期刊
PARKINSONISM & RELATED DISORDERS
卷 19, 期 11, 页码 966-969出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.parkreldis.2013.06.010
关键词
Parkinson disease; Deep brain stimulation; Subthalamic nucleus; Motor symptoms; Non-motor symptoms
资金
- National Center for Research Resources (NCRR) [UL1 RR024986]
- National Center for Advancing Translational Sciences (NCATS)
- University of Michigan Department of Neurosurgery
Background: The Movement Disorders Society revision of the Unified Parkinson Disease Rating Scale (MDS-UPDRS) improves upon the original UPDRS by adding more non-motor items, making it a more robust tool to evaluate the severity of motor and non-motor symptoms of Parkinson disease. Previous studies on deep brain stimulation have not used the MDS-UPDRS. Objective: To determine if the MDS-UPDRS could detect improvement in both motor and non-motor symptoms after bilateral subthalamic nucleus deep brain stimulation for Parkinson disease. Methods: We compared scores on the entire MDS-UPDRS prior to surgery (baseline) and approximately six months following the initial programming visit in twenty subjects (12M/8F) with Parkinson disease undergoing bilateral subthalamic nucleus deep brain stimulation. Results: STN DBS significantly improved the scores for every section of the MDS-UPDRS at the 6 month follow-up. Part improved by 3.1 points (22%), Part II by 5.3 points (29%), Part III by 13.1 points (29%) with stimulation alone, and Part IV by 7.1 points (74%). Individual non-motor items in Part I that improved significantly were constipation, light-headedness, and fatigue. Conclusions: Both motor and non-motor symptoms, as assessed by the MDS-UPDRS, improve with bilateral subthalamic nucleus stimulation six months after the stimulator is turned on. We recommend that the MDS-UPDRS be utilized in future deep brain stimulation studies because of the advantage of detecting change in non-motor symptoms. (C) 2013 Elsevier Ltd. All rights reserved.
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