Article
Biochemistry & Molecular Biology
Jaroslaw Goracy, Anna Bogacz, Izabela Uzar, Marlena Wolek, Malgorzata Lochynska, Pawel Zietek, Boguslaw Czerny, Aneta Cymbaluk-Ploska, Piotr Modliborski, Adam Kaminski
Summary: This study aimed to evaluate the association between NQO1 gene 609C > T polymorphism and colorectal cancer risk in the Polish population, finding that carriers of the TT genotype have an elevated risk for colorectal cancer. The analysis also revealed a significant increase in colorectal cancer risk in carriers of the TT genotype, particularly related to tumor stage and location.
Review
Biochemistry & Molecular Biology
Zainab Ahmed Rashid, Sanaa K. Bardaweel
Summary: Matrix metalloproteinases (MMPs), especially MMP-9, play a significant role in cancer pathogenesis and progression. However, no effective MMP-9 inhibitor has been approved by the FDA. This review focuses on exploring the strategies for designing MMP-9 inhibitors and their anticancer effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Min-Seob Kim, Se-Eun Ha, Moxin Wu, Hannah Zogg, Charles F. Ronkon, Moon-Young Lee, Seungil Ro
Summary: The composition and changes of the cellular microenvironment play a crucial role in cancer development, with alterations in the ECM significantly impacting the tumor microenvironment. ECM components are important in colorectal cancer and have potential roles as biomarkers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Jielin Chen, Qijia Yan, Jingyue Sun, Qingyi Wang, Yongguang Tao, Desheng Xiao, Bin Xie
Summary: Precision medical treatment for colorectal cancer relies on accurate assessment of microsatellite status, which can be detected using a combination of polymerase chain reaction (PCR) and immunohistochemistry (IHC). MSI-H is a predictive biomarker for immune checkpoint inhibitors (ICIs). Misdiagnosis of microsatellite status can lead to resistance to ICIs. Therefore, it is important to rapidly and accurately assess microsatellite status for precision medicine in colorectal cancer.
Article
Radiology, Nuclear Medicine & Medical Imaging
Qian Pei, Xiaoping Yi, Chen Chen, Peipei Pang, Yan Fu, Guangwu Lei, Changyong Chen, Fengbo Tan, Guanghui Gong, Qingling Li, Hongyan Zai, Bihong T. Chen
Summary: The study developed a radiomics nomogram incorporating radiomics signatures and clinical indicators for predicting pre-treatment MSI status in CRC patients. The nomogram showed good discrimination between non-MSI-H and MSI-H patients with AUC of 0.74 in the training cohort and 0.77 in the validation cohort. Decision curve analysis demonstrated favorable clinical application of the nomogram, while the addition of pathological characteristics did not provide additional prognostic value.
EUROPEAN RADIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Cheng-Yi Huang, Jenq-Lin Yang, Jih-Jung Chen, Shun-Ban Tai, Yu-Hsuan Yeh, Pei-Feng Liu, Ming-Wei Lin, Chih-Ling Chung, Chun-Lin Chen
Summary: The study showed that FQs inhibit MMP-9 expression in cancer cells, leading to a decrease in cell migration and invasion, demonstrating their potential value in cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ya-Tang Chiang, Yu-Bai Xiao, Shan-hui Hsu, Shu-Wei Chang, Chia-Ching Chou
Summary: Tannic acid (TA) has antibacterial, antioxidant, and anti-inflammatory properties and acts as an adhesive, hemostatic, and crosslinking agent in hydrogels. TA has been reported to inhibit MMP-2/- 9 activities, thereby improving tissue remodeling and wound healing. In this study, atomistic modeling was used to explore the mechanisms and structures of TA binding with MMP-2 and MMP-9, revealing the specific binding regions and molecular interactions involved. Understanding the binding mechanism and dynamics of TA with these MMPs provides crucial knowledge on the effects of TA on MMPs.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Article
Biochemical Research Methods
Weidu Song, Chuanhao Zhang, Huichao Lin, Taiyi Zhang, Haixia Liu, Xiaowen Huang
Summary: The proposed real-time rotary PCR reaction system (RRP) meets the requirements of low cost, low-power consumption, potential for miniaturization, and portability. Experimental and theoretical results demonstrate its feasibility in the rapid quantitative detection of Pseudomonas aeruginosa and have broad application prospects in bacteria detection and food safety.
Article
Biochemical Research Methods
Shaolei Huang, Yiquan An, Bangchao Xi, Xianglian Gong, Zhongfu Chen, Shan Shao, Shengxiang Ge, Jun Zhang, Dongxu Zhang, Ningshao Xia
Summary: Nucleic acid detection is a method that directly identifies the presence of pathogenic microorganisms and has advantages of high sensitivity, commendable specificity, and a short window period. A real-time PCR system based on multiple temperature zones was proposed to solve the time-consuming problem, enabling fast detection speed and high sensitivity under extreme conditions.
Review
Biochemistry & Molecular Biology
Shinji Takai, Denan Jin
Summary: Chymase-activated MMP-9 is closely related to the pathogenesis of various diseases, especially inflammation-related diseases. Upregulated chymase and MMP-9 have been observed in tissues from patients and animal models of these diseases. Chymase inhibitors attenuate MMP-9 formation and reduce inflammatory cell numbers, thereby ameliorating the development and progression of these disorders.
Article
Pharmacology & Pharmacy
Yen-Chang Chen, Jia-Hong Chen, Cheng-Fang Tsai, Chen-Teng Wu, Miao-Hsiang Wu, Pei-Chun Chang, Wei-Lan Yeh
Summary: The study found that nicardipine can inhibit the migration and colony formation of breast cancer cells, and increase the expression of Nrf2 and HO-1. The reduction of matrix metalloproteinase-9 by nicardipine is regulated by Nrf2/HO-1 axis and its catalytic end products.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medical Laboratory Technology
Davood Mohammadi, Yazdan Zafari, Zohreh Estaki, Mahdi Mehrabi, Sahar Moghbelinejad
Summary: This study focused on the non-invasive and rapid detection of colorectal cancer through the molecular biomarker circRNA. The results showed that hsa_circ_0006282 was significantly upregulated in CRC patients, decreased to normal levels post-surgery, and when combined with CEA and CA199, exhibited high specificity and sensitivity in CRC detection. Plasma hsa_circ_0006282 can be a promising diagnostic and monitoring biomarker for CRC patients.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Multidisciplinary Sciences
Jae Jong Kim, Hyoung-Min Park, A. Young Kyoung, In Kyung Park, Si-Kyu Lim, Byoung Chul Park
Summary: Genetic mutations like SNP are common in genetic disorders and cancers, and PCR methods are widely used for SNP detection. The specifically designed PCR platform STexS can efficiently distinguish small amounts of SNP mixed in normal DNA, aiding in targeting potential SNPs or genetically mutated biomarkers in human clinical samples.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Ionut Luchian, Mihaela Moscalu, Ancuta Goriuc, Ludovica Nucci, Monica Tatarciuc, Ioana Martu, Mihai Covasa
Summary: Periodontitis results in destructive effects on periodontium, with increased levels of MMP-9. Periodontal treatment alone or combined with orthodontic treatment can improve clinical parameters and lower MMP-9 levels. The degree of malocclusion affects the treatment's impact on MMP-9 levels.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Gastroenterology & Hepatology
Pim Edomskis, Max R. Goudberg, Cloe L. Sparreboom, Anand G. Menon, Albert M. Wolthuis, Andre D'Hoore, Johan F. Lange
Summary: Through the collection and analysis of human and animal studies, it was found that most studies indicate a close relationship between MMP-9 and colorectal anastomotic leakage, but there are also inconsistent findings in some studies. Innovative techniques are needed to further investigate the value of MMP-9 as a clinical biomarker for early detection, prevention, or treatment of anastomotic leakage.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2021)
Article
Medicine, General & Internal
Dubravcsik Zsolt, Hritz Istvan, Szepes Attila, Madacsy Laszlo
Summary: The study analyzed the method of treating high-risk patients with prophylactic pancreatic stents, showing that the incidence and severity of pancreatitis in the successfully stented group were significantly lower compared to the no-stent group and unsuccessfully stented group. Complications mainly included early dislodgment and proximal migration, with the Freeman type stent showing fewer issues.
Article
Gastroenterology & Hepatology
Zsolt Dubravcsik, Istvan Hritz, Bank Keczer, Peter Novak, Barbara Dorottya Lovasz, Laszlo Madacsy
Summary: In this study, prophylactic pancreatic stent placement was found to be more effective in preventing moderate-to-severe PEP in both average- and high-risk patients compared to rectal NSAID.
Article
Gastroenterology & Hepatology
Lorant Gonczi, Kata Szanto, Klaudia Farkas, Tamas Molnar, Tamas Szamosi, Eszter Schafer, Petra A. Golovics, Laszlo Barkai, Livia Lontai, Barbara Lovasz, Mark Juhasz, Arpad Patai, Krisztina Sarang, Aron Vincze, Patricia Sarlos, Alexandra Farkas, Zsolt Dubravcsik, Tamas G. Toth, Pal Miheller, Akos Ilias, Peter L. Lakatos
Summary: The clinical efficacy, drug sustainability, dose intensification, and therapeutic drug monitoring of ustekinumab therapy in patients with Crohn's disease were evaluated in this prospective, nationwide, multicenter cohort study. The study found that ustekinumab showed favorable drug sustainability and clinical efficacy in patients with severe disease phenotype and previous anti-tumor necrosis factor failure. However, frequent dose intensification was required.
DIGESTIVE AND LIVER DISEASE
(2022)
Article
Gastroenterology & Hepatology
Gavin Johnson, George Webster, Ivo Boskoski, Sara Campos, Stefan Karl Goelder, Christoph Schlag, Andrea Anderloni, Urban Arnelo, Abdenor Badaoui, Noor Bekkali, Dimitrios Christodoulou, Laszlo Czako, Michael Fernandez Y. Viesca, Istvan Hritz, Tomas Hucl, Evangelos Kalaitzakis, Leena Kylanpaa, Ivan Nedoluzhko, Maria Chiara Petrone, Jan-Werner Poley, Andrada Seicean, Juan Vila, Marianna Arvanitakis, Mario Dinis-Ribeiro, Thierry Ponchon, Raf Bisschops
Article
Biology
Eva Anna Piros, Akos Szabo, Fanni Rencz, Valentin Brodszky, Norbert Wikonkal, Pal Miheller, Miklos Horvath, Peter Hollo
Summary: This study found that anti-interleukin-17 therapy does not significantly affect body composition parameters in severe psoriatic patients, but can improve lipid and inflammatory parameters, potentially benefiting the cardiometabolic status of patients, especially high-risk obese individuals with psoriasis.
Article
Infectious Diseases
Marton Papp, Norbert Solymosi
Summary: With the increasing prevalence of antimicrobial resistance genes, the number of studies on antibiotic resistance and its spread in the environment is rapidly growing. This review compares and analyzes the differences in structure and content of several widely used antibiotic resistance gene databases. Understanding these differences is crucial for selecting the appropriate database and developing new annotation tools and resources for resistance genes.
Article
Entomology
Andreja Urbanek Krajnc, Tamas Bakonyi, Istvan Ando, Eva Kurucz, Norbert Solymosi, Paula Pongrac, Rebeka Lucijana Bercic
Summary: This study assessed the suitability of locally adapted mulberry trees in Slovenia and Hungary for sericulture and found that they are suitable for high-quality silk cocoon and raw silk production. The study also identified connections between leaf compounds and silkworm performance parameters.
Correction
Infectious Diseases
Marton Papp, Norbert Solymosi
Article
Infectious Diseases
Adrienn Greta Toth, Imre Toth, Bernadett Rozsa, Attila Dubecz, Arpad Patai, Tibor Nemeth, Selcuk Kaplan, Eszter Gabriella Kovacs, Laszlo Makrai, Norbert Solymosi
Summary: Bacteria with potentially transferable antimicrobial resistance genes have been found in canine saliva, suggesting that it could be a source of antimicrobial resistance transmission.
Article
Medicine, General & Internal
Bank Keczer, Marton Benke, Tamas Marjai, Miklos Horvath, Pal Miheller, Akos Szucs, Laszlo Harsanyi, Attila Szijarto, Istvan Hritz
Summary: Analyzing EUS images of pancreatic cystic lesions using image processing software can accurately determine the echogenicity of the lesions, making it a potential diagnostic tool for the evaluation and differentiation of such lesions.
Article
Agriculture, Dairy & Animal Science
Sara Agnes Nagy, Oz Kilim, Istvan Csabai, Gyorgy Gabor, Norbert Solymosi
Summary: Body condition scoring of dairy cattle is crucial but time-consuming. This study explores the use of computer vision-based deep learning to automate the scoring process. Trained neural networks achieved similar or better results compared to expert scoring, and the pretrained models are freely available for further research.
Article
Multidisciplinary Sciences
Laszlo Makrai, Bettina Fodroczy, Sara Agnes Nagy, Peter Czeiszing, Istvan Csabai, Geza Szita, Norbert Solymosi
Summary: This article presents a method for automated counting of bacterial colonies using convolutional neural networks. By culturing 24 bacteria species of veterinary importance and manually annotating 56,865 colonies in a dataset of 369 digital images, it provides a resource for developing artificial intelligence-based approaches to count bacterial colonies.
Article
Veterinary Sciences
Sorin Morariu, Catalin Bogdan Sirbu, Adrienn Greta Toth, Gheorghe Darabus, Ion Oprescu, Narcisa Mederle, Marius Stelian Ilie, Mirela Imre, Beatrice Ana-Maria Sirbu, Norbert Solymosi, Tiana Florea, Kalman Imre
Summary: This study identified the presence of two rumen fluke species in wild ruminants from western Romania, which are highly pathogenic to their hosts. This is the first report of these parasites in deer in Romania.
VETERINARY SCIENCES
(2023)
Article
Multidisciplinary Sciences
Marton Papp, Laszlo Bekesi, Robert Farkas, Laszlo Makrai, Maura Fiona Judge, Gergely Maroti, Dora Tozser, Norbert Solymosi
Summary: The composition of honey bee bacteriota varies depending on climatic and seasonal conditions, and plays a crucial role in their body's functioning.
Article
Medicine, General & Internal
Keczer Bank, Dubravcsik Zsolt, Szepes Attila, Madacsy Laszlo, Szijarto Attila, Hritz Istvan
Summary: The aim of this study was to assess the diagnostic accuracy of endoscopic ultrasonography in patients with suspected choledocholithiasis. The results showed that endoscopic ultrasonography had high sensitivity and specificity in detecting and evaluating common bile duct stones.