Editorial Material
Hematology
James B. B. Bussel
Summary: The use of intravenous anti-D for treating ITP has been largely abandoned due to the risk of intravascular hemolysis. Intramuscular delivery of anti-D could be a safer approach and needs further evaluation. IV anti-D was widely used for ITP treatment in the United States in the 1990s until the discovery of its risk for intravascular hemolysis. As a result, it is now rarely used due to the availability of alternative treatments. IM anti-D, on the other hand, does not carry the risk of intravascular hemolysis and should be reconsidered as an option for certain adult patients with ITP.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Multidisciplinary Sciences
Anastasia A. Ignatova, Elena Suntsova, Alexey Pshonkin, Alexey A. Martyanov, Evgeniya A. Ponomarenko, Dmitry M. Polokhov, Daria Fedorova, Kirill A. Voronin, Natalia N. Kotskaya, Natalia M. Trubina, Marina Krasilnikova, Selima Sh Uzueva, Irina Serkova, Galina S. Ovsyannikova, Ksenia Romanova, Lili A. Hachatryan, Irina I. Kalinina, Viktor E. Matveev, Maya N. Korsantiya, Natalia S. Smetanina, Dmitry A. Evseev, Maria N. Sadovskaya, Kristina S. Antonova, Anna L. Khoreva, Pavel A. Zharkov, Anna Shcherbina, Anastasia N. Sveshnikova, Aleksey A. Maschan, Galina A. Novichkova, Mikhail A. Panteleev
Summary: Immune thrombocytopenia (ITP) is characterized by platelet size enlargement and pre-activation, with CD62p pre-activation potentially associated with bleeding in chronic ITP patients. Romiplostim treatment can reduce platelet size and pre-activation in ITP patients.
SCIENTIFIC REPORTS
(2021)
Article
Hematology
Sunil Lakhwani, Alberto Lopez-Las Heras, Pablo Rodriguez-Garcia, Sandra Iraheta, Taida Martin-Santos, Maria Jose Rodriguez-Salazar, Patricia Machado, Miguel-Teodoro Hernandez
Summary: The report retrospectively reviews the use of IM Anti-D treatment in 74 adult patients, and concludes that it is an effective and safe treatment option for immune thrombocytopenia.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Iason Thomas, Ioannis Panagoulias, Ioanna Aggeletopoulou, Anastasia Varvarigou, Bessie E. Spiliotis, Athanasia Mouzaki
Summary: In children with acute ITP, leptin levels were significantly increased and inversely correlated with platelet count. IVIg treatment maintained high leptin levels, while steroid treatment lowered leptin below control levels. Leptin acts as an active anti-inflammatory agent in childhood ITP by promoting IL-10 secretion by monocytes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Mona A. Abdelrahman, Aya Ahmed, Abdullah S. Alanazi, Hasnaa Osama
Summary: There is currently no consensus on anticoagulation therapy among COVID-19 patients, and predicting bleeding events accurately is crucial. Therapeutic anticoagulation is associated with increased bleeding risk, and the HAS-BLED score shows better accuracy in predicting bleeding risk.
JOURNAL OF CLINICAL MEDICINE
(2022)
Editorial Material
Emergency Medicine
Patrick P. Lowe, Daniel J. Egan, Susan R. Wilcox, Kathleen A. Wittels
Summary: A 47-year-old woman presented to the emergency department with symptoms of bloody urine, dark tarry stools, red spots on her skin, and widespread bruising. She had a history of intermittent fevers, headache, shortness of breath, and a dry cough, and tested positive for SARS-CoV-2. She also experienced worsening headaches, dark and bright red blood in her urine, and tar-like stools. Additionally, she developed a red rash and had a self-limited episode of nosebleed.
JOURNAL OF EMERGENCY MEDICINE
(2022)
Article
Medicine, General & Internal
Chao-Neng Cheng, Yuan-Ning Yang, Yun-Hsuan Yeh, Li-Wen Chen, Jiann-Shiuh Chen, Yung-Chieh Lin
Summary: Childhood immune thrombocytopenia (ITP) is a common bleeding disorder in children. Severe cases require investigation and monitoring, as some children may develop chronic ITP. This retrospective study aimed to analyze the shared clinical factors among different definitions of disease remission at three arbitrarily set timepoints after diagnosis.
Article
Critical Care Medicine
Romain Chopard, Gregory Piazza, Nicolas Falvo, Fiona Ecarnot, Mathieu Besutti, Gilles Capellier, Francois Schiele, Marc Badoz, Nicolas Meneveau
Summary: A risk score, PE-SARD, was developed to predict early major bleeding in acute PE patients. Three predictors - Syncope, Anemia, and Renal Dysfunction - were identified. The novel score showed better performance than existing models, allowing for accurate risk classification and reclassification.
Article
Medicine, General & Internal
Bogdan Silviu Ungureanu, Dan Ionut Gheonea, Dan Nicolae Florescu, Sevastita Iordache, Sergiu Marian Cazacu, Vlad Florin Iovanescu, Ion Rogoveanu, Adina Turcu-Stiolica
Summary: This study developed an Artificial Neural Network (ANN) for the non-endoscopic triage of nonvariceal upper gastrointestinal bleeding (NVUGIB), with mortality as a primary outcome. The machine learning models were more accurate at identifying patients who met the endpoint of mortality than any of the existing risk scores.
FRONTIERS IN MEDICINE
(2023)
Article
Pediatrics
Francesco Saettini, Alessandro Cattoni, Martina Redaelli, Daniela Silvestri, Giulia Maria Ferrari, Andrea Biondi, Momcilo Jankovic, Marco Spinelli
Summary: The study found that the prevalence of autoimmune hyperthyroidism, systemic lupus erythematosus, and coeliac disease in children with immune thrombocytopenia was not increased compared to the general pediatric population. However, the prevalence of underlying primary immunodeficiencies was significantly higher. Regular screening for primary immunodeficiencies during follow-up of immune thrombocytopenia patients is recommended.
Article
Immunology
Dimitris Stogiannis, Kostas Blanas, Eleni Tsapra, Marianna Theodora
Summary: This article discusses a rare case of a 2.5-year-old healthy boy who developed acute ITP after a Toxoplasma gondii infection. After excluding other potential causes, the boy underwent three intravenous immunoglobulin treatments and gradually recovered. The authors suggest that routine testing for toxoplasmosis may be crucial in accelerating the healing process and improving the quality of life for children with ITP.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2023)
Article
Medicine, General & Internal
Erin K. McCreary, J. Ryan Bariola, Richard J. Wadas, Judith A. Shovel, Mary Kay Wisniewski, Michelle Adam, Debbie Albin, Tami Minnier, Mark Schmidhofer, Russell Meyers, Oscar C. Marroquin, Kevin Collins, William Garrard, Lindsay R. Berry, Scott Berry, Amy M. Crawford, Anna McGlothlin, Kelsey Linstrum, Anna Nakayama, Stephanie K. Montgomery, Graham M. Snyder, Donald M. Yealy, Derek C. Angus, Paula L. Kip, Christopher W. Seymour, David T. Huang, Kevin E. Kip
Summary: Through observation of high-risk outpatient patients, it was found that subcutaneous injection of casirivimab and imdevimab could reduce hospitalization and death rates compared to no treatment. These results provide preliminary evidence for the potential expanded use of subcutaneous monoclonal antibody treatment, particularly in areas facing treatment capacity and/or staffing shortages.
Article
Hematology
Qiuni Chen, Yijing Zhang, Yunjie Li, Lijuan Zhang, Wenting Shi, Hong Tao, Kankan Chen, Zhengmei He, Chunling Wang, Liang Yu
Summary: There is a linear relationship between platelet count and bleeding score, regardless of the scoring system used; a negative correlation was found in patients with extremely low platelet counts (< 10*10(9)/L); ITP-2016 is more time-efficient compared to IBLS for scoring.
Article
Immunology
Jennifer R. Blase, David Frame, Thomas F. Michniacki, Kelly Walkovich
Summary: This case report discusses a young female patient with Evans syndrome who developed serum sickness, acute respiratory distress syndrome, and platelet refractoriness due to neutralizing antibodies to rituximab. Treatment with obinutuzumab led to symptom resolution. The importance of recognizing subtle or rare symptoms of rituximab-induced serum sickness for rapid intervention is highlighted.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Andrea Alemany, Pere Millat-Martinez, Marc Corbacho-Monne, Clara Suner, Cristina Galvan-Casas, Caty Carrera, Dan Ouchi, Nuria Prat, Jordi Ara, Nuria Nadal, Ricard Riel, Blanca Funollet, Carmen Ojeda-Ciurana, Lluis Esteve Balague, Betlem Salvador-Gonzalez, Anna Forcada Arcarons, Josep Vidal-Alaball, Maria Isabel Del Cura-Gonzalez, Ricardo Rodriguez Barrientos, Rafel Ramos-Blanes, Alberto Alum Bou, Elsa Mondou, Mireia Torres, Neus Campins, Ana Sanz, Yonggiang Tang, Miquel Angel Rodriguez-Arias, Quique Bassat, Bonaventura Clotet, Oriol Mitja
Summary: This study assessed the safety and efficacy of subcutaneous anti-COVID-19 hyperimmune immunoglobulin 20% (C19-IG20%) in preventing the development of symptomatic COVID-19 in asymptomatic individuals with SARS-CoV-2 infection. The results showed that C19-IG20% did not prevent asymptomatic individuals from developing symptomatic COVID-19.
Article
Cell Biology
Eva Leinoe, Mimi Kjaersgaard, Eva Zetterberg, Sisse Ostrowski, Andreas Greinacher, Maria Rossing
Summary: Heterozygous variants in the IKZF5 gene have been identified as causal of inherited thrombocytopenia, with novel variants found in two Danish families, where carriers exhibited developmental delay and significant bleeding tendency. Through comprehensive characterizations, new insights into IKZF5-associated thrombocytopenia were gained, aiding in the identification and classification of more cases with this condition.
Review
Hematology
Anne-Sofie Skou, Kristian Lovvik Juul-Dam, Hans B. Ommen, Henrik Hasle
Summary: Longitudinal molecular measurable residual disease (MRD) sampling post-therapy completion is an effective tool for identifying imminent relapse of AML among patients in long-term hematological complete remission. Superiority of peripheral blood MRD assessment in distinguishing disease states and potential for preemptive intervention in AML relapse are highlighted.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Article
Biophysics
Rachel Bortnick, Marcin Wlodarski, Valerie de Haas, Barbara De Moerloose, Michael Dworzak, Henrik Hasle, Riccardo Masetti, Jan Stary, Dominik Turkiewicz, Marek Ussowicz, Emilia Kozyra, Michael Albert, Peter Bader, Victoria Bordon, Gunnar Cario, Rita Beier, Johannes Schulte, Dorine Bresters, Ingo Muller, Herbert Pichler, Petr Sedlacek, Martin G. Sauer, Marco Zecca, Gudrun Goehring, Ayami Yoshimi, Peter Noellke, Miriam Erlacher, Franco Locatelli, Charlotte M. Niemeyer, Brigitte Strahm
Summary: In pediatric MDS, patients with GATA2 mutations who underwent HSCT had a 5-year overall survival of 75% and disease-free survival of 70%. Non-relapse mortality and relapse were equal contributors to treatment failure. Organ toxicities and infection rates did not show significant increase, suggesting early consideration of HSCT in young individuals with GATA2 deficiency.
BONE MARROW TRANSPLANTATION
(2021)
Review
Oncology
Stefan M. Pfister, Miguel Reyes-Mugica, John K. C. Chan, Henrik Hasle, Alexander J. Lazar, Sabrina Rossi, Andrea Ferrari, Jason A. Jarzembowski, Kathy Pritchard-Jones, D. Ashley Hill, Thomas S. Jacques, Pieter Wesseling, Dolores H. Lopez Terrada, Andreas von Deimling, Christian P. Kratz, Ian A. Cree, Rita Alaggio
Summary: Pediatric tumors, although uncommon, are the leading cause of cancer-related death in childhood. The development of the first WHO Classification of Pediatric Tumors recognizes the unique characteristics and origin of these tumors, incorporating morphology, IHC, and molecular characteristics. The classification provides a comprehensive understanding of pediatric tumor types, with a special emphasis on blastomas.
Article
Oncology
Anne Sophie Lind Helligsoe, Line Kenborg, Louise Tram Henriksen, Aparna Udupi, Henrik Hasle, Jeanette Falck Winther
Summary: Incidence rates of childhood CNS tumors in Denmark remain stable but among the highest in the world. Despite improved survival rates in recent years for children aged 0-4 years, some subtypes still have a poor prognosis.
Article
Pediatrics
Ninna Brix, Jesper Amstrup, Mette Norgaard, Soren Hagstrom, Henrik Hasle, Troels Herlin
Summary: This study found that 7% of children with cancer had a musculoskeletal diagnosis within 6 months before the cancer diagnosis, but this did not affect their overall survival.
JOURNAL OF PEDIATRICS
(2022)
Article
Hematology
Lene Karlsson, Charlotte Guldborg Nyvold, Anastasia Soboli, Pegah Johansson, Lars Palmqvist, Anne Tierens, Henrik Hasle, Birgitte Lausen, Olafur Gisli Jonsson, Gitte Wulff Jurgensen, Lene Hyldahl Ebbesen, Jonas Abrahamsson, Linda Fogelstrand
Summary: This study compared the results of RT-qPCR and MFC methods for MRD analysis in childhood AML and found discrepancies between the two methods. RT-qPCR measurements suggested slower response kinetics compared to MFC, presumably due to the presence of mature cells.
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
(2022)
Letter
Oncology
Charlotte M. Niemeyer, Martina Rudelius, Akiko Shimamura, Christian Flotho, Henrik Hasle, Elliot Stieglitz, Brigitte Strahm, Lucy A. Godley, Olga K. Weinberg, Attilio Orazi, Katherine R. Calvo
Article
Clinical Neurology
Anne Sophie L. Helligsoe, Louise T. Henriksen, Line Kenborg, Yasmin Lassen-Ramshad, Lisa M. Wu, Jeanette F. Winther, Henrik Hasle, Ali Amidi
Summary: This study examined neurocognitive function in childhood brain tumor survivors and its associations with quality of life (QoL) and symptom burden. The majority of survivors exhibited overall neurocognitive impairment, reduced QoL, and high symptom burden.
NEURO-ONCOLOGY PRACTICE
(2023)
Article
Pediatrics
Nadine G. Andersson, Birgitte Lausen, Annika Martensson, Ulf Tedgard, Mimi Kjaersgaard
Article
Genetics & Heredity
Johannes Gojo, Mimi Kjaersgaard, Barbara Zezschwitz, David Capper, Anna Tietze, Marcel Kool, Christine Haberler, Barry Pizer, Katja Hoff
Summary: The introduction of molecular methods has had a significant impact on paediatric neurooncology, leading to the identification of novel tumour types in rare CNS tumours. The rarity and novelty of these tumour types result in diagnostic and therapeutic challenges, but comprehensive molecular diagnostics and joint international efforts are encouraged to overcome these challenges and optimize patient management.
EUROPEAN JOURNAL OF MEDICAL GENETICS
(2023)
Letter
Biophysics
Luca Vinci, Christian Flotho, Peter Noellke, Dirk Lebrecht, Riccardo Masetti, Valerie de Haas, Barbara De Moerloose, Michael Dworzak, Henrik Hasle, Tayfun Guengoer, Jan Stary, Dominik Turkiewicz, Marek Ussowicz, Cristina Diaz de Heredia, Jochen Buechner, Kirsi Jahnukainen, Krisztian Kallay, Ivana Bodova, Owen P. P. Smith, Marco Zecca, Dorine Bresters, Peter Lang, Tania Nicole Masmas, Roland Meisel, Herbert Pichler, Miriam Erlacher, Gudrun Goehring, Franco Locatelli, Brigitte Strahm, Charlotte M. M. Niemeyer, Ayami Yoshimi
BONE MARROW TRANSPLANTATION
(2023)
Article
Hematology
Sarah Weischendorff, Silvia De Pietri, Mathias Rathe, Thomas Leth Frandsen, Henrik Hasle, Claus H. Nielsen, Claus Moser, Klaus Mueller
Summary: This study investigated whether measurements of neutrophil chemotaxis could be used as risk markers for bloodstream infections (BSI) in children with acute lymphoblastic leukemia (ALL). The results showed that patients who developed BSI during induction treatment had increased levels of chemokines CXCL1 and CXCL8, suggesting that these markers may help identify patients at increased risk of BSI during chemotherapy-induced neutropenia.
EUROPEAN JOURNAL OF HAEMATOLOGY
(2023)
Letter
Oncology
Daniella Elisabet Ostergaard, Isak Wahlstedt, Morten Jorgensen, Mimi Kjaersgaard, Rene Mathiasen, Karsten Nysom, Astrid Sehested, Ivan Richter Vogelius, Maja Vestmo Maraldo
Article
Oncology
Thomas N. N. Nissen, Catherine Rechnitzer, Birgitte K. K. Albertsen, Lotte Borgwardt, Vibeke B. B. Christensen, Eva Fallentin, Henrik Hasle, Lars S. S. Johansen, Lisa L. L. Maroun, Karin B. B. Nissen, Allan Rasmussen, Mathias Rathe, Steen Rosthoj, Nicolai A. A. Schultz, Peder S. S. Wehner, Marianne H. H. Jorgensen, Jesper Brok
Summary: This study reports the incidence, outcomes, and long-term adverse events of malignant liver tumors in Danish children over the past 35 years. The overall incidence of liver tumors in Danish children was approximately 2.29 per 1 million children per year, with hepatoblastoma being the most common tumor. The overall 5-year survival rate was 84% and 78% for hepatoblastomas and hepatocellular carcinomas, respectively, with age≥8 years being the most significant factor associated with a poorer prognosis. Adverse events included reduced renal and cardiac function, as well as impaired hearing function, affecting a significant number of patients.
