Review
Oncology
Eran Ben-Arye, Ofer Lavie, Wolfgang Heyl, Lois Ramondetta, Tara Berman, Noah Samuels
Summary: Integrative oncology services play a significant role in improving the care for ovarian cancer patients by combining complementary medicine therapies with conventional treatment. This study evaluates the current state of research in integrative oncology for ovarian cancer care.
CURRENT ONCOLOGY REPORTS
(2023)
Review
Oncology
Satoe Fujiwara
Summary: Ovarian clear cell carcinoma (OCCC) is a rare and distinct type of epithelial ovarian cancer with unique histopathological, clinical, and genetic features. It is associated with younger age at diagnosis and earlier stages compared to the most common type of ovarian cancer. OCCC is considered to have endometriosis as a direct precursor, and the most frequent gene mutations in OCCC are AT-rich interaction domain 1A and phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha. Patients with early-stage OCCC have a favorable prognosis, while those at advanced stages or with recurrent disease have a poor prognosis due to the resistance of OCCC to standard platinum-based chemotherapy. Aggressive cytoreductive surgery and adjuvant platinum-based chemotherapy are the recommended treatment strategies, but alternative therapies based on OCCC's specific molecular characteristics are urgently needed. Well-designed international clinical trials are necessary to improve outcomes and quality of life for patients with OCCC.
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
(2023)
Review
Immunology
Sarah Rumler
Summary: This article discusses the immune therapies for pediatric CNS tumors, including checkpoint inhibitors, vaccines, radiation therapy, and early studies of antibody-mediated immunogenic therapies. The article also highlights the importance of combination immunotherapy and addresses the neurologic toxicities associated with immunotherapies.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Giorgia Mangili, Giorgio Giorda, Gabriella Ferrandina, Gennaro Cormio, Chiara Cassani, Antonella Savarese, Saverio Danese, Marco Carnelli, Francesca Maria Vasta, Anna Myriam Perrone, Giovanna Scarfone, Sandro Pignata, Francesco Legge, Francesco Raspagliesi, Gianluca Taccagni, Massimo Candiani, Giorgio Bogani, Floriana Mascilini, Alice Bergamini
Summary: Our study revealed that close surveillance alone could be considered as an alternative option to avoid adjuvant chemotherapy in properly staged IB-C dysgerminomas, IA-IC G2-G3 immature teratomas, and IA mixed malignant ovarian germ cell tumors with yolk sac tumor component.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2021)
Article
Oncology
Adrianne Mallen, Sarah Todd, Sharon E. Robertson, Jongphil Kim, Marina Sehovic, Robert M. Wenham, Martine Extermann, Hye Sook Chon
Summary: The study revealed that older women aged 70 and above with advanced epithelial ovarian cancer tended to receive less specific treatments, had decreased platinum sensitivity, and significantly lower survival rates. Patients who were younger, received intraperitoneal therapy, completed adjuvant chemotherapy, and had platinum sensitivity showed better overall survival.
GYNECOLOGIC ONCOLOGY
(2021)
Review
Medicine, General & Internal
Qiancheng Hu, Wenli Kang, Qiuji Wu, Xin Wang, Qingfeng Wang, Ting Luo
Summary: This study aims to compare different maintenance strategies for patients with advanced ovarian cancer, analyzing their impact on progression-free survival, overall survival, toxicities, quality-adjusted life years, and cost-effectiveness. The results will be disseminated through international conferences and peer-reviewed manuscripts.
Article
Oncology
Samir Patel, Jennifer Vogel, Kristin Bradley, Paul J. Chuba, Jeffrey Buchsbaum, Matthew J. Krasin
Summary: The role of surgery, chemotherapy, and radiation therapy for retinoblastoma has evolved, with proton therapy potentially reducing the risk of secondary malignancies; pediatric nasopharyngeal carcinoma is treated with induction chemotherapy followed by chemoradiation therapy, and for adrenocortical carcinoma, surgery and chemotherapy are the mainstay with the role of radiation therapy yet to be defined.
PEDIATRIC BLOOD & CANCER
(2021)
Review
Pediatrics
Juan Fierro C. Pineda, Mary Frances Wedekind, John W. Glod
Summary: This article discusses immunotherapy for pediatric rare tumors, describing four major immunotherapies used in pediatrics and discussing the results and challenges of utilizing immunotherapy in rare pediatric tumors.
CURRENT OPINION IN PEDIATRICS
(2023)
Article
Multidisciplinary Sciences
Ignacio Vazquez-Garcia, Florian Uhlitz, Nicholas Ceglia, Jamie L. P. Lim, Michelle Wu, Neeman Mohibullah, Juliana Niyazov, Arvin Eric B. Ruiz, Kevin M. Boehm, Viktoria Bojilova, Christopher J. Fong, Tyler Funnell, Diljot Grewal, Eliyahu Havasov, Samantha Leung, Arfath Pasha, Druv M. Patel, Maryam Pourmaleki, Nicole Rusk, Hongyu Shi, Rami Vanguri, Marc J. Williams, Allen W. Zhang, Vance Broach, Dennis S. Chi, Arnaud Da Cruz Paula, Ginger J. Gardner, Sarah H. Kim, Matthew Lennon, Kara Long Roche, Yukio Sonoda, Oliver Zivanovic, Ritika Kundra, Agnes Viale, Fatemeh N. Derakhshan, Luke Geneslaw, Shirin Issa Bhaloo, Ana Maroldi, Rahelly Nunez, Fresia Pareja, Anthe Stylianou, Mahsa Vahdatinia, Yonina Bykov, Rachel N. Grisham, Ying L. Liu, Yulia Lakhman, Ines Nikolovski, Daniel Kelly, Jianjiong Gao, Andrea Schietinger, Travis J. Hollmann, Samuel F. Bakhoum, Robert A. Soslow, Lora H. Ellenson, Nadeem R. Abu-Rustum, Carol Aghajanian, Claire F. Friedman, Andrew McPherson, Britta Weigelt, Dmitriy Zamarin, Sohrab P. Shah
Summary: This study provides insights into the relationship between mutational processes, anatomical sites, and immune resistance mechanisms in HGSOC, highlighting the importance of personalized immunotherapeutic approaches and early detection research.
Article
Medicine, General & Internal
Anita Mansouri, Naomi McGregor, Rachel Dunn, Sam Dobbie, Jane Holmes, Linda Collins, Shibani Nicum
Summary: This study aims to conduct a randomized trial on patients with ovarian, fallopian tube, or primary peritoneal cancer who relapsed within 12 months of platinum-based chemotherapy, to investigate the efficacy and tolerability of novel agents for treatment.
Review
Oncology
Anca Chelariu-Raicu, Lauren P. Cobb, David M. Gershenson
Summary: The article discusses the preservation of fertility in the treatment of rare ovarian tumors, focusing on key factors such as preoperative assessment, choice of surgical approach, frozen section examination, intraoperative decision making, and postoperative management. Some rare ovarian tumors have characteristics that are compatible with fertility preservation, such as a high proportion of stage I disease and unilateral ovarian involvement.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2021)
Article
Oncology
Francois Gernier, Djihane Ahmed-Lecheheb, Patricia Pautier, Anne Floquet, Cedric Nadeau, Sophie Frank, Jerome Alexandre, Frederic Selle, Dominique Berton-Rigaud, Elsa Kalbacher, Hubert Orfeuvre, Alain Lortholary, Paule Augereau, Fabien Labombarda, Lionel Perrier, Jean-Michel Grellard, Idlir Licaj, Benedicte Clarisse, Aude-Marie Savoye, Heloise Bourien, Thibaut De La Motte Rouge, Jean-Emmanuel Kurtz, Katia Kerdja, Anais Lelaidier, Amandine Charreton, Isabelle Ray-Coquard, Florence Joly
Summary: The study aims to assess the potential long-term physical side-effects of chemotherapy in survivors of Germ Cell Tumors (GCT) and Sex Cord Stromal Tumors (SCST), especially cardiovascular and pulmonary disorders. The results will contribute to adjusting treatment and follow-up management with adapted recommendations to reduce toxicity while maintaining efficacy. Intervention strategies based on the results could improve patient management during treatment and in the long term.
Article
Surgery
Stephanie F. Polites, Todd E. Heaton, Michael P. LaQuaglia, Eugene S. Kim, Wesley E. Barry, Catherine J. Goodhue, Andrew J. Murphy, Andrew M. Davidoff, Max R. Langham, Rebecka L. Meyers, Scott S. Short, Timothy B. Lautz, Richard D. Glick, Sanjeev A. Vasudevan, Christina M. Bence, Dave R. Lal, Reto M. Baertschiger, Bryanna Emr, Marcus M. Malek, Roshni Dasgupta
Summary: This study retrospectively analyzed pneumonectomy in 38 children and adolescents with cancer from 1990 to 2017, showing lower rates of postoperative complications and survival rates that were related to tumor type and metastatic status.
Article
Oncology
Wei-feng Liang, Li-juan Wang, Hui Li, Chang-hao Liu, Miao-fang Wu, Jing Li
Summary: This study found that combining the chemotherapy response system and post-NACT CA125 normalization can effectively predict the risk of recurrence in patients with tubo-ovarian high-grade serous carcinoma, stratifying them into different risk groups.
Review
Oncology
Ilaria Bertacca, Francesco Pegoraro, Annalisa Tondo, Claudio Favre
Summary: The treatment of childhood solid cancer has evolved with refined molecular characterization and the use of targeted drugs. Larger sequencing studies have identified different mutations in pediatric tumors compared to adults. However, targeted drugs have shown inconsistent results in preclinical and clinical studies, and many have been tested only in relapsed or refractory patients.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Stefan S. Bielack, Sigbjorn Smeland, Jeremy S. Whelan, Neyssa Marina, Gordana Jovic, Jane M. Hook, Mark D. Krailo, Mark Gebhardt, Zsuzsanna Papai, James Meyer, Helen Nadel, R. Lor Randall, Claudia Deffenbaugh, Rajaram Nagarajan, Bernadette Brennan, G. Douglas Letson, Lisa A. Teot, Allen Goorin, Daniel Baumhoer, Leo Kager, Mathias Werner, Ching C. Lau, Kirsten Sundby Hall, Hans Gelderblom, Paul Meyers, Richard Gorlick, Reinhard Windhager, Knut Helmke, Mikael Eriksson, Peter M. Hoogerbrugge, Paula Schomberg, Per-Ulf Tunn, Thomas Kuehne, Heribert Juergens, Henk van den Berg, Tom Bohling, Susan Picton, Marleen Renard, Peter Reichardt, Joachim Gerss, Trude Butterfass-Bahloul, Carol Morris, Pancras C. W. Hogendoorn, Beatrice Seddon, Gabriele Calaminus, Maria Michelagnoli, Catharina Dhooge, Matthew R. Sydes, Mark Bernstein
JOURNAL OF CLINICAL ONCOLOGY
(2015)
Review
Immunology
Julianne N. P. Smith, Vikramjit S. Kanwar, Katherine C. MacNamara
FRONTIERS IN IMMUNOLOGY
(2016)
Article
Oncology
Tyler James Kenning, Vikramjit S. Kanwar, Jiang Qian, Eric M. Deshaies
JOURNAL OF NEURO-ONCOLOGY
(2009)
Article
Medicine, General & Internal
David L. Baker, Mary L. Schmidt, Susan L. Cohn, John M. Maris, Wendy B. London, Allen Buxton, Daniel Stram, Robert P. Castleberry, Hiroyuki Shimada, Anthony Sandler, Robert C. Shamberger, A. Thomas Look, C. Patrick Reynolds, Robert C. Seeger, Katherine K. Matthay
NEW ENGLAND JOURNAL OF MEDICINE
(2010)
Letter
Oncology
Claudia Busse, Tipu Nazeer, Vikramjit S. Kanwar, Suzanne Wolden, Michael P. LaQuaglia, Marc Rosenblum
PEDIATRIC BLOOD & CANCER
(2009)
Letter
Oncology
Lubbna Valliani, Vikramjit S. Kanwar, Adam Schwartz
PEDIATRIC BLOOD & CANCER
(2009)
Letter
Oncology
Vikramjit S. Kanwar, Mary Abraham
PEDIATRIC BLOOD & CANCER
(2012)
Review
Oncology
Vikramjit S. Kanwar, Kevin R. Schwartz, Nihad Salifu, Ahmed M. Abdelfattah, Bernard Anim, Julie Cayrol, Elizabeth Sniderman, Tim Eden
PEDIATRIC BLOOD & CANCER
(2020)
Review
Oncology
Shyam Srinivasan, Vikramjit Kanwar, Soumitra Saha, Raghavendra Gulabrao Mali, Tanveer Ahmed Shaikh, Renu Yadav, Anubha Jain
Summary: This case report discusses a young boy with childhood acute lymphoblastic leukemia (ALL) who experienced multiple complications, including pancreatitis, gastrointestinal perforation, and left ventricular thrombus, simultaneously due to L-asparaginase during induction chemotherapy. Despite immediate surgical intervention and anticoagulation therapy, the patient eventually died. This report highlights the importance of being aware of toxicities associated with the use of L-asparaginase.
INDIAN JOURNAL OF MEDICAL AND PAEDIATRIC ONCOLOGY
(2022)
Meeting Abstract
Oncology
Lauren Weintraub, Vikramjit Kanwar, Jeffrey Ross
Meeting Abstract
Oncology
Andrea Matho, Michael Jordan, Jeffrey Andolina, Vikramjit Kanwar, Lauren Weintraub
PEDIATRIC BLOOD & CANCER
(2015)
Meeting Abstract
Oncology
Samantha Ouinn, Alexander Gozman, Vikramjit Kanwar
PEDIATRIC BLOOD & CANCER
(2015)
Meeting Abstract
Oncology
S. Quinn, A. Gozman, V. Kanwar
PEDIATRIC BLOOD & CANCER
(2014)
Meeting Abstract
Clinical Neurology
Osama Elkadi, Matthew Adamo, Vikramjit Kanwar, Jiang Qian
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
(2013)
Meeting Abstract
Oncology
V. S. Kanwar, A. Broniscer