Article
Medicine, General & Internal
Antonella Meloni, Laura Pistoia, Paolo Ricchi, Vincenzo Positano, Filomena Longo, Zelia Borsellino, Valerio Cecinati, Giuseppe Messina, Elisabetta Corigliano, Rosamaria Rosso, Riccardo Righi, Giuseppe Peritore, Stefania Renne, Antonino Vallone, Filippo Cademartiri
Summary: The value of pancreatic T2* magnetic resonance imaging (MRI) for predicting cardiac events in transfusion-dependent thalassemia patients was assessed. The study found that pancreatic T2* values were a significant predictor of future arrhythmia-related events, suggesting that monitoring pancreatic iron overload may help improve patient outcomes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Antonella Meloni, Mario Nobile, Petra Keilberg, Vincenzo Positano, Maria Filomena Santarelli, Laura Pistoia, Anna Spasiano, Tommaso Casini, Maria Caterina Putti, Liana Cuccia, Pier Paolo Bitti, Giuseppe Messina, Giuseppe Peritore, Stefania Renne, Emanuele Grassedonio, Emilio Quaia, Filippo Cademartiri, Alessia Pepe
Summary: This multicenter study assessed the extent of pancreatic fatty replacement and its correlation with demographics, iron overload, glucose metabolism, and cardiac complications in a cohort of well-treated patients with thalassemia major. The results showed that pancreatic fatty replacement was associated with age, body mass index, and history of hepatitis C virus infection. It was also found that pancreatic fatty replacement was a risk marker for alterations of glucose metabolism, cardiac iron, and complications in thalassemia major patients.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Antonella Meloni, Laura Pistoia, Gennaro Restaino, Massimiliano Missere, Vincenzo Positano, Anna Spasiano, Tommaso Casini, Antonella Cossu, Liana Cuccia, Antonella Massa, Francesco Massei, Filippo Cademartiri
Summary: This study evaluated the feasibility and reproducibility of bone marrow T2* measurements in a cohort of healthy subjects and established the lower limit of normal values. In patients with thalassemia major (TM), significantly lower bone marrow T2* values were observed. These values were inversely correlated with serum ferritin levels and hepatic iron load. Incorporating bone marrow T2* measurements into clinical practice may provide new insights into iron deposition.
Article
Chemistry, Multidisciplinary
Mengxing Wei, Lulu Wang, Yanfang Wang, Tong Zhang, Chenchen Wang, Chengfan Wu, Changlin Tian, Gaolin Liang, Yue Yuan
Summary: Magnetic resonance imaging (MRI) is an excellent imaging technique with unlimited tissue penetration depth and superb spatiotemporal resolution. However, the use of intracellular self-assembled Gd-containing nanoparticles to enhance T-2-weighted MR contrast in vivo for precise tumor MRI is rarely reported. This study developed a CTSB-responsive small molecular contrast agent VC-Gd-CBT, which can self-assemble into large intracellular Gd-containing nanoparticles, and it has the potential to be used as a T-2 contrast agent for early-stage cancer diagnosis.
Article
Radiology, Nuclear Medicine & Medical Imaging
Ping-Huei Tsai, Chin-Chean Wong, Wing P. Chan
Summary: This study validated a 2D radial T2* mapping method for revealing subtle alterations in the menisci of patients with knee osteoarthritis (OA). The results showed that the radial T2* mapping method provided better discrimination than the conventional method. It was found that the T2* values in the menisci were significantly higher in the OA group compared to the control group, and there were correlations between the T2* values and the Lequesne index.
EUROPEAN RADIOLOGY
(2022)
Article
Multidisciplinary Sciences
Shakthi Kumaran Ramasamy, Raheleh Roudi, Wipawee Morakote, Lisa C. Adams, Laura J. Pisani, Michael Moseley, Heike E. Daldrup-Link
Summary: T2* relaxometry is an established method for measuring the effect of superparamagnetic iron oxide nanoparticles on tumor tissues using MRI. This study presents a protocol for measuring tumor T2* relaxation times using multi-echo gradient echo sequences and external software, which allows for scanner-independent comparison of imaging data from different sources. The protocol has been validated with preclinical and clinical data, and could improve the standardization and reproducibility of tumor T2* measurements in multi-center studies.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Narumol Chaosuwannakit, Pattarapong Makarawate, Chinnadol Wanitpongpun
Summary: Cardiac T2* MRI is a valuable tool for monitoring cardiac iron overload in thalassemia major patients, allowing for early diagnosis and treatment of patients at risk of cardiac siderosis, thus reducing cardiac mortality associated with myocardial siderosis.
Article
Radiology, Nuclear Medicine & Medical Imaging
Jingwen Huang, Jun Shen, Qihua Yang, Ziliang Cheng, Xiaodong Chen, Taihui Yu, Jinglian Zhong, Yun Su, Hua Guo, Biling Liang
Summary: Pediatric TM patients can have homogeneous iron siderosis and heterogeneous fat infiltration in the pancreas as measured by gradient-echo imaging, both of which are risk factors for diabetes.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sean C. L. Deoni, Jonathan O'Muircheartaigh, Emil Ljungberg, Mathew Huentelman, Steven C. R. Williams
Summary: Low magnetic field systems provide an important opportunity for expanding MRI to new clinical and research study populations. However, they have lower signal-to-noise ratios compared to higher field strength systems, resulting in compromises in spatial resolution and imaging time. This study introduces a super-resolution approach to reconstruct high-resolution T-2-weighted images from low-resolution anisotropic images acquired in orthogonal orientations, allowing for simultaneous quantitative T-2 imaging without sacrificing time. The results demonstrate the feasibility and accuracy of this approach in acquiring high-resolution images and quantitative T-2 maps.
MAGNETIC RESONANCE IN MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Jin Wang, Yinhang Jia, Qiyue Wang, Zeyu Liang, Guangxu Han, Zejun Wang, Jiyoung Lee, Meng Zhao, Fangyuan Li, Ruiliang Bai, Daishun Ling
Summary: The article introduces a T-1-T-2 dual-mode contrast agent designed for ultrahigh-field MRI, which not only improves resolution and signal-to-noise ratio, but also effectively displays microvasculature structures with high sensitivity and accuracy in detecting tumor vascular permeability.
ADVANCED MATERIALS
(2021)
Article
Cardiac & Cardiovascular Systems
Alessia Pepe, Laura Pistoia, Maria Rita Gamberini, Liana Cuccia, Roberto Lisi, Valerio Cecinati, Aurelio Maggio, Francesco Sorrentino, Aldo Filosa, Rosamaria Rosso, Giuseppe Messina, Massimiliano Missere, Riccardo Righi, Stefania Renne, Antonino Vallone, Stefano Dalmiani, Vincenzo Positano, Massimo Midiri, Antonella Meloni
Summary: The tailored chelation therapy guided by MRI in the MIOT network has shown significant improvement in the prognosis of TM patients. Continuous monitoring of cardiac iron levels and personalized treatment can reduce cardiac burden, improve cardiac function, and reduce complications and death from heart failure related to myocardial iron overload.
EUROPEAN HEART JOURNAL
(2022)
Article
Multidisciplinary Sciences
Qinrui Lin, Yuhong Yang, Zhengzhong Shao
Summary: This study reports MRI-active conjugated polymer nanoparticles based on polypyrrole (PPy) for in vivo imaging, extending the applications of conjugated polymers from optical imaging to MRI.
NATURE COMMUNICATIONS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hwan Kim, Young Joong Yang, Kyunghwa Han, Pan Ki Kim, Byoung Wook Choi, Jin Young Kim, Young Joo Suh
Summary: This study evaluated the reliability and diagnostic performance of a deep learning-based software for automated T2 measurement in cardiac MRI. The software showed good performance in myocardial segmentation and T2 measurement, and could detect myocardial segments with elevated T2 values.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Article
Oncology
Sebastian Gassenmaier, Saif Afat, Marcel Dominik Nickel, Mahmoud Mostapha, Judith Herrmann, Haidara Almansour, Konstantin Nikolaou, Ahmed E. Othman
Summary: Multiparametric magnetic resonance imaging (mpMRI) is an important tool for diagnosing clinically significant prostate cancer, but the long examination time and limited availability can be disadvantages. This study introduces an accelerated deep learning image reconstructed T2-weighted turbo spin echo sequence, which significantly reduces acquisition time and improves image quality.
Article
Oncology
Katsuo Usuda, Masahito Ishikawa, Shun Iwai, Aika Yamagata, Yoshihito Iijima, Nozomu Motono, Munetaka Matoba, Mariko Doai, Keiya Hirata, Hidetaka Uramoto
Summary: This study compared the diagnostic efficacy of FDG-PET/CT and MRI in discriminating malignant from benign pulmonary nodules and masses (PNMs). The results showed that MRI had significantly higher sensitivity and accuracy compared to FDG-PET/CT for differential diagnosis of PNMs.
Article
Medicine, General & Internal
Wan-Ling Ho, Giun-Yi Hung, Hsiu-Ju Yen, Yung-Li Yang, Hsiu-Hao Chang, Meng-Yao Lu, Kai-Hsin Lin, Jiann-Shiuh Chen, Chao-Neng Cheng, Iou-Jih Hung, Chao-Ping Yang, Shih-Hsiang Chen, Hsi-Che Liu, Ting-Chi Yeh, Jen-Yin Hou, Chih-Cheng Hsiao, Jiunn-Ming Sheen, Tai-Tsung Chang, Tai-Tong Wong, James S. Miser, Yen-Lin Liu, Rong-Long Chen, Bow-Wen Chen, Ching-Tien Peng, Te-Kau Chang, Kang-Hsi Wu, Yu-Hsiang Chang, Jinn-Li Wang, Shih-Chung Wang, Ming-Tsan Lin, Fu-Chang Hu, Shiann-Tarng Jou, Dong-Tsamn Lin
Summary: Children with primary cancer who develop a second cancer face an increased risk of unfavorable outcomes, particularly with early occurrence of secondary hematological malignancies. Age at diagnosis of the second cancer and prior radiation doses are associated with the type of second cancer, impacting treatment and survival rates for second cancers.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kuan-Yin Ko, Ruoh-Fang Yen, Chi-Lun Ko, Shu-Wei Chou, Hsiu-Hao Chang, Yung-Li Yang, Shiann-Tarng Jou, Wen-Ming Hsu, Meng-Yao Lu
Summary: This study found that midtreatment FDG and FDOPA PET/CT could serve as prognostic markers in stage 3-4 neuroblastoma patients. The interim tumor FDG/FDOPA SUVmax and interim FDOPA whole-body metabolic burden scores were significantly associated with overall survival (OS).
CLINICAL NUCLEAR MEDICINE
(2022)
Article
Oncology
Hsin-Yi Huang, Chih-Hsiang Yu, Yung-Li Yang, Ya-Hsuan Chang, Shiann-Tarng Jou, Kai-Hsin Lin, Meng-Yao Lu, Hsiu-Hao Chang, Shu-Wei Chou, Yu-Ling Ni, Dong-Tsamn Lin, Hsuan-Yu Chen, Steven Shinn-Forng Peng, Meng-Fai Kuo, Shih-Hung Yang
Summary: This study used immunohistochemistry and RNA sequencing for the molecular classification of medulloblastoma, and multiplex ligation-dependent probe amplification to determine chromosomal alterations and gene amplifications. The results showed that immunohistochemistry can provide rapid subgroup stratification of medulloblastoma, but may lead to misclassification. Therefore, validation of immunohistochemistry results with genomic data analysis by RNA sequencing or other tools is recommended. In addition, multiplex ligation-dependent probe amplification can detect important genetic alterations and help identify high-risk patients.
PEDIATRIC BLOOD & CANCER
(2022)
Article
Pediatrics
Chi-Bo Chen, Hsiu-Hao Chang, Shu-Wei Chou, Yung-Li Yang, Meng-Yao Lu, Shiann-Tarng Jou, Huey-Ling Chen, Yen-Hsuan Ni, Dong-Tsamn Lin, Mei-Hwei Chang, Jia-Feng Wu
Summary: l-Asparaginase is an important therapeutic for childhood acute lymphoblastic leukemia, and the accumulated dosage of l-asparaginase is considered as a major risk factor of asparaginase-associated pancreatitis. This study found that the incidence of pancreatitis in childhood ALL patients is more strongly correlated with the dose intensity of l-asparaginase rather than with the cumulative dosage. High peak dose intensity and older age at diagnosis were identified as independent predictive factors for the development of AAP.
PEDIATRIC RESEARCH
(2022)
Article
Pathology
Chih-Hsiang Yu, Gang Wu, Chia-Ching Chang, Shiann-Tarng Jou, Meng-Yao Lu, Kai-Hsin Lin, Shu-Huey Chen, Kang-Hsi Wu, Chao-Neng Cheng, Fang-Liang Huang, Chao-Neng CHeng, Hsiu-Hao Chang, Dale Hedges, Jinn-Li Wang, Hsiu-Ju Yen, Meng-Ju Li, Shu-Wei Chou, Chen-Ting Hung, Ze-Shiang Lin, Chien-Yu Lin, Hsuan-Yu Chen, Yu-Ling Ni, Yin-Chen Hsu, Dong-Tsamn Lin, Shu-Wha Lin, Jun J. Yang, Ching-Hon Pui, Sung-Liang Yu, Yung-Li Yang
Summary: Identification of specific leukemia subtypes is crucial for risk-directed therapy in childhood acute lymphoblastic leukemia (ALL). Although RNA sequencing (RNA-seq) is the most effective method, its routine use is expensive in resource-limited countries. This study enrolled 295 pediatric ALL patients and used a combination of screening methods and RNA-seq to improve classification and clinical assessment of childhood ALL.
JOURNAL OF MOLECULAR DIAGNOSTICS
(2022)
Article
Oncology
Ting-Huan Huang, Giun-Yi Hung, Te-Fu Weng, Fu-Mien Wang, Chih-Ying Lee, Dong-Tsamn Lin, Bow-Wen Chen, Kai-Hsin Lin, Kang-Hsi Wu, Hsi-Che Liu, Jiann-Shiuh Chen, Shiann-Tarng Jou, Jen-Yin Hou, Yung-Li Yang, Shih-Hsiang Chen, Hsiu-Hao Chang, Shyh-Shin Chiou, Pei-Chin Lin, Rong-Long Chen, Chih-Cheng Hsiao, Hsiu-Ju Yen, Chao-Ping Yang, Te-Kau Chang, Meng-Yao Lu, Chao-Neng Cheng, Jiunn-Ming Sheen, Yu-Mei Liao, Min-Yu Su, Ting-Chi Yeh
Summary: This study retrospectively analyzed the prognostic factors and treatment outcomes of primary malignant mediastinal germ cell tumors (GCTs) in Taiwanese children. The results showed that surgical treatment was associated with better outcomes, while advanced disease stage and choriocarcinoma histology subtype were associated with poorer outcomes. Additionally, there was no difference in treatment outcomes between cisplatin-based and carboplatin-based chemotherapy.
Article
Oncology
Shu-Wei Chou, Ying-Hui Su, Meng-Yao Lu, Hsiu-Hao Chang, Yung-Li Yang, Dong-Tsamn Lin, Kai-Hsin Lin, Elaine Coustan-Smith, Shiann-Tarng Jou
Summary: This study aimed to find an effective way to monitor minimal residual disease (MRD) in patients with acute lymphoblastic leukemia (ALL) using flow cytometry. The study found that the combination of Hsp27 with CD73, CD58, CD24, and backbone markers can detect MRD in virtually all ALL patients.
PEDIATRIC BLOOD & CANCER
(2023)
Article
Oncology
Chih-Hsiang Yu, Shiann-Tarng Jou, Ying-Hui Su, Elane Coustan-Smith, Gang Wu, Chao-Neng Cheng, Meng-Yao Lu, Kai-Hsin Lin, Kang-Hsi Wu, Shu-Huey Chen, Fang-Liang Huang, Hsiu-Hao Chang, Jinn-Li Wang, Hsiu-Ju Yen, Meng-Ju Li, Shu-Wei Chou, Wan-Ling Ho, Yen-Lin Liu, Chia-Ching Chang, Ze-Shiang Lin, Chien-Yu Lin, Hsuan-Yu Chen, Yu-Ling Ni, Dong-Tsamn Lin, Shu-Wha Lin, Jun J. Yang, Yen-Hsuan Ni, Ching-Hon Pui, Sung-Liang Yu, Yung-Li Yang
Summary: This study analyzed data from two consecutive protocols to determine the clinical impact of minimal/measurable residual disease (MRD) and tumor genetic subtypes in newly diagnosed pediatric acute lymphoblastic leukemia (ALL) patients. The results showed that MRD-directed therapy improved outcomes for pediatric ALL, especially for standard-risk patients. This study provides important data to inform the design of future clinical trials in Taiwan.
Article
Genetics & Heredity
Yu-Kang Hsu, Yin-Hsiu Chien, Steven Shinn-Forng Peng, Wuh-Liang Hwu, Wang-Tso Lee, Ni-Chung Lee, Eric Po-Yu Huang, Wen-Chin Weng
Summary: The study aimed to investigate the CNS progression in patients with infantile-onset Pompe disease (IOPD) and its clinical impact and predictors. The findings showed that CNS involvement in IOPD expanded from white matter to gray matter, and the MRI scores were positively correlated with age and negatively correlated with IQ scores. Neuroaxonal injury and decreased IQ scores may be associated with the progression of CNS involvement in IOPD. Neurofilament light chain could serve as a biomarker for CNS involvement in IOPD.
GENETICS IN MEDICINE
(2023)
Letter
Immunology
Yu-Chia Chen, Shiann-Tarng Jou, Ni-Chung Lee, Bor-Luen Chiang, Hsin-Hui Yu
JOURNAL OF CLINICAL IMMUNOLOGY
(2023)
Article
Gastroenterology & Hepatology
Jia-Feng Wu, Steven Shinn-Forng Peng, Chi-San Tai, Wen-Hsi Lin, Yung-Ming Jeng, Wen-Ming Hsu, Huey-Ling Chen, Yen-Hsuan Ni, Mei-Hwei Chang
Summary: This study investigated the utility of liver-to-psoas apparent diffusion coefficient ratios (LTPAR) and age-adjusted serum matrix metalloproteinase-7 (MMP-7) for diagnosing biliary atresia (BA) in cholestatic infants. The results showed that LTPAR was significantly lower in BA infants, while age-adjusted MMP7 ratio was significantly higher. Considering both serum and imaging parameters may improve the diagnostic performance of BA in cholestatic infants.
JOURNAL OF GASTROENTEROLOGY
(2023)