Article
Microbiology
Feiyang Zhang, Qin Li, Jiawei Bai, Manlin Ding, Xiangjin Yan, Guangxi Wang, Baoli Zhu, Yingshun Zhou
Summary: This study revealed that 8.39% of Klebsiella pneumoniae strains were amikacin-heteroresistant, with potential association with increased expression of aminoglycoside resistance genes. The majority of heteroresistant phenotypes were unstable, with partial or full reversion of minimal inhibitory concentrations to the level of susceptibility.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Immunology
Anthony Sophonsri, Corey Kelsom, Mimi Lou, Paul Nieberg, Annie Wong-Beringer
Summary: The study found that patients coinfected with CRKP and another carbapenem-resistant pathogen have more significant morbidity and require longer hospital stays compared to those with CRKP monoinfection. Empiric therapy targeting both CRKP and carbapenem-resistant Pseudomonas aeruginosa may be beneficial for at-risk patients with pneumonia.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Microbiology
Yu-Ping Wang, Yen-Hao Chen, I-Cheng Hung, Po-Hsun Chu, Yu-Han Chang, Yi-Tsung Lin, Hung-Chih Yang, Jin-Town Wang
Summary: This study investigated the fosfomycin resistance mechanism of carbapenem-resistant Klebsiella pneumoniae (CRKP). The study found that the genes fosA(KP) I91V and transporter deficiencies were two common mechanisms leading to resistance. The study highlights the need for new therapeutic agents for CRKP infections in Taiwan.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Microbiology
Kosuke Kamio, J. Luis Espinoza
Summary: The emergence of carbapenem-resistant Enterobacteriaceae (CRE) poses a significant global public health concern due to their potential for widespread dissemination, limited treatment options, and high mortality rates. Active surveillance, early diagnosis, and contact isolation are important strategies for controlling and preventing the occurrence and spread of CRE bacteria. This study provides an overview of the epidemiology of CRE infections in Japan from 2015 to 2019, highlighting the stable but increasing number of reported cases. The majority of CRE infections were observed in patients over the age of 65, with men representing 60% of the cases and a mortality rate of approximately 3.5%. Notably, Enterobacter cloacae and Klebsiella aerogenes were the most common pathogens responsible for CRE infections, with Klebsiella aerogenes becoming the leading pathogen since 2017. The IMP carbapenemase type was the most commonly isolated carbapenemase. Further research is needed to determine the prevalence and mechanisms behind the local predominance of Klebsiella aerogenes and Enterobacter cloacae, particularly in healthcare settings.
Article
Immunology
Fei Zhang, Jinbiao Zhong, Handong Ding, Jiashan Pan, Jing Yang, Tianchi Lan, Yiding Chen, Guiyi Liao
Summary: The prevalence of early infections after kidney transplant is high, with CRKP infection closely associated with poor prognosis. Prolonged mechanical ventilation and CRKP infection are independent risk factors for one-year postoperative mortality.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Microbiology
Min Yi Lau, Fui Enn Teng, Kek Heng Chua, Sasheela Ponnampalavanar, Chun Wie Chong, Kartini Abdul Jabar, Cindy Shuan Ju Teh
Summary: The study reported the epidemiology of carbapenem-resistant Klebsiella pneumoniae (CRKP) in a Malaysian teaching hospital, with bla(OXA-48) identified as the predominant carbapenemase gene. Infection or colonization by CRKP, especially NDM-producers, central venous catheter usage, and stoma were associated with higher in-hospital mortality. Early detection of CRKP isolates was crucial due to the potential high mortality rate associated with infection.
Article
Microbiology
Li Wei, Linfei Wu, Hongxia Wen, Yu Feng, Shichao Zhu, Ying Liu, Li Tang, Emma Doughty, Willem van Schaik, Alan McNally, Zhiyong Zong
Summary: Through a study conducted in a medical intensive care unit, it was found that environmental contamination of CRKP was extensive but usually transient, with little impact on CRKP acquisition by ICU patients. This highlights the ability to control CRKP transmission through infection prevention efforts even in high-prevalence settings.
MICROBIOLOGY SPECTRUM
(2021)
Article
Infectious Diseases
Mykhailo Savin, Gabriele Bierbaum, Nico T. Mutters, Ricarda Maria Schmithausen, Judith Kreyenschmidt, Isidro Garcia-Menino, Silvia Schmoger, Annemarie Kaesbohrer, Jens Andre Hammerl
Summary: This study characterizes carbapenem-resistant Klebsiella spp. in wastewater and surface water in Germany. The isolates showed resistance to multiple antibiotics and a high diversity of antibiotic-resistance genes. Virulence factors were also present in most isolates. The findings suggest the possible dissemination of resistant bacteria in the environment and the risk of colonization and infection in humans, livestock, and wildlife.
Article
Immunology
Sabrina Cardile, Federica Del Chierico, Manila Candusso, Sofia Reddel, Paola Bernaschi, Andrea Pietrobattista, Marco Spada, Giuliano Torre, Lorenza Putignani
Summary: This study aimed to evaluate the impact of carbapenem-resistant Klebsiella pneumoniae colonization in pediatric liver transplant candidates. The findings showed that antibiotic prophylaxis did not affect the outcomes of liver transplantation or the risk of intestinal bacterial translocation, but in the standard prophylaxis group, gut microbiota richness increased.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Infectious Diseases
Fei Zhang, Jinbiao Zhong, Handong Ding, Guiyi Liao
Summary: This study retrospectively evaluated the efficacy of ceftazidime-avibactam (CAZ-AVI) in treating carbapenem-resistant Klebsiella pneumoniae (CRKP) infection in kidney transplant recipients. Results showed that recipients treated with CAZ-AVI had significantly lower 30-day mortality, higher 14-day clinical cure, and 14-day microbiological cure rates compared to those receiving other antibiotic regimens, indicating that CAZ-AVI may be more valuable for the treatment of CRKP infection after kidney transplantation. Further large randomized controlled trials are needed to confirm these findings.
INFECTION AND DRUG RESISTANCE
(2021)
Review
Infectious Diseases
Mihret Tilahun, Yeshimebet Kassa, Alemu Gedefie, Melaku Ashagire
Summary: Infections due to multidrug-resistant Enterobacteriaceae have become a major global public health issue, with transmission facilitated by inappropriate antimicrobial use and increased global connectivity. Carbapenems, the current medications of choice, are facing increasing resistance globally, necessitating the search for alternative treatment options. Ceftazidime-avibactam is currently the most common treatment option, with other novel drugs under trial for different populations. Treatment should be tailored to patient susceptibility, infection type, and personal characteristics.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Immunology
Luana Soares de Moraes, Gerusa Luciana Gomes Magalhaes, Joao Gabriel Material Soncini, Marsileni Pelisson, Marcia Regina Eches Perugini, Eliana Carolina Vespero
Summary: This study evaluated clinical data from 107 patients with bloodstream infection caused by Klebsiella pneumoniae and conducted phenotypic and molecular analyses on 50.5% (54/107) of samples that exhibited resistance to carbapenems. The bla(NDM) gene was present in 90.4% (49/54) of these samples, bla(KPC) gene was found in one sample, and 7.4% (4/54) of samples showed no carbapenemase gene. The study identified four main clones and found that 11 samples were not genetically related. The median age of the patients was 58 years old, with a majority of males (60.7%). Comparing patients with and without carbapenem resistance, several factors including ICU stay, renal failure, previous antimicrobial use, Charlson's comorbidity index, invasive procedures, and death showed statistically significant differences. Additionally, renal failure, liver failure, and BSI with extensive-drug resistance (XDR) or pan-drug resistance (PDR) were predictors of increased mortality. The study concluded that patients with carbapenem-resistant pneumonia, regardless of additional resistance to polymyxins, experienced higher mortality rates.
MICROBIAL PATHOGENESIS
(2022)
Review
Medicine, General & Internal
Wioletta Medrzycka-Dabrowska, Sandra Lange, Katarzyna Zorena, Sebastian Dabrowski, Dorota Ozga, Lucyna Tomaszek
Summary: The study highlights the importance of paying attention to carbapenem-resistant Klebsiella pneumoniae infections in patients with COVID-19. Rational antibiotic therapy should be used to prevent the increase of bacterial resistance, along with continuous monitoring and surveillance of hospital infections caused by multidrug-resistant organisms.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Infectious Diseases
Lijia Ni, Zhixian Zhang, Rui Shen, Xiaoqiang Liu, Xuexue Li, Baiji Chen, Xiquan Wu, Hongyu Li, Xiaoying Xie, Songyin Huang
Summary: Disinfectant resistance is a serious concern for hospital infection control due to the extensive use of disinfectants. Carbapenem-resistant Klebsiella pneumoniae (CRKP) is a common and challenging pathogen in nosocomial infections. This study found that CRKP strains exhibited extensive resistance to various clinical disinfectants.
Article
Immunology
Dakang Hu, Wenjie Chen, Qi Zhang, Meng Li, Zehua Yang, Yong Wang, Yunkun Huang, Gang Li, Dongxing Tian, Pan Fu, Weiwen Wang, Ping Ren, Qing Mu, Lianhua Yu, Xiaofei Jiang
Summary: This study investigated the epidemiology of carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-HvKP) and hypervirulent carbapenem-resistant Klebsiella pneumoniae (Hv-CRKP) in mainland China. Molecular determination of CR-HvKP and Hv-CRKP showed biases compared to mouse lethality test, with the exact prevalence of CR-HvKP being less than 1.0% and that of Hv-CRKP even lower.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Editorial Material
Immunology
Marcus R. Pereira
Letter
Surgery
David M. Salerno, Danielle Kovac, Heather Corbo, Douglas L. Jennings, Jennifer Lee, Jason Choe, Jenna Scheffert, Jessica Hedvat, Justin Chen, Demetra Tsapepas, Russell Rosenblatt, Benjamin Samstein, Karim Halazun, Elizabeth Verna, Marcus Pereira, Corey Brennan, Syed A. Husain, Sumit Mohan, Robert S. Brown
CLINICAL TRANSPLANTATION
(2021)
Article
Immunology
Nikole A. Neidlinger, Jeannina A. Smith, Anthony M. D'Alessandro, David Roe, Tim E. Taber, Marcus R. Pereira, Amy L. Friedman
Summary: Although limited data exist regarding organ donation from deceased donors with a history of COVID-19 infection, a case series of six deceased donors with a prior history of COVID-19 showed no transmission of SARS-CoV-2 to recipients or medical personnel. This suggests that organ donation from deceased donors who have recovered from COVID-19 should be considered, pending further research.
TRANSPLANT INFECTIOUS DISEASE
(2021)
Article
Multidisciplinary Sciences
Monica Mehta, Lawrence J. Purpura, Thomas H. McConville, Matthew J. Neidell, Michaela R. Anderson, Elana J. Bernstein, Donald E. Dietz, Justin Laracy, Shauna H. Gunaratne, Emily Happy Miller, Jennifer Cheng, Jason Zucker, Shivang S. Shah, Shaoli Chaudhuri, Christian A. Gordillo, Shreena R. Patel, Tai Wei Guo, Lara E. Karaaslan, Ran Reshef, Benjamin A. Miko, Joan M. Bathon, Marcus R. Pereira, Anne-Catrin Uhlemann, Michael T. Yin, Magdalena E. Sobieszczyk
Summary: There was no evidence to support an improvement in hypoxemia or ventilator-free survival with the use of tocilizumab 400 mg in the absence of corticosteroids in patients with severe COVID-19. No increase in secondary bacterial infections was observed in the group receiving tocilizumab.
Article
Immunology
Tae Jin Yun, Suzu Igarashi, Haoquan Zhao, Oriana A. Perez, Marcus R. Pereira, Emmanuel Zorn, Yufeng Shen, Felicia Goodrum, Adeeb Rahman, Peter A. Sims, Donna L. Farber, Boris Reizis
Summary: Plasmacytoid dendritic cells (pDCs) can recognize live infected cells and produce a unique antiviral immune response, including high amounts of interferons, prolonged and efficient responses to CMV-infected cells, and activation of natural killer cells. Patients with CMV viremia show activated pDCs and increased circulating IFN-I and IFN-III.
SCIENCE IMMUNOLOGY
(2021)
Article
Surgery
Lawrence J. Purpura, Michelle Chang, Medini K. Annavajhala, Hiroshi Mohri, Lihong Liu, Jayesh Shah, Anyelina Cantos, Nicola Medrano, Justin Laracy, Brian Scully, Benjamin A. Miko, Marlena Habal, Marcus R. Pereira, Moriya Tsuji, David D. Ho, Anne-Catrin Uhlemann, Michael T. Yin
Summary: In immunosuppressed patients, the persistence of SARS-CoV-2 infection may be prolonged, leading to potential viral evolution. Immune response peaks around days 44-72 after diagnosis but wanes over time, allowing for increased viral genetic diversity and the emergence of variants.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Immunology
William A. Werbel, Diane M. Brown, Oyinkansola T. Kusemiju, Brianna L. Doby, Shanti M. Seaman, Andrew D. Redd, Yolanda Eby, Reinaldo E. Fernandez, Niraj M. Desai, Jernelle Miller, Gilad A. Bismut, Charles S. Kirby, Haley A. Schmidt, William A. Clarke, Michael Seisa, Christos J. Petropoulos, Thomas C. Quinn, Sander S. Florman, Shirish Huprikar, Meenakshi M. Rana, Rachel J. Friedman-Moraco, Aneesh K. Mehta, Peter G. Stock, Jennifer C. Price, Valentina Stosor, Shikha G. Mehta, Alexander J. Gilbert, Nahel Elias, Michele Morris, Sapna A. Mehta, Catherine B. Small, Ghady Haidar, Maricar Malinis, Jennifer S. Husson, Marcus R. Pereira, Gaurav Gupta, Jonathan Hand, Varvara A. Kirchner, Avinash Agarwal, Saima Aslam, Emily A. Blumberg, Cameron R. Wolfe, Kevin Myer, R. Patrick Wood, Nikole Neidlinger, Sara Strell, Marion Shuck, Harry Wilkins, Matthew Wadsworth, Jennifer D. Motter, Jonah Odim, Dorry L. Segev, Christine M. Durand, Aaron A. R. Tobian
Summary: This study investigates the clinical, immunologic, and virologic characteristics of HIV-positive organ donors. The findings suggest that the use of HIV-positive donor organs is increasing but the prevalence of HIV drug resistance is relatively low, especially for integrase strand transfer inhibitors.
CLINICAL INFECTIOUS DISEASES
(2022)
Editorial Material
Gastroenterology & Hepatology
Marcus R. Pereira, Jean C. Emond
LIVER TRANSPLANTATION
(2021)
Letter
Surgery
Nicholas W. Lange, David M. Salerno, Douglas L. Jennings, Jason Choe, Jessica Hedvat, Danielle (Bley) Kovac, Jenna Scheffert, Tara Shertel, Lloyd E. Ratner, Robert S. Brown, Marcus R. Pereira
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Surgery
David M. Salerno, Douglas L. Jennings, Nicholas W. Lange, Danielle (Bley) Kovac, Tara Shertel, Justin K. Chen, Jessica Hedvat, Jenna Scheffert, Robert S. Brown, Marcus R. Pereira
Summary: The use of Nirmatrelvir/ritonavir (NR) in solid organ transplant recipients (SOTRs) with mild COVID-19 has not been described yet. The objective of this study was to evaluate outcomes among SOTRs and describe the drug-drug interaction of NR. The results show that the clinically significant interaction between NR and immunosuppressive agents can be reasonably managed with a standardized dosing protocol.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Chemistry, Physical
M. V. Pereira, L. H. de Oliveira, J. F. do Nascimento, P. A. Arroyo
Summary: This study investigates the potential usage of FAU NaX and NaY for natural gas sweetening using adsorption processes. The simulations indicate that both materials have favorable adsorption isotherms for H2S and CO2, with higher selectivity for NaX.
ADSORPTION-JOURNAL OF THE INTERNATIONAL ADSORPTION SOCIETY
(2023)
Article
Immunology
Rebecca Kumar, Marcus Pereira, Sarah Taimur, Karin True, Randall Detwiler, David van Duin
Summary: Limited evidence is available to determine the optimal duration of antibiotic treatment for bacterial acute graft pyelonephritis in kidney transplant recipients. This study surveyed members of the Infectious Diseases and the Kidney Pancreas Communities of Practice of the American Society of Transplantation to understand the current standard of practice for treatment duration.
TRANSPLANT INFECTIOUS DISEASE
(2023)
Article
Chemistry, Multidisciplinary
Leonardo H. de Oliveira, Marcus V. Pereira, Joziane G. Meneguin, Maria Angelica S. D. de Barros, Jailton F. do Nascimento, Pedro A. Arroyo
Summary: This work investigated the influence of different regeneration conditions on CO2 adsorption on NaA zeolite at high pressures. The characterization of NaA zeolite showed a stable and highly porous structure, with a specific surface area of 247 m2 g-1. The adsorption isotherms of CO2 on NaA zeolite were highly favorable, and the heats of adsorption indicated a physisorption process. The working capacity of NaA zeolite was found to be highly sensitive to pressure and less affected by adsorption temperature.
JOURNAL OF CO2 UTILIZATION
(2023)
Meeting Abstract
Surgery
C. K. Ching, Y. R. Nobel, M. R. Pereira, E. C. Verna
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Meeting Abstract
Hematology
Marcus Pereira, Carlos Cervera, Camille Kotton, Joe Sasadeusz, Jackie Wu, Martha Fournier, Richard Shardlow
BRITISH JOURNAL OF HAEMATOLOGY
(2022)