Article
Geriatrics & Gerontology
Annie Brooks
Summary: People with Parkinson's disease are more prone to aspiration pneumonia compared to others. Aspiration pneumonia, caused by swallowing issues, is a major cause of death among Parkinson's patients, accounting for 25% of Parkinson's deaths. Limited evidence exists regarding the most effective strategies to balance the competing needs of each Parkinson's patient.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Mathematics
Derek Ka-Hei Lai, Ethan Shiu-Wang Cheng, Bryan Pak-Hei So, Ye-Jiao Mao, Sophia Ming-Yan Cheung, Daphne Sze Ki Cheung, Duo Wai-Chi Wong, James Chung-Wai Cheung
Summary: This study aimed to evaluate the classification performance of Transformer models and convolutional networks in identifying swallowing and non-swallowing tasks through depth video data. The results showed that convolutional neural networks outperformed the Transformer models, and X3D was the best model with good-to-excellent performance in classifying swallowing and non-swallowing conditions. Future studies should consider collecting more data for pretraining and developing a hyperparameter tuning strategy for Transformer models.
Review
Respiratory System
Rumi Ueha, Redentor B. Magdayao, Misaki Koyama, Taku Sato, Takao Goto, Tatsuya Yamasoba
Summary: Severe dysphagia can lead to life-threatening conditions such as intractable pneumonia. Surgical intervention is necessary to prevent intractable aspiration and its complications. This review aims to increase awareness among medical professionals about aspiration prevention surgeries and guide the selection of appropriate surgical options.
RESPIRATORY RESEARCH
(2023)
Article
Multidisciplinary Sciences
Jun Hee Won, Seong Jun Byun, Byung-Mo Oh, Sang Jun Park, Han Gil Seo
Summary: Patients with Parkinson's disease are at an increased risk for aspiration pneumonia, with approximately two-thirds of patients dying within a year after experiencing it. Further studies are needed to prevent aspiration pneumonia and implement effective treatments to reduce mortality in PD patients.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Bendix Labeit, Thalia Grond, Achim G. Beule, Maik Boehmer, Christian Thomas, Paul Muhle, Inga Claus, Malte Roderigo, Claudia Rudack, Heinz Wiendl, Rainer Dziewas, Tobias Warnecke, Sonja Suntrup-Krueger
Summary: The specific diagnostic algorithm presented in this study helps identify patients with an IIM-compatible dysphagia pattern and provides further IIM-focused diagnostic and therapeutic procedures. Treatment of patients diagnosed with IIM resulted in improvement of dysphagia in some cases post-therapy.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Eungseok Oh, Sungju Jee, Beom Keun Kim, Jung Seon Lee, Kanghee Cho, Soyoung Ahn
Summary: This study found that dysphagia associated with Parkinson's disease impacts patients' mortality and quality of life. A swallowing supplement was developed to improve swallowing ability in PD patients. Assessments showed that PD patients had worse swallowing quality of life, MMSE scores, and oral conditions compared to healthy controls.
NEUROLOGICAL SCIENCES
(2021)
Article
Health Care Sciences & Services
Min Cheol Chang, Ho Yong Choi, Donghwi Park
Summary: This study evaluated the usefulness of the modified videofluoroscopic dysphagia scale (mVDS) in determining whether to allow oral feeding in patients with dysphagia due to deconditioning or frailty. The results showed a significant association between the mVDS total score and oral feeding methods, as well as a correlation between mVDS and the presence of aspiration pneumonia.
Review
Otorhinolaryngology
Min Cheol Chang, Jin-Sung Park, Byung Joo Lee, Donghwi Park
Summary: In patients with Parkinson's disease, the effects of deep brain stimulation on swallowing function remains controversial, with some studies reporting positive effects and others showing no significant improvement. However, high-quality evidence is lacking and more randomized controlled trials are needed in the future.
Article
Otorhinolaryngology
Apoorva T. Ramaswamy, Daniel Cates, Lisa Evangelista, Mayuri Srikanth, Peter Belafsky
Summary: This study aimed to evaluate the feasibility of using Calcium Hydroxylapatite (CaHA) for tongue base augmentation in patients with swallowing impairment due to tongue base atrophy. The results showed that the procedure was easily performed and the CaHA flowed easily into the tongue base without any complications. Further investigation is needed to evaluate the clinical safety and efficacy of this method.
LARYNGOSCOPE INVESTIGATIVE OTOLARYNGOLOGY
(2023)
Article
Neurosciences
Matthew Dumican, Christopher Watts
Summary: This study compared the differences in dysphagia presentation between Parkinson's disease (PD) and cerebrovascular accident (CVA) patients. The results showed that the PD group had more severe pharyngeal stage impairments, with reduced laryngeal elevation and increased vallecular residue. The CVA group had more severe oral stage impairments. Time-to-laryngeal vestibule closure was a strong predictor of airway invasion in the PD group but not in the CVA group.
JOURNAL OF PARKINSONS DISEASE
(2022)
Article
Veterinary Sciences
Megan Grobman, Enrico Carluen, Carol R. Reinero
Summary: The study utilized VFSS to identify the incidence of penetration-aspiration (P-A) in dogs, finding a 39% incidence rate, with some dogs presenting with P-A without respiratory clinical signs. Pharyngeal and esophageal dysphagia were more common in dogs with P-A, and pharyngeal weakness and esophago-oropharyngeal reflux were identified as independent predictors of P-A.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2022)
Review
Pediatrics
Vivienne Norman, Liesl Zuhlke, Katherine Murray, Brenda Morrow
Summary: Feeding and swallowing difficulties are common comorbidities in infants and children with congenital heart disease, adversely affecting their health and quality of life. This scoping review provides an integrated summary of published literature on the prevalence of these difficulties in the last 25 years, revealing a wide range of prevalence rates. The review confirms the need to assess and manage feeding and swallowing difficulties as part of standard care.
FRONTIERS IN PEDIATRICS
(2022)
Article
Otorhinolaryngology
Isuru Dharmarathna, Anna Miles, Jacqui Allen
Summary: This study found associations between quantitative fluoroscopic swallow measures and likelihood of penetration-aspiration in children, with pharyngeal constriction ratio being the most predictive factor. Risk of aspiration was more than 100 times higher when specific measures such as bolus clearance ratio and total pharyngeal transit time reached certain values.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2021)
Article
Microbiology
Natalia S. Rozas, Gena D. Tribble, Cameron B. Jeter
Summary: This study found significant differences in the oral microbiota of patients with PD compared to healthy controls, possibly due to factors such as dysphagia, drooling, and salivary pH. Understanding the factors influencing their oral microbiota could lead to the development of diagnostic and treatment strategies to improve the quality of life and survival of these patients.
Review
Medicine, General & Internal
D'Marleanne Koomson, Heather Freeth, Alexander Goodwin, Vivek Srivastava
Summary: The National Confidential Enquiry into Patient Outcome and Death has assessed the quality of dysphagia care given to Parkinson's disease patients admitted to hospitals during acute illness. It highlights the need for clinical and organizational changes to enhance patient care and outcomes.
BRITISH JOURNAL OF HOSPITAL MEDICINE
(2023)
Article
Psychology, Clinical
Adrianna M. Ratajska, Francesca Lopez, Lauren Kenney, Charles Jacobson, Kelly D. Foote, Michael S. Okun, Dawn Bowers
Summary: The study identified three cognitive subtypes of ET patients undergoing DBS, with 27.4% meeting criteria for MCI. The majority of MCI cases were in the Low Executive or Low Memory Multi-Domain groups, with the latter having a higher percentage of members classified as MCI. Future work should focus on examining these subgroups for progression to dementia.
CLINICAL NEUROPSYCHOLOGIST
(2022)
Article
Otorhinolaryngology
James A. Curtis, James C. Borders, Sarah E. Perry, Avery E. Dakin, Zeina N. Seikaly, Michelle S. Troche
Summary: The study developed and implemented a standardized method, VASES, to rate pharyngeal residue, penetration, and aspiration during FEES, with training novices showing significant improvements in accuracy and efficiency post-training. This method has the potential to enhance subjective analysis of swallowing safety and efficiency in clinical and research settings.
Article
Otorhinolaryngology
Sarah E. Perry, James C. Borders, Avery E. Dakin, Michelle S. Troche
Summary: The study examined how objective measures of dysphagia in people with Parkinson's disease impacted their caregivers' quality of life. All caregivers reported reduced quality of life, with 28% severely affected. The combination of older care recipient age and longer disease duration was associated with poorer caregiver quality of life, while airway invasion and pharyngeal residue in care recipients were not related to caregiver quality of life.
Article
Audiology & Speech-Language Pathology
James A. Curtis, Jessica E. Huber, Avery E. Dakin, Michelle S. Troche
Summary: The aim of this study was to examine the effects of bolus holding on respiratory-swallow coordination in people with Parkinson's disease (PD). The results showed that bolus holding significantly influences respiratory-swallow coordination in PD, with held swallows exhibiting shorter respiratory pauses, lower lung volumes at swallow initiation, more frequent exhale-swallow-exhale patterns, and less frequent paradoxical respiratory movements.
AMERICAN JOURNAL OF SPEECH-LANGUAGE PATHOLOGY
(2022)
Article
Medicine, Research & Experimental
Caroline L. Cole, Victoria X. Yu, Sarah Perry, Anisa Seenauth, Ellen A. Lumpkin, Michelle S. Troche, Michael J. Pitman, Yalda Moayedi
Summary: This study aims to understand the somatosensory feedback from upper airway structures in humans, particularly the identities and distributions of upper airway neurons. The findings reveal differences in neuronal and chemosensory cell density among different sites in the upper airway, with the arytenoid region having the highest density. Furthermore, the study documents a decline in innervation density in the arytenoid region with aging.
Article
Otorhinolaryngology
Jordanna S. Sevitz, Sarah E. Perry, James C. Borders, Avery E. Dakin, James A. Curtis, Michelle S. Troche
Summary: This retrospective study aimed to investigate the association between reduced lingual strength and functional swallowing outcomes in individuals with Parkinson's disease (PD). The results showed that higher lingual strength was associated with less airway invasion of thin liquids, and both lingual pressure measures could differentiate between those with and without dysphagia. Lingual strength was also significantly associated with the amount of residue observed when thin liquid residue was present. These findings highlight the importance of lingual strength in the screening, assessment, and management of dysphagia in PD.
Article
Otorhinolaryngology
James A. Curtis, James C. Borders, Avery E. Dakin, Michelle S. Troche
Summary: The aim of this study was to investigate the relationship between airway protective responses (such as coughing or throat clearing) and aspiration amount, trial volume, disease diagnosis, and disease duration in people with neurologic disease. The study analyzed 422 aspirated swallows across 86 flexible endoscopic evaluations of swallowing (FEES). The results showed that airway protective responses were significantly related to aspiration amount and disease duration, but not to trial volume or disease diagnosis.
Article
Clinical Neurology
Michelle S. Troche, James A. Curtis, Jordanna S. Sevitz, Avery E. Dakin, Sarah E. Perry, James C. Borders, Alessandro A. Grande, Yuhan Mou, Nora Vanegas-Arroyave, Karen W. Hegland
Summary: Disorders of airway protection are common in Parkinson's disease (PD) and can lead to aspiration pneumonia and death. This study compared expiratory muscle strength training (EMST) and sensorimotor training for airway protection (smTAP) to improve cough-related outcomes in PD patients. The results showed that smTAP was more effective than EMST in improving cough function.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Frederick L. Hitti, Alik S. Widge, Patricio Riva-Posse, Donald A. Malone Jr, Michael S. Okun, Maryam M. Shanechi, Kelly D. Foote, Sarah H. Lisanby, Elizabeth Ankudowich, Srinivas Chivukula, Edward F. Chang, Aysegul Gunduz, Clement Hamani, Ashley Feinsinger, Cynthia S. Kubu, Winston Chiong, Jennifer A. Chandler, Rafael Carbunaru, Binith Cheeran, Robert S. Raike, Rachel A. Davis, Casey H. Halpern, Nora Vanegas-Arroyave, Dejan Markovic, Sarah K. Bick, Cameron C. McIntyre, R. Mark Richardson, Darin D. Dougherty, Brian H. Kopell, Jennifer A. Sweet, Wayne K. Goodman, Sameer A. Sheth, Nader Pouratian
Summary: Despite advances in treatment, neuromodulation, such as deep brain stimulation, has not gained widespread adoption as a potential therapy for psychiatric diseases. In 2016, the American Society for Stereotactic and Functional Neurosurgery organized a meeting to discuss the future path forward. A follow-up meeting in 2022 aimed to review the current state of the field and identify barriers and milestones for progress.
Article
Audiology & Speech-Language Pathology
James A. Curtis, James C. Borders, Avery E. Dakin, Michelle S. Troche
Summary: The aim of this study was to establish preliminary reference values for the Visual Analysis of Swallowing Efficiency and Safety (VASES) in flexible endoscopic evaluation of swallowing (FEES). The study analyzed the swallowing behavior of healthy adults and provided expected results for future clinical and research work.
JOURNAL OF SPEECH LANGUAGE AND HEARING RESEARCH
(2023)
Article
Neurosciences
Bradley J. Wilkes, Emily R. Tobin, David J. Arpin, Wei-en Wang, Michael S. Okun, Michael S. Jaffee, Nikolaus R. McFarland, Daniel M. Corcos, David E. Vaillancourt
Summary: Objective measures of disease progression using the Purdue Pegboard Test (PPT) were conducted in patients with Parkinson's disease (PD), atypical Parkinsonism, and healthy controls. The decline in PPT performance in PD patients correlated with motor symptom progression, while no such decline was seen in controls. Neuroimaging measures from the basal ganglia were significant predictors of PPT performance in PD, and cortical, basal ganglia, and cerebellar regions were predictors for atypical Parkinsonism. Accelerometry in PD patients showed diminished acceleration range and irregular patterns, which correlated with PPT scores.
NPJ PARKINSONS DISEASE
(2023)
Article
Clinical Neurology
Robert S. Eisinger, Michael S. Okun, Stephanie Cernera, Jackson Cagle, Matthew Beke, Adolfo Ramirez-Zamora, B. Hope Kim, Daniel A. N. Barbosa, Liming Qiu, Pavan Vaswani, Whitley W. Aamodt, Casey H. Halpern, Kelly D. Foote, Aysegul Gunduz, Leonardo Almeida
Summary: Weight loss in Parkinson's disease patients accelerates before death. Patients who underwent deep brain stimulation surgery gained weight, and higher post-operative weight correlates with longer survival.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Neurosciences
Emilie R. Lowell, James C. Borders, Sarah E. Perry, Avery E. Dakin, Jordanna S. Sevitz, Sheng-Han Kuo, Michelle S. Troche
Summary: Cerebellar ataxia patients have sensorimotor cough dysfunction, which may increase the risk of pneumonia. There is a small inverse relationship between the severity of ataxia and voluntary cough function.
Article
Clinical Neurology
Yoon Jin Choi, Basma Yacoubi, Agostina Casamento-Moran, Stefan Delmas, Bradley J. Wilkes, Christopher W. Hess, Aparna Wagle Shukla, Kelly D. Foote, David E. Vaillancourt, Michael S. Okun, Evangelos A. Christou
Summary: The study found that VIM DBS was effective in improving gait and balance in ET DBS patients. The improvements in gait and postural balance were associated with a reduction in axial tremor during the tasks.
TREMOR AND OTHER HYPERKINETIC MOVEMENTS
(2022)
Article
Clinical Neurology
Jun-Pyo Hong, Hanim Kwon, Euyhyun Park, Sun-Uk Lee, Chan-Nyoung Lee, Byung-Jo Kim, Ji-Soo Kim, Kun-Woo Park
Summary: In patients with mild-to-moderate PD, vestibular function assessed by video head-impulse tests appears relatively preserved and has minimal impact on the risk of falls. Risk of postural instability is associated with the severity of clinical symptoms in PD.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yaqin Xiang, XiuRong Huang, Qian Xu, Zhenhua Liu, Yase Chen, Qiying Sun, Junling Wang, Hong Jiang, Lu Shen, Xinxiang Yan, Beisha Tang, Jifeng Guo
Summary: Using the novel data-driven method DEBM, this study determined the sequence of several common biomarker changes in Parkinson's disease (PD). The left putamen was found to be the earliest biomarker to become abnormal, followed by the right putamen, CSF alpha-synuclein, right caudate, left caudate, and serum NfL. The estimated disease stages showed significant differences between PD and healthy controls, and achieved a high accuracy for distinguishing PD from HC.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yan Li, David J. McLernon, Carl E. Counsell, Angus D. Macleod
Summary: This study aimed to investigate the incidence and risk factors for institutionalisation in Parkinson's disease (PD) and atypical parkinsonism (AP). The study found that institutionalisation was more frequent in AP compared to PD and controls. Age, poorer cognition, and more-severe parkinsonian impairment were independent predictors of institutionalisation.
PARKINSONISM & RELATED DISORDERS
(2024)
