期刊
PEDIATRIC BLOOD & CANCER
卷 59, 期 5, 页码 776-779出版社
WILEY
DOI: 10.1002/pbc.24215
关键词
case-control studies; hepatoblastoma; prematurity
资金
- Cancer Research UK [13274] Funding Source: researchfish
- Cancer Research UK [13274] Funding Source: Medline
Few causes of hepatoblastoma have been conclusively identified, mainly due to the extreme rarity of the disease. Inherited conditions including Familial Adenomatous Polyposis and BeckwithWiedemann Syndrome dramatically raise risk of hepatoblastoma but account for few cases overall. A small number of casecontrol studies investigating risk factors for sporadic hepatoblastoma have been conducted to date. Although most of these studies feature fewer than 200 cases, several clues have emerged. Most notably there is a roughly 20-fold increased risk of hepatoblastoma among children with very low birth weight (<1,500?g) and a doubling of risk among those with moderately low birth weight (1,5002,500?g). A modicum of evidence points to a possible role of parental tobacco use prior to or during pregnancy in the causation of hepatoblastoma as well. Pediatr Blood Cancer 2012; 59: 776779. (C) 2012 Wiley Periodicals, Inc.
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