Article
Multidisciplinary Sciences
Julia Merkenschlager, Shlomo Finkin, Victor Ramos, Julian Kraft, Melissa Cipolla, Carla R. Nowosad, Harald Hartweger, Wenzhu Zhang, Paul Dominic B. Olinares, Anna Gazumyan, Thiago Y. Oliveira, Brian T. Chait, Michel C. Nussenzweig
Summary: The germinal centre is a dynamic microenvironment where B cells expressing high-affinity antibody variants are selected for clonal expansion by limiting the number of T follicular helper cells. T follicular helper cells undergo antigen-dependent selection throughout the germinal centre reaction, resulting in differential proliferative expansion and contraction. Competition between T follicular helper cell clones is mediated by the affinity of T cell receptors for peptide-major-histocompatibility-complex ligands.
Review
Rheumatology
Gaetane Nocturne, Elena Pontarini, Michele Bombardieri, Xavier Mariette
Summary: Lymphoma development is a serious complication of Sjögren's syndrome, commonly presenting as B-cell lymphomas. The progression towards lymphoma may be influenced by chronic antigenic stimulation and autoreactive B cell clones. Early identification and controlling disease activity could potentially reduce the risk of lymphoma in patients.
Article
Immunology
Carmen Gomez-Escolar, Ester Marina-Zarate, Almudena R. Ramiro
Summary: Germinal centers are important for secondary antibody diversification and vaccination strategies. Activation-induced deaminase (AID) plays a crucial role in this process but can also cause genomic mutations and chromosome translocations with oncogenic potential. Many human lymphomas originate from mature B cells that have undergone germinal center reactions and carry chromosome translocations. Mouse models employing genetic introduction of chromosome translocations have contributed to the understanding of mature B cell lymphomagenesis.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Elizabeth Katherine Anna Triumbari, David Morland, Riccardo Laudicella, Matteo Bauckneht, Domenico Albano, Salvatore Annunziata
Summary: This systematic review assessed the clinical applications of immuno-PET in patients with lymphoma. The limited literature data currently available suggest that immuno-PET could be a useful tool to visualize the individual immunological environment and guide treatment planning in lymphoma patients. However, further research is needed to overcome obstacles and fully exploit the potential of immuno-PET in this context.
Article
Multidisciplinary Sciences
Katherine Dittrich, Ummugulsum Yildiz-Altay, Fatima Qutab, Danny A. Kwong, Zechuan Rao, Sebastian A. Nievez-Lozano, Heather L. Gardner, Jillian M. Richmond, Cheryl A. London
Summary: This study explored treatment selection for canine DLBCL using gene expression analysis and identified potential biomarkers that may guide the choice of chemoimmunotherapy treatment in dogs.
Article
Chemistry, Medicinal
Yong Ai, Lucia Hwang, Alexander D. MacKerell, Ari Melnick, Fengtian Xue
Summary: BCL6 is a master regulator of germinal center formation, playing a crucial role in immune responses, and the protein-protein interaction between BCL6 and its corepressors has become a focus for cancer treatment research.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Maria Perticone, Raffaele Maio, Simona Gigliotti, Franco Arturi, Elena Succurro, Angela Sciacqua, Francesco Andreozzi, Giorgio Sesti, Francesco Perticone
Summary: Inflammation plays a key role in atherosclerosis, and individuals with high 1-hour post-load plasma glucose have an increased risk of diabetes and target organ damage. This study aimed to investigate the differences in immune-mediated inflammatory parameters in newly-diagnosed hypertensive patients with or without 1-hour post-load hyperglycemia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Marion Lacroix, Hugues Beauchemin, Cyrus Khandanpour, Tarik Moroy
Summary: DDX3X is an RNA helicase involved in various RNA metabolism processes, but also plays a role in transcription regulation and signaling pathways. Mutations in DDX3X are frequently found in GC-derived B-cell lymphomas with c-MYC translocations, primarily in males. DDX3Y, the male homologue, is not mutated in any type of malignancy and its upregulation is observed in lymphomas with DDX3X mutations. These findings suggest that DDX3Y could be a potential therapeutic target for male patients with BL and DLBCL with LOF mutations in the DDX3X gene.
FRONTIERS IN ONCOLOGY
(2023)
Article
Immunology
Hengshu Chen, Fan Liu, Dongren Sun, Jingyuan Zhang, Shihang Luo, Qiao Liao, Fafa Tian
Summary: CRP polymorphisms, splenic attenuation based on CRP genotype, and peripheral monocytes are associated with the risk of early-onset PSD, suggesting a link between peripheral immuno-inflammatory responses and post-stroke depression.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Yajing Xing, Weikai Guo, Min Wu, Jiuqing Xie, Dongxia Huang, Pan Hu, Miaoran Zhou, Lin Zhang, Qiansen Zhang, Peili Wang, Xin Wang, Guixue Wang, Huangan Wu, Cili Zhou, Yihua Chen, Mingyao Liu, Zhengfang Yi, Zhenliang Sun
Summary: Researchers have identified a small molecule compound named WK500B that can block the inhibition of BCL6, reactivate target genes, kill DLBCL cells, and display strong anti-tumor effects in animal models. Therefore, WK500B holds promise as an effective orally available therapeutic agent for DLBCL.
Article
Oncology
Michal Marek Hoppe, Patrick Jaynes, Shuangyi Fan, Yanfen Peng, Shruti Sridhar, Phuong Mai Hoang, Clementine Xin Liu, Sanjay De Mel, Limei Poon, Esther Hian Li Chan, Joanne Lee, Choon Kiat Ong, Tiffany Tang, Soon Thye Lim, Chandramouli Nagarajan, Nicholas F. Grigoropoulos, Soo-Yong Tan, Susan Swee-Shan Hue, Sheng-Tsung Change, Shih-Sung Chuange, Shaoying Li, Joseph D. Khoury, Hyungwon Choi, Carl Harris III, Alessia Bottos, Laura J. Gay, Hendrik F. P. Runge, Ilias Moutsopoulos, Irina Mohorianu, Daniel J. Hodson, Pedro Farinha, Anja Mottok, David W. Scott, Jason J. Pitt, Jinmiao Chen, Gayatri Kumar, Kasthuri Kannan, Wee Joo Chug, Yen Lin Chee, Siok-Bia Ng, Claudio Tripodoe, Anand D. Jeyasekharan
Summary: This study demonstrates that combinations of oncogenes in cellular subpopulations within a cancer can influence clinical outcomes. The percentage of cells with a unique combination of MYC, BCL2, and BCL6 predicts survival in diffuse large B-cell lymphoma (DLBCL), and can be derived mathematically from quantitative measurements of the individual oncogenes. Comparative analysis of DLBCL samples and transformed B cells identifies potential regulators of the unfavorable biology associated with this combination. These findings have implications for understanding cancer evolution and therapy resistance.
Article
Multidisciplinary Sciences
V. Tollemar, H. Arvidsson, H. Habel, N. Tudzarovski, K. Garming Legert, K. Le Blanc, G. Warfvinge, R. V. Sugars
Summary: The study aims to evaluate the histopathological profiles of minor salivary gland tissue after allogenic hematopoietic cell transplantation for chronic Graft-versus-Host Disease (cGVHD). The use of two grading schemes validated the diagnosis of salivary gland cGVHD and the NIH grading scheme was found to be more suitable for research purposes.
Article
Psychology, Multidisciplinary
Qinghong Xu, Shujun Zhang, Jie Li, Baizhou Wu, Helin Qiu, Qilimuge
Summary: This study investigates the processing of Mongolian contradictory negative sentences, supporting the fusion model and verifying the post-verbal effect of negators. Results showed that Mongolian contradictory negative sentences were processed based on representing actual conditions rather than the negated state of affairs, and that despite a post-verbal effect of negators being measured, Mongolian-Mandarin bilinguals adopted the same representational strategy for contradictory negation in both languages.
FRONTIERS IN PSYCHOLOGY
(2021)
Review
Oncology
Anurag Kumar Srivastava, Giorgia Guadagnin, Paola Cappello, Francesco Novelli
Summary: Tumor-associated antigens (TAAs) are antigens present in tumor cells, but are also expressed in normal cells. This article provides an overview of how post-translational modifications in TAAs play a role in eliciting a specific immune response, making them targets for immuno-oncology therapy. Both preclinical and clinical studies will be discussed.
Article
Hematology
Sarah Haebe, William Keay, Stefan Alig, Anne-Wiebe Mohr, Larissa K. Martin, Michael Heide, Ramona Secci, Stefan Krebs, Helmut Blum, Andreas Moosmann, Abner Louissaint, David M. Weinstock, Silvia Thoene, Michael von Bergwelt-Baildon, Juergen Ruland, Deepak Bararia, Oliver Weigert
Summary: This study found that in relapsed follicular lymphoma, the BCL2/IGH translocation may precede CPC-defining mutations, and cells with BCL2/IGH translocation can persist in clinical remission.
BRITISH JOURNAL OF HAEMATOLOGY
(2022)