Article
Neurosciences
Joachim Brumberg, Anastasia Kuzkina, Constantin Lapa, Sona Mammadova, Andreas Buck, Jens Volkmann, Claudia Sommer, Ioannis U. Isaias, Kathrin Doppler
Summary: Pathological aggregates of alpha-synuclein can be detected in peripheral dermal nerve fibers of patients with idiopathic Parkinson's disease and multiple system atrophy, indicating overlapping pathophysiological mechanisms between the two diseases and suggesting that alpha-synuclein may contribute to cardiac sympathetic neurons impairment in patients with synucleinopathies.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Clinical Neurology
Yasuo Miki, Eiki Tsushima, Sandrine C. Foti, Kate M. Strand, Yasmine T. Asi, Adam Kenji Yamamoto, Conceicao Bettencourt, Marcos C. B. Oliveira, Eduardo De Pablo-Fernandez, Zane Jaunmuktane, Andrew J. Lees, Koichi Wakabayashi, Thomas T. Warner, Niall Quinn, Janice L. Holton, Helen Ling
Summary: The study focused on patients with multiple system atrophy who presented symptoms closely resembling Parkinson's disease or progressive supranuclear palsy, pointing out the difficulties in diagnosing these mimicking cases accurately using current criteria. Differences in red flag features and autonomic dysfunction were observed in these atypical cases compared to typical ones.
Article
Clinical Neurology
Christine Eckhardt, Florian Krismer, Eveline Donnemiller, Sabine Eschlboeck, Alessandra Fanciulli, Cecilia Raccagni, Sylvia Boesch, Katherina Mair, Christoph Scherfler, Atbin Djamshidian, Christian Uprimny, Bernhard Metzler, Klaus Seppi, Werner Poewe, Stefan Kiechl, Irene Virgolini, Gregor K. Wenning
Summary: The purpose of this study was to evaluate the diagnostic accuracy of the dual imaging method combining cardiac iodine-(123)-metaiodobenzylguanidine single-photon emission computed tomography combined with low-dose chest computed tomography compared to routine cardiac scintigraphy, and assess regional differences in tracer distribution and the relationships between imaging and autonomic function in Parkinson's disease and multiple system atrophy.
CLINICAL AUTONOMIC RESEARCH
(2022)
Review
Clinical Neurology
Ivan Adamec, Magdalena Krbot Skoric, Mario Habek
Summary: Multiple sclerosis (MS) is traditionally considered a disease of the central nervous system (CNS), but emerging evidence suggests that it also affects the peripheral nervous system (PNS). Studies have shown signs of demyelination and functional involvement in the PNS of individuals with MS, particularly in the autonomic nervous system (ANS). Further research is needed to fully understand the frequency and significance of PNS involvement in MS.
NEUROLOGICAL SCIENCES
(2021)
Review
Clinical Neurology
Effrosyni Koutsouraki, Koukoulidis Theodoros, Georgiadou Eleni, Kalampouka Marianna, Nikolaidou Areti, Koukoulidou Ariadni, Michmizos Dimitrios
Summary: Multiple sclerosis (MS) is a chronic progressive disease affecting both the central nervous system (CNS) and autonomic nervous system (ANS), leading to a range of urological, sexual, gastrointestinal, cardiovascular, and thermoregulatory disorders as well as increased fatigue. The manifestations of ANS dysfunction in MS are often underestimated due to the non-specificity of symptoms and limited evaluation in clinical practice. The underlying mechanisms causing these disorders have yet to be fully investigated, hindering targeted etiological treatment. Early diagnosis and individualized treatment regimens, incorporating multiple approaches, have shown the best results in managing ANS dysfunction in MS patients.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Heidrun H. Kraemer, Cora Rebhorn, Christian Geber, Frank Birklein
Summary: Patients with Parkinson's disease and multiple system atrophy exhibit autonomic and sensory dysfunction, with features such as frequent orthostatic hypotension, decreased cold and warm detection thresholds, and increased mechanical pain thresholds.
JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Timo Siepmann, Martin Arndt, Annahita Sedghi, Szabolcs Szatmari Jr, Tamas Horvath, Annamaria Takats, Daniel Bereczki, Mats Leif Moskopp, Sylvia Buchmann, Cornelia Skowronek, Wagner Zago, Warunya Woranush, Razvan Lapusca, Marie Luise H. Weidemann, Christopher Gibbons, Roy Freeman, Heinz Reichmann, Volker Puetz, Kristian Barlinn, Alexandra Pinter, Ben Min-Woo Illigens
Summary: This study characterized autonomic pilomotor and sudomotor skin function in early Parkinson's disease (PD) longitudinally. The results showed that pilomotor function and sympathetic skin response (SSR) were impaired in PD, indicating sympathetic pathophysiology. However, cholinergic sudomotor function and parasympathetic neurocardiac function remained unchanged. This finding suggests that a pilomotor axon-reflex test may be useful for monitoring PD-related pathology.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Review
Biochemistry & Molecular Biology
Do Hyeon Kwon, Ji Su Hwang, Seok Gi Kim, Yong Eun Jang, Tae Hwan Shin, Gwang Lee
Summary: Parkinson's disease and multiple system atrophy are two types of neurodegenerative diseases that are difficult to differentiate, especially in early stages. Identifying metabolic biomarkers is crucial for diagnosis. The metabolic profile in the cerebrospinal fluid has been found to be altered in both diseases, but the specific metabolites are still uncertain. In this study, we created a network of altered metabolites and assessed their biological functions using bioinformatics methods.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Neurosciences
Jeann L. Sabino-Carvalho, Barbara Falquetto, Ana C. Takakura, Lauro C. Vianna
Summary: The incidence of Parkinson's disease is increasing worldwide, with nonmotor dysfunctions gaining recognition. Research suggests that baroreflex dysfunction may be an underlying mechanism of cardiovascular dysregulation in PD patients. This review summarizes potential altered central and peripheral mechanisms affecting the feedback-controlled loops in PD patients.
JOURNAL OF NEUROPHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Maddalena De Bernardo, Giulio Salerno, Marco Gioia, Luigi Capasso, Maria Claudia Russillo, Marina Picillo, Roberto Erro, Marianna Amboni, Paolo Barone, Nicola Rosa, Maria Teresa Pellecchia
Summary: The study found that intraocular pressure (IOP) in patients with multiple system atrophy (MSA) varied significantly in different positions compared to Parkinson's disease (PD) patients and healthy controls (HC), while differences in choroidal thickness (ChT) also showed differences between diseases. Changes in IOP and ChT may serve as additional indicators of autonomic dysfunction and could potentially assist in the differential diagnosis with PD.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Jae-Gyum Kim, Sung-Hwan Kim, Sun-Uk Lee, Chan-Nyoung Lee, Byung-Jo Kim, Ji-Soo Kim, Kun-Woo Park
Summary: The integrity of the vestibulo-ocular reflex in parkinsonism patients has yet to be determined. Head-impulse tests revealed more reversed and perverted catch-up saccades in multiple system atrophy (MSA) compared to Parkinson's disease (PD), indicating potential value for differentiation and as a surrogate marker for clinical decline.
JOURNAL OF NEUROLOGY
(2022)
Review
Clinical Neurology
Lukasz Rzepinski, Pietro Emiliano Doneddu, Claudia Cutelle, Monika Zawadka-Kunikowska, Eduardo Nobile-Orazio
Summary: The aim of this review was to investigate the prevalence and type of autonomic dysfunction (AD) in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). It was found that AD in CIDP may indicate comorbid diseases and facilitate differentiation from other neuropathies. Further research is needed to understand the impact of autonomic impairment on disability and response to therapy in CIDP.
NEUROLOGICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Jonas Folke, Emil Bergholt, Bente Pakkenberg, Susana Aznar, Tomasz Brudek
Summary: This study investigates the autoimmune aberrancies towards alpha-synuclein in prodromal phases of multiple-system trophy and Parkinson's Disease. The results indicate impaired reactivity towards alpha-synuclein occurs before disease onset, which may result in reduced clearance and aggregation of the protein.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Victoria Sidoroff, Cecilia Raccagni, Christine Kaindlstorfer, Sabine Eschlboeck, Alessandra Fanciulli, Roberta Granata, Bjorn Eskofier, Klaus Seppi, Werner Poewe, Johann Willeit, Stefan Kiechl, Philipp Mahlknecht, Heike Stockner, Kathrin Marini, Oliver Schorr, Gregorio Rungger, Jochen Klucken, Gregor Wenning, Heiko Gassner
Summary: The study compared gait variability at different walking speeds between patients with Parkinson-variant multiple system atrophy, idiopathic Parkinson's disease, and a control group of older adults. Multiple system atrophy patients displayed higher gait variability in various parameters compared to controls, while Parkinson's patients did not. Variability parameters were significantly correlated with the postural instability/gait difficulty subscore in both disease groups.
JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Kelvin L. Chou, Praveen Dayalu, Robert A. Koeppe, Sid Gilman, C. Chauncey Spears, Roger L. Albin, Vikas Kotagal
Summary: This study compared the serotoninergic innervation in patients with multiple system atrophy (MSA) and Parkinson's disease (PD) using serotonin transporter [C-11]3-amino-4-(2-dimethylaminomethyl-phenylsulfaryl)-benzonitrile positron emission tomography (PET). The results showed that MSA patients exhibited more severe deficits in brainstem and some forebrain subcortical regions compared to PD patients, and these deficits correlated with the severity of motor impairments in MSA.
MOVEMENT DISORDERS
(2022)
Article
Geriatrics & Gerontology
Ryoichi Nakamura, Genki Tohnai, Naoki Atsuta, Masahiro Nakatochi, Naoki Hayashi, Hazuki Watanabe, Daichi Yokoi, Hirohisa Watanabe, Masahisa Katsuno, Yuishin Izumi, Akira Taniguchi, Kazuaki Kanai, Mitsuya Morita, Osamu Kano, Satoshi Kuwabara, Masaya Oda, Koji Abe, Masashi Aoki, Ikuko Aiba, Koichi Okamoto, Kouichi Mizoguchi, Nobutaka Hattori, Kenji Nakashima, Ryuji Kaji, Gen Sobue
Summary: Two recent genetic studies found that loss-of-function mutation of the C-terminal cargo-binding tail domain of the KIF5A gene cause amyotrophic lateral sclerosis (ALS). This study in Japanese patients with sporadic ALS identified a novel loss-of-function variant in KIF5A, highlighting its rare occurrence as a cause of ALS.
NEUROBIOLOGY OF AGING
(2021)
Article
Dermatology
Kenji Sano, Masato Asahina, Takeshi Uehara, Nobuyuki Araki, Yoshitaka Yamanaka, Kazuhiko Matsumoto, Ryuhei Okuyama
Summary: AIGA is characterized by anhidrosis/hypohidrosis without other autonomic and neurological dysfunctions. Recent studies have revealed morphological damage in eccrine glands of AIGA patients, particularly in the clear cells, leading to edematous and destructive changes. Immunohistochemistry showed reduced CA II expression in clear cells of non-sweating skin, indicating a potential link to the etiology of AIGA.
JOURNAL OF DERMATOLOGY
(2021)
Editorial Material
Clinical Neurology
Satoshi Kuwabara, Tomoki Suichi, Sonoko Misawa
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2021)
Article
Biology
Alexa Callovini, Alessandro Fornasiero, Aldo Savoldelli, Federico Stella, David A. Low, Barbara Pellegrini, Federico Schena, Lorenzo Bortolan
Summary: The short-term heat acclimation training has a positive impact on improving exercise performance in hot environments, as well as enhancing physiological and perceptual adaptability. Additionally, this method can be effectively implemented in situations where a long acclimatization period is not possible.
JOURNAL OF THERMAL BIOLOGY
(2021)
Article
Clinical Neurology
Hiroki Masuda, Masahiro Mori, Shigeki Hirano, Akiyuki Uzawa, Tomohiko Uchida, Mayumi Muto, Ryohei Ohtani, Reiji Aoki, Satoshi Kuwabara
Summary: The research found that patients with NMOSD were older and had a higher disability status score at baseline MRI compared to those with MS. There were no significant differences in disease duration, annual relapse rate, and intervals from the last attack and from disease-modifying drugs initiation between the two groups.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Clinical Neurology
Christine Verboon, Thomas Harbo, David R. Cornblath, Richard A. C. Hughes, Pieter A. van Doorn, Michael P. Lunn, Kenneth C. Gorson, Fabio Barroso, Satoshi Kuwabara, Giuliana Galassi, Helmar C. Lehmann, Susumu Kusunoki, Ricardo C. Reisin, Davide Binda, Guido Cavaletti, Bart C. Jacobs
Summary: In patients with mild GBS, treatment with one course of IVIg did not improve the disease course overall. Despite some benefits such as shorter time to regain muscle strength, residual symptoms were often present after one year, indicating the need for better treatments for mild GBS.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2021)
Editorial Material
Clinical Neurology
Hiroki Masuda, Masahiro Mori, Satoshi Kuwabara
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2021)
Article
Immunology
Manato Yasuda, Akiyuki Uzawa, Yukiko Ozawa, Yuta Kojima, Yosuke Onishi, Hiroyuki Akamine, Satoshi Kuwabara
Summary: A retrospective study comparing IA and IVIg treatment in 19 AChR antibody-positive generalized MG patients showed that IA was safer and more effective in improving MG-ADL scores compared to IVIg. More large prospective studies are needed to confirm these findings.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2022)
Editorial Material
Clinical Neurology
Atsuhiko Sugiyama, Satoshi Kuwabara
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Editorial Material
Clinical Neurology
Satoshi Kuwabara, Tomoki Suichi
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Environmental Sciences
Madeleine France-Ratcliffe, Nicola D. Hopkins, David A. Low, Matthew S. Cocks, Helen Jones, Kayleigh S. Sheen, Victoria S. Sprung
Summary: Exercise during pregnancy has many benefits, but studies show that exercise decreases during pregnancy. The COVID-19 pandemic has worsened barriers to antenatal exercise, according to a recent study. The findings highlight the importance of psychosocial support and accurate information.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Physiology
Daniel J. Bannell, Fabio T. Montrezol, Joseph D. Maxwell, Yasina B. Somani, David A. Low, Dick H. J. Thijssen, Helen Jones
Summary: Ischemic preconditioning and handgrip exercise both offer protection against endothelial ischemia-reperfusion injury, regardless of the arm involved.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2023)
Article
Clinical Neurology
Akiyuki Uzawa, Shigeaki Suzuki, Satoshi Kuwabara, Hiroyuki Akamine, Yosuke Onishi, Manato Yasuda, Yukiko Ozawa, Naoki Kawaguchi, Tomoya Kubota, Masanori P. Takahashi, Yasushi Suzuki, Genya Watanabe, Takashi Kimura, Takamichi Sugimoto, Makoto Samukawa, Naoya Minami, Masayuki Masuda, Shingo Konno, Yuriko Nagane, Kimiaki Utsugisawa
Summary: Early fast-acting treatment (EFT), including plasmapheresis, intravenous immunoglobulin and/or intravenous high-dose methylprednisolone (IVMP), is beneficial for achieving minimal manifestations (MM) or <= 5 mg/day prednisolone (MM5mg) in patients with myasthenia gravis (MG). This study aimed to identify the effective EFT regimen and patient characteristics. The results showed that EFT was effective for all types of MG, and the inclusion of IVMP and early use of calcineurin inhibitors promoted the achievement of MM5mg.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Hiroaki Yoshikawa, Yumi Adachi, Yosikazu Nakamura, Nagato Kuriyama, Hiroyuki Murai, Yoshiko Nomura, Yasunari Sakai, Kazuo Iwasa, Yutaka Furukawa, Satoshi Kuwabara, Makoto Matsui
Summary: This study is the first nationwide epidemiological survey of Lambert-Eaton myasthenic syndrome (LEMS) in Japan. The results show that the prevalence of LEMS in Japan is similar to that in other countries. A significant proportion of LEMS patients have associated tumors, with a predominance of men in tumor-associated LEMS (paraneoplastic LEMS, P-LEMS), and women in LEMS without tumors (a primary autoimmune form of LEMS, AI-LEMS).
BMJ NEUROLOGY OPEN
(2022)
Article
Physiology
Kirsty A. Roberts, Richard Draijer, Nicola D. Hopkins, Young de Graaf, Sophie M. Holder, Sophie E. Carter, Dick H. J. Thijssen, David A. Low
Summary: The study revealed that 7 days of unhealthy lifestyle have negative effects on insulin homeostasis and vascular function, but these effects can be mitigated by daily intake of catechin-rich green tea.
PHYSIOLOGICAL REPORTS
(2021)
Article
Clinical Neurology
Jun-Pyo Hong, Hanim Kwon, Euyhyun Park, Sun-Uk Lee, Chan-Nyoung Lee, Byung-Jo Kim, Ji-Soo Kim, Kun-Woo Park
Summary: In patients with mild-to-moderate PD, vestibular function assessed by video head-impulse tests appears relatively preserved and has minimal impact on the risk of falls. Risk of postural instability is associated with the severity of clinical symptoms in PD.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yaqin Xiang, XiuRong Huang, Qian Xu, Zhenhua Liu, Yase Chen, Qiying Sun, Junling Wang, Hong Jiang, Lu Shen, Xinxiang Yan, Beisha Tang, Jifeng Guo
Summary: Using the novel data-driven method DEBM, this study determined the sequence of several common biomarker changes in Parkinson's disease (PD). The left putamen was found to be the earliest biomarker to become abnormal, followed by the right putamen, CSF alpha-synuclein, right caudate, left caudate, and serum NfL. The estimated disease stages showed significant differences between PD and healthy controls, and achieved a high accuracy for distinguishing PD from HC.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yan Li, David J. McLernon, Carl E. Counsell, Angus D. Macleod
Summary: This study aimed to investigate the incidence and risk factors for institutionalisation in Parkinson's disease (PD) and atypical parkinsonism (AP). The study found that institutionalisation was more frequent in AP compared to PD and controls. Age, poorer cognition, and more-severe parkinsonian impairment were independent predictors of institutionalisation.
PARKINSONISM & RELATED DISORDERS
(2024)
