期刊
PARKINSONISM & RELATED DISORDERS
卷 20, 期 11, 页码 1279-1282出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.parkreldis.2014.09.005
关键词
Basal ganglia; Movement disorders; Functional neurosurgery
资金
- Dystonia Medical Research Foundation
Introduction: Generalized dystonia, both primary and secondary forms, and axial dystonias such as tardive dystonia, and idiopathic cervical dystonia are responsive to globus pallidus interna (GPi) DBS. There is a paucity of investigations probing the impact of DBS on adult-onset axial dystonia. We assessed the efficacy of GPi DBS in four patients with rare adult-onset axial dystonia. Methods: Primary outcome measure was improvement in the motor component of the Burke-Fahn-Marsden (BFM) rating scale. Secondary outcome measures were quality of life as determined by the SF-36 questionnaire, time to achieve best possible benefit and DBS parameters that accounted for the best response. In patients with prominent concomitant cervical dystonia we also used the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS). Results: GPi DES improved BFM scores by 87.63 +/- 11.46%. Improvement in total severity scale of TWSTRS was 71.5 +/- 12.7%. Quality of life also remarkably improved as evidenced by 109.38 +/-. 82.97 and 7.05 +/- 21.48% percent change in psychometrically-based physical component summary (PCS), and a mental component summary (MCS) score respectively. Conclusions: GPi DBS is a very effective treatment for adult-onset axial dystonia. Considering its refractoriness to medical therapy and significant impact on quality of life DBS should be considered for this disorder. (C) 2014 Elsevier Ltd. All rights reserved.
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