Article
Endocrinology & Metabolism
Qing Li, Jie Yu, Hanjie Yi, Qiongyu Lan
Summary: This study investigated the patterns and prognosis of distant organ metastasis in neuroendocrine carcinoma of the cervix (NECC). The results showed that NECC was prone to single and multi-site metastases, and distant metastasis was an independent predictor of poor prognosis in NECC patients. Additionally, surgery, radiotherapy, and chemotherapy were found to improve the overall survival of patients with distant organ metastases.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Xiaofei Chen, Chenyang Zhang, Dingjie Guo, Yashan Wang, Junjun Hu, Jiayi Hu, Song Wang, Xin Liu
Summary: This study aimed to explore the risk factors and prognostic factors of invasive ductal carcinoma (IDC) and predict the survival of IDC patients with metastasis. Risk factors included age, race, marital status, income, geographic region, grade, T stage, N stage, subtype, surgery, and radiotherapy, while prognostic factors included age, race, marital status, income, geographic region, grade, T stage, N stage, subtype, surgery, and chemotherapy. A nomogram was established with a C-index of 0.701, showing good consistency between actual observation and prediction. Survival curves varied significantly among different metastatic patterns.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Otorhinolaryngology
Lianlian Yang, Yinyin Xue, Zhigong Wei, Kexing Ren, Zheran Liu, Tangel Chang, Xingchen Peng, Yonglin Su, Yan Li
Summary: Local radiotherapy to metastatic lesions might be a protective factor for patients with metastatic nasopharyngeal carcinoma (mNPC) as shown in the study involving 109 patients with mNPC. The overall survival rates were significantly higher in patients who received local radiotherapy compared to those who did not receive radiotherapy to metastatic lesions.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Oncology
Zhao Shu, Junfeng Guo, Qian Xue, Qi Tang, Bingqiang Zhang
Summary: This study constructed a single-cell atlas of ESCC and revealed a novel subpopulation of SAA1+ malignant cells that are closely associated with distant metastasis of ESCC. A prediction model based on the gene expression pattern of SAA1+ cells was also established to identify high-risk patients with worse prognosis. These findings enhance our understanding of the mechanisms underlying distant metastasis in ESCC and provide a theoretical basis for improved therapies.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Hao Zhan, Xue Zhao, Zhaoxue Lu, Yuanhu Yao, Xuguang Zhang
Summary: The study found that patients with hepatocellular carcinoma who had single organ metastasis had a better prognosis than those with multiple organ metastasis. Certain factors such as age, gender, tumor differentiation, tumor size, and metastatic sites were found to be associated with the prognosis of patients with distant metastasis of hepatocellular carcinoma.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Jin-Seok Lee, Jun Sung Lee, Hyeok Jun Yun, Hojin Chang, Seok Mo Kim, Yong Sang Lee, Hang-Seok Chang, Cheong Soo Park
Summary: This study aimed to exhibit the clinical characteristics of anaplastic thyroid cancer (ATC) with distant metastasis, which is associated with a high mortality risk. Brain MRI or CT should be considered at diagnosis and follow-up, even in patients without neurological symptoms.
Article
Otorhinolaryngology
Li Luo, Honggang Liu
Summary: This study aimed to determine the impact of tumor budding on the survival of patients with laryngeal squamous cell carcinoma. The results showed that high-grade tumor budding was associated with disease-free survival and overall survival in these patients, and smaller tumor cell nests, low levels of tumor-infiltrating lymphocytes, and higher pathological T staging were closely associated with high-grade tumor budding in laryngeal squamous cell carcinoma.
BRAZILIAN JOURNAL OF OTORHINOLARYNGOLOGY
(2023)
Article
Oncology
Yongqiang Yang, Xiaole Li, Pengcheng Zhou, Xiaoyu Deng, Yingyi Wang, Qianqian Dang, Yingjuan Zheng, Daoke Yang
Summary: The study analyzed the effects of radiotherapy and its timing on the survival and safety of patients with nasopharyngeal carcinoma, finding that both early and late combined radiotherapy prolonged PFS and OS for patients compared to those who did not receive radiotherapy.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Immunology
De-song Shen, Chang Yan, Kai-hua Chen, Ling Li, Song Qu, Xiao-dong Zhu
Summary: In this study, a prognostic nomogram was established and validated to identify high-risk patients with distant metastasis in nasopharyngeal carcinoma (NPC). The nomogram, based on multiple factors, showed high predictive ability and accuracy. Serving as a supplement to the TNM staging system, the nomogram has the potential to guide individualized treatment and improve survival outcomes for NPC patients.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Oncology
Dong Soo Lee, Chang Wook Kim, Hee Yeon Kim, Young-Mi Ku, Yoo Dong Won, Su-Lim Lee, Der Sheng Sun
Summary: This study investigated whether serum immune and inflammatory parameters can predict distant metastasis in patients with unresectable hepatocellular carcinoma undergoing radiation therapy. The results showed that posttreatment serum PLR and PNI levels could be used as predictors of distant metastasis. Further research is needed to validate these findings.
Article
Endocrinology & Metabolism
Bo Chen, Yuan Zeng, Bo Liu, Gaoxiang Lu, Zhouxia Xiang, Jiyang Chen, Yan Yu, Ziyi Zuo, Yangjun Lin, Jinfeng Ma
Summary: This study identified independent risk factors for distant metastasis (DM) and established two nomograms to predict the occurrence and prognosis of DM in osteosarcoma patients. The nomograms were validated using various analysis methods and were found to be effective tools for predicting the risk of DM and personalized prognosis prediction for patients with DM.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Oncology
Jianxin Xue, Wensun Chen, Wenbo Xu, Zicheng Xu, Xiao Li, Feng Qi, Zengjun Wang
Summary: This study aimed to describe distant metastasis patterns in ccRCC patients, with the lung being the most common metastatic site. Different survival outcomes and prognostic factors were identified for different metastatic patterns. This research would be valuable for future clinical practice.
Article
Cell Biology
Haizhou Liu, Zihan Zhang, Yi Huang, Wene Wei, Shufang Ning, Jilin Li, Xinqiang Liang, Kaisheng Liu, Litu Zhang
Summary: The study demonstrated the association of pre-treatment plasma HSP90AA1 with the risk of breast cancer onset and metastasis, showing that combining with other markers could conveniently predict patients' risk.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Pathology
Huan Wang, Yu Zhang, Ziqi Yang, Yong Jiang, Lixue Wu, Rui Wang, Zhang Zhang
Summary: This study explores the expression patterns of Syndecan-1 (SDC-1) in invasive breast carcinoma (IBC) with distant metastasis (DM). It found that the cytoplasmic and stromal expressions of SDC-1 are closely associated with DM, and the stromal expression of SDC-1 is correlated with tumor immune microenvironment. SDC-1 shows potential as a new marker for predicting the risk of distant metastasis in IBC.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Oncology
Parbatraj Regmi, Aliza Paudyal, Pranita Paudyal, Hai-Jie Hu, Fei Liu, Wen-Jie Ma, Yan-Wen Jin, Fu-Yu Li
Summary: Tumor budding is identified as a significant predictor of poor survival for biliary tract cancer (BTC), associated with poor histologic differentiation, lymphovascular invasion, and other factors. It has the potential to serve as a prognostic marker for BTC, pending the development of a standardized international consensus.
Article
Environmental Sciences
Aysegul Yurt, Ismail Ozsoykal, Recep Kandemir, Emel Ada
RADIATION PROTECTION DOSIMETRY
(2020)
Review
Pathology
M. Hasan Toper, Sulen Sarioglu
Summary: Salivary gland neoplasms are a rare and heterogeneous group of tumors with diverse molecular characteristics. Recent advancements in molecular pathology have provided insights into the genetic aberrations and potential diagnostic, prognostic, and predictive biomarkers in these tumors.
ADVANCES IN ANATOMIC PATHOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hande Melike Bulbul, Ogun Bulbul, Sulen Sarioglu, Ozhan Ozdogan, Ersoy Dogan, Nuri Karabay
Summary: This study found significant correlations between DWI, DCE-MRI, and PET/CT parameters, providing effective evaluation of tumor cellularity, vascular permeability, and glucose metabolism. MTV may play a key role in predicting T4 tumors.
MOLECULAR IMAGING AND RADIONUCLIDE THERAPY
(2021)
Article
Otorhinolaryngology
Beyhan Ceylaner Bicakci, Teuta Zoto Mustafayev, Oguz Cetinayak, Sefik Igdem, Sumerya Duru Birgi, Deniz Meydan, Fatih Demircioglu, Banu Atalar, Enis Ozyar, Fadime Akman
Summary: This study retrospectively analyzed the clinical outcomes of patients with early stage laryngeal cancer treated with carotid sparing intensity-modulated radiotherapy. The results showed excellent oncologic outcomes and acceptable side effects. Longer follow-up is needed to evaluate the long-term effect on stroke.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Letter
Rheumatology
B. Karakaya, S. Gulle, D. Gurel, S. Sarioglu, S. Ozkal, M. Birlik, F. Onen, M. O. Tarhan
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
(2022)
Article
Health Care Sciences & Services
Ender Berat Ellidokuz, Tolga Sever, Gizem Calibasi Kocal, Aras Emre Canda, Sulen Sarioglu, Hasan Kurter, Ilhan Oztop, Yesim Tuncok, Yasemin Basbinar
Summary: This study investigated the cellular biology and physiology of colon cancer tissues in in vitro. The results showed that isolating cells from larger and non-necrotic tumor tissues resulted in better growth patterns for 3D cultures. Size and presence of necrotic areas were found to be important factors affecting the viability of cancer cells.
JOURNAL OF BASIC AND CLINICAL HEALTH SCIENCES
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hakki Celik, Funda Barlik, Selman Sokmen, Cem Terzi, Aras Emre Canda, Ozgul Sagol, Sulen Sarioglu, Mehtat Unlu, ilknur Bilkay Gorken, Zuemre Arican Alicikus, Ilhan Oztop
Summary: This study aims to investigate the diagnostic performance of MRI in predicting the pathologic stage of LARC after neoadjuvant CRT and the role of MRI in selecting patients with ypCR. The results showed moderate accuracy and sensitivity in predicting ypT and N stages, mainly due to underestimating tumor stage and overestimating nodal status. Furthermore, high specificity and NPV but low sensitivity were observed in predicting the complete response.
DIAGNOSTIC AND INTERVENTIONAL RADIOLOGY
(2023)
Article
Otorhinolaryngology
Halil Cumhur Yildirim, Gulnihan Eren Kupik, Teuta Zoto Mustafayev, Tanju Berber, Berrin Yavuz, Oguz Cetinayak, Ozlem Akagunduz, Beyhan Ceylaner Bicakci, Suheyla Aytac Arslan, Ela Delikgoz Soykut, Mete Gundog, Metin Figen, Fatma Teke, Emine Canyilmaz, Sumerya Duru Birgi, Mursel Duzova, Sefik Igdem, Candan Demiroz Abakay, Beste Atasoy, Nuri Kaydihan, Murtaza Parvizi, Gonca Hanedan Uslu, Halil Saginc, Fadime Akman, Enis Ozyar
Summary: This study evaluated patients with nasopharyngeal carcinoma (NPC) in a nonendemic population. The patients in Turkey have mixed clinical features of both east and west, and their survival outcomes are comparable to other reported series, although the rate of distant relapse seems to be lower.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2023)
Article
Dentistry, Oral Surgery & Medicine
Ozlem Ozkaya Akagunduz, Demet Etit, Gozde Yazici, Ali Veral, Oguz Cetinayak, Sulen Sarioglu, Gaye Guler Tezel, Sumerya Duru Birgi, Seher Yuksel, Gulsen Kara, Teuta Zoto Mustafayev, Fatma Tokat, Beyhan Ceylaner Bicakli, Kayhan Basak, Mustafa Esassolak, Fadime Akman, Enis Ozyar
Summary: The aim of this study was to categorize the risk groups of patients with oropharyngeal carcinoma based on p16 and p53 status, smoking/alcohol consumption history, and other prognostic factors. The results showed that p16 negativity was an important prognostic factor for oropharyngeal cancer patients, especially for those with lower p53 expression and not smoking/consuming alcohol.
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
(2023)
Article
Health Care Sciences & Services
Ozlem Ugur, Ezgi Karadag, Oguz cetinayak, Volkan Semiz, Fadime Akman
Summary: The aim of this study is to examine the effect of honey treatment on oral mucositis management in patients with head and neck cancer receiving radiotherapy. The study was conducted as a randomized controlled, single-blind, parallel group study with 32 patients. The results showed no significant difference between the honey treatment group and the bicarbonate group in terms of days with mucositis, mucositis score, and pain score.
JOURNAL OF BASIC AND CLINICAL HEALTH SCIENCES
(2023)
Article
Oncology
Ozan Cem Guler, Ezgi Oymak, Gozde Yazici, Ozlem Ozkaya Akagunduz, Oguz Cetinayak, Petek Erpolat, Atil Aksoy, Mursel Duzova, Berna Akkus Yildirim, Meral Kurt, Emine Canyilmaz, Guler Yavas, Serap Akyurek, Didem Colpan Oksuz, Esra Kaytan Saglam, Omur Karakoyun Celik, Enis Ozyar, Mustafa Cengiz, Cem Onal
Summary: The aim of this study was to analyze the prognostic factors and treatment outcomes of cervical esophageal carcinoma (CEC) patients who underwent definitive chemoradiotherapy (CRT). Clinical data of 175 biopsy-confirmed CEC patients treated with definitive CRT were analyzed retrospectively. The study found that treatment response and patient performance status were significant prognostic factors for overall survival, progression-free survival, and local recurrence-free survival. In addition, higher radiation doses did not affect treatment outcomes. The study concluded that definitive CRT is a safe and effective treatment for CEC patients.
Review
Health Care Sciences & Services
Zohal Alnour Ahmed Emam, Emel Ada
Summary: This paper presents the application and development of machine learning and deep learning techniques in the fields of medical physics, radiology, and radiation oncology, and discusses the potential challenges and solutions.
JOURNAL OF BASIC AND CLINICAL HEALTH SCIENCES
(2022)
Article
Medicine, General & Internal
Gercek Can, Sulen Sarioglu, Merih BIrlIk, Gokce Kenar, Ozgul Soysal, Dilek Solmaz, Vedat Gerdan, Fatos Onen, Nurullah Akkoc, Servet Akar
Summary: This study investigated the prevalence of sicca symptoms and secondary Sjogren's syndrome (SjS) in patients with systemic sclerosis (SSc), as well as evaluated the expression of alpha-smooth muscle actin (alpha-SMA) in minor salivary gland (MSG) specimens. Results showed that sicca symptoms were common among SSc patients, with nearly one-third fulfilling the criteria for SjS, particularly in the limited subtype. Older age and positive anti-SS-A antibodies were identified as predictors for SjS, and glandular fibrosis was significant but alpha-SMA staining was rare in patients with SSc.
TURKISH JOURNAL OF MEDICAL SCIENCES
(2021)
Meeting Abstract
Oncology
B. C. Bicakci, T. Z. Mustafayev, O. Cetinayak, S. Igdem, S. Duru Birgi, D. Meydan, F. Demircioglu, B. Atalar, E. Ozyar, F. Akman
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2020)
Meeting Abstract
Clinical Neurology
R. Ala, G. Akdal, M. Soylev Bajin, A. Yaman, B. Donmez Colakoglu, E. Ozer, E. Ada, S. Men, G. Yener
EUROPEAN JOURNAL OF NEUROLOGY
(2020)
Article
Pathology
Xiaobo Zhang, Chen Wang, Danhua Shen
Summary: This study investigated the Clinicopathological features and FH mutation in FH-dUL. FH-dUL is rare and the combination of predictive Clinicopathological evaluation, FH and 2SC IHC test, and molecular test were helpful for the screening of FH-dUL or even HLRCC.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Review
Pathology
Gaurav Dubey, Mithilesh Singh, Himmat Singh, Mohit Agarwal, Shailendra Singh Chandel, Anurag Mishra, Ravindra Pal Singh, Neelima Kukreti
Summary: SnoRNAs play a crucial role in autoimmune diseases, influencing gene expression, immune cell development, and immune regulation. They have the potential to be biomarkers or therapeutic targets for disease management. However, further research is needed to elucidate their precise molecular mechanisms.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Article
Pathology
P. Suhaj, D. Do, T. Olejar, R. Pichova, O. Lang, R. Matej
Summary: Pancreatic polypeptide cell hyperplasia (PPY-H) is a multiplication of neuroendocrine cells producing pancreatic polypeptide (PPY). The development and role of PPY-H still need to be further elucidated. This study analyzed 12 cases of PPY-H accompanying pancreatic neuroendocrine neoplasias (NEN) and found that gastrointestinal symptoms may be more related to PPY-H rather than NEN hormonal production. Strong SSTR2 expression in PPY-H suggests the potential utility of radiotracers in clinical diagnostics, but further studies are needed.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Article
Pathology
Ruyun Zhang, Xiaofei Liao, Bin Zhang, Xiaohong Huang, Guanjie Qin, Xiangyun Kong, Yuan Xie, Yunyan Mo, Jinxuan Dai, Chunqiao Gan, Zan Luo, Jingyan Lu, Wei Jiang
Summary: This study found that patients with high COV+TIL score had worse prognosis in nasopharyngeal carcinoma.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Review
Pathology
Waleed Hassan Almalki
Summary: Understanding the molecular pathways behind cardiovascular illnesses is crucial. Recent studies have revealed the role of Xist RNA in cardiovascular diseases, including epigenetic changes, gene expression, cellular identity, and sex chromosomal inactivation. Dysregulation of Xist RNA expression is associated with conditions such as atherosclerosis, hypertrophy, and cardiac fibrosis.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Article
Pathology
Yanxin Dong, Boshi Fan, Mingyang Li, Jiale Zhang, Shun Xie, Shouyin Dia, Qingge Jia, Taiqian Gong
Summary: Tescalcin (TESC) is upregulated in esophageal squamous carcinoma (ESCC) and is associated with poor prognosis, tumor infiltration, staging, and lymph node metastasis. TESC promotes proliferation, invasion, migration, and epithelial-mesenchymal transition (EMT) progression in ESCC, as well as activates the AKT pathway. TESC may serve as a prognostic factor and provide a new therapeutic strategy for ESCC.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Article
Pathology
Ozge Sukruoglu Erdogan, Demet Akdeniz Odemis, Zubeyde Yalniz Kayim, Orkun Gurbuz, Seref Bugra Tuncer, Seda Kilic, Betul Celik, Samuray Tuncer, Sema Buyukkapu Bay, Rejin Kebudi, Hulya Yazici
Summary: This study found that methylation of the RB1 gene promoter does not influence the hereditary transmission of familial retinoblastoma.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Review
Pathology
Syam Mohan, Mohammed Ageeli Hakami, Hamad Ghaleb Dailah, Asaad Khalid, Asim Najmi, Khalid Zoghebi, Maryam A. Halawi, Thaifallah Munahi Alotaibi
Summary: Cancer is a complex disease caused by multiple factors, and miR-155 plays a significant role as a regulator of the NF-kappa B signaling pathway, contributing to cancer development and progression.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
