期刊
PEDIATRIC BLOOD & CANCER
卷 65, 期 12, 页码 -出版社
WILEY
DOI: 10.1002/pbc.27346
关键词
acute lymphoblastic leukaemia; EFS; survival; t(1;19); TCF3-PBX1
资金
- Children&apos
- s Cancer Foundation of Hong Kong Funding Source: Medline
Objective The aim of this study was to review clinical outcomes and prognosis of paediatric patients with acute lymphoblastic leukaemia (ALL) with TCF3-PBX1 rearrangement. PatientsMethodsAll children in Hong Kong diagnosed with ALL with TCF3-PBX1 rearrangement over the past two decades were included. Six hundred and twenty-four newly diagnosed patients with ALL from four consecutive studies were enrolled from 1997 to 2016. Patients carrying TCF3-PBX1 rearrangement and patients at intermediate risk without the gene expression were compared for clinical characteristics, overall survival and event-free survival (EFS). ResultsConclusionThe TCF3-PBX1 rearrangement was detected in 30 of 624 patients (4.8%). Results were consistent across the consecutive clinical trials employed in the past two decades. Compared with 239 intermediate risk patients without TCF3-PBX1 rearrangement, the 5-year overall survival and EFS for patients with TCF3-PBX1 rearrangement was superior, with both at 100% (P=0.12 and P=0.029). This population-based study over the past 20 years demonstrated that patients with TCF3-PBX1 rearrangement had favourable EFS compared with other intermediate risk patients treated with a similar chemotherapy backbone.
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