Article
Oncology
Lukasz Lewczuk, Anna Pryczynicz, Katarzyna Guzinska-Ustymowicz
Summary: The study aimed to examine the protein expression levels of E-, N- and P-cadherin in cancer tissue from patients with endometrial cancer and their effects on clinicopathological parameters. Immunohistochemistry revealed uneven distribution of these cadherins in endometrial cancer tissue, with higher expression levels at the tumor front. Additionally, lower membrane expression levels of the 3 cadherin proteins were observed in metastatic cancer cells compared to primary tumor cells.
Review
Oncology
Pengbo Wang, Zengkuan Zhu
Summary: Expression of E-cadherin is closely associated with the risk, clinical features, and prognosis of pancreatic cancer, suggesting it may serve as an effective biomarker for clinical assessments and predicting prognosis in patients with pancreatic cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Zongxian Zhao, Shuliang Li, Shilong Li, Jun Wang, Hai Lin, Weihua Fu
Summary: The study revealed that upregulated expression of CDH6 in gastric cancer is associated with diagnosis and prognosis, making it a potential independent molecular biomarker.
CANCER CELL INTERNATIONAL
(2021)
Review
Biochemistry & Molecular Biology
Huichen Zhao, Huihui Hu, Beibei Chen, Weifeng Xu, Jing Zhao, Chen Huang, Yishu Xing, Huifang Lv, Caiyun Nie, Jianzheng Wang, Yunduan He, Sai-Qi Wang, Xiao-Bing Chen
Summary: Gastric cancer ranks fifth in global cancer incidence and third in cancer mortality. E-cadherin is crucial in tumorigenesis, tumor progression, metastasis, with soluble E-cadherin playing a role in promoting invasion and metastasis in gastric cancer.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Cell Biology
Qianwen Wang, Chenxiang Qi, Pengxiang Min, Yueyuan Wang, Fengwen Ye, Tianxiang Xia, Yujie Zhang, Jun Du
Summary: By regulating MICAL2, the migratory ability of gastric cancer cells can be influenced, and it involves changes in the E-cadherin/beta-catenin signaling pathway.
CELL COMMUNICATION AND SIGNALING
(2022)
Review
Oncology
Giovanni Corso, Federica Corso, Federica Bellerba, Patricia Carneiro, Susana Seixas, Antonio Cioffi, Carlo La Vecchia, Francesca Magnoni, Bernardo Bonanni, Paolo Veronesi, Sara Gandini, Joana Figueiredo
Summary: E-cadherin germline mutations, particularly CDH1 gene mutations, are associated with hereditary diffuse gastric cancer syndrome. The frequency of CDH1 mutations varies across different geographical areas, with a higher incidence in low-prevalence countries. The type and relative frequency of CDH1 mutations also differ between study groups and regions, with missense variants more common in high-incidence areas. Identifying individuals with clinically significant CDH1 mutations is crucial for effective genetic screening and patient management in gastric cancer.
Article
Oncology
Mourad Assidi
Summary: This study investigates the expression patterns of N-CAD protein in ovarian cancer (OC) patients and its correlations with clinicopathological features. The study finds that N-CAD protein is often overexpressed in OC and its cytoplasmic overexpression is significantly correlated with tumor grade, subtype, necrosis, and age at menarche. Patients with cytoplasmic N-CAD overexpression have a shorter disease-free survival and higher recurrence rate. These findings highlight the poor prognostic role of N-CAD in OC and its involvement in EMT and distant metastasis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Obstetrics & Gynecology
Nora Karsten, Thomas Kolben, Sven Mahner, Susanne Beyer, Sarah Meister, Christina Kuhn, Elisa Schmoeckel, Rachel Wuerstlein, Nadia Harbeck, Nina Ditsch, Udo Jeschke, Klaus Friese, Theresa Maria Kolben
Summary: The study revealed that increased E-Cadherin expression in primary tumor tissue of breast cancer patients is associated with poor prognosis, contrary to previous beliefs that loss of E-Cadherin promotes metastasis and invasiveness.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2022)
Article
Gastroenterology & Hepatology
Soyoung Im, Yu Kyung Cho, Donghoon Kang, Ga-Yeong Shin, Eun Sun Jung, Kyo Young Song, Sung Hak Lee, Jae Myung Park
Summary: The expression of NEDD9 and E-cadherin in gastric cancer is associated with clinical outcomes and pathological parameters. Immunohistochemical staining for NEDD9 and E-cadherin can serve as prognostic markers for gastric cancer, especially when used in combination.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Oncology
Weimin Wang, Jun Jin, Zhen Zhou, Yunfan Wang, Ke Min, Xin Zuo, Jiaping Jiang, Yan Zhou, Jun Shi
Summary: The overall survival rate of colorectal cancer patients is low, and the identification of valuable prognostic markers is urgently needed. This study investigated the clinical significance of Snail and E-cad expression in colorectal cancer and found that low Snail and high E-cad expression are associated with better prognosis.
Article
Veterinary Sciences
Ana R. Flores, Alexandra Rema, Joao R. Mesquita, Marian Taulescu, Fernanda Seixas, Fatima Gartner, Irina Amorim
Summary: This study found that abnormal expression of E-cadherin is associated with canine gastric cancer, and it may play a role in tumor progression and serve as a prognostic tool.
VETERINARY SCIENCES
(2022)
Article
Immunology
Rui M. Ferreira, Joana Figueiredo, Ines Pinto-Ribeiro, Irene Gullo, Dionyssios N. Sgouras, Laura Carreto, Patricia Castro, Manuel A. Santos, Fatima Carneiro, Raquel Seruca, Ceu Figueiredo
Summary: Helicobacter pylori infection induces overexpression of laminin gamma 2 in gastric cancer cells, promoting cell invasion and resistance to apoptosis through modulation of Src, JNK, and AKT activity. Laminin gamma 2 and its downstream effectors could be potential therapeutic targets, and H. pylori eradication may delay the onset and progression of gastric cancer.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Oncology
Bilal Asif, Amber Leila Sarvestani, Lauren A. Gamble, Sarah G. Samaranayake, Amber L. Famiglietti, Grace -Ann Fasaye, Martha Quezado, Markku Miettinen, Louis Korman, Christopher Koh, Theo Heller, Jeremy L. Davis
Summary: This study aimed to evaluate the safety and effectiveness of endoscopy in individuals with CDH1 variants, particularly in those who declined prophylactic total gastrectomy. The study found that endoscopy had a certain level of safety and effectiveness in early detection and interception of gastric cancer.
Article
Oncology
Han Xu, Katie A. Bunde, Joana Figueiredo, Raquel Seruca, Michael L. Smith, Dimitrije Stamenovic
Summary: Tensional homeostasis is crucial for maintaining cellular and tissue integrity, and its disruption is associated with disease progression, including cancer. This study investigates the impact of E-cadherin mutations on tensional homeostasis in gastric cancer cells. The findings suggest that mutations affecting specific domains of E-cadherin impair tensional homeostasis. Understanding the mechanisms underlying tensional homeostasis could offer new insights into disease progression and potential therapeutic interventions.
Article
Biochemistry & Molecular Biology
Seon-Young Kim, Song-Yi Park, Hwan-Seok Jang, Yong-Doo Park, Sun-Ho Kee
Summary: Yes-associated protein (YAP) regulates cell migration by influencing ZO-1, potentially through the NF-kappa B signaling pathway. The association of YAP with ZO-1 via angiomotin (AMOT) at TJs at high expression levels helps maintain TJ integrity.