Review
Computer Science, Interdisciplinary Applications
Wenqing Wei, Tianyuan Zhang, Zifang Huang, Junlin Yang
Summary: This article reviews the use of finite element analysis (FEA) in assisting brace treatment for adolescent idiopathic scoliosis (AIS). It discusses the technical choices encountered during the construction of the finite element model (FEM) and explores the different fields and limitations of FEA. The article also collects observation items based on FEA and provides guidance and directions to improve brace treatment.
MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING
(2022)
Review
Genetics & Heredity
Duan Sun, Zihao Ding, Yong Hai, Yunzhong Cheng
Summary: Scoliosis, a three-dimensional deformity of the spine, is closely related to genetic, hormonal, and environmental factors. Epigenetic alterations in scoliosis have been studied but a comprehensive review is lacking. We analyzed 25 studies on DNA methylation, non-coding RNAs, histone modifications, and chromatin remodeling in scoliosis. DNA methylation and non-coding RNAs are well-researched, providing insights into prevention and treatment strategies. However, there is limited research on histone modifications and chromatin remodeling in scoliosis. Further exploration is needed to understand the overall effects of epigenetics in scoliosis.
FRONTIERS IN GENETICS
(2023)
Review
Medicine, General & Internal
Wichuda Siripanyakhemakul, Kwannate Permpool, Sirirat Seng-iad
Summary: This study aims to improve the efficacy of spinal orthosis treatment in patients with AIS through evaluating systematic reviews of studies. Quantitative and qualitative analysis of the data will be conducted to gain a better understanding of the effectiveness of this treatment.
Article
Pediatrics
Noelia Zagalaz-Anula, Felipe Leon-Morillas, Juan Alfonso Andradre-Ortega, Alfonso Javier Ibanez-Vera, Silvana Loana de Oliveira-Sousa, Rafael Lomas-Vega
Summary: This study found that AIS patients undergoing conservative treatment showed worse perception of verticality in subjective tests compared to those under observation, while posturographic parameters showed similar values in both groups. This suggests that treatment may affect the previous adaptation of vertical perception to the curvature.
FRONTIERS IN PEDIATRICS
(2021)
Article
Clinical Neurology
Jean-Francois Catanzariti, Alexandre Rimetz, Florence Genevieve, Gemma Renaud, Natacha Mounet
Summary: This study aims to verify the link between obesity and adolescent idiopathic scoliosis (AIS). By conducting X-ray measurements on obese adolescents, it was found that the prevalence of AIS in this population is twice as high as in the general population.
EUROPEAN SPINE JOURNAL
(2023)
Article
Medicine, General & Internal
Jakub Glowacki, Joanna Latuszewska, Adam Okret, Natalia Skowron, Ewa Misterska, Justyna Opydo-Szymaczek
Summary: Patients with adolescent idiopathic scoliosis (AIS) treated with a Milwaukee brace for at least 23 years show higher levels of temporomandibular joint disorders (TMD) compared to healthy controls, with clinical and radiological factors influencing the results and indicating limitations in everyday activities related to the temporomandibular joint.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Orthopedics
Abdulmajeed Alzakri, Faisal AlMuhid, Nasser Almousa, Muaath Aljehani, Hashem Alhalabi
Summary: This study aims to explore the factors that affect patient satisfaction with surgical treatment of scoliosis and evaluate the impact of satisfaction on the different domains of the SRS-22 questionnaire and radiographic parameters. The analysis reveals a significant positive correlation between self-image and satisfaction, indicating its crucial role in postoperative quality of life and surgical decision making.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Clinical Neurology
Cesare Faldini, Francesca Barile, Fabrizio Perna, Stefano Pasini, Michele Fiore, Giovanni Viroli, Alberto Di Martino, Alberto Ruffilli
Summary: This article presents an original surgical technique for the treatment of rigid Adult Idiopathic Scoliosis (AdIS) and evaluates the results in a cohort of 40 patients. The surgical technique, Hi-PoAD, proved to be safe and effective in correcting spinal deformity and improving clinical outcomes.
EUROPEAN SPINE JOURNAL
(2021)
Review
Health Care Sciences & Services
Nicola Montemurro, Luca Ricciardi, Alba Scerrati, Giorgio Ippolito, Giorgio Lofrese, Sokol Trungu, Andrea Stoccoro
Summary: This study found that approximately 35.1% of individuals with 22q11.2 deletion syndrome develop scoliosis. By studying miRNAs in both 22q11.2DS and AIS, two shared miRNAs were identified, supporting the hypothesis of common molecular alterations in these two diseases.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Medicine, General & Internal
James Meyers, Lily Eaker, Jessica Zhang, Theodor di Pauli von Treuheim, Baron Lonner
Summary: This study retrospectively analyzed the clinical outcomes of Adolescent Idiopathic Scoliosis patients treated with Vertebral Body Tethering. The results showed that VBT can achieve satisfactory correction in patients with limited skeletal growth, with significant improvement in post-operative clinical outcomes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Orthopedics
Mingzheng Zhang, Wenxuan Chen, Shengru Wang, You Du, Jianguo Zhang, Fang Pu
Summary: The study aimed to assess whether supine flexibility can predict postoperative correction in adolescent idiopathic scoliosis (AIS) patients. The results showed a significant correlation between supine flexibility and postoperative correction, which can be expressed by linear regression models. Therefore, supine radiographs can be used in clinical practice instead of current flexibility test techniques.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Chao Wu, Gedong Meng, Jie Lian, Jingxu Xu, Mingjie Gao, Chencui Huang, Shu Zhang, Yunfeng Zhang, Yizhou Yu, Haiyan Wang, Yujie He, Xiaohe Li, Zhijun Li
Summary: This study developed a deep learning algorithm to automatically evaluate and diagnose scoliosis on full spinal X-ray images. The model achieved high sensitivity and accuracy for parameters such as the Cobb angle, apical vertebrae, and demonstrated potential to improve diagnostic efficiency for radiologists.
EUROPEAN RADIOLOGY
(2022)
Article
Clinical Neurology
Benjamin Sherman, Peymon Madi, Afshin Aminian
Summary: The study found that performing thoracoplasty with posterior spinal fusion for adolescent idiopathic scoliosis did not increase immediate post-operative pain, narcotic use or oxygen consumption. Additionally, patients showed improved self-image scores after thoracoplasty.
EUROPEAN SPINE JOURNAL
(2021)
Article
Genetics & Heredity
Zhe Su, Yang Yang, Shengru Wang, Sen Zhao, Hengqiang Zhao, Xiaoxin Li, Yuchen Niu, Guixing Qiu, Zhihong Wu, Nan Wu, Terry Jianguo Zhang, Deciphering Disorders Involving Scoliosis COmorbidities DISCO Study Grp
Summary: Depletion of ptk7 is associated with both congenital scoliosis (CS) and adolescent idiopathic scoliosis (AIS) in zebrafish models. The study identified rare variants and loss-of-function variants in PTK7 by analyzing 583 patients with CS and 302 patients with AIS. The findings suggest different types of PTK7 variants are linked to CS and AIS.
Article
Orthopedics
Aymeric Guy, Carl-Eric Aubin
Summary: Adolescent idiopathic scoliosis (AIS) is a spine deformity affected by asymmetrical loads acting on the spine. The study developed a patient-specific finite element model (FEM) to simulate the effects of brace treatment on spinal correction and growth modulation over 2 years. The FEM accurately predicted the Cobb angles and other measurements immediately after brace correction and at the 2-year follow-up, providing confidence in its ability to improve brace design. The simulations also showed the importance of brace-wear compliance in preventing progression of spine deformities over treatment.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)