期刊
TRANSPLANT INFECTIOUS DISEASE
卷 17, 期 5, 页码 751-755出版社
WILEY-BLACKWELL
DOI: 10.1111/tid.12435
关键词
cytomegalovirus; multidrug resistance; maribavir; adoptive T-cell transfer; allogeneic hematopoietic stem cell transplantation
资金
- Swiss National Foundation [PZ00P3_142403I]
Multidrug-resistant (MDR) cytomegalovirus (CMV) emerged after transient responses to ganciclovir, foscarnet, and cidofovir in a CMV-seropositive recipient who underwent allogeneic hematopoietic stem cell transplantation from a CMV-seronegative donor. Experimental treatments using leflunomide and artesunate failed. Re-transplantation from a CMV-seropositive donor supported by adoptive transfer of pp65-specific T cells and maribavir was followed by lasting suppression. This case illustrates that successful MDR CMV therapy may require individualized multidisciplinary approaches.
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