Article
Cardiac & Cardiovascular Systems
Vinzenz Boos, Felix Berger, Mi-Young Cho, Joachim Photiadis, Christoph Buehrer, Constanze Pfitzer
Summary: This study aimed to investigate the morbidity, long-term mortality, and neurodevelopmental outcomes in very low birthweight infants who underwent cardiac surgery for severe congenital heart defect within 1 year after birth. The findings revealed that survival rates decreased with increasing STAT mortality category of the surgical procedure, and the type of cardiac malformation may affect early- and long-term outcomes.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Pediatrics
Serdar Basgoze, Bahar Temur, Zeynep Sila Ozcan, Ibrahim Gokce, Osman Guvenc, Selim Aydin, Fusun Guzelmeric, Aylin Altan Kus, Ersin Erek
Summary: This study aimed to analyze the neurodevelopmental outcomes in patients who received ECMO support after congenital heart surgery. The results showed that 60% of patients in the ECMO group had neurodevelopmental delay, compared to only 20% in the non-ECMO group. Therefore, it is recommended to screen for neurodevelopmental issues in all patients with congenital heart disease, especially those who received ECMO support.
FRONTIERS IN PEDIATRICS
(2023)
Review
Pediatrics
Charlotte E. Verrall, Shrujna Patel, Leksi Travitz, Jason Tchieu, Russel C. Dale, Nadine A. Kasparian, David S. Winlaw, Gillian M. Blue
Summary: Neurodevelopmental disability is a common comorbidity in children with congenital heart disease, associated with altered brain structure and growth. The causes and contributors to this paradigm are not fully understood, but likely involve patient factors, prenatal haemodynamic consequences, and factors affecting the fetal-placental-maternal environment. Understanding the biological and structural phenotypes associated with neurodevelopmental disability in congenital heart disease is important for developing effective intervention strategies.
TRANSLATIONAL PEDIATRICS
(2023)
Review
Pediatrics
Johanna Calderon, Jane W. Newburger, Caitlin K. Rollins
Summary: Children, adolescents, and adults living with Fontan circulation face various neurological and developmental challenges. They may experience difficulties in cognition, visual spatial reasoning, and psychosocial development, as well as being at high risk for mental health disorders. Hemodynamic risk factors during fetal development can influence brain growth and development, leading to abnormal outcomes. Other factors such as brain injuries and surgical procedures also play a detrimental role in neurodevelopmental prognosis. Therefore, prevention and intervention are crucial in optimizing long-term outcomes for this vulnerable population.
FRONTIERS IN PEDIATRICS
(2022)
Article
Neurosciences
Kaitlyn Easson, Guillaume Gilbert, Charles Rohlicek, Christine Saint-Martin, Maxime Descoteaux, Sean C. L. Deoni, Marie Brossard-Racine
Summary: This study compares and quantifies myelin content in the brains of youth born with congenital heart disease (CHD) and healthy controls. It finds that CHD patients have widespread deficits in myelination, which may be a consequence of early-life brain dysmaturation and potentially serve as a biomarker for neuropsychological function.
HUMAN BRAIN MAPPING
(2022)
Article
Cardiac & Cardiovascular Systems
Shabnam Peyvandi, Jessie Mei Lim, Davide Marini, Duan Xu, V. Mohan Reddy, A. James Barkovich, Steven Miller, Patrick McQuillen, Mike Seed
Summary: This study examined the relationship between delayed brain development in fetuses with certain heart conditions and their susceptibility to postnatal white matter injury. Lower total brain volume in late gestation was associated with increased risk of white matter injury in fetuses with d-transposition of the great arteries, but not in those with hypoplastic left heart syndrome. Rate of brain growth was not found to be a risk factor for white matter injury in either group, indicating different implications for postnatal risk of white matter injury.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Immunology
Sophia Finn Tiene, Jessica S. Cranston, Karin Nielsen-Saines, Tara Kerin, Trevon Fuller, Zilton Vasconcelos, Peter B. Marschik, Dajie Zhang, Marcos Pone, Sheila Pone, Andrea Zin, Elizabeth Brickley, Dulce Orofino, Patricia Brasil, Kristina Adachi, Ana Carolina C. da Costa, Maria Elisabeth Lopes Moreira
Summary: This study aimed to identify early predictors of poor neurodevelopment in infants with antenatal Zika virus exposure. The findings suggest that smaller head circumference and auditory abnormalities are associated with poor neurodevelopment in these infants. Language delay is the most prominent developmental concern.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Benjamin J. Landis, Lindsey R. Helvaty, Gabrielle C. Geddes, Jiuann-Huey Ivy Lin, Svetlana A. Yatsenko, Cecilia W. Lo, William L. Border, Stephanie Burns Wechsler, Chaya N. Murali, Mahshid S. Azamian, Seema R. Lalani, Robert B. Hinton, Vidu Garg, Kim L. McBride, Jennelle C. Hodge, Stephanie M. Ware
Summary: This study analyzes the association between abnormal chromosomal microarray analysis (CMA) and cardiac phenotypes in patients with congenital heart disease (CHD). The results show that some CHD cases are caused by genomic disorders, some are caused by copy number variants (CNVs), and some are caused by regions of homozygosity. The classification analysis reveals different types of CHD and identifies new CHD types. Different types of CNVs are associated with the complexity of CHD. CNVs containing specific genes are associated with specific phenotypes of CHD. In addition, single-gene CNVs are associated with neuronal-related pathways.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Virology
Morgan L. Sherer, Elise A. Lemanski, Rita T. Patel, Shannon R. Wheeler, Mark S. Parcells, Jaclyn M. Schwarz
Summary: In this study, a unique rat model of prenatal Zika virus infection was used to investigate potential long-term outcomes, revealing that offspring prenatally infected with ZIKV exhibited behavioral deficits and abnormal immune responses later in life. Despite the absence of detectable levels of ZIKV in the brain and serum, these consequences could have significant impacts on the health of the offspring.
Article
Obstetrics & Gynecology
Shannon L. Son, Lauren L. Hosek, Miranda C. Stein, Amanda A. Allshouse, Anna B. Catino, Arvind K. Hoskoppal, Daniel A. Cox, Kevin J. Whitehead, Ian M. Lindsay, Sean Esplin, Torri D. Metz
Summary: This retrospective longitudinal cohort study found an association between pregnancy and subsequent long-term adverse cardiovascular outcomes in individuals with congenital heart disease. These findings can provide important information for counseling and guidance of individuals with congenital heart disease who are considering pregnancy.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
John D. Cleveland, Michael E. Bowdish, Wendy J. Mack, Richard W. Kim, S. Ram Kumar, Kristopher Kallin, Cynthia S. Herrington, Winfield J. Wells, Vaughn A. Starnes
Summary: This study aimed to investigate the impact of education on surgical outcomes. Through data collection, multivariable logistic regression modeling, and propensity score matching, it was revealed that there were no differences in mortality, major morbidity, or length of stay between attending surgeons and resident surgeons when similar cases were compared.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Clinical Neurology
Yuting Liu, Mingwen Yang, Mingcui Fu, Siyu Ma, Meijiao Zhu, Shujie Wang, Shuting Cheng, Zhangzhi Feng, Ying Wang, Xuming Mo, Ming Yang
Summary: This study investigated microstructural changes in white matter and their relationship with neurodevelopmental outcomes in children with tetralogy of Fallot (ToF). The results showed that impaired white matter integrity was associated with worse language and working memory performance in ToF children.
PEDIATRIC NEUROLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Richard D. Mainwaring, L. Mac Felmly, R. Thomas Collins, Frank L. Hanley
Summary: This study retrospectively reviewed 69 patients with Alagille syndrome who underwent congenital heart surgery and found that liver dysfunction had a significant impact on their surgical survival.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Psychology, Clinical
Samantha D. Roberts, Vanna Kazazian, Meghan K. Ford, Davide Marini, Steven P. Miller, Vann Chau, Michael Seed, Linh G. Ly, Tricia S. Williams, Renee Sananes
Summary: This study highlights the importance of parent mental health and coping strategies on early child cognitive outcomes in children with congenital heart disease (CHD). Additionally, more severe types of CHD are associated with lower language scores.
CLINICAL NEUROPSYCHOLOGIST
(2021)
Article
Cardiac & Cardiovascular Systems
Yihan Lin, Taylor J. Davis, Andres Zorrilla-Vaca, Brandon M. Wojcik, Shelley D. Miyamoto, Melanie D. Everitt, David N. Campbell, James J. Jaggers, T. Konrad Rajab
Summary: The study reviewed the outcomes of neonatal heart transplants at Children's Hospital Colorado over nearly 30 years. It found an early survival rate of 95.2%, with 1- and 5-year survival rates of 85.7% and 75%, respectively. Long-term follow-up at 10 and 20 years showed survival rates of 72.2% and 50%.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Linda G. McWhorter, Jennifer Christofferson, Trent Neely, Aimee K. Hildenbrand, Melissa A. Alderfer, Amy Randall, Anne E. Kazak, Erica Sood
Summary: The study explored the relationships between parental post-traumatic stress symptoms, overprotective parenting, and child emotional/behavioral problems in families of children with critical CHD. It found that overprotective parenting fully mediated the association between parental post-traumatic stress symptoms and child emotional/behavioral problems. Both parental post-traumatic stress symptoms and overprotective parenting were identified as modifiable risk factors for poor child outcomes.
CARDIOLOGY IN THE YOUNG
(2022)
Article
Nursing
Melanie K. Franklin, Allison Karpyn, Jennifer Christofferson, Linda G. McWhorter, Abigail C. Demianczyk, Cheryl L. Brosig, Emily A. Jackson, Stacey Lihn, Sinai C. Zyblewski, Anne Kazak, Erica Sood
Summary: This study investigates the barriers and facilitators to discussing parent mental health within child health care for parents of children with CHD. Parents identified multiple barriers to communication, such as the perception that mental health support is beyond the scope of practice, fear of negative judgment, and the preference for compartmentalizing emotions. On the other hand, they also highlighted the importance of a supportive care team who normalizes the impact of the child's illness and creates a comfortable environment for discussions.
JOURNAL OF CHILD HEALTH CARE
(2023)
Article
Psychology, Developmental
Paul T. Enlow, Thao-Ly T. Phan, Amanda M. Lewis, Aimee K. Hildenbrand, Erica Sood, Kimberly S. Canter, Gaby Vega, Melissa A. Alderfer, Anne E. Kazak
Summary: The study found that CEFIS is a psychometrically sound measure of the impact of the COVID-19 pandemic on family and caregiver functioning, and may be useful in identifying families in need of psychological supports.
JOURNAL OF PEDIATRIC PSYCHOLOGY
(2022)
Review
Obstetrics & Gynecology
Theresa A. Tacy, Nadine A. Kasparian, Ruchika Karnik, Miwa Geiger, Erica Sood
Summary: Prenatal diagnosis of congenital heart disease can have a significant impact on expectant parents, leading to psychological distress and the need to make high-stakes medical decisions. Training for physicians in this area varies, and there is a need for improved guidance and support for both parents and physicians.
SEMINARS IN PERINATOLOGY
(2022)
Article
Psychology, Developmental
Lisa A. Schwartz, Amanda M. Lewis, Melissa A. Alderfer, Gabriela Vega, Lamia P. Barakat, Sara King-Dowling, Alexandra M. Psihogios, Kimberly S. Canter, Lori Crosby, Kamyar Arasteh, Paul Enlow, Aimee K. Hildenbrand, Nancy Kassam-Adams, Ahna Pai, Thao-Ly Phan, Julia Price, Corinna L. Schultz, Erica Sood, Jordan Wood, Anne Kazak
Summary: This study aimed to understand the impact of the COVID-19 pandemic on adolescents and young adults and developed the CEFIS-AYA scale specifically for this population. The results showed that the pandemic had a slightly negative impact on AYAs, with various factors contributing to their exposure and the resulting impact, and there were differences in scores based on gender and age.
JOURNAL OF PEDIATRIC PSYCHOLOGY
(2022)
Review
Psychology, Clinical
Danielle R. Hatchimonji, Jennie David, Carmelita Foster, Franssy Zablah, Alexandra Cross-Knorr, Erica Sood, Meghan Lines, Cheyenne Hughes-Reid
Summary: Retrospective chart review is a commonly used research method in medical fields but is underutilized in behavioral health. The field of pediatric integrated primary care (IPC) would benefit from guidelines for conducting a methodologically sound chart review study. This article provides strategies for optimizing reliability, validity, and efficiency based on experiences in a pediatric IPC research project, aiming to guide researchers in conducting chart review studies in this specific setting.
JOURNAL OF CLINICAL PSYCHOLOGY IN MEDICAL SETTINGS
(2022)
Article
Cardiac & Cardiovascular Systems
Jessica Bainton, Felicia Trachtenberg, Brian W. McCrindle, Ke Wang, Richard Boruta, Cheryl L. Brosig, D'Andrea Egerson, Erica Sood, Johanna Calderon, Tammy Doman, Katrina Golub, Amanda Graham, Karen Haas, Michelle Hamstra, Bergen Lindauer, Donna Sylvester, Frances Woodard, Lisa Young-Borkowski, Kathleen A. Mussatto
Summary: This study aimed to determine the prevalence and factors associated with post-traumatic stress disorder symptoms in parents of infants with single ventricle heart disease who underwent staged palliation. The results showed that 50% of mothers and 39% of fathers had probable post-traumatic stress disorder symptoms after the Norwood surgery, with a decrease to 27% of mothers and 24% of fathers at the final follow-up. Intrusive and hyperarousal symptoms were particularly elevated, and higher levels of anxiety, reduced coping, and decreased satisfaction with parenting were significantly associated with post-traumatic stress disorder symptoms.
CARDIOLOGY IN THE YOUNG
(2023)
Article
Surgery
Jonathan B. Edelson, Xuemei Zhang, Andrew B. Goldstone, Joseph W. Rossano, Matthew J. O'Connor, J. William Gaynor, Jonathan J. Edwards, Carol Wittlieb-Weber, Katsuhide Maeda
Summary: Rejection remains a primary cause of graft loss after heart transplant. Combining heart transplant with kidney or liver transplant reduces the risk of rejection compared to isolated heart transplant.
CLINICAL TRANSPLANTATION
(2023)
Article
Critical Care Medicine
Colleen F. B. Driscoll, Jennifer Christofferson, Linda G. McWhorter, Abigail C. Demianczyk, Cheryl L. Brosig, Emily A. Jackson, Colette Gramszlo, Sinai C. Zyblewski, Anne E. Kazak, Erica Sood
Summary: This study developed a model of family-based psychosocial care for congenital heart disease (CHD) based on qualitative research with 100 parents of young children with CHD. Three pillars of family-based psychosocial care were identified, with corresponding subthemes of intervention strategies. Most parents expressed the need for intervention strategies across multiple pillars. Parents' preferences for psychosocial support changed with changes in their child's medical status and care settings.
PEDIATRIC CRITICAL CARE MEDICINE
(2023)
Article
Medicine, Research & Experimental
Richard F. Ittenbach, J. William Gaynor, Jenny M. Dorich, Nancy B. Burnham, Guixia Huang, Madisen T. Harvey, Jeremy J. Corsmo
Summary: The purpose of this study was to establish a new measure of understanding of informed consent for use in clinical research. A total of 109 teens/young adults completed the consenting process of a hypothetical biobanking study. The final uConsent scale consisted of 19 items that mapped directly onto the Basic Elements of Informed Consent. The scale showed good reliability and validity.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2023)
Article
Cardiac & Cardiovascular Systems
Priya Nigam, Colette Gramszlo, Shubhika Srivastava, Erica Sood
Summary: This study explores the impact of the COVID-19 pandemic on fetal care, social support, and emotional functioning for women carrying a fetus with CHD. The findings indicate that while women had consistent access to fetal care during the pandemic, they experienced negative impacts such as limited family support, restricted social support, and loss of pregnancy traditions. Many women felt isolated and had worries and fears about COVID-19. However, they also noted feeling supported by their healthcare team and recommended partner/family support during appointments and connection to peer-to-peer support as mitigating factors.
CARDIOLOGY IN THE YOUNG
(2023)
Article
Genetics & Heredity
Helen M. Stanley, Brian R. White, Christopher J. LaRosa, Mark W. Cocalis, J. William Gaynor, Alanna Strong, Balram Gangaram
Summary: Pathogenic variants in PRDM6 have been found to be etiologically associated with non-syndromic PDA. We present three patients with PDA and CoA found to harbor PRDM6 variants, including a novel, likely-pathogenic variant.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
(2023)
Article
Biochemistry & Molecular Biology
Emilie J. Benson, Danielle I. Aronowitz, Rodrigo M. Forti, Alec Lafontant, Nicolina R. Ranieri, Jonathan P. Starr, Richard W. Melchior, Alistair Lewis, Jharna Jahnavi, Jake Breimann, Bohyun Yun, Gerard H. Laurent, Jennifer M. Lynch, Brian R. White, J. William Gaynor, Daniel J. Licht, Arjun G. Yodh, Todd J. Kilbaugh, Constantine D. Mavroudis, Wesley B. Baker, Tiffany S. Ko
Summary: The effects of cardiopulmonary bypass on cerebral oxygen supply and metabolic demands during neonatal congenital heart surgery are generally unknown. However, a study using swine models found that following the initiation of cardiopulmonary bypass, oxygen extraction fraction increased while cerebral blood flow and oxygen metabolism decreased, and this persisted for up to 8 hours after cardiopulmonary bypass.
Article
Genetics & Heredity
Alyssa L. Rippert, Sarah Trackman, Danielle Burstein, J. William Gaynor, Heather Griffis, Christine Seymour, Rebecca Ahrens-Nicklas
Summary: This study aimed to assess the association between CB scores and clinical outcomes in pediatric CM patients. The results showed no significant association between CB scores and clinical outcomes in pediatric CM patients. The study highlights the deficits in variant interpretation for pediatric CM and cautions the use of this tool for stratifying clinical outcomes in the pediatric population.
Article
Health Care Sciences & Services
Erica Sood, Colette Gramszlo, Alejandra Perez Ramirez, Katherine Braley, Samantha C. Butler, Jo Ann Davis, Allison A. Divanovic, Lindsay A. Edwards, Nadine Kasparian, Sarah L. Kelly, Trent Neely, Cynthia M. Ortinau, Erin Riegel, Amanda J. Shillingford, Anne E. Kazak
Summary: Input from diverse stakeholders is critical in designing healthcare interventions. This study applied a mixed-methods approach and engaged stakeholders to co-design a psychosocial intervention for parents expecting a baby with congenital heart disease, aiming to promote family wellbeing. This approach could be used in the development of healthcare interventions across chronic diseases.
JOURNAL OF PATIENT EXPERIENCE
(2022)