期刊
PATHOLOGY
卷 42, 期 3, 页码 229-234出版社
ELSEVIER
DOI: 10.3109/00313021003631379
关键词
Pancreatic cancer; PanIN; prognosis; tissue microarray; immunohistochemistry
类别
Methods: We analysed the expression of p21, p27, p53 and Ki-67, in 210 ductal pancreatic adenocarcinomas, 40 PanIN-3 cases and 40 normal controls combined in a tissue microarray. The results were correlated with clinicopathological and follow-up data. Results: Our study revealed a differential p27, p21, p53, and Ki-67 expression between ductal adenocarcinoma, PanIN-3 and normal pancreas. p27 expression progressively decreased from normal pancreas to PanIN and to pancreatic cancer. Decreased p27 and increased p53 expression showed a significant association with the T stage. A Ki-67 > 5% correlated with reduced survival. Conclusions: In pancreatic cancer, loss of p27 and increased p53 expression is associated with a more aggressive phenotype. p27 may play an important role in pancreatic carcinogenesis. A Ki-67 > 5% independently predicted poor outcome.
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