Review
Chemistry, Analytical
Anjali Tomar, Reeta R. Gupta, S. K. Mehta, Shilpee Sachar, Shweta Sharma
Summary: This review comprehensively explores the forensic examination of photocopied documents, analyzing trends and advances in analytical techniques over the past four decades. Various methods including spectroscopic, microscopic, and chromatographic techniques have been discussed for examination of printing toner samples. The use of nondestructive techniques, data fusion, and chemometric methods has enhanced sample discrimination and identification in forensic investigations.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2021)
Article
Oncology
Zhaoshi Bai, Qing Zhou, Huayun Zhu, Xinyue Ye, Pingping Wu, Lingman Ma
Summary: The study introduces a potential anticancer agent, Quaternized thiourea main-chain polymer (QTMP), which is not a P-gp substrate and exhibits potent cytotoxic activity against CRC cells. It induces ROS and RNS production in cells, leading to DNA damage and apoptosis through caspase activation. QTMP is considered a promising strategy for addressing MDR in CRC treatment.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Wedad S. Sarawi, Ahlam M. Alhusaini, Laila M. Fadda, Hatun A. Alomar, Awatif B. Albaker, Amjad S. Aljrboa, Areej M. Alotaibi, Iman H. Hasan, Ayman M. Mahmoud
Summary: This study demonstrates that CUR and N-CUR can protect against Cu-induced cardiotoxicity by reducing oxidative injury, suppressing inflammatory response and apoptosis, and modulating TLR4/NF-kappa B and MAPK signaling pathways. The cardioprotective effect of N-CUR is more potent than the native form.
Article
Engineering, Environmental
Hongrui Guo, Yujuan Ouyang, Jiaqi Wang, Hengmin Cui, Huidan Deng, Xinyue Zhong, Zhijie Jian, Huan Liu, Jing Fang, Zhicai Zuo, Xun Wang, Ling Zhao, Yi Geng, Ping Ouyang, Huaqiao Tang
Summary: Copper is essential but over-exposure can lead to adverse health effects. CuSO4 was found to induce spermatogenesis disorder through oxidative stress-mediated DNA damage and apoptosis, impairing male reproductive function.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Review
Biochemistry & Molecular Biology
Gwyneth Welch, Li-Huei Tsai
Summary: Neurons are highly susceptible to DNA damage, and deficient DNA damage repair is the underlying cause of neurological disorders. DNA damage may play a central role in neuroinflammation associated with neurodegenerative diseases.
Review
Biotechnology & Applied Microbiology
Xiaofei Zhou, Weitao Jin, Jingjun Ma
Summary: In recent years, the widespread use of nanoparticles in various fields has raised concerns about the potential health risks they may pose, particularly on lung health. This review focuses on the pulmonary toxic effects of nanoparticles and summarizes their impact on pulmonary inflammatory responses. It discusses the activation and aggravation of lung inflammation by nanoparticles, the inhibition of ongoing lung inflammation by nanoparticles loaded with anti-inflammatory drugs, and the influence of nanoparticles' physicochemical properties on pulmonary inflammatory disturbance. The review also highlights the gaps in current research and the challenges and countermeasures for future studies.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Chemistry, Analytical
Chi Zhang, Man Fang, Yuanbo Gao, Yunchao Li, Louzhen Fan, Xiaohong Li
Summary: In this study, a Cu-A nanozyme was synthesized and found to catalyze the oxidation of aromatic amines with high specificity. A colorimetric sensor array was also constructed to detect and identify aromatic amines with high accuracy. The practical application of this method in environmental water samples was demonstrated.
ANALYTICAL CHEMISTRY
(2023)
Article
Materials Science, Multidisciplinary
Sachin Patil, Vishnu S. Mishra, Puli Chandramouli Reddy, Bimlesh Lochab
Summary: Researchers have developed a nanoformulation using nanodiamonds and iron oxide, which effectively delivers artesunate (ART) to cancer cells, increasing its anticancer properties. This nanoformulation enhances the production of reactive oxygen species (ROS), leading to DNA damage and cellular apoptosis.
ACS MATERIALS LETTERS
(2023)
Article
Biotechnology & Applied Microbiology
Robert G. Sears, Stephen B. Rigoulot, Alessandro Occhialini, Britany Morgan, Tayebeh Kakeshpour, Holly Brabazon, Caitlin N. Barnes, Erin M. Seaberry, Brianna Jacobs, Chandler Brown, Yongil Yang, Tayler M. Schimel, Scott C. Lenaghan, C. Neal Stewart
Summary: Nuclear energy is expected to grow in order to meet climate goals, leading to an increased need to detect leakage from nuclear plants and assess their impact on ecosystems. Mechanical sensors currently used to detect gamma radiation have limitations, prompting the development of a plant biosensor that utilizes synthetic biology to detect low-dose ionizing radiation. The radiation phytosensor has shown promising results in detecting gamma radiation exposure and functioning effectively in real-world scenarios.
PLANT BIOTECHNOLOGY JOURNAL
(2023)
Article
Multidisciplinary Sciences
Alejandro Damian La Greca, Nelba Perez, Sheila Castaneda, Paula Melania Milone, Maria Agustina Scarafia, Alan Miqueas Mobbs, Ariel Waisman, Lucia Natalia Moro, Gustavo Emilio Sevlever, Carlos Daniel Luzzani, Santiago Gabriel Miriuka
Summary: Cell death experiments are crucial for drug development, and predicting cell death with neural networks can outperform human ability. A simple Python tool has been developed by the research team for broadly detecting cell death.
Review
Chemistry, Multidisciplinary
Gudivaka Sri Kanaka Durga Vijayalakshmi, Nagaprasad Puvvada
Summary: Stroke is a serious public health problem, and nanotechnology has emerged as a viable option to bypass drug restrictions and enhance treatment efficacy. This includes creating safe thrombolytic medications using nanoparticle-based methods, as well as exploring the application of immunotherapy and stem cell therapy in stroke treatment.
Article
Biochemistry & Molecular Biology
Basma Salama, Khalid J. Alzahrani, Khalid S. Alghamdi, Osama Al-Amer, Khalid E. Hassan, Mohamed A. Elhefny, Alaa Jameel A. Albarakati, Fahad Alharthi, Hussam A. Althagafi, Hassan Al Sberi, Hatem K. Amin, Maha S. Lokman, Khalaf F. Alsharif, Ashraf Albrakati, Ahmed E. Abdel Moneim, Rami B. Kassab, Ayah S. Fathalla
Summary: This study investigated the protective effect of thymoquinone (TQ) against hepatic and renal cytotoxicity induced by silver nanoparticles (AgNPs). The results showed that TQ can reverse AgNPs-induced liver and kidney dysfunction, alleviate oxidative stress and inflammation, and inhibit apoptosis. These findings suggest that TQ can control the toxicological effects of AgNPs and improve their safety.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Medicine, Research & Experimental
Hongmei Tang, Yun Zhang, Qiao Wang, Ziling Zeng, Xiaoyun Wang, Yuejiao Li, Zhibin Wang, Ning Ma, Guofeng Xu, Xiaolin Zhong, Linlin Guo, Xiefang Yuan, Xing Wang
Summary: This study found that astaxanthin can attenuate DNA damage and apoptosis caused by cigarette smoke, and reduce the activation of Caspase-3. Astaxanthin can also decrease the production of intracellular reactive oxygen species by suppressing the expression of NOX4 and DUOX1.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Chemistry, Multidisciplinary
Maria Joao Bessa, Fatima Brandao, Paul H. B. Fokkens, Daan L. A. C. Leseman, A. John F. Boere, Flemming R. Cassee, Apostolos Salmatonidis, Mar Viana, Adriana Vulpoi, Simion Simon, Eliseo Monfort, Joao Paulo Teixeira, Sonia Fraga
Summary: Diverse industries have incorporated engineered nanoparticles (ENP) into their production processes, increasing the risk of worker inhalation exposure. In vitro models, particularly using air-liquid interface (ALI) cell cultures, are valuable for studying ENP toxicity. When comparing submerged and ALI conditions for ENP exposure, it was found that ALI cultures were more sensitive to the cytotoxic effects of ENP on human alveolar epithelial-like cells.
Article
Biochemistry & Molecular Biology
Tatsuya Shimada, Yohsuke Yabuki, Takuya Noguchi, Mei Tsuchida, Ryuto Komatsu, Shuhei Hamano, Mayuka Yamada, Yusuke Ezaki, Yusuke Hirata, Atsushi Matsuzawa
Summary: LKB1 promotes p53 activation and apoptosis induced by cisplatin in human fibrosarcoma cells, while AMPK negatively regulates p53 activation and apoptosis. Furthermore, AMPK can suppress p53 activation through oxidative stress, as shown by the cancellation of apoptosis with antioxidants in AMPK DKO cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Environmental
Jiaqi Lan, Man Hu, Ce Gao, Akram Alshawabkeh, April Z. Gu
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2015)
Article
Engineering, Environmental
Ce Gao, David Weisman, Jiaqi Lan, Na Gou, April Z. Gu
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2015)
Article
Nanoscience & Nanotechnology
Anoop K. Pal, Dhimiter Bello, Joel Cohen, Philip Demokritou
Article
Toxicology
Glen M. DeLoid, Joel M. Cohen, Georgios Pyrgiotakis, Sandra V. Pirela, Anoop Pal, Jiying Liu, Jelena Srebric, Philip Demokritou
PARTICLE AND FIBRE TOXICOLOGY
(2015)
Article
Toxicology
Anoop K. Pal, Christa Y. Watson, Sandra V. Pirela, Dilpreet Singh, Marie-Cecile G. Chalbot, Ilias Kavouras, Philip Demokritou
TOXICOLOGICAL SCIENCES
(2015)
Article
Engineering, Environmental
Jiaqi Lan, Na Gou, Sheikh Moklies Rahman, Ce Gao, Miao He, April Z. Gu
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2016)
Article
Chemistry, Multidisciplinary
C. Y. Watson, G. M. DeLoid, A. Pal, P. Demokritou
Article
Chemistry, Multidisciplinary
Anoop K. Pal, Iraj Aalaei, Suresh Gadde, Peter Gaines, Daniel Schmidt, Philip Demokritou, Dhimiter Bello
Article
Engineering, Environmental
Jiaqi Lan, Na Gou, Ce Gao, Miao He, April Z. Gu
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2014)
Article
Engineering, Environmental
Na Gou, Songhu Yuan, Jiaqi Lan, Ce Gao, Akram N. Alshawabkeh, April Z. Gu
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2014)
Article
Chemistry, Multidisciplinary
Lin Wang, Anoop K. Pal, Jacqueline A. Isaacs, Dhimiter Bello, Rebecca L. Carrier
JOURNAL OF NANOPARTICLE RESEARCH
(2014)
Article
Chemistry, Multidisciplinary
Anoop K. Pal, Shu-Feng Hsieh, Madhu Khatri, Jacqueline A. Isaacs, Philip Demokritou, Peter Gaines, Daniel F. Schmidt, Eugene J. Rogers, Dhimiter Bello
JOURNAL OF NANOPARTICLE RESEARCH
(2014)
Article
Chemistry, Multidisciplinary
Soumitra Satapathi, Anoop K. Pal, Lian Li, Lynne A. Samuelson, Dhimiter Bello, Jayant Kumar
Meeting Abstract
Chemistry, Multidisciplinary
April Gu, Na Gou, Jiaqi Lan, Sheikh Mokhlesur Rahman, YiShan Lin
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2017)
Article
Neurosciences
Sangmook Lee, Ikjot S. Sohal, Mikaela A. Therrien, Anoop K. Pal, Dhimiter Bello, Thomas B. Shea
JOURNAL OF ALZHEIMERS DISEASE
(2015)