Article
Endocrinology & Metabolism
Wenxiu Su, Lianping Zhao, Shisan Bao, Rui Qin, Jiancang Cao, Jing Tian, Yalan Han, Taotao Zhang, Chen Chen, Qian Shi, Qian Guo, Feifei Shao, Limin Tian
Summary: This study investigated the brain morphological and functional abnormalities associated with cognition and emotion in adults with untreated hypothyroidism. The results showed that hypothyroid patients had lower scores on cognitive and emotional assessments compared to healthy controls. Morphological analysis revealed reduced gray matter volumes in specific brain regions, while functional connectivity analysis showed abnormal connections between different brain regions in hypothyroid patients. These findings reveal the neuropathological mechanisms underlying cognitive and emotional impairment in hypothyroid adults.
Article
Clinical Neurology
Xuelei Xu, Hui Xiang, Yan Qiu, Ziwei Teng, Sujuan Li, Jing Huang, Jindong Chen, Hui Tang, Kun Jin, Lili Jiang, Bolun Wang, Ziru Zhao, Haishan Wu
Summary: The study revealed that male patients with first-diagnosed, drug-naive bipolar disorder had worse cognitive dysfunction compared to female patients, particularly in attention and delayed memory. Additionally, deficits in visuospatial/constructional ability were negatively associated with mania severity only in male patients.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Biochemistry & Molecular Biology
Georgios K. Vasileiadis, Anna-Carin Lundell, Yuan Zhang, Kerstin Andersson, Inger Gjertsson, Anna Rudin, Cristina Maglio
Summary: The study found a positive association between total adiponectin and pro-inflammatory chemokines, as well as markers of inflammation in patients with untreated newly diagnosed RA. However, high-molecular weight adiponectin was only associated with specific chemokines. Leptin and resistin showed no association with plasma chemokines, markers of inflammation, or disease activity scores.
Article
Clinical Neurology
Jodi Maple-Grodem, Ingvild Dalen, Ole-Bjorn Tysnes, Angus D. Macleod, Lars Forsgren, Carl E. Counsell, Guido Alves
Summary: The study found that carriers of GBA gene variants show a faster progression of motor symptoms in Parkinson's disease over a 7-year period compared to non-carriers. Recruiting only GBA carriers in clinical trials can significantly reduce trial size and improve trial design.
Article
Nutrition & Dietetics
Francesco Fisicaro, Giuseppe Lanza, Carmela Cinzia D'Agate, Raffaele Ferri, Mariagiovanna Cantone, Luca Falzone, Giovanni Pennisi, Rita Bella, Manuela Pennisi
Summary: This study found an intracortical and interhemispheric motor disinhibition in CD patients using transcallosal inhibition research. There was a positive correlation between MoCA scores and iSP, suggesting GABA-mediated cortical and callosal circuitries involvement in CD. Further studies correlating clinical, TMS, and neuroimaging data are needed.
Article
Oncology
Cecilie R. Buskbjerg, Robert Zachariae, Simon Buus, Claus H. Gravholt, Lene Haldbo-Classen, S. M. Hadi Hosseini, Ali Amidi
Summary: The study assessed cognitive impairment in untreated prostate cancer patients referred to androgen-deprivation therapy (ADT) and found a higher frequency of cognitive impairment compared to healthy controls. Results showed that cognitive performance was associated with patient-reported outcome measures, brain networks structure, and testosterone levels.
Article
Clinical Neurology
Hanne Lie Kjaerstad, Emilie Poulsen, Maj Vinberg, Lars Vedel Kessing, Kamilla Woznica Miskowiak
Summary: This study investigated cognitive impairments and changes in individuals with bipolar disorder and their unaffected relatives. The results showed that patients could be grouped into three neurocognitive subgroups, with the "globally impaired" subgroup exhibiting stable impairments and the "mild-moderately impaired" subgroup and unaffected relatives showing normative cognitive improvement over time.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Nutrition & Dietetics
Marios Hadjivassiliou, Iain D. Croall, Richard A. Grunewald, Nick Trott, David S. Sanders, Nigel Hoggard
Summary: A previous study found that many newly diagnosed coeliac disease patients exhibit neurological dysfunction, including headaches and loss of coordination, and abnormal brain imaging. A follow-up study revealed a reduction in headache prevalence but an increase in incoordination prevalence, with patients testing positive for gluten-sensitive antibodies showing a higher risk of cerebellar atrophy. Adherence to a strict gluten-free diet is important for patients with CD to prevent neurological issues.
Article
Immunology
Klaske Oberman, Iris Hovens, Jacco de Haan, Joana Falcao-Salles, Barbara van Leeuwen, Regien Schoemaker
Summary: A single injection of ibuprofen before surgery improved short-term spatial memory and increased hippocampal neurogenesis in rats, although associated with increased microglia activity. Plasma cytokine levels were not significantly affected, but VEGF levels increased and IFABP levels decreased after ibuprofen treatment. The gut microbiome was not significantly impacted by surgery or ibuprofen, with effects in aged rats similar to those in young rats, although less pronounced.
JOURNAL OF NEUROINFLAMMATION
(2021)
Review
Psychology, Clinical
Eleni Petkari, Natalia Martin-Maria, Teresa Sanchez-Gutierrez, Belen Fernandez-Castilla, Ana Calvo
Summary: Cognitive interventions do not appear to improve functioning in patients with recent onset psychosis. Further research is needed to determine their applicability for these patients.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Sung-Chun Tang, Yen-Bin Liu, Lian-Yu Lin, Hui-Chun Huang, Li-Ting Ho, Ling-Ping Lai, Wen-Jone Chen, Yi-Lwung Ho, Chih-Chieh Yu
Summary: This study aims to clarify the impact of atrial fibrillation burden on cognitive function through detailed electrophysiological recordings and standardized assessments.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Review
Psychiatry
Andrew J. Watson, Lauren Harrison, Antonio Preti, Til Wykes, Matteo Cella
Summary: The trajectory of cognitive deficits in the years following psychosis onset remains debated, with small improvements observed in early psychosis patients that are likely due to practice effects. Longitudinal studies over longer follow-up periods are needed to further evaluate cognitive decline and improvement, as well as the role of social cognition in early psychosis.
BRITISH JOURNAL OF PSYCHIATRY
(2022)
Article
Oncology
Paul D. Brown, Caroline Chung, Diane D. Liu, Sarah McAvoy, David Grosshans, Karine Al Feghali, Anita Mahajan, Jing Li, Susan L. McGovern, Mary-Fran Mcaleer, Amol J. Ghia, Erik P. Sulman, Marta Penas-Prado, John F. de Groot, Amy B. Heimberger, Jihong Wang, Terri S. Armstrong, Mark R. Gilbert, Nandita Guha-Thakurta, Jeffrey S. Wefel
Summary: The study found that proton radiotherapy (PT) did not delay time to cognitive failure in patients with newly diagnosed gliobiastoma (GBM) compared to intensity-modulated radiotherapy (IMRT), but it reduced toxicity and patient-reported fatigue. PT significantly reduced the radiation dose for almost all structures analyzed. Larger randomized trials are needed to further explore the potential benefits of PT in GBM and cognitive preservation in patients with lower-grade gliomas.
Article
Oncology
Mi Sook Jung, Moira Visovatti, Mijung Kim, Kyengin Cha, Nondumiso Dlamini, Xirong Cui
Summary: The study aimed to assess cognitive function in women newly diagnosed with non-metastatic thyroid cancer before any treatment and identify factors associated with cognitive problems. Findings showed that approximately 95% of these women had impaired neuropsychological test scores on attention and cognitive control. Older age, fewer years of education, greater depressed mood, and having a hypothyroid state were associated with worse neuropsychological test performance.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Clinical Neurology
Aleksandra A. Szwedo, Camilla Christina Pedersen, Anastasia Ushakova, Lars Forsgren, Ole-Bjorn Tysnes, Carl E. Counsell, Guido Alves, Johannes Lange, Angus D. Macleod, Jodi Maple-Grodem
Summary: The study showed that the rs356219 variant of SNCA may have a minor impact on modifying disease progression in patients with Parkinson's disease, while other SNCA variants were not significantly associated with differences in disease progression.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Gianpaolo Maggi, Alfonsina D'Iorio, Edoardo Nicolo Aiello, Barbara Poletti, Nicola Ticozzi, Vincenzo Silani, Marianna Amboni, Carmine Vitale, Gabriella Santangelo
Summary: This study assessed the psychometric and diagnostic properties of the Beck Depression Inventory-II (BDI-II) in an Italian Parkinson's disease (PD) cohort. The results showed that the BDI-II performed well in terms of internal consistency and construct validity, making it a reliable tool for screening depression in PD patients.
NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
A. Scaravilli, M. Tranfa, G. Pontillo, F. Falco, C. Criscuolo, M. Moccia, S. Monti, R. Lanzillo, V. Brescia Morra, G. Palma, M. Petracca, E. Tedeschi, A. Elefante, A. Brunetti, S. Cocozza
Summary: This study aimed to evaluate the long-term impact of gadolinium retention in the dentate nuclei on motor and cognitive disability in patients with MS. The findings showed no significant association between gadolinium retention and long-term motor or cognitive outcomes in these patients.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2023)
Review
Psychology, Clinical
Manuela Altieri, Francesco Cerciello, Antonio Gallo, Gabriella Santangelo
Summary: This meta-analytic study aimed to assess the relationship between depressive symptomatology and cognitive abilities in patients with multiple sclerosis (MS). The results showed a small effect size for the association between depression and verbal memory, spatial memory, verbal fluency, and inhibitory control, and a medium effect size for the association between depression and global cognition, attention, processing speed, and working memory. The relationship between depression and set-shifting abilities was not significant. These findings suggest that MS patients with higher levels of depressive symptomatology may experience difficulties in various cognitive domains.
CLINICAL NEUROPSYCHOLOGIST
(2023)
Article
Clinical Neurology
Edoardo Nicolo Aiello, Alfonsina D'Iorio, Federica Solca, Silvia Torre, Ruggero Bonetti, Francesco Scheveger, Eleonora Colombo, Alessio Maranzano, Luca Maderna, Claudia Morelli, Alberto Doretti, Marianna Amboni, Carmine Vitale, Federico Verde, Roberta Ferrucci, Sergio Barbieri, Eleonora Zirone, Alberto Priori, Gabriella Pravettoni, Gabriella Santangelo, Vincenzo Silani, Nicola Ticozzi, Andrea Ciammola, Barbara Poletti
Summary: This study assessed the clinimetrics and feasibility of the FAB in non-demented PD patients, revealing that the FAB is a reliable and feasible screener for detecting cognitive impairment in these patients.
JOURNAL OF NEURAL TRANSMISSION
(2023)
Article
Clinical Neurology
Alfonsina D'Iorio, Edoardo Nicolo Aiello, Assunta Trinchillo, Vincenzo Silani, Nicola Ticozzi, Andrea Ciammola, Barbara Poletti, Marcello Esposito, Gabriella Santangelo
Summary: This study aimed to evaluate the clinimetrics of the Montreal Cognitive Assessment (MoCA) in Italian patients with adult-onset idiopathic focal dystonia (AOIFD). The MoCA was administered to 86 AOIFD patients and 92 healthy controls (HCs). The results showed that the MoCA had a reliable structure and was correlated with TMT, BMT, and DAS scores, but not with BDI-II scores. The adjusted MoCA scores accurately detected cognitive impairment and discriminated between patients and HCs. It was also unrelated to disease duration, severity, and motor phenotypes.
JOURNAL OF NEURAL TRANSMISSION
(2023)
Article
Clinical Neurology
Manuela Altieri, Gianpaolo Maggi, Valentina Rippa, Gabriella Santangelo
Summary: This study validated the reliability and validity of the AMI in a healthy Italian population and provided normative data for the scale. The results showed that the AMI had good psychometric properties and a three-factor structure. The study also found that the variation in AMI scores was not related to sociodemographic variables and identified three cut-offs for mild, moderate, and severe apathy using the Youden's J statistic.
NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Gianpaolo Maggi, Carmine Vitale, Francesco Cerciello, Gabriella Santangelo
Summary: Sleep disorders are common in Parkinson's disease and have variable prevalence rates. They are multifactorial in etiology, resulting from degenerative processes, drug interactions, and clinical features. A meta-analytic study found that RBD had a prevalence of 46% and was associated with older age, lower education, longer disease duration, higher medication doses, and more severe symptoms. EDS had a prevalence of 35% and was associated with older age, longer disease duration, more severe symptoms, higher medication doses, and reduced autonomy. Insomnia was reported in 44% of patients and was related to longer disease duration, higher medication doses, and more severe depression. Sleep disorders are associated with a more severe clinical phenotype of Parkinson's disease, and further research is needed to understand their underlying mechanisms and develop targeted therapies.
SLEEP MEDICINE REVIEWS
(2023)
Editorial Material
Clinical Neurology
Roberto Erro, Marina Picillo, Maria Teresa Pellecchia, Paolo Barone
JOURNAL OF MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Daniel Weintraub, Marina Picillo, Hyunkeun Ryan Cho, Chelsea Caspell-Garcia, Cornelis Blauwendraat, Ethan G. Brown, Lana M. Chahine, Christopher S. Coffey, Roseanne D. Dobkin, Tatiana Foroud, Doug Galasko, Karl Kieburtz, Kenneth Marek, Kalpana Merchant, Brit Mollenhauer, Kathleen L. Poston, Tanya Simuni, Andrew Siderowf, Andrew Singleton, John Seibyl, Caroline M. Tanner
Summary: This study used data from a multi-site, international, prospective cohort study to investigate the impact of dopamine system-related biomarkers on cognitive impairment in Parkinson's disease. The results showed that alterations in the dopamine system were associated with the development of cognitive impairment in Parkinson's disease. If confirmed causative, these findings suggest that the dopamine system is instrumental to cognitive health status throughout the disease course.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Review
Clinical Neurology
Gianpaolo Maggi, Chiara Giacobbe, Federica Iannotta, Gabriella Santangelo, Carmine Vitale
Summary: OSA affects nearly half of PD patients and is associated with older age, male sex, higher BMI, more severe motor disturbances, and periodic limb movements. However, it has no relationship with cognitive functioning and neuropsychiatric manifestations. Future studies should focus on determining the impact of clinical features and dopaminergic medication on the development of PD-OSA.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Letter
Clinical Neurology
Antonio Esposito, Lorenzo Ugga, Enrico Tedeschi, Rosa Iodice, Marcello Moccia
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Simona Raimo, Gabriella Santangelo, Maria Cropano, Mariachiara Gaita, Lidia Ammendola, Daniela Malangone, Giacomo Lus, Elisabetta Signoriello
Summary: This study evaluated the feasibility and reliability of teleneuropsychology (TeleNP) in assessing the cognitive profile of people with multiple sclerosis (PwMS) compared to face-to-face assessment (F-F). The results showed similar cognitive test performance regardless of the administration type, but better visuospatial test performance in the F-F condition. Therefore, TeleNP is a feasible and highly reliable approach in MS clinical practice.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Letter
Clinical Neurology
Daniele Caliendo, Maria Carmela Grassia, Antonio Carotenuto, Maria Petracca, Roberta Lanzillo, Vincenzo Brescia Morra, Marcello Moccia
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2024)
Article
Clinical Neurology
Jun-Pyo Hong, Hanim Kwon, Euyhyun Park, Sun-Uk Lee, Chan-Nyoung Lee, Byung-Jo Kim, Ji-Soo Kim, Kun-Woo Park
Summary: In patients with mild-to-moderate PD, vestibular function assessed by video head-impulse tests appears relatively preserved and has minimal impact on the risk of falls. Risk of postural instability is associated with the severity of clinical symptoms in PD.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yaqin Xiang, XiuRong Huang, Qian Xu, Zhenhua Liu, Yase Chen, Qiying Sun, Junling Wang, Hong Jiang, Lu Shen, Xinxiang Yan, Beisha Tang, Jifeng Guo
Summary: Using the novel data-driven method DEBM, this study determined the sequence of several common biomarker changes in Parkinson's disease (PD). The left putamen was found to be the earliest biomarker to become abnormal, followed by the right putamen, CSF alpha-synuclein, right caudate, left caudate, and serum NfL. The estimated disease stages showed significant differences between PD and healthy controls, and achieved a high accuracy for distinguishing PD from HC.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yan Li, David J. McLernon, Carl E. Counsell, Angus D. Macleod
Summary: This study aimed to investigate the incidence and risk factors for institutionalisation in Parkinson's disease (PD) and atypical parkinsonism (AP). The study found that institutionalisation was more frequent in AP compared to PD and controls. Age, poorer cognition, and more-severe parkinsonian impairment were independent predictors of institutionalisation.
PARKINSONISM & RELATED DISORDERS
(2024)
