Article
Food Science & Technology
Shucen Feng, Haitao Wang, Xinping Lin, Huipeng Liang, Sufang Zhang, Yingxi Chen, Chaofan Ji
Summary: The increasing demand for healthy food has sparked interest in developing new food products containing probiotics. This study assessed the potential of probiotics and prebiotics to create novel gummies. The results confirmed the safety of 25 strains of Lactobacillus plantarum derived from fermented foods, showing their tolerance to simulated gastrointestinal fluids. Moreover, mushroom polysaccharides were found to have a proliferative effect on potential probiotics and protected their survival in the gastrointestinal fluids. These findings demonstrate the promising application of probiotics and prebiotics in the form of gummies as a probiotic food.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Caterina Anania, Giulia Brindisi, Ivana Martinelli, Edoardo Bonucci, Miriam D'Orsi, Sara Ialongo, Anna Nyffenegger, Tonia Raso, Mattia Spatuzzo, Giovanna De Castro, Anna Maria Zicari, Carlo Carraro, Maria Grazia Piccioni, Francesca Olivero
Summary: Atopic dermatitis is a chronic inflammatory skin disorder with increasing prevalence in children and adults. The potential role of probiotics in preventing atopic dermatitis has generated considerable interest, as they can modulate systemic inflammation and immune responses. However, the molecular mechanisms and efficacy of probiotics in anti-allergic effects are still unclear and controversial.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Ezgi Ozcan, Michelle R. Rozycki, David A. Sela
Summary: The study reveals that the probiotic Lactobacillus plantarum demonstrates varied physiological responses to different dietary oligosaccharides and cranberry polyphenols, with PAC1 fraction increasing growth and PAC2 positively impacting growth during xyloglucan metabolism. This differential response is also reflected in the metabolite ratios of acetic acid to lactic acid, indicating the potential synergistic effects of oligosaccharides and polyphenols on the physiology of L. plantarum.
Article
Food Science & Technology
Yuhan Xu, Qiaoling Xie, Wei Zhang, Meizhen Zhu, Xiaoxuan Chen, Dongbei Guo, Lili Pan, Junru Li, Hui Lan, Hongwei Li
Summary: The effects of probiotics Lp662 and Lp299v on severe inflammatory bowel disease induced by dextran sodium sulfate were evaluated. The results showed that these probiotics can reduce weight loss caused by colitis, decrease tissue injury, and lower inflammatory factor levels. Additionally, probiotics can also increase bone density. Therefore, probiotics have the potential to be a treatment option for inflammatory bowel disease.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Food Science & Technology
Li-Long Pan, Ming Zhang, Zhengying Li, Binbin Li, Xiaohua Pan, Xiaopei Chen, Bo Yang, Hao Zhang, Wei Chen, Le Zhang, Jia Sun
Summary: In this study, engineered probiotics encoding CRAMP were shown to increase colonic CRAMP production, reduce colon shortening and weight loss, and suppress inflammatory responses in experimental colitis. These findings suggest that CRAMP-encoding L. plantarum may have therapeutic potential for colitis through modulation of colonic CRAMP production.
Article
Food Science & Technology
Mengwei Wang, Yang Li, Jie Yang, Rui Shi, Liu Xiong, Qingjie Sun
Summary: This study investigated the adsorption amounts and antibacterial effects of inorganic nanoparticles on probiotic bacteria. Results showed that food-grade NPs have bactericidal effects on L. plantarum and L. fermentum.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Multidisciplinary Sciences
Faranak Gholipour, Mohammad Amini, Behzad Baradaran, Ahad Mokhtarzadeh, Morteza Eskandani
Summary: Probiotic bacteria treated with curcumin showed unaffected anticancer properties, ability to combat pathogenic bacteria, and survival in acidic conditions. They exhibited stronger inhibitory effects on colon cancer cells compared to untreated bacteria, inducing cell apoptosis.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Qi Guo, Jiaxin Tang, Shidong Li, Liyue Qiang, Shuaidan Chang, Gengan Du, Tianli Yue, Yahong Yuan
Summary: This study investigates the encapsulation of Lactobacillus plantarum into whey protein isolate and dextran conjugates, and finds that this method can enhance the viability of the probiotics under processing stress conditions, gastrointestinal conditions, and storage. Microencapsulation of probiotics offers better protection and can be a useful technique in the development of functional food products.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Nutrition & Dietetics
Bozena Cukrowska, Aldona Ceregra, Elzbieta Maciorkowska, Barbara Surowska, Maria Agnieszka Zegadlo-Mylik, Ewa Konopka, Ilona Trojanowska, Magdalena Zakrzewska, Joanna Beata Bierla, Mateusz Zakrzewski, Ewelina Kanarek, Ilona Motyl
Summary: Probiotics were found to significantly improve the severity of AD symptoms in children under 2 years old with both AD and CMP allergy, with the effect still noticeable after three months. Probiotics had a main effect on patients sensitized to allergens, but this effect diminished after nine months. Further research is needed to assess the impact of probiotic supplementation on immune tolerance development.
Article
Agriculture, Multidisciplinary
Qingqing Zhou, Bingyao Xue, Rongcheng Gu, Ping Li, Qing Gu
Summary: The study found that Lactobacillus plantarum ZJ316 had significant anti-H. pylori ability, decreased IFN-gamma and IL-6 levels, increased IL-10 levels, repaired mucosal damage, and reduced the abundance of H. pylori. Different microbial families were more prevalent in the prevention and treatment groups, indicating that L. plantarum ZJ316 could be a potential candidate for the prevention and treatment of H. pylori-induced gastritis by modulating the gastric microbiota and reducing mucosal inflammation.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Review
Biotechnology & Applied Microbiology
Leila Maidana, Marielen de Souza, Ana Paula F. R. L. Bracarense
Summary: Mycotoxins are toxic metabolites produced by fungi that contaminate animal feeds, causing economic losses due to direct effects on animal health and rejection of contaminated grains. L. plantarum, a lactic acid bacteria, has shown promise in reducing DON levels and toxicity through inhibition of fungal growth, adsorption, and biotransformation.
JOURNAL OF FOOD PROTECTION
(2022)
Article
Cell Biology
Agnieszka Magrys, Mateusz Pawlik
Summary: Probiotic bacteria, such as Lactobacillus spp., produce bioactive molecules called postbiotics that play important roles in supporting the immune system in the intestinal mucosa. This study investigated the potential effect of postbiotic fractions from L. rhamonosus and L. plantarum on immune responses induced by inflammation. The results showed that these fractions have a beneficial effect on controlling inflammation and protecting the intestinal barrier. They also found that these fractions can regulate cytotoxic activity in intestinal epithelial cells.
Article
Agriculture, Dairy & Animal Science
Matteo Dell'Anno, Maria Luisa Callegari, Serena Reggi, Valentina Caprarulo, Carlotta Giromini, Ambra Spalletta, Simona Coranelli, Carlo Angelo Sgoifo Rossi, Luciana Rossi
Summary: This study assessed the effects of Lactobacillus plantarum and Lactobacillus reuteri on in-feed supplementation in weaned piglets, showing that these probiotics can effectively reduce diarrhoea occurrence and serve as interesting functional additives to prevent antibiotic overuse.
Article
Biochemistry & Molecular Biology
Sihyun Jeong, Yuju Kim, Soyeong Park, Doyeon Lee, Juho Lee, Shwe Phyu Hlaing, Jin-Wook Yoo, Sang Hoon Rhee, Eunok Im
Summary: In this study, the potential mechanisms underlying the anticancer effect of Lactobacillus plantarum metabolites were investigated. The results showed that the metabolites had a synergistic effect with chloroquine, reducing cell viability and downregulating the expression of autophagy-related proteins in Caco-2 cells. This study provides new insights into new therapeutic methods via inhibiting autophagy.
Article
Chemistry, Applied
Yun-Yang Zhu, Kiran Thakur, Wang-Wei Zhang, Jing-Yu Feng, Jian-Guo Zhang, Fei Hu, Chenzhong Liao, Zhao-Jun Wei
Summary: Microcapsule encapsulation using double-layer gelatin-mucin-alginate and chitosan-mucin-alginate can enhance the resistance of the Lactobacillus plantarum B2 strain to adverse environments and its adhesiveness to the intestine. The encapsulation not only maintains the viability of the strain but also improves its resistance during storage and digestion, as well as its adherence to the intestinal mucus, leading to increased production of vitamin B2.
FOOD HYDROCOLLOIDS
(2023)
Article
Neurosciences
Nick A. Weaver, Jae-Sung Lim, Janniek Schilderinck, Geert Jan Biessels, Yeonwook Kang, Beom Joon Kim, Hugo J. Kuijf, Byung-Chul Lee, Keon-Joo Lee, Kyung-Ho Yu, Hee -Joon Bae, J. Matthijs Biesbroek
Summary: This study used lesion-symptom mapping to identify infarct locations and white matter disconnections associated with poststroke depressive symptoms (PSDS). The results showed that infarcts in the right amygdala, right hippocampus, and right pallidum were consistently associated with PSDS. Disconnectome-based analyses revealed disconnections in the right parahippocampal white matter, right thalamus and pallidum, and right anterior thalamic radiation were significantly associated with PSDS.
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2023)
Article
Clinical Neurology
Jeong-Yoon Choi, Seok Kim, Dachung Boo, Sooyoung Yoo, Hyo-Jung Kim, Jun Yup Kim, Keon-Joo Lee, Jihoon Kang, Beom Joon Kim, Moon-Ku Han, Hee-Joon Bae, Ji-Soo Kim
Summary: The temporal characteristics of stroke risks in emergency department patients with peripheral vertigo were evaluated and it was found that the stroke risk varied with time and individual factors.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Do Yeon Kim, Seok-Gil Han, Han-Gil Jeong, Keon-Joo Lee, Beom Joon Kim, Moon-Ku Han, Kang-Ho Choi, Joon-Tae Kim, Dong-Ick Shin, Jae-Kwan Cha, Dae-Hyun Kim, Dong-Eog Kim, Wi-Sun Ryu, Jong-Moo Park, Kyusik Kang, Jae Guk Kim, Soo Joo Lee, Mi-Sun Oh, Kyung-Ho Yu, Byung-Chul Lee, Hong-Kyun Park, Keun-Sik Hong, Yong-Jin Cho, Jay Chol Choi, Sung Il Sohn, Jeong-Ho Hong, Tai Hwan Park, Kyung Bok Lee, Jee-Hyun Kwon, Wook-Joo Kim, Jun Lee, Ji Sung Lee, Juneyoung Lee, Philip B. Gorelick, Hee-Joon Bae
Summary: This study aimed to evaluate the impact of covert brain infarction (CBI) on the risk of stroke recurrence in patients with atrial fibrillation (AF). A prospective cohort study was conducted on patients with acute ischemic stroke, and AF patients without a history of stroke or transient ischemic attack were enrolled. The results showed that CBI may increase the risk of stroke recurrence in patients with AF.
Meeting Abstract
Clinical Neurology
Do Yeon Kim, Jonguk Kim, Hee-Joon Bae, Jun Y. Kim, Jihoon Kang, Moon-Ku Han, Cheolkyu Jung, Sung Hyun Baik, Leonard Sunwoo, Jae Hyoung Kim, Beom J. Kim
Meeting Abstract
Clinical Neurology
Jeong-Yoon Lee, Kyusik Kang, Yong Soo Kim, Soo Joo Lee, Jae G. Kim, Jae-Kwan Cha, Dae Hyun Kim, Byeol-A Yoon, Moon-Ku Han, Beom J. Kim, Jihoon Kang, Jun Y. Kim, Tai H. Park, Sang-Soon Park, Jin-Kyo Choi, Kyung Bok Lee, Jun Lee, Doo Hyuk Kwon, Keun-Sik Hong, Yong-Jin Cho, Hong-Kyun Park, Byung-Chul Lee, Kyung-Ho Yu, Mi S. Oh, Minwoo Lee
Meeting Abstract
Clinical Neurology
Jong-moo Park, Hong-kyun Park, Seong-eun Kim, Yong-jin Cho, Jun Yup Kim, Beom Joon Kim, Kwang-yeol Park, Kyung Bok Lee, Soo Joo Lee, Ji Sung Lee, Juneyoung Lee, Hee-Joon Bae
Meeting Abstract
Clinical Neurology
Minwoo Lee, Byung-Chul Lee, Kyung-Ho Yu, Mi-Sun Oh, Beom J. Kim, Jun Y. Kim, Jihoon Kang, Jong-Moo Park, Kyusik Kang, Tai H. Park, Kyung Bok Lee, Keun-Sik Hong, Hong-Kyun Park, Yong-Jin Cho, Dong-Eog E. Kim, Soo Joo Lee, Jae G. Kim, Jun Lee, Jae-Kwan Cha, Dae Hyun Kim, Joon-Tae Kim, Kangho Choi, Jay Chol Choi, Sung-il Sohn, Jeong-Ho Hong, Sanghwa Lee
Meeting Abstract
Clinical Neurology
Hyung Seok Guk, Do Yeon Kim, Keun-Sik Hong, Jun Yup Kim, Jihoon Kang, Beom J. Kim, Moon Ku Han, Kang-Ho Choi, Joon-Tae Kim, Man Seok Park, Kyu Sun Yum, Dong-Ick Shin, Dong-Seok Gwak, Dong-Eog Kim, Yong Soo Kim, Kyusik Kang, Jae G. Kim, Soo Joo Lee, Minwoo Lee, Mi-Sun Oh, Kyung-Ho Yu, Byung-Chul Lee, Hong-Kyun Park, Yong-Jin Cho, Chul-Hoo Kang
Meeting Abstract
Clinical Neurology
Jonguk Kim, Do Y. Kim, Hee-Joon Bae, Jun Y. Kim, Jihoon Kang, Moon-Ku Han, Cheolkyu Jung, Sung Hyun Baik, Leonard Sunwoo, Jae Hyoung Kim, Beom J. Kim
Article
Clinical Neurology
K. Zhu, F. Bala, J. Zhang, F. Benali, P. Cimflova, B. J. Kim, R. McDonough, N. Singh, M. D. Hill, M. Goyal, A. Demchuk, B. K. Menon, W. Qiu
Summary: This article aims to develop an automated approach to quantify thrombus on NCCT and CTA in patients with stroke. The deep learning model obtained reliable results in both internal and external datasets.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2023)
Article
Clinical Neurology
F. Bala, B. J. Kim, M. Najm, J. Thornton, E. Fainardi, P. Michel, K. Alpay, D. Herlihy, M. Goyal, I. Casetta, S. Nannoni, P. Ylikotila, S. Power, V. Saia, A. Hegarty, G. Pracucci, R. Rautio, A. Ademola, A. Demchuk, S. Mangiafico, K. Boyle, M. D. Hill, D. Toni, S. Murphy, B. K. Menon, M. A. Almekhlafi
Summary: This study demonstrated that in the late time window, patients with M2 occlusions treated with endovascular thrombectomy achieved better clinical outcomes, similar reperfusion, and lower symptomatic intracranial hemorrhage rates compared with patients with M1 occlusion.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2023)
Article
Clinical Neurology
Joon-Tae Kim, Jihoon Kang, Beom Joon Kim, Jun Yup Kim, Moon-Ku Han, Ki-Hyun Cho, Man-Seok Park, Kang-Ho Choi, Jong-Moo Park, Kyusik Kang, Yong Soo Kim, Soo Joo Lee, Jae Guk Kim, Jae-Kwan Cha, Dae-Hyun Kim, Tai Hwan Park, Sang-Soon Park, Jin Kyo Choi, Kyungbok Lee, Kwang-Yeol Park, Hae-Bong Jeong, Jun Lee, Doo Hyuk Kwon, Yong-Jin Cho, Keun-Sik Hong, Hong-Kyun Park, Byung-Chul Lee, Kyung-Ho Yu, Mi Sun Oh, Minwoo Lee, Dong-Eog Kim, Dong-Seok Gwak, Jay Chol Choi, Joong-Goo Kim, Chul-Hoo Kang, Jee-Hyun Kwon, Wook-Joo Kim, Dong-Ick Shin, Kyu Sun Yum, Sung Il Sohn, Jeong-Ho Hong, Hyungjong Park, Chulho Kim, Sang-Hwa Lee, Juneyoung Lee, Philip B. Gorelick, Bo Norrving, Hee-Joon Bae
Summary: The goal of this study is to determine whether a longer duration of dual antiplatelet therapy with clopidogrel-aspirin can reduce the risk of recurrent vascular events in patients with large artery atherosclerotic (LAA) stroke subtype. This is a multicenter, prospective, randomized study comparing the efficacy and safety of a 12-month duration of DAPT versus a 3-month duration of DAPT in LAA stroke subtype patients. The results of this study will help stroke physicians determine the appropriate duration of dual therapy for LAA stroke subtype patients.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Article
Clinical Neurology
Beom Joon Kim, Kairan Zhu, Wu Qiu, Nishita Singh, Rosalie McDonough, Petra Cimflova, Fouzi Bala, Jongwook Kim, Yong Soo Kim, Hee-Joon Bae, Bijoy K. Menon
Summary: In this study, a deep learning model based on the nnU-net architecture was used to predict ischemic lesions visible on diffusion-weighted imaging (DWI) and fluid-attenuated inversion recovery (FLAIR) images using non-contrast computed tomography (NCCT) images. The results showed that the evaluation accuracy of DWI-FLAIR mismatch improved when using NCCT images in the subgroup with lesion volume greater than or equal to 15 mL.
FRONTIERS IN NEUROLOGY
(2023)
Article
Public, Environmental & Occupational Health
Eun Hye Park, Seung-sik Hwang, Juhwan Oh, Beom-Joon Kim, Hee-Joon Bae, Ki-Hwa Yang, Ah -Rum Choi, Mi-Yeon Kang, S. V. Subramanian
Summary: Patients with acute ischemic stroke and moderate-to-severe neurological deficits may benefit from thrombectomy-capable hospitals that have a stroke unit, stroke specialists, and a substantial endovascular thrombectomy case volume.
JOURNAL OF PREVENTIVE MEDICINE & PUBLIC HEALTH
(2023)
Correction
Cardiac & Cardiovascular Systems
Keon-Joo Lee, Beom Joon Kim, Moon-Ku Han, Joon-Tae Kim, Kang Ho Choi, Dong-Ick Shin, Jae-Kwan Cha, Dae-Hyun Kim, Dong-Eog Kim, Wi-Sun Ryu, Jong-Moo Park, Kyusik Kang, Soo Joo Lee, Mi-Sun Oh, Kyung-Ho Yu, Byung-Chul Lee, Keun-Sik Hong, Yong-Jin Cho, Jay Chol Choi, Tai Hwan Park, Sang-Soon Park, Jee-Hyun Kwon, Wook-Joo Kim, Jun Lee, Sung Il Sohn, Jeong-Ho Hong, Kyung Bok Lee, Ji Sung Lee, Juneyoung Lee, Philip B. Gorelick, Hee-Joon Bae
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)