Review
Chemistry, Multidisciplinary
Catia Domingues, Ana Santos, Carmen Alvarez-Lorenzo, Angel Concheiro, Ivana Jarak, Francisco Veiga, Isabel Barbosa, Marilia Dourado, Ana Figueiras
Summary: Worldwide development and application of nanotechnology have led to significant scientific advancements. It is important to balance the high expectations and concerns associated with this field. Nanomedicine, a specific arm of nanotechnology, focuses on the diagnosis, treatment, and monitoring of various diseases. However, the concept of nanotoxicology has also emerged as a crucial aspect of nanomedicine. More research is needed to identify potential adverse effects and ensure the safety of nanomedicines.
Review
Chemistry, Multidisciplinary
Qian Wu, Siyuan Fu, Hanyang Xiao, Jiaxin Du, Fang Cheng, Shuangshuang Wan, Houjuan Zhu, Dan Li, Fei Peng, Xianguang Ding, Lianhui Wang
Summary: Extracellular vesicles (EVs) are important cell surrogates that have wide applications in clinical diagnosis and treatment. However, the heterogeneity and small size of EVs present technical barriers to their clinical translation. This article provides a critical overview of emerging technologies in EVs field for biomedical applications, discusses the current methods for EVs isolation and identification, and presents engineering strategies for scalable production and improved cargo loading. The superior clinical potential of EVs, particularly in terms of different cell origins and their application in the next generation of diagnostic and treatment platforms, is emphasized.
Review
Pharmacology & Pharmacy
Panoraia Siafaka, Neslihan Ustundag Okur, Ioannis D. Karantas, Mehmet Evren Okur, Evren Atlihan Gundogdu
Summary: Nanotheranostics, as emerging diagnostic and therapeutic tools, have gained attention in the past decade for their targeted treatment and diagnostic properties, allowing real-time monitoring of therapy response and reducing the risk of dosage errors. Various imaging techniques are used for monitoring drug delivery processes, with radiolabeling of nanomaterials widely used in nuclear medicine imaging.
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Chemistry, Analytical
Silvia Picciolini, Francesca Roda, Marzia Bedoni, Alice Gualerzi
Summary: Extracellular Vesicles (EVs) are naturally secreted nanoparticles with diverse functions and potential in diagnostics and therapeutics. Though their nanoscale dimensions have posed challenges, advancements in microtechnology and nanotechnology have accelerated research on EVs. Multidisciplinary knowledge exchange and efforts are crucial for further progress in EV research.
Review
Chemistry, Multidisciplinary
Yu Cai, Xiaoyi Chen, Jingxing Si, Xiaozhou Mou, Xiaochen Dong
Summary: The development of theranostic nanoplatforms integrating imaging and therapy is crucial for cancer precision medicine. Single-component nanoparticles offer advantages of facile preparation, defined structure, and reduced risks to biological systems.
Review
Pharmacology & Pharmacy
Melgious Jin Yan Ang, Siew Yin Chan, Yi-Yiing Goh, Zichao Luo, Jun Wei Lau, Xiaogang Liu
Summary: The review focuses on recent developments of advanced nanomaterials and nanotheranostics in cancer treatment, particularly in the areas of stimulus-responsive nanomaterials and nanocarriers targeting the tumor microenvironment. The review also discusses the potential cytotoxicity and future prospects of next-generation nanomaterials for clinical implementation.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Review
Pharmacology & Pharmacy
Nazurah Binti Sazali, Lai Wah Chan, Tin Wui Wong
Summary: Nanoscale medicine has the potential for targeted drug delivery, but there are challenges in processing and administration. Agglomeration and compaction techniques are used to overcome the aggregation and poor flowability of nanoparticles, but there are risks of altering their geometry and surface chemistry. This study reviews the risk factors and discusses ways to modulate the effects of material, formulation, processing, and environmental variables to maintain the physicochemical and biological behavior of nanoparticles during agglomeration and compaction.
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Review
Chemistry, Multidisciplinary
Letao Yang, Kapil D. Patel, Christopher Rathnam, Ramar Thangam, Yannan Hou, Heemin Kang, Ki-Bum Lee
Summary: Extracellular vesicles (e.g., exosomes) carrying various biomolecules have great potential in biomedical applications, but their heterogeneity and inefficient uptake by recipient cells are critical barriers. Multifunctional nanomaterials, such as magnetic nanomaterials, can play crucial roles in addressing these issues and enhancing the applications of extracellular vesicles.
Review
Chemistry, Multidisciplinary
David G. Calatayud, Sotia Neophytou, Eleni Nicodemou, S. Giuseppe Giuffrida, Haobo Ge, Sofia I. Pascu
Summary: This article introduces recent developments in the field of theranostics, with a focus on imaging and sensing technologies for prostate cancer diagnosis and therapeutic monitoring. Nanotechnological approaches show great potential for the detection and treatment of prostate cancer. Biomarker-based biosensing methods using nanoparticles can contribute to the early detection of prostate cancer. However, social concerns and worries about the toxicity of nanoparticles hamper the clinical advancements of nano-theranostics.
FRONTIERS IN CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Velaphi C. Thipe, Alice Raphael Karikachery, Pinar Cakilkaya, Umer Farooq, Hussein H. Genedy, Norraseth Kaeokhamloed, Dieu-Hien Phan, Refaya Rezwan, Gozde Tezcan, Emilie Roger, Kattesh Katti
Summary: This review highlights recent advances in green nanotechnology, particularly in the synthesis of biocompatible and medically relevant gold nanoparticles. It provides detailed information on synthetic protocols and characterization tools for gold nanoparticles, as well as their applications in diagnostic imaging, drug delivery, and cancer therapy. The review also emphasizes the importance of green processes and the role of nanomedicine in human health and hygiene.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Lin Lin, Chuanhui Song, Zheng Wei, Huihui Zou, Shengwei Han, Zichen Cao, Xinyu Zhang, Guorong Zhang, Jianchuan Ran, Yu Cai, Wei Han
Summary: This study developed a novel organic photosensitive nanoparticle for photodynamic/photothermal therapy of oral leukoplakia. The results showed that the nanoparticles effectively treated the condition without apparent toxicity.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Xiao Zhang, Pengyu Wei, Zhengyang Yang, Yishan Liu, Kairui Yang, Yuhao Cheng, Hongwei Yao, Zhongtao Zhang
Summary: Designing wound dressings by combining novel materials and drugs is crucial for wound management. Hydrogels and nanomaterials have shown great potential in promoting wound healing due to their unique properties. This paper reviews and analyzes different types of nano-based hydrogel wound dressings and discusses their design concepts, advantages, and challenges. Future directions for wound dressings are also proposed to guide further research in wound management.
Article
Chemistry, Multidisciplinary
Feng Li, Zhaoyue Lv, Xue Zhang, Yuhang Dong, Xiaohui Ding, Zhemian Li, Shuai Li, Chi Yao, Dayong Yang
Summary: This study reports a supramolecular self-assembled DNA nanosystem that reprogrammed the cellular antioxidant system through synergistic chemical and gene regulations, significantly promoting metabolic reprogramming of cancer cells, showing great potential in cancer therapy.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Orest Kochan, Svitlana Boitsaniuk, Mariana Levkiv, Krzysztof Przystupa, Nadiia Manashchuk, Khrystyna Pohoretska, Natalia Chornij, Iryna Tsvyntarna, Liudmyla Patskan
Summary: Nanotechnology offers new approaches to improve dental biomaterials and disease diagnosis and prevention in dentistry, making oral health care services more acceptable.
APPLIED SCIENCES-BASEL
(2022)
Review
Biochemistry & Molecular Biology
Francisco Rodriguez, Pablo Caruana, Noa De la Fuente, Pia Espanol, Maria Gamez, Josep Balart, Elisa Llurba, Ramon Rovira, Raul Ruiz, Cristina Martin-Lorente, Jose Luis Corchero, Maria Virtudes Cespedes
Summary: This review provides an overview of nanomedicine for cancer treatment, focusing on the rationale behind their designs and applications. It highlights the tumor microenvironment and tumor disseminate cells as the most attractive and effective strategies for cancer treatments. The perspectives and challenges for nanopharmaceuticals in this field are also discussed.
Article
Biochemical Research Methods
Hye-Been Kim, Bin Jin, Dinesh K. Patel, Jin-Woo Kim, Jangho Kim, Hoon Seonwoo, Ki-Taek Lim
IEEE TRANSACTIONS ON NANOBIOSCIENCE
(2019)
Article
Materials Science, Paper & Wood
Kalavathy Rajan, Angele Djioleu, Gurshagan Kandhola, Nicole Labbe, Joshua Sakon, Danielle Julie Carrier, Jin-Woo Kim
Article
Materials Science, Paper & Wood
Gurshagan Kandhola, Angele Djioleu, Kalavathy Rajan, Joseph Batta-Mpouma, Nicole Labbe, Joshua Sakon, Benjamin A. Babst, Anindya Ghosh, Danielle Julie Carrier, Jin-Woo Kim
Summary: Cellulose nanocrystals (CNCs) are renewable and biocompatible nanomaterials with unique properties. The production and properties of CNCs from different wood species were investigated. The results showed that the type of wood species had an impact on the yield, purity, and properties of CNCs. This study provides insights into optimizing CNC production and usage for different applications.
Article
Biochemical Research Methods
J. Curran Henson, Anna Brickell, Jin-Woo Kim, Hanna Jensen, Jawahar L. Mehta, Morten Jensen
Summary: This study evaluated the direct toxicity of PEGylated GNPs on cardiomyocytes and found a relationship between cell viability and particle size and concentration. These new findings could advance the application of gold nanoparticles in cardiovascular medicine.
IEEE TRANSACTIONS ON NANOBIOSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Jin-Woo Kim, Joseph Batta-Mpouma, Gurshagan Kandhola, Joshua Sakon
Summary: Cellulose nanocrystals (CNCs) can be crosslinked to form nanoparticle-based hydrogels with tunable physicochemical properties, which improves the instability issue of CNCs in moist environments. The strength of intermolecular hydrogen bonding can be controlled by the type and concentration of crosslinkers as well as the CNC concentration. By changing the crosslinking conditions, the surface chemistry of CNCs can be transformed from hydrophilic to hydrophobic, and the topology and aqueous stability of self-assembled structures can be tuned.
Review
Cell & Tissue Engineering
Gurshagan Kandhola, Sunho Park, Jae-Woon Lim, Cody Chivers, Young Hye Song, Jong Hoon Chung, Jangho Kim, Jin-Woo Kim
Summary: In the past decade, nanoscale biomaterials have attracted significant attention in the scientific community. This review focuses on three nanomaterials, namely graphene and its derivatives, carbon nanotubes (CNTs), and nanocellulose, and their applications in regenerating various types of tissues. These nanomaterials possess excellent physical, chemical, mechanical, electrical, thermal, and optical properties, making them suitable for a wide range of biomedical applications. The review provides insights into composite tissue scaffolds fabricated using these nanomaterials, including their physicochemical properties, mechanisms of cell adhesion, growth, and differentiation, as well as their cytotoxic effects and biodegradation behavior. Challenges and gaps in research that need to be addressed before the clinical translation of these nanomaterials are discussed.
TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2023)
Article
Nanoscience & Nanotechnology
Y. Moon, H. Lee, J. Lim, G. Lee, J. Kim, H. Han
Summary: In this work, a quantitative analysis model based on reference-free self-calibration is proposed for the analysis of scattered fields and approach curves on a dielectric substrate in terahertz scattering-type scanning near-field optical microscopy. The model is compared with experimental data and numerical analysis, showing good agreement. It is used to extract the effective tip radius and substrate relative permittivity. The results demonstrate the feasibility of using the model for accurate measurement of geometric and optical parameters in a tip-based THz scattering-type scanning near-field optical microscope.
Article
Medicine, Research & Experimental
Raquel de Castro, Gurshagan Kandhola, Jin-Woo Kim, Quincy C. Moore, Audie K. Thompson
Summary: Drug delivery systems (DDS) face challenges such as high systemic uptake and low bioavailability. This study developed a new DDS using chitosan (Cs) particles and composite films to encapsulate gentamicin (GtS). Lysozyme can degrade chitosan to release GtS, and poly(ethylene glycol) diacrylate (PEGDA) can increase drug encapsulation efficiency. Cross-linking can prevent premature drug release.
MOLECULAR PHARMACEUTICS
(2023)
Article
Biotechnology & Applied Microbiology
Humendra Poudel, Ambar B. RanguMagar, Pooja Singh, Adeolu Oluremi, Nawab Ali, Fumiya Watanabe, Joseph Batta-Mpouma, Jin Woo Kim, Ahona Ghosh, Anindya Ghosh
Summary: Injectable hydrogels offer numerous advantages in various areas due to their unique properties such as tunability, excellent carrier properties, and biocompatibility. In this study, an injectable hydrogel was synthesized by rehydrating lyophilized mixtures of guar adamantane (Guar-ADI) and poly-β-cyclodextrin (p-βCD) in a phosphate-buffered saline (PBS) solution. The hydrogel displayed controlled drug release, biocompatibility, and promoted the growth of mouse osteoblastic MC3T3 cells.
BIOENGINEERING-BASEL
(2023)
Article
Nanoscience & Nanotechnology
Bo Ma, Jin-Woo Kim, Steve Tung
Summary: This article describes an atomic force microscopy-based method for controlling the translocation of DNA and characterizing its electrical properties. The method involves the electrostatic attachment and lifting of DNA to enable its movement and measurement across a substrate and a nanoelectrode gap.
IEEE OPEN JOURNAL OF NANOTECHNOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Heeyuen Koh, Jae Gyung Lee, Jae Young Lee, Ryan Kim, Osamu Tabata, Jin-Woo Kim, DO-Nyun Kim
Summary: Structural DNA nanotechnology enables the design of nanoscale structures with desired shape and properties through evolved design strategies and computational tools, allowing for fine control over both shape and physicochemical properties of the structure.
IEEE OPEN JOURNAL OF NANOTECHNOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Hyangwoo Kim, Hyeonsu Cho, Byoung Don Kong, Jin-Woo Kim, Meyya Meyyappan, Chang-Ki Baek
IEEE OPEN JOURNAL OF NANOTECHNOLOGY
(2020)
Article
Biotechnology & Applied Microbiology
Gurshagan Kandhola, Angele Djioleu, Kalavathy Rajan, Nicole Labbe, Joshua Sakon, Danielle Julie Carrier, Jin-Woo Kim
BIORESOURCES AND BIOPROCESSING
(2020)
Article
Chemistry, Multidisciplinary
Ambar B. RanguMagar, Bijay P. Chhetri, Anil Parameswaran-Thankam, Fumiya Watanabe, Arvind Sinha, Jin-Woo Kim, Viney Saini, Alexandru S. Biris, Anindya Ghosh
Review
Energy & Fuels
Gurshagan Kandhola, Angele Djioleu, D. Julie Carrier, Jin-Woo Kim
BIOENERGY RESEARCH
(2017)