Article
Clinical Neurology
Naomi Hannaway, Nicholas P. Lao-Kaim, Antonio Martin-Bastida, Andreas-Antonios Roussakis, Jonathan Howard, Matthew B. Wall, Clare Loane, Roger A. Barker, Paola Piccini
Summary: The study found that there are changes over time in the blood-oxygen-level dependent response of Parkinson's disease patients undertaking a simple motor task. These changes primarily occur in the ipsilateral cerebellum and may be compensatory in nature.
PARKINSONISM & RELATED DISORDERS
(2021)
Article
Clinical Neurology
Sahar Yassine, Ute Gschwandtner, Manon Auffret, Sophie Achard, Marc Verin, Peter Fuhr, Mahmoud Hassan
Summary: Tracking the longitudinal functional brain dysconnectivity in PD patients over 5 years revealed a gradual impairment in alpha 2 and beta frequency bands, strongly correlated with global cognitive decline. Additionally, these disrupted networks were associated with the lateralization of motor symptoms, highlighting potential biomarkers for PD progression.
MOVEMENT DISORDERS
(2022)
Article
Chemistry, Multidisciplinary
Marianna Capecci, Nicolo Baldini, Francesca Campignoli, Lorenzo Pasquale Lombardo, Elisa Andrenelli, Maria Gabriella Ceravolo
Summary: This retrospective study evaluates the impact of COVID-19 on the clinical and functional evolution of 221 consecutively referred PD patients. The findings show that all primary endpoint measures worsened in 2020 compared to 2019, and the percentage of patients receiving neurologic visits or rehabilitation sessions reduced significantly. However, patients who received at least one cycle of rehabilitation sessions in 2020 maintained their independence level.
APPLIED SCIENCES-BASEL
(2023)
Article
Neurosciences
Yi-Hui Qiu, Zhi-Heng Huang, Yu-Yuan Gao, Shu-Jun Feng, Biao Huang, Wan-Yi Wang, Qi-Huan Xu, Jie-Hao Zhao, Yu-Hu Zhang, Li-Min Wang, Kun Nie, Li-Juan Wang
Summary: The aim of this research was to investigate alterations in functional brain networks in Parkinson's disease patients with depression (DPD). The study found that DPD patients had decreased local efficiency in certain brain regions compared to healthy controls, and showed weaker connections between different brain regions compared to the control group. These results suggest that PD depression is associated with disruptions in the topological organization of functional brain networks.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Geriatrics & Gerontology
Weifang Yin, Anming Li, Baiyuan Yang, Chao Gao, Yanfei Hu, Zhenglong Luo, Yuxia Li, Yongyun Zhu, Chuanbin Zhou, Hui Ren, Shimei Li, Xinglong Yang
Summary: This study investigates the association of altered cortical thickness and functional connectivity with depression in Parkinson's disease. The findings suggest that cortical thickness and functional connectivity may serve as neuroimaging-based diagnostic biomarkers for depression in Parkinson's disease.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Geriatrics & Gerontology
Flavia Silva Arbex Borim, Daniela de Assumpcao, Anita Liberalesso Neri, Samila Sathler Tavares Batistoni, Priscila Maria Stolses Bergamo Francisco, Monica Sanches Yassuda
Summary: The study found that among older adults in Brazil, 39.3% did not change their self-rated health over a 9-year period, while 21.7% rated it as worse and 39.0% rated it as better. Individuals who were independent in basic activities of daily living had a higher relative risk ratio for an improvement in self-rated health compared to those with disabilities. Understanding the factors influencing the improvement of health perception could provide insights into the wellbeing of older adults.
Review
Clinical Neurology
S. M. Cartella, C. Terranova, V. Rizzo, A. Quartarone, P. Girlanda
Summary: The article discusses the relationship between Covid-19 and Parkinson's Disease, focusing on five aspects: the increased risk of severe Covid-19 infection for frail, old, multi-pathological patients; the impact on PD patients' health and risk of developing severe Covid-19; the consequences of lockdown and restrictive measures on mental and cognitive health of patients and caregivers; considerations for patient care and management during this unprecedented time; and the possibility of Covid-19-induced parkinsonism.
JOURNAL OF NEUROLOGY
(2021)
Article
Neurosciences
Jingsheng Yang, Quanhao Guo, Xianwei Zou, Meng Wang, Yanxia Wen, Xiaqing Chen, Xiechuan Weng, Fan Xu
Summary: The study found that the range of head tremor in Parkinson's disease patients is positively correlated with the severity of the disease, with significantly greater head displacement compared to healthy individuals, and positively correlated with the severity of the disease.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Behavioral Sciences
Xulian Zhang, Xuan Cao, Chen Xue, Jingyi Zheng, Shaojun Zhang, Qingling Huang, Weiguo Liu
Summary: The radiomic approach was used to extract large-scale features of functional connectivity and activity for distinguishing among DPD, NDPD, and HC. Prediction accuracies varied from 0.85 to 1 using Lasso, random forest, and SVM methods in the testing sets.
BRAIN AND BEHAVIOR
(2021)
Article
Geriatrics & Gerontology
Jianxia Xu, Miao Yu, Hui Wang, Yuqian Li, Lanting Li, Jingru Ren, Chenxi Pan, Weiguo Liu
Summary: This study aimed to investigate the dynamic changes in de novo patients with Parkinson's disease and depression. The findings revealed altered dynamic functional connectivity, primarily involving the default mode network and cognitive executive network, in patients with Parkinson's disease and depression compared to patients without depression and healthy controls.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Cell Biology
Marion Criaud, Chloe Laurencin, Alice Poisson, Elise Metereau, Jerome Redoute, Stephane Thobois, Philippe Boulinguez, Benedicte Ballanger
Summary: Research suggests that slow movement initiation in Parkinson's disease is related to dysfunction of inhibitory control, with noradrenaline modulating movement initiation through the proactive inhibitory network. Targeting noradrenergic dysfunction may represent a new treatment approach for movement initiation disorders in Parkinson's disease.
Review
Clinical Neurology
Monica M. Kurtis, Isabel Parees
Summary: Functional movement disorders are commonly seen in neurology services and may coexist with other neurological diseases. There has been an increasing interest in functional overlay, particularly in patients with Parkinson's disease, and this review provides a comprehensive summary of the current knowledge on this topic, including potential mechanisms and risk factors.
PARKINSONISM & RELATED DISORDERS
(2021)
Article
Immunology
Revati Sabat, Orrin L. L. Dayton, Amit Agarwal, Vinata Vedam-Mai
Summary: This study investigated the effect of COVID-19 vaccines on Parkinson's disease patients. The results showed that 41% of the patients reported worsening of their symptoms to some extent after receiving the vaccine, but most of the symptoms were mild and had limited duration. In addition, vaccine hesitancy and post-vaccine general side effects were moderately positively correlated with symptom worsening. This study fills a research gap in this area.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Vincenzo Alfano, Giovanni Federico, Giulia Mele, Federica Garramone, Marcello Esposito, Marco Aiello, Marco Salvatore, Carlo Cavaliere
Summary: This study investigated the brain networks involved in depression in patients with frontotemporal dementia (FTD) and Parkinson's disease (PD), compared to healthy controls. The findings suggest the presence of specific connectivity patterns in depressed patients that may be related to neurocognitive disorders.
Article
Geriatrics & Gerontology
Jiangnan Ma, Kaixin Dou, Ruize Liu, Yajin Liao, Zengqiang Yuan, Anmu Xie
Summary: Sleep disorders, including pRBD and daytime sleepiness, are associated with depression in early and prodromal PD patients, partially mediated by autonomic dysfunction.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Clinical Neurology
Jun-Pyo Hong, Hanim Kwon, Euyhyun Park, Sun-Uk Lee, Chan-Nyoung Lee, Byung-Jo Kim, Ji-Soo Kim, Kun-Woo Park
Summary: In patients with mild-to-moderate PD, vestibular function assessed by video head-impulse tests appears relatively preserved and has minimal impact on the risk of falls. Risk of postural instability is associated with the severity of clinical symptoms in PD.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yaqin Xiang, XiuRong Huang, Qian Xu, Zhenhua Liu, Yase Chen, Qiying Sun, Junling Wang, Hong Jiang, Lu Shen, Xinxiang Yan, Beisha Tang, Jifeng Guo
Summary: Using the novel data-driven method DEBM, this study determined the sequence of several common biomarker changes in Parkinson's disease (PD). The left putamen was found to be the earliest biomarker to become abnormal, followed by the right putamen, CSF alpha-synuclein, right caudate, left caudate, and serum NfL. The estimated disease stages showed significant differences between PD and healthy controls, and achieved a high accuracy for distinguishing PD from HC.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yan Li, David J. McLernon, Carl E. Counsell, Angus D. Macleod
Summary: This study aimed to investigate the incidence and risk factors for institutionalisation in Parkinson's disease (PD) and atypical parkinsonism (AP). The study found that institutionalisation was more frequent in AP compared to PD and controls. Age, poorer cognition, and more-severe parkinsonian impairment were independent predictors of institutionalisation.
PARKINSONISM & RELATED DISORDERS
(2024)