期刊
TRANSFUSION MEDICINE REVIEWS
卷 29, 期 2, 页码 110-119出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.tmrv.2014.11.006
关键词
Platelets; Inflammation; Thrombosis; Leukocytes; Cancer
类别
资金
- CSL Prof Heimburger Award
- NHMRC
- National Heart Foundation
Although the role of platelets as central mediators of hemostasis and thrombosis has been the primary focus of research into platelet biology for more than a century, over the last decade, nonhemostatic functions of platelets have been increasingly defined. As such, a large body of experimental evidence now exists, which places the platelet as a key player in mediating a diverse range of immune, inflammatory, and malignant disease processes. This review outlines the central mechanisms that underpin the nonhemostatic role of platelets and provides a summary of evidence demonstrating a role for platelets in mediating selected inflammatory, immune, and malignant disease processes. Crown Copyright (C) 2015 Published by Elsevier Inc. All rights reserved.
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