期刊
PEDIATRIC BLOOD & CANCER
卷 61, 期 2, 页码 360-362出版社
WILEY-BLACKWELL
DOI: 10.1002/pbc.24696
关键词
ataxia-telangiectasia; children; Hodgkin lymphoma; non-Hodgkin lymphoma
资金
- National Cancer Institute [CA 21765]
- American Lebanese Syrian Associated Charities
Children with ataxia-telangiectasia (A-T) and cancer have a poorer prognosis due in part to increased treatment-related toxicity. We piloted a curative intent approach in five children with A-T who presented with advanced stage (III, n=2; IV, n=3) B-NHL (diffuse large B-cell lymphoma, n=4; Burkitt leukemia, n=1) using a modified LMB-based protocol. Two achieved sustained CCR (one, CCR at 6 years; one, pulmonary death after 3 years in CCR). Two died from toxicity during induction and 1 failed induction with progressive disease. Novel therapeutic approaches which overcome drug resistance and are less toxic are needed for children with A-T and B-NHL. Pediatr Blood Cancer 2014;61:360-362. (c) 2013 Wiley Periodicals, Inc.
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