Inactivation of Merlin in malignant mesothelioma cells and the Hippo signaling cascade dysregulation

LATS2 Is a Tumor Suppressor Gene of Malignant Mesothelioma

(2011) H. Murakami et al.   CANCER RESEARCH

Activation of the phosphoinositide-3-kinase and mammalian target of rapamycin signaling pathways are associated with shortened survival in patients with malignant peritoneal mesothelioma

(2010) Sheelu Varghese et al.   CANCER

Merlin/NF2 Suppresses Tumorigenesis by Inhibiting the E3 Ubiquitin Ligase CRL4DCAF1 in the Nucleus

(2010) Wei Li et al.   CELL

Ajuba LIM Proteins Are Negative Regulators of the Hippo Signaling Pathway

(2010) Meghna Das Thakur et al.   CURRENT BIOLOGY

Merlin, a “Magic” Linker Between the Extracellular Cues and Intracellular Signaling Pathways that Regulate Cell Motility, Proliferation, and Survival

(2010) Ivan Stamenkovic et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

The WW Domain Protein Kibra Acts Upstream of Hippo in Drosophila

(2010) Roland Baumgartner et al.   DEVELOPMENTAL CELL

Kibra Functions as a Tumor Suppressor Protein that Regulates Hippo Signaling in Conjunction with Merlin and Expanded

(2010) Jianzhong Yu et al.   DEVELOPMENTAL CELL

The NF2 Tumor Suppressor, Merlin, Regulates Epidermal Development through the Establishment of a Junctional Polarity Complex

(2010) Andrew B. Gladden et al.   DEVELOPMENTAL CELL

The Hippo Signaling Pathway in Development and Cancer

(2010) Duojia Pan   DEVELOPMENTAL CELL

Kibra Is a Regulator of the Salvador/Warts/Hippo Signaling Network

(2010) Alice Genevet et al.   DEVELOPMENTAL CELL

CD44, a therapeutic target for metastasising tumours

(2010) Véronique Orian-Rousseau   EUROPEAN JOURNAL OF CANCER

Merlin in organ size control and tumorigenesis: Hippo versus EGFR?

(2010) C. Yi et al.   GENES & DEVELOPMENT

A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF -TRCP

(2010) B. Zhao et al.   GENES & DEVELOPMENT

YAP1 and VGLL3, encoding two cofactors of TEAD transcription factors, are amplified and overexpressed in a subset of soft tissue sarcomas

(2010) Zofia Hélias-Rodzewicz et al.   GENES CHROMOSOMES & CANCER

Inhibition of Met/HGF receptor and angiogenesis by NK4 leads to suppression of tumor growth and migration in malignant pleural mesothelioma

(2010) Yoshinori Suzuki et al.   INTERNATIONAL JOURNAL OF CANCER

Hippo signaling at a glance

(2010) Bin Zhao et al.   JOURNAL OF CELL SCIENCE

Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes

(2010) Gillian L. Dalgliesh et al.   NATURE

Components of the Hippo pathway cooperate with Nek2 kinase to regulate centrosome disjunction

(2010) Balca R. Mardin et al.   NATURE CELL BIOLOGY

Organizing the cell cortex: the role of ERM proteins

(2010) Richard G. Fehon et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

AXL regulates mesothelioma proliferation and invasiveness

(2010) W-B Ou et al.   ONCOGENE

NF2-deficient cells depend on the Rac1-canonical Wnt signaling pathway to promote the loss of contact inhibition of proliferation

(2010) E E Bosco et al.   ONCOGENE

p21-Activated Kinases Are Required for Transformation in a Cell-Based Model of Neurofibromatosis Type 2

(2010) Hoi Yee Chow et al.   PLoS One

Yes-associated protein is an independent prognostic marker in hepatocellular carcinoma

(2009) Michelle Z. Xu et al.   CANCER

Combined inhibition of MET and EGFR suppresses proliferation of malignant mesothelioma cells

(2009) Koji Kawaguchi et al.   CARCINOGENESIS

Rac1 GTPase: A “Rac” of All Trades

(2009) E. E. Bosco et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferation

(2009) A. Fernandez-L et al.   GENES & DEVELOPMENT

CDKN2A,NF2, andJUNare dysregulated among other genes by miRNAs in malignant mesothelioma-A miRNA microarray analysis

(2009) Mohamed Guled et al.   GENES CHROMOSOMES & CANCER

Multicenter Phase II Trial of Neoadjuvant Pemetrexed Plus Cisplatin Followed by Extrapleural Pneumonectomy and Radiation for Malignant Pleural Mesothelioma

(2009) Lee M. Krug et al.   JOURNAL OF CLINICAL ONCOLOGY

Targeting the mTOR Signaling Network for Cancer Therapy

(2009) Funda Meric-Bernstam et al.   JOURNAL OF CLINICAL ONCOLOGY

Combined treatment with cisplatin and sirolimus to enhance cell death in human mesothelioma

(2009) Mor-Li Hartman et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

Neurofibromatosis type 2

(2009) Ashok R Asthagiri et al.   LANCET

Accuracy of pathological diagnosis of mesothelioma cases in Japan: Clinicopathological analysis of 382 cases

(2009) Yukio Takeshima et al.   LUNG CANCER

Fluorescence Resonance Energy Transfer Analysis of Merlin Conformational Changes

(2009) R. F. Hennigan et al.   MOLECULAR AND CELLULAR BIOLOGY

Loss of the Tumor Suppressor Gene NF2, Encoding Merlin, Constitutively Activates Integrin-Dependent mTORC1 Signaling

(2009) M. A. Lopez-Lago et al.   MOLECULAR AND CELLULAR BIOLOGY

NF2/Merlin Is a Novel Negative Regulator of mTOR Complex 1, and Activation of mTORC1 Is Associated with Meningioma and Schwannoma Growth

(2009) M. F. James et al.   MOLECULAR AND CELLULAR BIOLOGY

YAP-dependent induction of amphiregulin identifies a non-cell-autonomous component of the Hippo pathway

(2009) Jianmin Zhang et al.   NATURE CELL BIOLOGY

The Increasing Complexity of the Cancer Stem Cell Paradigm

(2009) J. M. Rosen et al.   SCIENCE

Merlin and the ERM proteins – regulators of receptor distribution and signaling at the cell cortex

(2009) Andrea I. McClatchey et al.   TRENDS IN CELL BIOLOGY

A Conditional Mouse Model for Malignant Mesothelioma

(2008) Johan Jongsma et al.   CANCER CELL

A Role for TAZ in Migration, Invasion, and Tumorigenesis of Breast Cancer Cells

(2008) S. W. Chan et al.   CANCER RESEARCH

YAP1 is involved in mesothelioma development and negatively regulated by Merlin through phosphorylation

(2008) Toshihiko Yokoyama et al.   CARCINOGENESIS

The Hippo–YAP pathway: new connections between regulation of organ size and cancer

(2008) Bin Zhao et al.   CURRENT OPINION IN CELL BIOLOGY

TEAD mediates YAP-dependent gene induction and growth control

(2008) B. Zhao et al.   GENES & DEVELOPMENT

Problems in mesothelioma diagnosis

(2008) Bruce Addis et al.   HISTOPATHOLOGY

Expression of Yes-associated protein in common solid tumors

(2008) Angela A. Steinhardt et al.   HUMAN PATHOLOGY

Mammalian Target of Rapamycin Contributes to the Acquired Apoptotic Resistance of Human Mesothelioma Multicellular Spheroids

(2008) Dario Barbone et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional inactivation of NF2/merlin in human mesothelioma

(2008) Claudio Thurneysen et al.   LUNG CANCER

PML, YAP, and p73 Are Components of a Proapoptotic Autoregulatory Feedback Loop

(2008) Eleonora Lapi et al.   MOLECULAR CELL