iterative discussions to guide their care goals.
PEDIATRIC CLINICS OF NORTH AMERICA
(2024)
Article
Pediatrics
Margaret R. Moon
PEDIATRIC CLINICS OF NORTH AMERICA
(2024)
Article
Pediatrics
Mark T. Hughes
PEDIATRIC CLINICS OF NORTH AMERICA
(2024)
