Article
Biology
Claudia Paterson, Ethan J. Kilmister, Helen D. Brasch, Nicholas Bockett, Josie Patel, Erin Paterson, Gordon Purdie, Sean Galvin, Paul F. Davis, Tinte Itinteang, Swee T. Tan
Summary: The expression of stemness-associated markers in lung adenocarcinoma tissue suggests the presence of cancer stem cells. Further investigation is needed to explore the therapeutic potential of these markers for lung adenocarcinoma.
Article
Pharmacology & Pharmacy
Weiyu Wang, Shengyao Ma, Zhenyu Ding, Yang Yang, Huaijie Wang, Kunning Yang, Xiaoshan Cai, Hanyue Li, Zhiqin Gao, Meihua Qu
Summary: XPC expression levels in lung adenocarcinoma have been found to influence patients' prognosis and inhibit tumor invasion and metastasis by regulating the stemness of lung cancer cells.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Oncology
Kota Ishioka, Hiroyuki Yasuda, Junko Hamamoto, Hideki Terai, Katsura Emoto, Tae-Jung Kim, Shigemichi Hirose, Takashi Kamatani, Sachiyo Mimaki, Daisuke Arai, Keiko Ohgino, Tetsuo Tani, Keita Masuzawa, Tadashi Manabe, Taro Shinozaki, Akifumi Mitsuishi, Toshiki Ebisudani, Takahiro Fukushima, Mari Ozaki, Shinnosuke Ikemura, Ichiro Kawada, Katsuhiko Naoki, Morio Nakamura, Takashi Ohtsuka, Hisao Asamura, Katsuya Tsuchihara, Yuichiro Hayashi, Ahmed E. Hegab, Susumu S. Kobayashi, Takashi Kohno, Hideo Watanabe, David M. Ornitz, Tomoko Betsuyaku, Kenzo Soejima, Koichi Fukunaga
Summary: In this study, FGF9 was found to play a crucial role in the transdifferentiation of lung adenocarcinoma to small cell lung cancer. The upregulation of FGF9 was confirmed to induce neuroendocrine differentiation in established human lung adenocarcinoma cells, providing direct evidence for FGF9-mediated SCLC transdifferentiation and proposing the FGF9-FGFR axis as a therapeutic target for transdifferentiated SCLC.
Article
Cell Biology
Shuzhen Tan, Zesong Li, Kai Li, Yingqi Li, Guosheng Liang, Zhenye Tang, Jianhao Kang, Wenqing Chen, Minhua Li, Zhilin Zou, Guoliang Pi, Xiao Zhu
Summary: The study analyzed the correlation between m(6)A RNA methylation regulators and the occurrence and development of lung cancer, revealing that some m(6)A regulators have high expression in lung cancer and risk score is an independent prognostic factor in lung cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Immunology
Rihan Wu, Ru Ma, Xiaojun Duan, Jiandong Zhang, Kexin Li, Lei Yu, Mingyang Zhang, Pengxia Liu, Changshan Wang
Summary: This study aimed to develop a comprehensive LUSC-specific DEGs signature and identified a seven-gene signature for prognosis prediction of LUSC patients. These genes were found to be associated with tumor progression, immune infiltration, and stem index. Experimental models confirmed that one of the genes, FGG, was significantly upregulated in tumor cells and correlated with immune tumor progression, immune infiltration, and stem cell maintenance.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Pathology
Ting Yuan, Sijin Sun, Zheng Cao, Xiaoli Feng, Yibo Gao
Summary: The study reviewed prognostic IHC markers in SCLC from various databases until October 19th, 2019, focusing on markers evaluated in at least two independent studies. The results highlighted potential prognostic markers that could be incorporated into clinical care for SCLC patients based on their functions in the tumor.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Oncology
Dahua Liu, Min An, Guimin Wen, Yanan Xing, Pu Xia
Summary: With the high incidence and mortality rate of lung cancer, it is of great importance to analyze the molecular mechanism and identify early diagnosis markers. SLC3A2 protein, which is highly expressed in lung cancer, plays a crucial role in tumorigenesis and development, and has the potential to become a new target for tumor treatment. The levels of SLC3A2 in serum and tissue can serve as prognostic markers for lung cancer and provide valuable insights for diagnosis, treatment, and prognosis.
Article
Oncology
Linxiang Lan, Axel Behrens
Summary: The hierarchy of heterogeneous tumor cell populations, with a small population of cancer stem cells (CSCs) at the top, is explained by the CSC model. These CSCs have the ability to self-renew and generate other cancer cell populations, similar to the function of normal adult stem cells. However, controversies exist regarding the existence and identification of CSCs, which may be attributed to technical differences in experimentation, CSC niche-dependency and plasticity, and CSC heterogeneity itself.
Article
Otorhinolaryngology
Jennifer L. Spiegel, Mark Jakob, Marie Kruizenga, Saskia Freytag, Mattis Bertlich, Martin Canis, Friedrich Ihler, Frank Haubner, Julia Kitz, Bernhard G. Weiss
Summary: The study found that high expression of ALDH1 was correlated with higher grading, CD44 with tumor localization, size, pN-category, and advanced UICC stage, and SOX2 with negative perineural invasion in adenocarcinoma of the major salivary glands. However, there was no significant correlation between any investigated CSC marker and survival estimates. Overall, the CSCs ALDH1, BMI-1, CD44, Nanog, and SOX2 do not appear to be reliable prognostic parameters for the treatment of adenocarcinoma of the salivary glands.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2021)
Article
Oncology
S. M. Adnan Ali, Yumna Adnan, Saleema Mehboob Ali, Zubair Ahmad, Tabish Chawla, Hasnain Ahmed Farooqui
Summary: This report is the first of its kind internationally to assess pancreatic cancer stem cell markers and potential therapeutic targets in a single study. The study revealed significant associations between the expression of these markers and potential therapeutic targets, paving the way for precision medicine in pancreatic cancer patients.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Pathology
Hye Sung Kim, Hyun Joo Song, Heung Up Kim, In Ho Jeong, Hyun Min Koh, Jung Hyub Shin, Bo Gun Jang
Summary: No stem cell markers were found to be associated with increased LN metastasis in early GCs. Conversely, isolated expression of EPHB2 was linked to lower LN metastasis. EPHB2 and LGR5 exhibited a basal distribution pattern in early GCs with enhanced expression in submucosal invading cells induced by the niche factor RSPO2 from the muscularis mucosa.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Oncology
Yafei Liu, Bin Jiang, Chunjie Lin, Wanyinhui Zhu, Dingrui Chen, Yinuo Sheng, Zhiling Lou, Zhiheng Ji, Chuanqiang Wu, Ming Wu
Summary: This study found that m7G modification-related proteins are closely related to the tumor microenvironment, immune cell infiltration, responses to immunotherapy, and patients' prognosis in lung adenocarcinoma and could be useful biomarkers for the identification of patients who could benefit from immunotherapy. The m7G modification protein NUDT4 may be a novel biomarker in promoting the progression of lung cancer.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Xinying Xu, Yuhang Liu, Huiyi Hu, Jinshen Wang, Yuxin Cai, Jun Xie, Mingqiang Kang, Fei He
Summary: This study identified several single-nucleotide polymorphisms (SNPs) of cancer stem cell-related genes that are potentially associated with the prognosis of lung cancer patients. Some genotypes were found to be associated with an increased risk of lung cancer death, while others were associated with a reduced risk of lung cancer death.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Genetics & Heredity
Chong Zhang, Zhehao He, Ling Cheng, Jinlin Cao
Summary: The study focused on exploring potential prognostic markers of LUAD and successfully built a five-gene prognostic model, which effectively divided samples into high- and low-risk groups with favorable survival outcomes in the training set. Further analysis using GSEA, TMB, and immune infiltration revealed differences in gene expression, mutation frequency, and immune activity between the two risk groups.
FRONTIERS IN GENETICS
(2021)
Article
Oncology
Xuan Yi, Linlin Luo, Yanzhen Zhu, Hong Deng, Huitian Liao, Yang Shen, Yan Zheng
Summary: SPP1 plays a critical role in promoting cell migration and invasion in lung adenocarcinoma by upregulating COL11A1 expression.
CANCER CELL INTERNATIONAL
(2022)
