期刊
PATHOLOGY RESEARCH AND PRACTICE
卷 209, 期 6, 页码 345-352出版社
ELSEVIER GMBH
DOI: 10.1016/j.prp.2013.02.015
关键词
HAb18G/CD147; Non-small cell lung cancer; Localization; Survival; Progression and prognosis
类别
资金
- Science and Technology Program of Guangdong Province [20108060300001]
This study was designed to investigate the association of HAb18G/CD147 expression and localization with clinicopathological parameters and prognosis in NSCLC. Two hundred and eight (208) specimens of surgically resected NSCLC were stained by immunohistochemistry utilizing mouse anti-human HAb18G/CD147 monoclonal antibody. High levels of HAb18G/CD147 expression were associated with male gender, smoking history, tumor position, distant metastasis status, and clinical stage (p < 0.05) in squamous cell carcinoma. In adenocarcinomas, HAb18G/CD147 expression was associated with male gender, tumor diameter, differentiation, lymph node status, distant metastasis status, and clinical stage (p <0.05). HAb18G/CD147 expression with higher PU was predominantly localized in the tumor cell membranes rather than in cytoplasms. In squamous cell carcinomas, membranous localization of HAb18G/CD147 was linked to distant metastasis status and TNM stage (p< 0.05). Cytoplasmic localization of HAb18G/CD147 was associated with male gender and smoking history. In adenocarcinomas, membranous localization of HAb18G/CD147 correlated with tumor diameter, differentiation and distant metastasis (p <0.05). Univariate analysis indicated that patients with high HAb18G/CD147 expression and membranous localization predicted poor prognosis in both squamous cell carcinomas and adenocarcinomas. Multivariate analysis showed that lymph node status (HR= 1.762, 95%CI 1.105-2.811, p=0.017), distant metastasis status (HR =3.789, 95%CI 2.196-6.539, p = 0.000), expression (HR= 6.632, 95%CI 2.457-17.904, p = 0.000), and localization (HR= 0.520, 95%CI 0.341-0.794, p= 0.002) were good or excellent independent predictors of patient survival. HAb18G/CD147 is a biomarker characterizing progression and survival of NSCLC. More importantly, its cellular localizations should be considered in the analysis of clinicopathological characteristics and prognostic factors in NSCLC. Crown Copyright (C) 2013 Published by Elsevier GmbH. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据