Article
Gastroenterology & Hepatology
Aya Aly Ashraf, Sarah Mahmoud Gamal, Hend Ashour, Basma Emad Aboulhoda, Laila Ahmed Rashed, Inas Anas Harb, Gaber Hassan Abdelfattah, Eman Ahmed El-Seidi, Heba Mohamed Shawky
Summary: The pathogenic mechanisms of Helicobacter pylori-associated gastric motility disorders involve various theories. In this study, the impact of H. pylori infection on pyloric activity, ghrelin hormone alteration, pyloric fibrogenesis, and miR-1 expression in pyloric tissue samples was assessed in rats. The findings suggest that targeting miR-1 could be valuable in managing pyloric hypomotility caused by H. pylori infection.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Milad Shahini Shams Abadi, Korosh Ashrafi-Dehkordi, Reza Ahmadi, Ghorbanali Rahimian, Yousef Mirzaei, Rana Fereidani, Mojtaba Shohan, Fatemeh Azadegan-Dehkordi
Summary: The specific genotypes of H. pylori are closely related to the clinical outcomes and histological parameters in Iranian patients with gastroduodenal diseases.
Article
Microbiology
Michael Doulberis, Noah Thierry Pierre, Giulia Manzini, Apostolis Papaefthymiou, Jannis Kountouras, Jolanta Klukowska-Roetzler, Stergios A. Polyzos, Simone Srivastava, Aristomenis K. Exadaktylos, Jurg Knuchel, Thomas Kuntzen, David S. Srivastava
Summary: A study in Switzerland found that Helicobacter pylori infection is associated with premalignant gastric mucosa histologic lesions and components of metabolic syndrome in bariatric patients.
Article
Medicine, General & Internal
Priscilla Njenga, Allan Njau, Zahir Moloo, Gunturu Revathi, Evariste Tshibangu, Yoshio Yamaoka
Summary: This study investigated the association of H. pylori and its genotypes with gastric adenocarcinoma in the Kenyan population. The results showed that the VacA s1m1 genotype was positively associated with gastric adenocarcinoma, while the VacA s2m2 genotype was negatively associated. No association was found between CagA and gastric adenocarcinoma.
FRONTIERS IN MEDICINE
(2023)
Article
Microbiology
Yan Zhou, Zishao Zhong, Shengjuan Hu, Jing Wang, Yanhong Deng, Ximei Li, Xianmei Chen, Xue Li, Yuanyuan Tang, Xiaofei Li, Qian Hao, Jun Liu, Tian Sang, Yang Bo, Feihu Bai
Summary: Antibiotic resistance is the most important factor leading to failed Helicobacter pylori eradication therapy, and personalized treatment based on antibiotic susceptibility is becoming increasingly important. In this study, it was found that the inference of resistance to clarithromycin and levofloxacin from genotypic resistance is reliable, and whole-genome sequencing has been very helpful in discovering novel resistance loci of H. pylori.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Gastroenterology & Hepatology
Fidson-Juarismy Vesga, Adriana Rocio Beltran-Benavides, Ana Maria Marquez-Duque, Camilo Venegas, Alba-Alicia Trespalacios
Summary: This study identified the presence of H. pylori DNA in the Bogota River and wastewater treatment plants, demonstrating the potential risk of this pathogen in water sources.
Article
Gastroenterology & Hepatology
Jonathon P. Schubert, Richard J. Woodman, Arduino A. Mangoni, Christopher K. Rayner, Morgyn S. Warner, Ian C. Roberts-Thomson, Samuel P. Costello, Robert Bryant
Summary: Our study demonstrates the heterogeneous geospatial distribution of H. pylori positivity and antibiotic resistance, as well as its interaction with migrant status. Geographic location and migrant status are important factors to consider for H. pylori eradication therapy.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Oncology
Zishao Zhong, Zhenyu Zhang, Jing Wang, Yunlian Hu, Yang Mi, Bangshun He, Yushu Zhang, Ximei Zhang, Xingzhou Xia, Huang Huang, Yuexing Lai, Min Lin, Chengxia Su, Zhiyi Zhang, Zhengqi Wu, Linzhi Lu, Beiping Zhang, Suiping Huang, Cailing Zhong, Xiaoming Zeng, Yun Peng, Guangxia Chen, Haihan Zhang, Guangqing Zhou, Shiyu Liu, Changqing Yang, Lijuan Yan, Aojun Chen, Guiying Zhang, Ping Xu, Shukui Wang, Pengyuan Zheng, Shuchang Xu, Hengjun Gao
Summary: Helicobacter pylori antibiotic resistance is a serious concern in China, where personalized therapies based on genotype testing could partially replace traditional antibiotic susceptibility testing. Continuous monitoring and personalized treatments remain necessary for effective management of H. pylori infections in China.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Plant Sciences
Nada Elhefni, Sherif S. S. Ebada, Marwa M. M. Abdel-Aziz, El-Sayed M. Marwan, Saleh El-Sharkawy, Mona El-Neketi
Summary: Date palm waste from Egypt can be used to produce compounds with anti-Helicobacter pylori and anti-inflammatory activities, including a new sesquiterpene lactone derivative (phodactolide A) and other known compounds.
PHARMACEUTICAL BIOLOGY
(2023)
Article
Pathology
Maria Jose Fernandez-Nestosa, Omar Clavero, Diego F. Sanchez, Giovanna A. Giannico, Antonella Lobatti, Sofia Canete-Portillo, Elsa F. Velazquez, Laia Alemany, Nubia Munoz, Sylvia de San Jose, F. Xavier Bosch, Antonio L. Cubilla
Summary: There is limited research on pathologic and molecular studies of penile precancerous lesions, particularly non-invasive lesions. This study aimed to classify Penile Intraepithelial Neoplasia (PeIN) based on morphology and detect HPV genotypes, as well as evaluate p16INK4a immunostaining as a potential surrogate for high-risk HPV infection. The findings show distinct morphological subtypes of PeIN and highlight the importance of HPV in the development of penile in situ neoplasia.
Article
Cardiac & Cardiovascular Systems
Jaehoon Chung, Kyueng-Whan Min, Byoung Kwan Son, Dong-Hoon Kim, Hack-Lyoung Kim
Summary: This study found that HP infection was associated with younger subjects and the histological features of HP gastritis were related to cardiovascular risk scores. As the USS scores increased, the estimated 10-year cardiovascular risk scores also increased proportionally.
Article
Microbiology
Kimberly Sanchez-Alonzo, Lillian Matamala-Valdes, Cristian Parra-Sepulveda, Humberto Bernasconi, Victor L. Campos, Carlos T. Smith, Katia Saez, Apolinaria Garcia-Cancino
Summary: The study confirmed that Helicobacter pylori can be harbored and transmitted within vaginal yeast cells, carrying virulence genes that may pose a risk for vertical transmission of this pathogen.
Article
Gastroenterology & Hepatology
Ahmed Morad Asaad, Gasser El-Azab, Eman Abdelsameea, Osama Elbahr, Ahmed Kamal, Mohamed Abdel-Samiee, Ahmed Abdelfattah, Heba Abdallah, Doha Maher, Ahmed El-Refaie, Samar Ebrahim Ghanem, Shamshul Ansari, Samah Mohammed Awad
Summary: This study investigates H. pylori infection and resistance patterns in Egyptian patients, as well as the impact of H. pylori virulence genetic determinants on the success of 14-day triple therapy. The results show a low eradication rate with the triple therapy and high resistance to clarithromycin, amoxicillin, and metronidazole. Successful eradication is significantly associated with vacA s1-positive strains, while failed eradication is significantly associated with clarithromycin and amoxicillin-resistant strains.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Oncology
Jose Manuel Vazquez-Guillen, Gerardo C. Palacios-Saucedo, Alondra Yamileth Alanis-Valdez, Andrea Huerta-Escobedo, Angel Zavala-Pompa, Lydia Guadalupe Rivera-Morales, Ana Carolina Martinez-Torres, Vianey Gonzalez-Villasana, Julio Cesar Serna-Hernandez, Silvia Judith Hernandez-Martinez, Edmundo Erbey Castelan-Maldonado, Martha Socorro Montalvo-Banuelos, Cesar Alejandro Alonso-Tellez, Ethel Corinthia Sanchez-Fresno, Reyes S. Tamez-Guerra, Cristina Rodriguez-Padilla
Summary: This study compared the expression of pRb and p16(INK4a) in tumor tissues of LSCC patients and found that p16(INK4a) is not a reliable marker for HPV or EBV infection in LSCC. However, pRb expression may be associated with HPV negativity in LSCC. Further studies are needed to determine the role of p16(INK4a) and pRb in LSCC.
INFECTIOUS AGENTS AND CANCER
(2023)
Article
Gastroenterology & Hepatology
Qing-Hua Sun, Jing Zhang, Yan-Yan Shi, Wei-Wei Fu, Shi-Gang Ding
Summary: This study characterizes the microbial profiles of gastric mucosa and juice in patients with Helicobacter pylori-negative gastric cancer (HPNGC) and its precancerous stages. The results provide insights into potential taxonomic biomarkers for HPNGC, helping predict the prognosis of IM and Dys based on the mucosal microbiota profile.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Oncology
Ismael Augusto Silva Lombardi, Mario Henrique Girao Faria, Silvia Helena Barem Rabenhorst, Marco Antonio Zanini, Maria Ines De Moura Campos Pardini, Rejane Maria Tommasini Grotto, Adriana Camargo Ferrasi
ANTICANCER RESEARCH
(2018)
Article
Dentistry, Oral Surgery & Medicine
Everton Freitas de Morais, Hellen Bandeira de Pontes Santos, Israel Leal Cavalcante, Silvia Helena Barem Rabenhorst, Jean Nunes dos Santos, Hebei Cavalcanti Galvao, Roseana de Almeida Freitas
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
(2019)
Article
Medicine, General & Internal
Flavia Hebeler-Barbosa, Viviam Milanez Massolini, Thais Watanabe, Giovanni Faria Silva, Alexandre Naime Barbosa, Rafael Plana Simoes, Adriana Camargo Ferrasi, Paolo Marinho de Andrade Zanotto, Maria Ines de Moura Campos Pardini, Rejane Maria Tommasini Grotto
Article
Immunology
Eduardo Henrique Neves Filho, Carlos Gustavo Hirth, Igor Allen Frederico, Rommel Mario Burbano, Thiago Carneiro, Silvia Helena Rabenhorst
Article
Evolutionary Biology
Ana Paula Schaan, Leonor Gusmao, Juliana Jannuzzi, Antonio Modesto, Marcos Amador, Diego Marques, Silvia Helena Rabenhorst, Raquel Montenegro, Thayson Lopes, France Keiko Yoshioka, Giovanny Pinto, Sidney Santos, Lorenna Costa, Vivian Silbiger, Andrea Ribeiro-dos-Santos
BMC EVOLUTIONARY BIOLOGY
(2020)
Article
Multidisciplinary Sciences
Adriana Camargo Ferrasi, Geysson Javier Fernandez, Rejane Maria Tommasini Grotto, Giovanni Faria Silva, Joao Goncalves, Marina C. Costa, Francisco J. Enguita, Maria Ines de Moura Campos Pardini
SCIENTIFIC REPORTS
(2020)
Article
Microbiology
Flavia Hebeler-Barbosa, Ivan Rodrigo Wolf, Guilherme Targino Valente, Francisco Campello do Amaral Mello, Elisabeth Lampe, Maria Ines de Moura Campos Pardini, Rejane Maria Tommasini Grotto
Article
Microbiology
Morgana Maria de Oliveira Barboza, Francivandi Coelho Barbosa, Ana Paula Santos do Carmo, Fernanda Capelo Barroso, Silvia Helena Barem Rabenhorst
Summary: The study compared the expression of different interleukin gene polymorphisms in different types of gastric pathologies and found that the IL6-174 GC and IL8-251 T alleles may have a protective effect against ACG development in women. Virulent strains of H. pylori were found to be associated with different types of gastric lesions.
ARCHIVES OF MICROBIOLOGY
(2021)
Article
Rheumatology
Natalia Bronzatto Medolago, Adriana Camargo Ferrasi, Oswaldo Melo da Rocha, Maria Ines de Moura Campos Pardini, Rejane Maria Tommasini Grotto, Giovanni Faria Silva
Summary: This study aimed to investigate the association between HLA-DRB1 gene and rheumatologic manifestations in chronic hepatitis C patients. The results showed no association between HLA-DRB1 alleles and these rheumatologic symptoms, suggesting distinct pathophysiological pathways for DCTD-related RM and HCV-related RM.
CURRENT RHEUMATOLOGY REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Gabriel A. Kurokawa, Pedro T. Hamamoto Filho, Jeany Delafiori, Aline F. Galvani, Arthur N. de Oliveira, Flavia L. Dias-Audibert, Rodrigo R. Catharino, Maria Ines M. C. Pardini, Marco A. Zanini, Estela de O. Lima, Adriana C. Ferrasi
Summary: This study identified plasma metabolic alterations that can differentiate between low-grade and high-grade meningiomas, providing valuable information for surgeons to determine the ideal surgical strategy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Adriana C. Ferrasi, Ricardo Puttini, Aline F. Galvani, Pedro T. Hamamoto Filho, Jeany Delafiori, Victoria D. Argente, Arthur N. de Oliveira, Flavia L. Dias-Audibert, Rodrigo R. Catharino, Octavio C. Silva, Marco A. Zanini, Gabriel A. Kurokawa, Estela O. Lima
Summary: This study aimed to evaluate differential plasma biomarkers between glioblastoma (GB) patients and healthy individuals using metabolomics analysis. Seven GB biomarkers were identified, some of which were unprecedented biomarkers for GB, and their roles in epigenetic modulation, energy metabolism, protein catabolism or folding processes, and signaling pathways that activate cell proliferation and invasion were elucidated.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Parasitology
Natalia Bronzatto Medolago, Adriana Camargo Ferrasi, Oswaldo Melo da Rocha, Maria Ines de Moura Campos Pardini, Rejane Maria Tommasini Grotto, Aline Faria Galvani, Giovanni Faria Silva
REVISTA DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL
(2020)
Article
Parasitology
Rejane Maria Tommasini Grotto, Francielle Martins Santos, Natalia Picelli, Giovanni Faria Silva, Adriana Camargo Ferrasi, Valeria Cristina Rodrigues Sarnighausen, Maria Ines de Moura Campos Pardini
REVISTA DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL
(2019)