期刊
PEDIATRIC BLOOD & CANCER
卷 58, 期 6, 页码 836-839出版社
WILEY PERIODICALS, INC
DOI: 10.1002/pbc.23274
关键词
epidemiology; infants; leukemia; MLL
资金
- National Institutes of Health [R01 CA79940, T32 CA99936, U10 CA13539, U10 CA98543, P30 CA77588]
- Children's Cancer Research Fund, Minneapolis, MN
Background Infant leukemias have a high frequency of mixed lineage leukemia (MLL) gene rearrangements. Procedure. Using data from a large etiologic study, we evaluated the distribution of selected demographic factors among 374 infant leukemia cases by leukemic subtype, MLL status and diagnosis age. Results. Overall, 228 cases were MLL+. Compared to white infants, black infants were significantly less likely to have MLL+ leukemia. Further, there was a statistically significantly higher age at diagnosis for infants with t(9; 11) translocations compared to all other translocation partners in both acute lymphoblastic leukemia and acute myeloid leukemia cases. Conclusion. These patterns may provide important etiological insight into the biology of infant leukemia. Pediatr Blood Cancer 2012; 58: 836- 839. (C) 2011 Wiley Periodicals, Inc.
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