Article
Biochemistry & Molecular Biology
Barbara Lisowska-Myjak, Ewa Skarzynska, Monika Wrobel, Grzegorz Manka, Mariusz Kiecka, Michal Lipa, Damian Warzecha, Robert Spaczynski, Piotr Piekarski, Beata Banaszewska, Artur Jakimiuk, Tadeusz Issat, Wojciech Rokita, Jakub Mlodawski, Maria Szubert, Piotr Sieroszewski, Grzegorz Raba, Kamil Szczupak, Tomasz Kluz, Marek Kluza, Miroslaw Wielgos, Piotr Laudanski
Summary: An evaluation of the concentrations of vitamin D-binding protein and lactoferrin in the plasma and peritoneal fluid of women with suspected endometriosis revealed a correlation, suggesting their potential role in the molecular mechanisms of the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Lindsay C. Czuba, Emily E. Fay, Jeffrey LaFrance, Chase K. Smith, Sara Shum, Sue L. Moreni, Jennie Mao, Nina Isoherranen, Mary F. Hebert
Summary: This study aims to investigate the changes in maternal vitamin A levels during pregnancy. The findings reveal that plasma retinol concentrations are lower, but all-trans-retinoic acid concentrations are higher during pregnancy.
Article
Nutrition & Dietetics
Matthew D. Hart, Meron Girma, Morgan D. Strong, Birkneh Tilahun Tadesse, Biruk Mulugeta Taddesse, Fikadu Reta Alemayehu, Barbara J. Stoecker, Winyoo Chowanadisai
Summary: Ethiopian women have lower plasma 25-hydroxy-cholecalciferol concentrations despite abundant sunshine. This study suggests that polymorphisms in the vitamin D binding protein gene may be associated with reduced vitamin D levels in Ethiopian lactating women. Furthermore, these polymorphisms may impact the short-term response to vitamin D supplementation.
NUTRITION RESEARCH
(2022)
Article
Medicine, General & Internal
David Palmer, Steven Soule, Ravinder R. Gaddam, Peter Elder, Stephen Chambers, Matthew Doogue
Summary: In critically ill patients, total 25(OH)D concentration is decreased, but calculated free 25(OH)D concentration remains unchanged.
INTERNAL MEDICINE JOURNAL
(2022)
Article
Nutrition & Dietetics
Leila Setayesh, Abbas Amini, Reza Bagheri, Nariman Moradi, Habib Yarizadeh, Omid Asbaghi, Krista Casazza, Mir Saeed Yekaninejad, Alexei Wong, Katsuhiko Suzuki, Khadijeh Mirzaei
Summary: Lower concentrations of HDL and higher values of FMI are associated with higher concentrations of DBP in overweight and obese women. No significant relationships were observed among 25(OH)D and target variables. These findings provide new insight into the relationship between DBP and metabolic factors in overweight and obese women, but the causal relationship between DBP and target variables needs further consideration.
Article
Oncology
Robin Taylor Wilson, Susan E. Safford, Quinn T. Ostrom, Ming Wang, Alicia C. McDonald, Anna C. Salzberg, Jill S. Barnholtz-Sloan, John P. Richie
Summary: In this cross-sectional study, little is known regarding factors associated with calcitriol and the calcitriol-24,25-dihydroxyvitamin D3-calcifediol proportion ratio (C24CPR). The study found that calcitriol and C24CPR were both significantly, positively, and monotonically associated with West African genetic ancestry proportion (WGA). These findings suggest that C24CPR may be more suitable for personalized medicine.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Nutrition & Dietetics
Anna Zhu, Sabine Kuznia, Tobias Niedermaier, Bernd Holleczek, Ben Schoettker, Hermann Brenner
Summary: The study investigated the distributions and determinants of different vitamin D biomarkers in a large cohort of older adults. It found seasonal variations, correlations with age, body mass index, and C-reactive protein, as well as differential impacts of VDBP genotypes on 25(OH)D levels.
Article
Nutrition & Dietetics
Rajiv Erasmus, Setjie Maepa, Ian Machingura, Saarah Davids, Shanel Raghubeer, Tandi Matsha
Summary: This study investigated the association between 25(OH) vitamin D, vitamin D-binding proteins, and vitamin D receptor (VDR) polymorphisms in a South African population. The results showed a high prevalence of vitamin D deficiency/insufficiency in this population, with decreased vitamin D levels observed in hyperglycaemic individuals. These findings can contribute to further research on the diagnosis and treatment of hyperglycaemia.
Article
Nutrition & Dietetics
Sreedhar Subramanian, Jonathan M. Rhodes, Joseph M. Taylor, Anna M. Milan, Steven Lane, Martin Hewison, Rene F. Chun, Andrea Jorgensen, Paul Richardson, Darshan Nitchingham, Joseph Aslan, Maya Shah, Coonoor R. Chandrasekar, Amanda Wood, Mike Beadsworth, Munir Pirmohamed
Summary: Vitamin D status is not significantly associated with mortality from COVID-19, but extremely low and high levels may be associated with mortality risks.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Review
Plant Sciences
Saskya E. Carrera-Pacheco, Ben Hankamer, Melanie Oey
Summary: Microalgal chloroplasts, particularly those of C. reinhardtii, show promise as a new platform for recombinant protein production. Optimizing transgene expression and protein yields involves considering both environmental and cellular factors. This review focuses on the regulatory effects of environmental factors such as light, carbon source, and temperature on biomass and recombinant protein production, with implications for large-scale light-driven biotechnology applications.
TRENDS IN PLANT SCIENCE
(2023)
Article
Nutrition & Dietetics
Valentina Aristarco, Harriet Johansson, Sara Gandini, Debora Macis, Cristina Zanzottera, Gianluca Tolva, Irene Feroce, Chiara Accornero, Bernardo Bonanni, Aliana Guerrieri-Gonzaga, Davide Serrano
Summary: This study found that SNPs of VDR and GC genes may influence breast cancer recurrence and survival in patients, particularly with major alleles of BsmI and TaqI showing lower risk of relapse.
Article
Nutrition & Dietetics
Sarah E. Twardowski, Jean Wactawski-Wende, Kathleen M. Hovey, Christopher A. Andrews, Hailey R. Banack, Michael J. LaMonte, Amy E. Millen
Summary: The study found a negative association between plasma 25-hydroxyvitamin D (25[OH]D) concentrations and salivary CRP concentrations in postmenopausal women, which attenuated after adjusting for other factors. However, there was no significant association between 25[OH]D and serum CRP concentrations.
Article
Ecology
Emily Helliwell, Dongseok Choi, Justin Merritt, Jens Kreth
Summary: Membrane vesicles are produced by both Gram-negative and Gram-positive bacteria, and they can stimulate eukaryotic cells and participate in cell-to-cell communication. However, there is limited knowledge about their general biology in the context of community members and the environment. In this study, we discovered that the production and dissemination of membrane vesicles by the Gram-positive oral commensal Streptococcus sanguinis are influenced by environmental and community factors.
Review
Biochemistry & Molecular Biology
Nipith Charoenngam, Aunchalee Jaroenlapnopparat, Sofia K. Mettler, Ashna Grover
Summary: The activation of vitamin D receptor (VDR) has beneficial effects on mitigating the susceptibility and severity of COVID-19 infection. Vitamin D-binding protein (DBP) also affects the immune system and may influence inflammation associated with COVID-19. Low levels of serum 25-hydroxyvitamin D have been associated with increased risk and severity of COVID-19 infection. However, the effectiveness of vitamin D supplementation as a treatment for COVID-19 based on randomized clinical trials is still uncertain.
Review
Cardiac & Cardiovascular Systems
Byambaa Enkhmaa, Lars Berglund
Summary: An elevated level of lipoprotein(a) is a genetically regulated risk factor for cardiovascular disease, but non-genetic factors may also influence its levels. Diet, physical activity, hormones, and certain pathological conditions can all impact lipoprotein(a) levels.
Article
Biology
Nour Hawila, Arthur Berg
Summary: A novel confidence interval estimator is proposed for the risk difference in noninferiority binomial trials. The proposed estimator is consistent with an exact unconditional test and has improved power, particularly for smaller sample sizes, compared to existing methods. The improved performance of the proposed estimator is theoretically justified and demonstrated through simulations and examples. An R package is also provided for implementing the proposed methods.
Article
Oncology
Kyle M. Walsh, Corey Neff, Melissa L. Bondy, Carol Kruchko, Jason T. Huse, Christopher Amos, Jill S. Barnholtz-Sloan, Quinn T. Ostrom
Summary: The incidence and outcomes of glioma differ in association with the geographic origins of Hispanic communities, with predominantly Mexican/Central American-origin counties at reduced risk and predominantly Caribbean-origin counties at greater risk. Higher incidence and improved survival are associated with European admixture in Hispanic patients.
Article
Oncology
Joshua D. Palmer, Rahul N. Prasad, Gino Cioffi, Carol Kruchtko, Nicholas G. Zaorsky, Daniel M. Trifiletti, Vinai Gondi, Paul D. Brown, Haley K. Perlow, Mark Mishra, Arnab Chakravarti, Jill S. Barnholtz-Sloan, Quinn T. Ostrom
Summary: This study suggests a potential association between exposure to high levels of particulate pollution and radon and increased incidence of non-malignant brain tumors. However, more research is needed to confirm these findings in other populations.
Article
Clinical Neurology
Kailey Takaoka, Gino Cioffi, Kristin A. Waiter, Jonathan L. Finlay, Daniel Landi, Kaitlyn Greppin, Carol Kruchko, Quinn T. Ostrom, Jill S. Barnholtz-Sloan
Summary: This study provides the latest epidemiological analysis of choroid plexus tumors in the US from 2004 to 2017, showing that choroid plexus papilloma is the most common subtype and the incidence is highest among young patients, while choroid plexus carcinoma has the lowest survival rate.
NEURO-ONCOLOGY PRACTICE
(2023)
Review
Oncology
Julie J. Miller, L. Nicolas Gonzalez Castro, Samuel McBrayer, Michael Weller, Timothy Cloughesy, Jana Portnow, Ovidiu Andronesi, Jill S. Barnholtz-Sloan, Brigitta G. Baumert, Mitchell S. Berger, Wenya Linda Bi, Ranjit Bindra, Daniel P. Cahill, Susan M. Chang, Joseph F. Costello, Craig Horbinski, Raymond Y. Huang, Robert B. Jenkins, Keith L. Ligon, Ingo K. Mellinghoff, L. Burt Nabors, Michael Platten, David A. Reardon, Diana D. Shi, David Schiff, Wolfgang Wick, Hai Yan, Andreas von Deimling, Martin van den Bent, William G. Kaelin, Patrick Y. Wen
Summary: This article discusses the diagnosis and management of IDH-mutant gliomas, as well as new treatment methods and future research directions.
Article
Oncology
Quinn T. Ostrom, Madison L. Shoaf, Gino Cioffi, Kristin Waite, Carol Kruchko, Patrick Y. Wen, Daniel J. Brat, Jill S. Barnholtz-Sloan, J. Bryan Iorgulescu
Summary: This study utilized data from the U.S. National Cancer Database to estimate the national-level overall survival patterns of molecularly-defined diffuse gliomas. The findings demonstrate differences in survival rates among different glioma types, and the impact of WHO grade and MGMT promoter methylation on survival.
Article
Multidisciplinary Sciences
Nickolas Stabellini, Jennifer Cullen, Lifen Cao, John Shanahan, Nelson Hamerschlak, Kristin Waite, Jill S. Barnholtz-Sloan, Alberto J. Montero
Summary: The study aimed to analyze the differences in treatment patterns and treatment related adverse events in Non-Hispanic women with breast cancer based on race. The results showed that Non-Hispanic Black women were less likely to undergo surgery or receive endocrine therapy, but more likely to receive radiotherapy. They also had a higher risk of cognitive decline/dementia after treatment.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Nickolas Stabellini, Benjamin Tomlinson, Jennifer Cullen, John Shanahan, Kristin Waite, Alberto J. J. Montero, Jill S. S. Barnholtz-Sloan, Nelson Hamerschlak
Summary: This study conducted a comprehensive analysis of sex differences in acute myeloid leukemia (AML) and found that there are disparities in incidence and survival between males and females. Treatment and healthcare factors have important implications for survival rates.
Review
Public Administration
Robin T. Wilson, Brandon L. LaBarge, Lauren E. Stahl, David Goldenberg, Yuliya Lyamzina, Evelyn O. Talbott
Summary: The worst commercial nuclear accident in US history occurred at Three Mile Island in 1979, leading to the first large-scale voluntary evacuation due to a nuclear event. This accident had a significant impact on the mental health of nearby residents, especially pregnant women. Despite long-term follow-up and research on cancer outcomes, community concerns persist. This study reviews the fetal/maternal/child health and cancer outcomes of the TMI accident and compares them to subsequent accidents such as Chernobyl and Fukushima. The findings highlight the need for long-term follow-up, preaccident protocols, and inclusion of vulnerable populations and perceived risks.
RISK HAZARDS & CRISIS IN PUBLIC POLICY
(2023)
Article
Oncology
Robin Taylor Wilson, Susan E. Safford, Quinn T. Ostrom, Ming Wang, Alicia C. McDonald, Anna C. Salzberg, Jill S. Barnholtz-Sloan, John P. Richie
Summary: In this cross-sectional study, little is known regarding factors associated with calcitriol and the calcitriol-24,25-dihydroxyvitamin D3-calcifediol proportion ratio (C24CPR). The study found that calcitriol and C24CPR were both significantly, positively, and monotonically associated with West African genetic ancestry proportion (WGA). These findings suggest that C24CPR may be more suitable for personalized medicine.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Oncology
Nickolas Stabellini, Jennifer Cullen, Marcio S. Bittencourt, Justin X. Moore, Lifen Cao, Neal L. Weintraub, Ryan A. Harris, Xiaoling Wang, Biplab Datta, Steven S. Coughlin, Jorge Garcia, John Shanahan, Nelson Hamerschlak, Kristin Waite, Nathanael R. Fillmore, Martha Terris, Alberto J. Montero, Jill S. Barnholtz-Sloan, Avirup Guha
Summary: Cardiovascular disease is the leading cause of death in men with prostate cancer, and accumulated stress plays a crucial role in its development. This study examined the impact of allostatic load (AL) on major cardiac events (MACE) in prostate cancer patients. The results showed that AL and its changes over time are associated with an increased risk of MACE.
JNCI CANCER SPECTRUM
(2023)
Article
Medicine, General & Internal
Anne Darby, Jessica A. Parascando, Matthew Lipinski, Chang Lipinski, Megan Mendez-Miller, Arthur Berg, David Rabago, Tamara K. Oser
Summary: This study investigated the familiarity and interest of MD students in osteopathic manipulative treatment (OMT). The results showed a high level of familiarity and interest in OMT among MD students, and many students were interested in participating in an OMT elective course. These findings will inform the development of OMT curriculum for interested MD students and residents, providing them with theoretical and practical knowledge in OMT.
JOURNAL OF OSTEOPATHIC MEDICINE
(2023)
Article
Clinical Neurology
Mackenzie Price, Katherine Ryan, Madison L. Shoaf, Corey Neff, J. Bryan Iorgulescu, Daniel B. Landi, Gino Cioffi, Kristin A. Waite, Carol Kruchko, Jill S. Barnholtz-Sloan, Quinn T. Ostrom
Summary: This report summarizes the latest population-based incidence, mortality, and survival data for primary brain and other CNS tumors in the US, aiming to serve as a concise resource for neuro-oncology providers.
NEURO-ONCOLOGY PRACTICE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Charit Tippareddy, Louisa Onyewadume, Andrew E. Sloan, Gi-Ming Wang, Nirav T. Patil, Siyuan Hu, Jill S. Barnholtz-Sloan, Rasim Boyacioglu, Vikas Gulani, Jeffrey Sunshine, Mark Griswold, Dan Ma, Chaitra Badve
Summary: This study aimed to test the feasibility of using 3D MRF maps with radiomics analysis and machine learning in the characterization of adult brain intra-axial neoplasms. The results showed that MRF maps were able to differentiate tumors based on type, grade, and IDH1 status. Furthermore, the radiomics features of MRF maps can also characterize gliomas based on grade, IDH1 status, and survival.
EUROPEAN RADIOLOGY
(2023)