期刊
PEDIATRIC ALLERGY AND IMMUNOLOGY
卷 20, 期 5, 页码 467-470出版社
WILEY
DOI: 10.1111/j.1399-3038.2008.00813.x
关键词
infant; very low-birth-weight; glutamine; follow-up study; Th-1/Th-2 cytokines
In a previous study, we found that glutamine-enriched enteral nutrition in 102 very low-birth-weight (VLBW) infants decreased both the incidence of serious neonatal infections and atopic dermatitis during the first year of life. The aims of this follow-up study were to determine whether these beneficial effects are attended by changes in Th-1 and Th-2 cytokine profiles at age 1 yr. Furthermore, we studied changes in cytokine profiles during the first year of life in these VLBW infants. In total, 89 infants were eligible for the follow-up study (12 died, 1 exclusion due to a chromosomal abnormality). Th-1 (IFN-gamma, TNF- alpha and IL-2) and Th-2 cytokine (IL-10, IL-5, and IL-4) profiles following in vitro whole blood stimulation were measured at 1 yr. Cytokine profiles were measured in 59/89 (66%) infants. Glutamine-enriched enteral nutrition in neonatal period did not influence cytokine profiles at 1 yr. Cytokine profiles were not different in infants with and without allergic or infectious diseases. The beneficial effect of glutamine-enriched enteral nutrition on the incidence of serious neonatal infections and atopic dermatitis during the first year of life is not related to changes in the Th-1 and Th-2 cytokine profiles. Both Th-1 and Th-2 cytokine profiles increased during the first year of life in this cohort of VLBW infants.
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