Article
Multidisciplinary Sciences
Nadine Scholten, Alicia Fitzgerald, Katja Matthias, Mi-Ran Okumu, Tim Ohnhaeuser, Katharina Schmitz, Christine Schreiner, Isabella Schwab, Anna Stirner, Ricarda Wullenkord, Till Dresbach, Andreas Mueller, Till Dresbach, Martin Hellmich, Nicole Ernstmann, Antje Hammer, Friederike Eyssel, Angela Kribs, Juliane Koeberlein-Neu, Katharina Lugani, Eva Mildenberger, Jens Ulrich Rueffer, Katja Matthias, Anne Sunder-Plassmann, Daniel Wiesen, Dirk Horenkamp-Sonntag, Melanie Klein
Summary: Mother's own milk is the optimal nutrition for newborns, especially preterm infants with very low birth weight. If unavailable, human donor milk is the preferred alternative. Providing structured breastfeeding and lactation support, as well as promoting the establishment of human donor milk banks, is crucial for mothers of preterm infants who often struggle with insufficient milk production.
Editorial Material
Pediatrics
Maryanne T. Perrin, Linda L. Friend, Paula M. Sisk
Summary: This study measured the sodium content of donor human milk and found that the unfortified milk had a relatively low sodium content. Additionally, only a small percentage of the samples fortified with bovine milk met the recommended sodium content. Therefore, preterm infants fed predominantly with donor human milk may require additional sodium.
JOURNAL OF PEDIATRICS
(2022)
Article
Pediatrics
Shetal Shah, Emily Miller, Allison Rose, Krystle Perez
Summary: Pasteurized donor human milk (PDHM) has been shown to reduce the incidence of necrotizing enterocolitis in very low birth weight infants. However, lack of Medicaid and private insurance coverage for PDHM use in neonatal intensive care units leads to disparities based on birth state and socioeconomic status. Through collaboration between local and national American Academy of Pediatrics (AAP) chapters, a PDHM Advocacy Toolkit was created to promote Medicaid coverage. Over 5 years, advocacy efforts led by neonatologists and incentivized by AAP funds resulted in 5 additional states providing Medicaid payment for PDHM, increasing the coverage to over 55% of nationally born very low birth weight infants. This case study provides a template for other pediatric specialists to advocate for niche-focused issues at the state level.
Article
Medicine, General & Internal
Myoung Kyoung Kim, Tae Yeon Jeon, Kyunga Kim, Yu Jin Kim, So-Young Yoo, Ji Hye Kim, Yun Sil Chang, Sanghoon Lee, Jeong-Meen Seo, Sung-Hoon Moon
Summary: This study investigated the clinical outcomes of ultrasound-detected perforated NEC without radiographic pneumoperitoneum in very preterm infants. The study found that very preterm infants with US-detected perforated NEC without radiographic pneumoperitoneum had a lower risk of death before discharge. This suggests that bowel ultrasounds may have a potential role in surgical decision-making for infants with advanced NEC.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Obstetrics & Gynecology
Katherine E. Chetta, Elizabeth V. Schulz, Carol L. Wagner
Summary: Human milk has significant effects on the gut microbiome, somatic growth, and neurocognitive outcomes. Continued research promises to improve donor human milk and donor milk derived products to achieve better outcomes for infants who do not receive their own mother's milk. The promotion of human milk is well-founded on evidence from the previous half century.
SEMINARS IN PERINATOLOGY
(2021)
Article
Cell Biology
Shreyas Kumbhare, William-Diehl Jones, Sharla Fast, Christine Bonner, Geert 't Jong, Gary Van Domselaar, Morag Graham, Michael Narvey, Meghan B. Azad
Summary: The type of milk fortifier (human versus bovine) does not affect the overall gut microbiota of preterm infants, but may influence the colonization of specific bacterial strains. The intake of mother's own milk is strongly associated with weight gain and the composition of gut microbiota. The impact of fortifier type and mother's milk intake on oxidative stress varies.
CELL REPORTS MEDICINE
(2022)
Article
Pediatrics
Katherine E. Chetta, Katherine G. Vincent, Bresney Fanning, Ashley B. Klumb, Justin A. Chetta, Allison M. Rohrer, Leslie H. Spence, Jeanne G. Hill
Summary: This study examined whether delayed receipt of antibiotics is associated with disease severity in infants with necrotizing enterocolitis (NEC). The timing of antibiotic administration in medical and surgical NEC cases was compared in a retrospective, single-center cohort study. Delayed antibiotic receipt was more common in surgical NEC cases, and every hour of delay increased the odds of surgical NEC. Further studies are warranted to investigate if optimizing antibiotic timing can improve intestinal outcomes.
Article
Pediatrics
Shan He, Gang Liu, Xueping Zhu
Summary: This study demonstrates the beneficial effects of human breast milk-derived exosomes in preventing necrotizing enterocolitis by reducing inflammation and injury, and restoring intestinal tight-junction proteins.
PEDIATRIC RESEARCH
(2021)
Article
Nutrition & Dietetics
Valeria Melendez Hebib, Diana H. Taft, Barbara Stoll, Jinxin Liu, Lee Call, Gregory Guthrie, Nick Jensen, Amy B. Hair, David A. Mills, Douglas G. Burrin
Summary: Necrotizing enterocolitis (NEC) is the leading cause of death caused by gastrointestinal disease in preterm infants. Major risk factors include prematurity, formula feeding, and gut microbial colonization. Probiotics have been shown to reduce NEC incidence in infants, but their effectiveness depends on the specific species used.
Article
Pediatrics
Ahreen Allana, Kahmun Lo, Myra Batool, Ivan Hand
Summary: The use of donor human milk in preterm, very-low-birth-weight infants reduces the rate of necrotizing enterocolitis and promotes earlier initiation of enteral feeding and faster return to birth weight.
Article
Gastroenterology & Hepatology
Johannes W. W. Duess, Maame E. E. Sampah, Carla M. M. Lopez, Koichi Tsuboi, Daniel J. J. Scheese, Chhinder P. P. Sodhi, David J. J. Hackam
Summary: Necrotizing enterocolitis (NEC) is a devastating disease in premature infants, caused by dietary and bacterial factors in a vulnerable host. Intestinal perforation can lead to severe infection and sepsis. Toll-like receptor 4 has been identified as a critical regulator of NEC development. This review article presents recent findings on microbial signaling, the immature immune system, intestinal ischemia, systemic inflammation, and potential therapeutic approaches.
Article
Food Science & Technology
Lingyu Fang, Meili Zhang, Lianqiang Wu, Ruiquan Wang, Bangbang Lin, Jianfeng Yao, Dongmei Chen
Summary: The study demonstrated that preterm donor milk does not impact the growth of very-low-birth-weight infants, but significantly reduces feeding intolerance, shortens hospitalization time, and provides protective effects against necrotizing enterocolitis and sepsis. This suggests that preterm donor milk may lower the rate of infection in preterm infants and is worth promoting.
FOOD & NUTRITION RESEARCH
(2021)
Review
Pediatrics
Rosemary Moak, Neal Boone, Natalie Eidson, Allison Rohrer, Mindy Engevik, Kelli Williams, Katherine Chetta
Summary: A broad range of allergic disorders and intolerance are associated with cow's milk protein in the infant diet. The incidence of cow's milk protein intolerance varies widely but is commonly recognized in healthy term infants. The severity of these adverse reactions can range from mild gastrointestinal symptoms to severe sepsis-like episodes.
FRONTIERS IN PEDIATRICS
(2023)
Article
Obstetrics & Gynecology
A. Brown, N. Shenker
Summary: Receiving donor human milk has a positive impact on the health and development of infants and the mental and physical health of parents. It also promotes family wellbeing. Some parents may face challenges, but receiving donor human milk helps motivate mothers to continue breastfeeding.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Nutrition & Dietetics
Lila S. Nolan, Angela N. Lewis, Qingqing Gong, James J. Sollome, Olivia N. DeWitt, Robert D. Williams, Misty Good
Summary: Metabolomics analysis of breast milk from mothers of preterm infants revealed significant differences in metabolites related to fatty acid metabolism, oligosaccharides, amino sugars, amino acids, vitamins, and oxidative stress between mothers of infants with different birth weights. Understanding these differences may provide insights into tailored nutrition and care for preterm newborns in the future.
Article
Pediatrics
Rebecca R. Seltzer, Simone Thompson
PEDIATRIC CLINICS OF NORTH AMERICA
(2024)
Article
Pediatrics
Kimberly E. Sawyer, Douglas J. Opel
PEDIATRIC CLINICS OF NORTH AMERICA
(2024)
Article
Pediatrics
Micah Hester, Skye A. Miner
Summary: The process of soliciting a minor's assent has moral importance, even if it is not always required by regulations. It allows the child's opinion to be heard and respects their development and involvement in research. The extent of the child's involvement depends on their age, experience, and maturity.
PEDIATRIC CLINICS OF NORTH AMERICA
(2024)
Article
Pediatrics
Nicholas A. Jabre, Margaret R. Moon
PEDIATRIC CLINICS OF NORTH AMERICA
(2024)
Article
Pediatrics
Carrie M. Henderson, Renee D. Boss
Summary: An increasing number of children with serious/complex illness are living with long-term prognostic uncertainty, intensive interactions with medical systems, functional limitations, and the use of chronic medical technologies that affect their quality of life. These families often face multiple medical decision points and rely on intentional and iterative discussions to guide their care goals.
PEDIATRIC CLINICS OF NORTH AMERICA
(2024)
Article
Pediatrics
Margaret R. Moon
PEDIATRIC CLINICS OF NORTH AMERICA
(2024)
Article
Pediatrics
Mark T. Hughes
PEDIATRIC CLINICS OF NORTH AMERICA
(2024)