Article
Medicine, Research & Experimental
Jing Ruan, Chen Yang, Yali Du, Miao Chen, Bing Han
Summary: This study investigated the serum lipid profiles in patients with aplastic anemia (AA) before and after cyclosporin (CsA) treatment. The results showed that AA patients had decreased levels of certain lipid metabolites compared to hypocellular myelodysplastic syndrome (h-MDS) patients and healthy controls. Furthermore, CsA treatment significantly reduced the levels of certain lipid metabolites in AA patients.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Hematology
Anastasia Martynova, Victor Chiu, Melissa Mert, David Hermel, Ilene Ceil Weitz
Summary: Research suggests that tacrolimus may be a potential treatment option for aplastic anemia with a more favorable toxicity profile compared to CsA.
ANNALS OF HEMATOLOGY
(2021)
Article
Hematology
Yasushi Onishi, Takehiko Mori, Hirohito Yamazaki, Katsuto Takenaka, Hiroki Yamaguchi, Naoki Shingai, Yukiyasu Ozawa, Hiroatsu Iida, Shuichi Ota, Naoyuki Uchida, Toshihiro Miyamoto, Yuta Katayama, Jun Kato, Satoshi Yoshioka, Makoto Onizuka, Tatsuo Ichinohe, Yoshiko Atsuta
Summary: The study found that the choice between CSA + MTX or TAC + MTX did not significantly impact acute and chronic GVHD, OS, or GRFS. The use of ATG in conditioning reduced the risk of acute GVHD and improved GRFS in recipients of marrow from matched sibling donors.
ANNALS OF HEMATOLOGY
(2021)
Article
Oncology
Daijing Nie, Jing Zhang, Fang Wang, Xvxin Li, Lili Liu, Wei Zhang, Panxiang Cao, Xue Chen, Yang Zhang, Jiaqi Chen, Xiaoli Ma, Xiaosu Zhou, Qisheng Wu, Ming Liu, Mingyue Liu, Wenjun Tian, Hongxing Liu
Summary: The study suggests that heterozygous mutations in Fanconi anemia genes can contribute to hematologic disorders, particularly aplastic anemia and leukemia. Different genes have varying frequencies of mutations, with some genes showing associations with specific subgroups of hematologic malignancies.
FRONTIERS OF MEDICINE
(2022)
Article
Oncology
Hongchen Liu, Xiaoli Zheng, Chengtao Zhang, Jiajun Xie, Beibei Gao, Jing Shao, Yan Yang, Hengxiang Wang, Jinsong Yan
Summary: The study demonstrated the efficacy of haploidentical bone marrow transplantation (haplo-BMT) for patients with severe aplastic anemia II (SAA-II), achieving a 3-year overall survival and disease-free survival rate of 86.4% +/- 0.73%. This indicates that haplo-BMT could be considered as an alternative treatment strategy for SAA-II patients lacking HLA-matched donors.
FRONTIERS OF MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Xinyu Tang, Ruirong Xu, Yan Wang, Kaiqing Chen, Siyuan Cui
Summary: The TERC gene is crucial for telomerase-dependent telomere extension and maintenance. Cell reprogramming can reverse differentiation and enhance pluripotency, and also extend telomere length. This study investigates the role of TERC haploinsufficiency and cell reprogramming in aplastic anemia, aiming to identify diagnostic indicators and therapeutic strategies.
MOLECULAR MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Majda Sahman, Snezana Mugosa, Nemanja Rancic
Summary: The utilization of immunosuppressive drugs is increasing in transplant patients in Montenegro and other observed countries. However, despite a decrease in the price per defined daily dose (DDD) for certain drugs, the overall cost of immunosuppressants is rising annually, which poses a significant financial burden on healthcare systems.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Cell Biology
Yuanyuan Shao, Weiwei Qi, Xiaomei Zhang, Ningyuan Ran, Chunyan Liu, Rong Fu, Zonghong Shao
Summary: Patients with severe aplastic anemia (SAA) show abnormalities in both their plasma metabolomes and intestinal microbial compositions, which might reflect the molecular mechanisms involved in the defective immunity that characterizes SAA.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Endocrinology & Metabolism
Georgia Pitsava, Constantine A. Stratakis
Summary: Pediatric adrenocortical hyperplasias are rare conditions characterized by Cushing syndrome and genetic defects affecting the adrenal cortex. Most cases are caused by defects in the cyclic AMP/protein kinase A (cAMP/PKA) pathway, while a few cases have unidentified genetic defects. Congenital adrenal hyperplasia, mainly due to steroidogenic enzyme deficiencies, is another cause of adrenal hyperplasia in childhood.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Gastroenterology & Hepatology
Maxime Gonnot, Florent Neumann, Frederic Huet, Raphaelle Maudinas, Thierry Leblanc, Florence Lacaille
Summary: Hepatitis-associated aplastic anemia (HAAA) accounts for 4% of autoimmune hepatitis in children. This autoimmune disease could be due to a regulation defect in the immune response. Treatment options include hematopoietic stem cell transplantation and medication.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2022)
Article
Hematology
Xiaodi Ma, Yangyang Zuo, Zhengli Xu, Yuanyuan Zhang, Yifei Cheng, Tingting Han, Pan Suo, Yuqian Sun, Feifei Tang, Fengrong Wang, Chenhua Yan, Yuhong Chen, Yu Wang, Xiaohui Zhang, Kaiyan Liu, Xiaojun Huang, Lanping Xu
Summary: This study retrospectively compared the characteristics and outcomes of patients with hepatitis-associated aplastic anemia (HAAA) and non-hepatitis-associated aplastic anemia (non-HAAA) who underwent haploidentical hematopoietic stem cell transplantation (haplo-HSCT). The results showed no significant differences in neutrophil engraftment time, overall survival rates, and liver event-free survival rates between HAAA and non-HAAA patients. These findings suggest that haplo-HSCT is a feasible treatment option for HAAA when HLA-matched donors are not available, with low risks of transplant-related mortality and complications.
ANNALS OF HEMATOLOGY
(2022)
Article
Immunology
Pengpeng Pan, Congcong Chen, Jian Hong, Yue Gu
Summary: Acquired aplastic anemia (AA) is an autoimmune disease characterized by depleted hematopoietic stem and progenitor cells (HSPCs) and peripheral blood cells. Although immunosuppressive therapy (IST) is an effective treatment, its limitations necessitate further research into the pathogenesis of AA and identification of new drug targets to improve outcomes.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Mu-Lin Chiu, Yu-Lung Hsu, Chao-Jung Chen, Te-Mao Li, Jian-Shiun Chiou, Fuu-Jen Tsai, Ting-Hsu Lin, Chiu-Chu Liao, Shao-Mei Huang, Chen-Hsing Chou, Wen-Miin Liang, Ying-Ju Lin
Summary: The study investigated whether Chinese herbal medicine (CHM) is beneficial to aplastic anemia (AA) patients as a complementary therapy. It found that CHM-users had lower risks of overall and anemia-related mortalities when compared to non-users. Commonly prescribed herbs for AA patients include Ban-Zhi-Lian (BZL), Bai-Hua-She-She-Cao (BHSSC), Dang-Gui (DG), Huang-Qi (HQi), Xian-He-Cao (XHC), Gui-Pi-Tang (GPT), and Dan-Shen (DanS). Further studies are needed for these herbs in hematopoiesis-stimulating effect and large-scale randomized controlled trials (RCT) in bone marrow failure related diseases.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Xuan Gao, Zhu-Li Bian, Xiao-Hong Qiao, Xiao-Wen Qian, Jun Li, Guo-Mei Shen, Hui Miao, Yi Yu, Jian-Hua Meng, Xiao-Hua Zhu, Jun-Ye Jiang, Jun Le, Ling Yu, Hong-Sheng Wang, Xiao-Wen Zhai
Summary: This study developed a population pharmacokinetic model of cyclosporine (CsA) in Chinese pediatric patients with acquired aplastic anemia (AA) and identified body weight and total bilirubin level as important factors affecting the pharmacokinetics of CsA.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Hematology
Wenrui Yang, Xin Zhao, Guangsheng He, Hong Chang, Bing Han, Sujun Gao, Shunqing Wang, Tong Chen, Fei Li, Yi Wang, Xiaoyan Ge, Rong Fu, Zheng Ge, Yingmei Li, Hong Liu, Xinjian Liu, Miao Miao, Liansheng Zhang, Fengkui Zhang
Summary: Hetrombopag is the only CFDA-approved thrombopoietin receptor agonist for severe aplastic anemia in China. A post hoc analysis of a phase II clinical trial showed that hetrombopag had a powerful and rapid iron chelation effect.
ANNALS OF HEMATOLOGY
(2022)
