Article
Cardiac & Cardiovascular Systems
Antonella Meloni, Laura Pistoia, Vincenzo Positano, Nicola Martini, Rita Laura Borrello, Sara Sbragi, Anna Spasiano, Tommaso Casini, Pier Paolo Bitti, Maria Caterina Putti, Liana Cuccia, Massimo Allo, Francesco Massei, Paola Maria Grazia Sanna, Raffaele De Caterina, Emilio Quaia, Filippo Cademartiri, Alessia Pepe
Summary: In this study, myocardial T-2 values were measured by a segmental approach in patients with thalassaemia major (TM), comparing them with T-2* values for the detection of myocardial iron overload (MIO), evaluating their potential in detecting subclinical inflammation, and correlating with clinical status. The study found that T-2 values were significantly higher in TM patients than in a cohort of healthy subjects, and there was a significant correlation between T-2 and T-2* values. Patients with decreased T-2* values also had reduced T-2 values, and these patients had higher hepatic and pancreatic iron deposition.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jan M. Brendel, Alina Kratzenstein, Josephine Berger, Florian Hagen, Konstantin Nikolaou, Meinrad Gawaz, Simon Greulich, Patrick Krumm
Summary: The purpose of this study was to assess the diagnostic capabilities of cardiac magnetic resonance (CMR) T2* mapping in detecting incidental hepatic and cardiac iron overload. The study found that approximately 3.9% of patients had incidental hepatic iron overload and 1.1% of patients had incidental cardiac iron overload. The results suggest that T2* imaging can be used as a method for detecting iron overload and has implications for further patient management.
DIAGNOSTIC AND INTERVENTIONAL IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Narumol Chaosuwannakit, Pattarapong Makarawate, Chinnadol Wanitpongpun
Summary: Cardiac T2* MRI is a valuable tool for monitoring cardiac iron overload in thalassemia major patients, allowing for early diagnosis and treatment of patients at risk of cardiac siderosis, thus reducing cardiac mortality associated with myocardial siderosis.
Article
Radiology, Nuclear Medicine & Medical Imaging
Hang Zhou, Yuehan Wei, Dong-Aolei An, Zhaohui Ni, Jianrong Xu, Wei Fang, Renhua Lu, Liang Ying, Binghua Chen, Haijiao Jin, Jiaying Huang, Qiuying Yao, Luke Wesemann, Lian-Ming Wu, Shan Mou
Summary: This study explored myocardial iron content using Cardiac T2* Mapping in dialysis patients undergoing different iron therapies compared to healthy controls, finding that peritoneal dialysis patients have higher cardiac T2* values and may be at a higher risk of myocardial iron deficiency compared to hemodialysis patients. The T2* value was found to be negatively correlated with cardiac function indicators, suggesting it may be an independent predictor of left ventricular function and altered mechanics.
ACADEMIC RADIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Suyon Chang, Jinho Park, Young-Joong Yang, Kyongmin Sarah Beck, Pan Ki Kim, Byoung Wook Choi, Jung Im Jung
Summary: This study aimed to determine the conversion equations between different scanners using a phantom and evaluate the feasibility of the phantom-based conversion method. The results demonstrated that a site-specific equation derived from a phantom can be used to estimate T2* values at 1.5T in centers where only 3T scanners are available.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2022)
Article
Hematology
Alessia Pepe, Michele Rizzo, Sara Galimberti, Claudia Barate, Esther Natalie Oliva, Francesco Arcioni, Sergio Storti, Stefania Renne, Massimo Midiri, Gennaro Restaino, Vincenzo Positano, Maurizio Mangione, Antonella Meloni
Summary: In this study, MRI was used to evaluate changes in cardiac and hepatic iron overload, cardiac parameters, and myocardial fibrosis in MDS patients. The findings suggest that myocardial iron overload is common in MDS patients, can occur in non-transfused patients, and may be unrelated to hepatic iron levels. Additionally, myocardial fibrosis correlates with patient age. Further monitoring with periodic MRI scans is recommended for better management of MDS patients.
ANNALS OF HEMATOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Katia Menacho Medina, Amna Abdel-Gadir, Kartik Ganga, Vineeta Ojha, Surya Pratap, Redha Boubertakh, Louise McGrath, Joao B. Augusto, Alexander Rikowski, Nabila Mughal, V. K. Khanna, Tulika Seth, Sanjiv Sharma, Amita Mahajan, Rajiv K. Bansal, Prabhar Srivastava, Harsh Mahajan, Vidhur Mahajan, Judith Walker, Ms Tenzin Seldon, Emmanuel Ako, James C. Moon, J. Malcolm Walker
Summary: A study conducted in India showed that incorporating a faster cardiac magnetic resonance imaging protocol can improve the quality of chelation therapy for transfusion-dependent patients.
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2022)
Article
Cardiac & Cardiovascular Systems
Alessia Pepe, Laura Pistoia, Maria Rita Gamberini, Liana Cuccia, Roberto Lisi, Valerio Cecinati, Aurelio Maggio, Francesco Sorrentino, Aldo Filosa, Rosamaria Rosso, Giuseppe Messina, Massimiliano Missere, Riccardo Righi, Stefania Renne, Antonino Vallone, Stefano Dalmiani, Vincenzo Positano, Massimo Midiri, Antonella Meloni
Summary: The tailored chelation therapy guided by MRI in the MIOT network has shown significant improvement in the prognosis of TM patients. Continuous monitoring of cardiac iron levels and personalized treatment can reduce cardiac burden, improve cardiac function, and reduce complications and death from heart failure related to myocardial iron overload.
EUROPEAN HEART JOURNAL
(2022)
Article
Hematology
John Chapin, Alan R. Cohen, Ellis J. Neufeld, Elliott Vichinsky, Patricia J. Giardina, Jeanne Boudreaux, Binh C. Le, Kristy Kenney, Sean Trimble, Alexis A. Thompson
Summary: Thalassaemia is a genetic disorder causing anaemia and dependence on transfusions, with recent clinical advancements leading to reduced mortality and potential future gene therapies. Research revealed older patients with more iron-related comorbidities and complications, while younger patients had excess liver and heart iron and were on combination chelation therapy.
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Review
Medicine, General & Internal
Antonis Kattamis, Janet L. Kwiatkowski, Yesim Aydinok
Summary: Thalassaemia is a genetic disorder that affects globin chain synthesis and has a worldwide distribution. The unbalanced production of globin chains leads to ineffective erythropoiesis, increased haemolysis, and disrupted iron homeostasis. The clinical phenotype varies from mild to severe, with treatment options including transfusion, iron chelation, allogeneic haematopoietic stem cell transplantation, and gene therapy.
Article
Chemistry, Multidisciplinary
Jingjing Liu, Xiaodong Yu, Hui Jun Ting, Xiaoyuan Wang, Shidang Xu, Yuanbo Wang, Sitong Zhang, Jiong-Wei Wang, Bin Liu
Summary: Nonalcoholic steatohepatitis (NASH) is a critical stage in the development of nonalcoholic fatty liver disease (NAFLD) and its diagnosis is important for preventing its progress into a fatal condition. The expression of the oxidative enzyme myeloperoxidase (MPO) is higher in NASH than in nonalcoholic fatty liver (NAFL), making it a potential target for NASH diagnosis. A nanoparticle platform based on ultrasmall iron oxide (USIO) nanoparticles was designed to achieve MPO-sensitive NASH diagnosis, showing promise for improving NASH MR imaging diagnostic accuracy and sensitivity.
Article
Chemistry, Multidisciplinary
Tao Sun, Yiding Liu, Chunyu Zhou, Liang Zhang, Xun Kang, Shilin Xiao, Mengmeng Du, Zhongsheng Xu, Yun Liu, Gang Liu, Mingfu Gong, Dong Zhang
Summary: A new strategy utilizing fluoride ions as morphology controlling agents and dopants led to the synthesis of iron oxide nanostructures with superior r(2) values. The resulting nanostructures showed significant enhancement in T-2-weighted MRI images in vivo, indicating their potential as efficient MRI contrast agents.
Article
Computer Science, Information Systems
Nicola Martini, Antonella Meloni, Vincenzo Positano, Daniele Della Latta, Petra Keilberg, Laura Pistoia, Anna Spasiano, Tommaso Casini, Angelica Barone, Antonella Massa, Andrea Ripoli, Filippo Cademartiri
Summary: This study presents a fully-automated method using a deep convolutional neural network for the analysis of myocardial T2* distribution. The proposed method demonstrated excellent performance in testing and evaluating patients with iron overload diseases.
Article
Oncology
Yoshinori Tsukahara, Yukinori Okajima, Akira Yamada, Masanobu Momose, Takeshi Uehara, Akira Shimizu, Yuji Soejima, Yasunari Fujinaga
Summary: The presence of a peritumoral hypointense rim (PTHR) in hepatocellular carcinoma (HCC) on T2*WIs was strongly associated with peritumoral iron deposition in the iron-deposited background liver, but not with the fibrous capsule. Iron deposition showed significant differences in HCC patients.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Medicine, General & Internal
Antonella Meloni, Laura Pistoia, Paolo Ricchi, Vincenzo Positano, Filomena Longo, Zelia Borsellino, Valerio Cecinati, Giuseppe Messina, Elisabetta Corigliano, Rosamaria Rosso, Riccardo Righi, Giuseppe Peritore, Stefania Renne, Antonino Vallone, Filippo Cademartiri
Summary: The value of pancreatic T2* magnetic resonance imaging (MRI) for predicting cardiac events in transfusion-dependent thalassemia patients was assessed. The study found that pancreatic T2* values were a significant predictor of future arrhythmia-related events, suggesting that monitoring pancreatic iron overload may help improve patient outcomes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Letter
Oncology
Wilson Y. K. Chan, Pamela P. W. Lee, Daniel K. L. Cheuk, Eva W. M. Yeung, Kenneth C. W. Wong, C. K. Li, Godfrey C. F. Chan, Wing Leung
PEDIATRIC BLOOD & CANCER
(2023)
Article
Clinical Neurology
Joan Marti-Fabregas, Pol G. Camps-Renom, Jonathan G. Best, Anna Ramos-Pachon, Marina Guasch-Jimenez, Alejandro Martinez-Domeno, Daniel M. Guisado-Alonso, Beatriz M. Gomez-Anson, Gareth Ambler, Duncan Wilson, Keon-Joo Lee, Jae-Sung Lim, Hee-Joon Bae, Masayuki Shiozawa, Masatoshi Koga, Kazunori G. Toyoda, Michael G. Hennerici, Hugues Chabriat, Eric Jouvent, Debbie Yuen Kwun Wong, Henry Mak, Kui Kai Lau, Young Dae Kim, Tae-Jin Song, Ji-Hoe Heo, Sebastian Eppinger, Thomas Gattringer, Ender Uysal, Derya Selcuk Demirelli, Natan Bornstein, Einor Ben Assayag, Hen A. Hallevi, Jeremy A. Molad, Masashi Nishihara, Jun Tanaka, Hideo Hara, Yusuke B. Yakushiji, Shelagh B. Coutts, Eric A. Smith, Alexandros A. Polymeris, Benjamin Wagner, David A. Seiffge, Philippe A. Lyrer, Nils T. Peters, Stefan T. Engelter, Rustam Al-Shahi Salman, Hans Rudolf Jager, Gregory Y. H. Lip, Martina Goeldlin, Leonidas Panos, Christopher Charles G. Karayiannis, Thanh G. K. Phan, Velandai K. Srikanth, Nicolas Christ, Sarah Gunkel, Felix W. Fluri, Thomas W. Leung, Yannie O. Y. Soo, Winnie Chu, Jill Abrigo, Carmen Barbato, Simone Browning, Robert Simister, Anne-Marie Mendyk, Regis Bordet, Saima Hilal, Bibek Gyanwali, Christopher Chen, Simon Jung, Dilek Necioglu Orken, David Werring, Luis Prats-Sanchez
Summary: This study aimed to investigate the risk of future cerebrovascular events in patients with ischemic stroke (IS) or transient ischemic attack (TIA) and cortical superficial siderosis (cSS), as well as the benefits and safety of antithrombotic drugs for secondary prevention. The study found that cSS was associated with an increased risk of stroke, and the risk of IS was higher than that of intracranial hemorrhage (ICrH) in patients receiving antiplatelet or anticoagulant treatment alone, while the risk of ICrH was higher than that of IS in patients receiving both treatments. Therefore, the study suggests that using antiplatelet or anticoagulant drugs alone is safe in patients with cSS, but combined antithrombotic therapy might be hazardous.
Article
Clinical Neurology
Hoi Man Yuen, Kate Ching-ching Chan, Winnie Chiu Wing Chu, Joey W. Y. Chan, Yun Kwok Wing, Albert Martin Li, Chun Ting Au
Summary: This study aimed to examine the craniofacial phenotype of Chinese prepubertal children with and without obstructive sleep apnea (OSA) using a quantitative photographic analysis technique and to develop a prediction model for OSA diagnosis based on the photogrammetric data. Potential ethnic differences in the association between OSA and photogrammetric data between Chinese and Caucasian children were also examined. The results showed significant differences in craniofacial features between different OSA groups in prepubertal children, and a prediction model based on clinical measurements and photogrammetric features achieved a good performance in OSA diagnosis.
Article
Chemistry, Multidisciplinary
Qiao Deng, Rongli Zhang, Siyue Li, Jin Hong, Yu-Dong Zhang, Winnie Chiu Wing Chu, Lin Shi
Summary: Accurate and automatic segmentation of medical images is increasingly demanded for disease diagnosis and surgical planning. This study proposed a two-stage medical image segmentation framework based on contour-aware CNN and voting strategy, which considered contour information and meaningful learning order. Experimental results showed that the proposed framework outperformed recent popular models, achieving compelling performance with dice coefficients of 91.2 +/- 2.6% for the CHAOS dataset and 88.2 +/- 0.4% for the hippocampus dataset.
APPLIED SCIENCES-BASEL
(2023)
Article
Oncology
Yin Ting Cheung, Chung Tin Ma, Michael Can Heng Li, Keary Rui Zhou, Herbert Ho Fung Loong, Agnes Sui Yin Chan, Kwok Chuen Wong, Chi Kong Li
Summary: Young survivors of bone tumors and soft-tissue sarcoma are at risk of cognitive impairment. Physical inactivity, smoking, and long working hours are associated with worse attention and executive function among survivors. Chronic health conditions coupled with continued physical inactivity may exacerbate cognitive dysfunction.
Article
Oncology
Paul K. M. Poon, King Wa Tam, Thomas Lam, Arthur K. C. Luk, Winnie C. W. Chu, Polly Cheung, Samuel Y. S. Wong, Joseph J. Y. Sung
Summary: Low HL is associated with low mammography screening participation. This study surveyed participants of a cancer screening program and used validated tools and health belief model to assess the relationship between HL and screening-related beliefs and risk perception.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Calvin Pui Lun Hoo, Alex Wing Kwan Leung, Joyce Pui Kwan Chan, Yin Ting Cheung, Frankie Wai Tsoi Cheng, Terry Tin Wai Chow, Grace Kee See Lam, Sau Yin Ha, Alan Kwok Shing Chiang, Rever Chak Ho Li, Chi Kong Li
Summary: This study retrospectively evaluated the incidence, risk factors, and clinical outcomes of avascular necrosis (AVN) among Chinese children with acute lymphoblastic leukemia (ALL). The results showed that the incidence of AVN in Chinese ALL patients was comparable to Western population studies. Age was identified as the most important risk factor, with a significantly higher incidence in adolescents above 10 years old compared to those below 10 years old. Treatment protocol, immunophenotype, and gender were not predictive of AVN.
Article
Oncology
Yin Ting Cheung, Kenneth Kin-Wah To, Rong Hua, Chui Ping Lee, Agnes Sui-Ying Chan, Chi Kong Li
Summary: This study evaluated the associations of biomarkers of inflammation with attention and neurobehavioral outcomes in survivors of childhood acute lymphoblastic leukemia (ALL). The results suggest that cancer-related inflammation may be a mechanism underlying neurobehavioral problems in pediatric ALL survivors.
FRONTIERS IN ONCOLOGY
(2023)
Letter
Health Care Sciences & Services
Esther Chui Yan Wong, Phillip Lung Wai Au-Doung, Yvonne Yuen Ling Chu, Sandy Sin Yuet Wong, Chi Kong Li, Yin Ting Cheung
BMJ SUPPORTIVE & PALLIATIVE CARE
(2023)
Article
Biology
Chi-Keung Cheng, Yuk-Lin Yung, Hoi-Yun Chan, Kam-Tong Leung, Kathy Y. Y. Chan, Alex W. K. Leung, Frankie W. T. Cheng, Chi-Kong Li, Thomas S. K. Wan, Xi Luo, Herbert-Augustus Pitts, Joyce S. S. Cheung, Natalie P. H. Chan, Margaret H. L. Ng
Summary: A genomic analysis of pediatric acute myeloid leukemia patients reveals extensive gene fusion events and mutations, providing new insights into the genetic complexities of this cancer. The study highlights the importance of understanding the genetic basis of pediatric AML for improving prognostic classification and treatment options.
COMMUNICATIONS BIOLOGY
(2023)
Meeting Abstract
Oncology
Xi Luo, Chi Keung Cheng, Hoi Yun Chan, Yuet Fong Kam, Kam Tong Leung, Chi Kong Li, Margaret Heung-Ling Ng
Article
Pediatrics
Nasreen Mahomed, Tracy Kilborn, Elsabe Jacoba Smit, Winnie Chiu Wing Chu, Catherine Yee Man Young, Nonceba Koranteng, Joanna Kasznia-Brown, Abbey J. Winant, Edward Y. Y. Lee, Kushaljit Singh Sodhi
Summary: Despite advances in diagnosis and treatment, tuberculosis remains a major public health threat worldwide. In pediatric populations, tuberculosis is a leading cause of infectious chest diseases and is associated with significant morbidity and mortality, especially in low- and middle-income countries. Diagnosis of pulmonary tuberculosis in children is challenging due to the difficulty in obtaining microbiological confirmation, often requiring a combination of clinical and radiological findings. Presumptive diagnosis of central nervous system tuberculosis heavily relies on imaging.
Despite improved diagnostic and therapeutic methods, tuberculosis continues to be a significant global public health threat. In children, it is a major cause of infectious chest diseases and is particularly detrimental in low- and middle-income countries. Diagnosis of pulmonary tuberculosis in children is difficult, often relying on clinical and radiological findings. Presumptive diagnosis of central nervous system tuberculosis heavily depends on imaging.
PEDIATRIC RADIOLOGY
(2023)
Article
Medicine, General & Internal
Jill M. Abrigo, Ka -long Ko, Qianyun Chen, Billy M. H. Lai, Tom C. Y. Cheung, Winnie C. W. Chu, Simon C. H. Yu
Summary: The use of artificial intelligence to identify acute intracranial hemorrhage on CT scans can help with initial interpretation in the emergency department. We developed an AI model using a large dataset of expert-labelled CT slices and validated its performance on CT scans from our institution.
HONG KONG MEDICAL JOURNAL
(2023)
Meeting Abstract
Oncology
Terry Tin Wai Chow, Wilson Yau Ki Chan, Ka Ho Chiu, Cheng Man, Hin Mark, Chak Ho Li, Ka Fai To, Chit Chow, Rex Kwok Him Au-Yeung, Elaine Tin Yan Cheung, Chi Kong Li
PEDIATRIC BLOOD & CANCER
(2023)
Article
Medicine, General & Internal
Cindy Xue, Jing Yuan, Gladys G. Lo, Darren M. C. Poon, Winnie C. W. Chu
Summary: This study investigates the impact of randomly generated irrelevant features on MRI radiomics feature selection and performance. The results show that while the inclusion of random features slightly affects feature selection, it does not have a substantial impact on the performance of MRI radiomics models.
