Article
Oncology
Caitlyn Duffy, Dylan E. Graetz, Arturo M. Zapata Lopez, Angela K. Carrillo, Godwin Job, Yichen Chen, Meenakshi Devidas, Sandra Alarcon Leon, Sol Aponte Bonzi, Pedro Cardona Flores, Lizeth Escobar Torres, Eddy Hernandez Broncano, Soledad Jimenez Jaramillo, Ma Ofelia Zelada, Romulo Reano Novoa, Angelica Samudio, Gissela Sanchez-Fernandez, Erika Villanueva, Monika L. Metzger, Paola Friedrich, Sima Jeha
Summary: This retrospective study analyzed the clinical parameters of children diagnosed with acute lymphoblastic leukemia (ALL) in five pediatric centers across four countries in South America between 2013 and 2017. The study revealed that even in high-income countries, children with ALL in low- and middle-income countries have lower survival rates.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Sumit Gupta, David T. Teachey, Zhiguo Chen, Karen R. Rabin, Kimberly P. Dunsmore, Eric C. Larsen, Kelly W. Maloney, Leonard A. Mattano, Stuart S. Winter, Andrew J. Carroll, Nyla A. Heerema, Michael J. Borowitz, Brent L. Wood, William L. Carroll, Elizabeth A. Raetz, Naomi J. Winick, Mignon L. Loh, Stephen P. Hunger, Meenakshi Devidas
Summary: Boys with acute lymphoblastic leukemia continue to have lower survival rates compared to girls. This study found that the sex-based disparities still exist in contemporary therapy, with boys experiencing inferior event-free survival and overall survival, primarily due to higher rates of relapse, particularly involving the central nervous system.
Article
Oncology
Gerard Socie
Summary: The Oncology Grand Rounds series aims to help doctors better apply clinical research to actual patient treatment. This particular round focused on the management and complications of hematopoietic stem-cell transplantation (HSCT) in acute myelogenous leukemia (AML). The study found that while transplantation therapy provides long-term survival opportunities, it also increases the risk of late complications.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Jinhua Chu, Huaju Cai, Jiaoyang Cai, Xinni Bian, Yumei Cheng, Xianmin Guan, Xiaoqian Chen, Hua Jiang, Xiaowen Zhai, Yongjun Fang, Lei Zhang, Xin Tian, Fen Zhou, Yaqin Wang, Lingzhen Wang, Hong Li, Leung Wing Kwan Alex, Minghua Yang, Hanfang Yang, Aijun Zhan, Ningling Wang, Shaoyan Hu
Summary: This study investigates the relationship between response to dexamethasone and prognosis in children with acute lymphoblastic leukemia (ALL), and finds that good response to dexamethasone is associated with lower recurrence rate and higher survival rate.
FRONTIERS IN ONCOLOGY
(2022)
Article
Pediatrics
JinFang Zhang, LingJi Zeng, YuLian Wang, JianWei Pan, XingDong Li, Bei Feng, Quan Yang
Summary: The study found that TTN and NOTCH1 gene mutations were associated with glucocorticoid resistance in pediatric acute lymphoblastic leukemia (ALL). Additionally, TTN and MUC16 mutations were associated with a younger age at diagnosis, while NOTCH1 mutations were associated with T-cell ALL in female patients.
FRONTIERS IN PEDIATRICS
(2022)
Article
Oncology
Jinquan Wen, Min Zhou, Yali Shen, Yueting Long, Yuxia Guo, Lin Song, Jianwen Xiao
Summary: This study investigated the clinical characteristics and treatment response of Chinese children with B-ALL carrying KMT2Ar, and found that TL was more common in the infant group. There was no statistically significant difference in treatment response among different age groups. Poor prognosis was associated with an initial WBC count and positive FCM-MRD level.
Article
Pharmacology & Pharmacy
Gabriela Burgueno-Rodriguez, Yessika Mendez, Natalia Olano, Magdalena Schelotto, Luis Castillo, Ana Maria Soler, Julio da Luz
Summary: This study aims to identify genetic variants related to drugs used in the treatment of pediatric acute lymphoblastic leukemia in Uruguay and analyze their contribution to adverse effects. The study found that mucositis, Cushing syndrome, and neurotoxicity were linked to specific genetic variants and individual genetic ancestry.
FRONTIERS IN PHARMACOLOGY
(2023)
Editorial Material
Oncology
Etan Orgel, Steve D. Mittelman
Summary: Obesity during chemotherapy is linked to higher relapse risk and worse survival rate in acute lymphoblastic leukemia patients, extending from the first to the final days of treatment. New interventions targeting the multiple underlying mechanisms are urgently needed for this high-risk group.
Article
Biophysics
Akshay Sharma, Sujuan Huang, Ying Li, Russell J. Brooke, Ibrahim Ahmed, Heather B. Allewelt, Persis Amrolia, Alice Bertaina, Neel S. Bhatt, Marc B. Bierings, Joshua Bies, Claire Brisset, Jennifer E. Brondon, Ann Dahlberg, Jean-Hugues Dalle, Hesham Eissa, Mony Fahd, Adam Gassas, Nicholas J. Gloude, W. Scott Goebel, Erika S. Goeckerman, Katherine Harris, Richard Ho, Michelle P. Hudspeth, Jeffrey S. Huo, David Jacobsohn, Kimberly A. Kasow, Emmanuel Katsanis, Saara Kaviany, Amy K. Keating, Nancy A. Kernan, Yiouli P. Ktena, Colette R. Lauhan, Gerardo Lopez-Hernandez, Paul L. Martin, Kasiani C. Myers, Swati Naik, Alberto Olaya-Vargas, Toshihiro Onishi, Mohamed Radhi, Shanti Ramachandran, Kristie Ramos, Hemalatha G. Rangarajan, Philip A. Roehrs, Megan E. Sampson, Peter J. Shaw, Jodi L. Skiles, Katherine Somers, Heather J. Symons, Marie de Tersant, Allison N. Uber, Birgitta Versluys, Cheng Cheng, Brandon M. Triplett
Summary: The long-term outcomes for pediatric patients with therapy-related myeloid neoplasms (tMNs) after allogeneic hematopoietic cell transplantation (HCT) are poor. Both myeloablative conditioning (MAC) and reduced-intensity conditioning (RIC) regimens had no significant impact on overall survival (OS) or event-free survival (EFS), but exposure to total body irradiation (TBI) was associated with higher mortality rates. Reduced-toxicity regimens may help decrease relapse in these patients.
BONE MARROW TRANSPLANTATION
(2021)
Article
Oncology
Freddy A. Barragan, Lauren J. Mills, Andrew R. Raduski, Erin L. Marcotte, Kelsey E. Grinde, Logan G. Spector, Lindsay A. Williams
Summary: Black children have lower incidence yet worse survival in B-cell acute lymphoblastic leukemia (B-ALL). Genetic ancestry and differentially expressed genes associated with ancestry play a role in death risk. The impact of reported race/ethnicity on death risk varies after adjusting for genetic ancestry genes. Other factors also contribute to B-ALL survival.
Review
Oncology
Roberto Rivera-Luna, Patricia Perez-Vera, Cesar Galvan-Diaz, Liliana Velasco-Hidalgo, Alberto Olaya-Vargas, Rocio Cardenas-Cardos, Marco Aguilar-Ortiz, Jesus Ponce-Cruz
Summary: Acute lymphoblastic leukemia (ALL) is a major health issue among Mexican and Hispanic children, with a significant survival gap. This can be attributed to three main factors, including epidemiology and social, cultural, and economic burdens, cancer biology with unfavorable genetic characteristics and poor response to treatment, as well as sub-optimal treatment and support.
FRONTIERS IN ONCOLOGY
(2022)
Article
Urology & Nephrology
Deirdre Sawinski, Hanna Lindner, Robert Fitzsimmons, Justine Shults, Jayme E. Locke, Jordana B. Cohen, Paul A. MacLennan, Peter P. Reese
Summary: This study examined the association between nonadherent behaviors related to dialysis treatment and posttransplant outcomes, finding that certain nonadherence metrics were associated with allograft loss and patient mortality. Behavioral metrics were more closely associated with outcomes, highlighting the importance of considering the implications of nonadherent behaviors before excluding patients from transplantation.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2022)
Article
Health Care Sciences & Services
Emyal Alyaydin, Juergen Reinhard Sindermann, Jeanette Koeppe, Joachim Gerss, Patrik Droege, Thomas Ruhnke, Christian Guenster, Holger Reinecke, Jannik Feld
Summary: This study analyzed the prevalence and prognostic relevance of depression and anxiety in patients undergoing heart transplantation in Germany from 2010 to 2018. It found that one third of the patients were diagnosed with depression and anxiety before the transplantation. Patients with depression and anxiety were more likely to have comorbidities such as ischemic cardiomyopathy, myocardial infarction, and stroke.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Anne Dipchand, Osami Honjo, Rafael Alonso-Gonzalez, Michael McDonald, S. Lucy Roche
Summary: In the current era, Fontan patients have a high mortality rate and often require transplantation. Heart transplant can be successful, providing high survival rates for both children and adults. However, early Fontan failure is difficult to rescue with transplantation and there are challenges in referring and treating adult patients. Limited data on referral and mortality rates are needed to better understand the overall situation and improve the quality of transplantation. Recent revisions in listing prioritization aim to address the specific needs of the Fontan population. Prioritizing high-risk children and improving mechanical support options can help reduce post-listing mortality.
CANADIAN JOURNAL OF CARDIOLOGY
(2022)
Article
Oncology
Daniel N. Willis, Mary Claire McGlynn, Patrick J. Reich, Robert J. Hayashi
Summary: This study evaluated the risk of bloodstream infections (BSI) and death in pediatric oncology patients, finding that BSI is a significant cause of mortality in this population. Younger age, specific diagnoses, ethnicity, and history of hematopoietic stem cell transplant (HSCT) were identified as risk factors for BSI. The mortality rate for patients with BSI was 6.5%. Patients with febrile neutropenia had a lower mortality rate compared to those without. These findings highlight the importance of BSI prevention to reduce the risk of death in pediatric oncology patients.
FRONTIERS IN ONCOLOGY
(2023)
Article
Hematology
Marion K. Mateos, Glenn M. Marshall, Pasquale M. Barbaro, Michael Cj Quinn, Carly George, Chelsea Mayoh, Rosemary Sutton, Tamas Revesz, Jodie E. Giles, Draga Barbaric, Frank Alvaro, Francoise Mechinaud, Daniel Catchpoole, John A. Lawson, Georgia Chenevix-Trench, Stuart MacGregor, Rishi S. Kotecha, Luciano Dalla-Pozza, Toby N. Trahair
Summary: Symptomatic methotrexate-related central neurotoxicity is a severe toxicity commonly experienced during acute lymphoblastic leukemia therapy, which can have long-term neurological complications. This study analyzed data from 1,251 Australian children and identified age and elevated serum aspartate aminotransferase as major risk factors for MTX neurotoxicity.
Article
Oncology
Clarissa E. Schilstra, Joanna E. Fardell, Sarah J. Ellis, Kimberley M. Jones, Antoinette C. Anazodo, Toby N. Trahair, Suncica Lah, Richard J. Cohn, Claire E. Wakefield, Ursula M. Sansom-Daly
Summary: This study found that a subset of adolescent cancer survivors may experience symptoms of social anxiety disorder, impacting their daily social functioning and causing avoidance or distress in feared social situations. Identifying at-risk individuals and providing support for this vulnerable cohort is crucial.
JOURNAL OF ADOLESCENT AND YOUNG ADULT ONCOLOGY
(2022)
Editorial Material
Clinical Neurology
Marion K. Mateos, Nikhil Birdi, Anna P. Basu, Michael Wright, Abhijit Joshi, Srinivas Annavarapu, Thomas S. Jacques, Dipayan Mitra, Simon Bailey
Review
Oncology
Yashar Mesbahi, Toby N. Trahair, Richard B. Lock, Patrick Connerty
Summary: Targeting the metabolic characteristics of AML cells holds promise for the treatment of AML relapse. The metabolic differences between normal hematopoietic cells, AML cells, and LSCs are being studied, and drug interventions exploiting the metabolic vulnerabilities of AML cells are being explored.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Nicola C. Venn, Libby Huang, Lenka Hovorkova, Walter Muskovic, Marie Wong, Tamara Law, Susan L. Heatley, Seong Lin Khaw, Tom Revesz, Luciano Dalla Pozza, Peter J. Shaw, Chris Fraser, Andrew S. Moore, Siobhan Cross, Katerina Bendak, Murray D. Norris, Michelle J. Henderson, Deborah L. White, Mark J. Cowley, Toby N. Trahair, Jan Zuna, Rosemary Sutton
Summary: This study evaluated new DNA-based MRD tests for detecting ABL-class fusions and IKZF1 deletions, and found that these tests showed high concordance with conventional Ig/TCR markers. The results suggest that patient-specific assays detecting gene fusions or recurrent assays for IKZF1 deletions could be good alternatives to Ig/TCR tests for monitoring MRD in ABL-class ALL.
BRITISH JOURNAL OF CANCER
(2022)
Review
Biochemistry & Molecular Biology
Louise Doculara, Toby N. Trahair, Narges Bayat, Richard B. Lock
Summary: This review discusses the value and challenges of circulating tumor DNA (ctDNA) as a disease monitoring biomarker in pediatric malignancies. The data and conclusions from pediatric cancer studies on ctDNA are summarized, highlighting its applications in treatment response, disease monitoring, and subclonal disease detection.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Oncology
Lauren Ha, Claire E. Wakefield, David Mizrahi, Claudio Diaz, Richard J. Cohn, Christina Signorelli, Kalina Yacef, David Simar
Summary: This study aimed to evaluate the feasibility and acceptability of iBounce, a digital health intervention, for educating and engaging childhood cancer survivors in physical activity. The study found that iBounce was feasible and acceptable among survivors, but no significant changes were observed in physical activity levels or health-related quality of life.
Article
Oncology
Clarissa E. Schilstra, Karen McCleary, Joanna E. Fardell, Mark W. Donoghoe, Emma McCormack, Rishi S. Kotecha, Richard De Abreu Lourenco, Shanti Ramachandran, Ruelleyn Cockcroft, Rachel Conyers, Siobhan Cross, Luciano Dalla-Pozza, Peter Downie, Tamas Revesz, Michael Osborn, Frank Alvaro, Claire E. Wakefield, Glenn M. Marshall, Marion K. Mateos, Toby N. Trahair
Summary: This study aims to investigate the treatment-related toxicities (TRTs) and impaired quality of life during pediatric acute lymphoblastic leukemia (ALL) therapy, compare the outcomes of different treatment methods, and evaluate their impacts on children and parents.
Article
Pediatrics
Stefania Sorrentino, Shifra Ash, Riccardo Haupt, Dominique Plantaz, Isabelle Schiff, Barbara Hero, Thorsten Simon, Denis Kachanov, Tatyana Shamanskaya, Katheljine Kraal, Annemieke Littooij, Alexsandra Wieczoreck, Walentyna Balwierz, Genevieve Laureys, Catherine Trager, Fiammetta Sertorio, Giovanni Erminio, Martina Fragola, Maja Beck Popovic, Bruno De Bernardi, Toby Trahair
Summary: This prospective study confirms that children with neuroblastoma spinal canal invasion (NB-SCI) differ from children without NB-SCI. Compared to previous studies, it provides more detailed information regarding the symptoms, time intervals, and correlations between symptoms and imaging features in NB-SCI patients.
FRONTIERS IN PEDIATRICS
(2022)
Meeting Abstract
Hematology
Matthew Greenwood, Shane Gangatharan, Michael Philip Osborn, Ashley P. Ng, Shaun Fleming, Pasquale Fedele, Toby Trahair, John Casey, Sally Mapp, Carol Cheung, Tasman Armytage, Michelle Henderson, Rosemary Sutton, Philip McCloud, Stephen R. Larsen, Peter Presgrave, John Kwan, Samuel Bennett, Chun Yew Fong, Luciano Dalla Pozza
Article
Multidisciplinary Sciences
Jordan F. Hastings, Sharissa L. Latham, Alvin Kamili, Madeleine S. Wheatley, Jeremy Z. R. Han, Marie Wong-Erasmus, Monica Phimmachanh, Max Nobis, Chiara Pantarelli, Antonia L. Cadell, Yolande E. I. O'Donnell, King Ho Leong, Sophie Lynn, Fan-Suo Geng, Lujing Cui, Sabrina Yan, Joanna Achinger-Kawecka, Clare Stirzaker, Murray D. Norris, Michelle Haber, Toby N. Trahair, Frank Speleman, Katleen De Preter, Mark J. Cowley, Ozren Bogdanovic, Paul Timpson, Thomas R. Cox, Walter Kolch, Jamie I. Fletcher, Dirk Fey, David R. Croucher
Summary: Gene expression noise promotes stochastic drug resistance in rare cancer cells. However, when integrated across multiple components of an apoptotic signaling network, the influence of noise leads to a higher frequency of chemoresistant neuroblastoma cells. These cells are characterized by JNK impairment and retain a memory of their resistant state even after chemotherapy treatment.
Article
Clinical Neurology
Tiffany Li, Tejaswi Kandula, Richard J. Cohn, Matthew C. Kiernan, Susanna B. Park, Michelle A. Farrar
Summary: This study comprehensively assessed the outcomes of vincristine-induced peripheral neuropathy (VIPN) in pediatric patients with acute lymphoblastic leukemia (ALL) undergoing vincristine treatment. Clinical, neurophysiological, and quality-of-life evaluations were performed.
CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Health Care Sciences & Services
Rebecca Daly, Kate Hetherington, Emily Hazell, Bethany R. Wadling, Vanessa Tyrrell, Katherine M. Tucker, Glenn M. Marshall, David S. Ziegler, Loretta Lau, Toby N. Trahair, Tracey A. O'Brien, Kiri Collins, Andrew J. Gifford, Michelle Haber, Mark Pinese, David Malkin, Mark J. Cowley, Jonathan Karpelowsky, Donna Drew, Chris Jacobs, Claire E. Wakefield
Summary: Precision medicine programs aim to identify personalized treatments for children with cancer, but the various professional groups involved in delivering these programs are understudied. This study explored the experiences of professionals involved in Australia's first precision medicine trial for children with poor-prognosis cancer. The professionals expressed both complexity in their roles and positive views about the impact of precision medicine on their profession.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Hematology
Holly C. L. Pearson, Kooper Hunt, Toby N. Trahair, Richard B. Lock, Heather J. Lee, Charles E. de Bock
Summary: Single-cell sequencing provides detailed analysis of individual cell variation, offering new insights into the driving mechanisms of drug resistance and treatment failure in pediatric ALL. This technique improves clinical outcomes in ALL patients and has the potential to transform our understanding of the disease's fundamental biology.
