Article
Clinical Neurology
Yueh-Chi Wu, Elan D. Louis, John Gionco, Ming-Kai Pan, Phyllis L. Faust, Sheng-Han Kuo
Summary: This study found that patients with essential tremor have an increased number of climbing fiber crossings on Purkinje cell dendrites, potentially contributing to abnormal CF wiring and a positive correlation with tremor severity.
MOVEMENT DISORDERS
(2021)
Review
Neurosciences
Mohamed Fasil Ibrahim, Jessica C. Beevis, Ruth M. Empson
Summary: This article focuses on the role of the cerebellum in Essential Tremor and proposes mechanisms driving abnormal burst firing of deep cerebellar nuclei neurons as a key initiator of tremorgenesis in Essential Tremor. Targetting these mechanisms may generate more effective treatments for Essential Tremor.
Article
Neurosciences
Cecilia Tremblay, Geidy E. Serrano, Nathaniel Dunckley, Nan Zhang, Kimberly L. Fiock, Charles H. Adler, Erika Driver-Dunckley, Shyamal H. Mehta, Holly A. Shill, Thomas G. Beach
Summary: In this study, postmortem cerebellar volume measurements revealed no volume alterations in patients with essential tremor (ET) compared to controls, in contrast to significant cerebellar atrophy in patients with multiple system atrophy (MSA).
JOURNAL OF PARKINSONS DISEASE
(2023)
Article
Medicine, Research & Experimental
Ioannis Mavroudis, Dimitrios Kazis, Foivos Petridis, Simela Chatzikonstantinou, Eleni Karantali, Samuel Njau, Vasiliki Costa, Alin Ciobica, Constantin Trus, Ioana Balmus, Stavros Baloyannis
Summary: The study investigates the morphological changes in the cerebellum of patients with essential tremor, specifically focusing on the Purkinje cells.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Review
Neurosciences
Adrian Handforth, Eric J. Lang
Summary: The review discusses advances in understanding Purkinje cell complex spike physiology and factors related to tremor, such as coupling of IO neurons, the role of climbing fibers, and the increase in CS synchrony caused by GABA receptor antagonists. Studies suggest that increased CS synchrony may be a potential cause of syndromic essential tremor.
Article
Clinical Neurology
Whitney G. Hartstone, Mark H. Brown, Geoffrey C. Kelly, William J. Tate, Sheng-Han Kuo, Andrew J. Dwork, Elan D. Louis, Phyllis L. Faust
Summary: The study did not find significant differences in neuronal density or number in the dentate nucleus between essential tremor cases and controls.
MOVEMENT DISORDERS
(2021)
Review
Clinical Neurology
Roberto Erro, Cristiano Sorrentino, Maria Russo, Paolo Barone
Summary: This article systematically reviews studies on ET-plus rest tremor and concludes that it is a heterogeneous group of conditions, potentially related to late-stage ET, different disorders, the development of Parkinson's disease, or misdiagnosis of ET. The study highlights the need for further research to solve methodological issues.
JOURNAL OF NEURAL TRANSMISSION
(2022)
Article
Medicine, General & Internal
Robert F. Breiman, Dianna M. Blau, Portia Mutevedzi, Victor Akelo, Inacio Mandomando, Ikechukwu U. Ogbuanu, Samba O. Sow, Lola Madrid, Shams El Arifeen, Mischka Garel, Nana Bukiwe Thwala, Dickens Onyango, Antonio Sitoe, Ima-Abasi Bassey, Adama Mamby Keita, Addisu Alemu, Muntasir Alam, Sana Mahtab, Dickson Gethi, Rosauro Varo, Julius Ojulong, Solomon Samura, Ashka Mehta, Alexander M. Ibrahim, Afruna Rahman, Pio Vitorino, Vicky L. Baillie, Janet Agaya, Milagritos D. Tapia, Nega Assefa, Atique Iqbal Chowdhury, J. Anthony G. Scott, Emily S. Gurley, Karen L. Kotloff, Amara Jambai, Quique Bassat, Beth A. Tippett-Barr, Shabir A. Madhi, Cynthia G. Whitney
Summary: The study found that most child deaths have multiple causes, rather than a single underlying condition. Considering all conditions, rather than just the underlying condition, can better guide research priorities and strategies for preventing mortality.
Article
Clinical Neurology
Virginie Destrebecq, Gilles Naeije
Summary: This study aimed to assess the prevalence of cognitive impairment in patients with essential tremor (ET) and determine whether it corresponds to cerebellar cognitive affective syndrome (CCAS). Cognitive functions were evaluated using the CCAS-Scale (CCAS-S) in 20 ET patients and 20 matched controls. The results showed that ET patients performed significantly worse than controls, and the CCAS-S scores correlated with age at onset, disease duration, and tremor severity.
FRONTIERS IN NEUROLOGY
(2023)
Article
Neurosciences
Regina T. Martuscello, Karthigayini Sivaprakasam, Whitney Hartstone, Sheng-Han Kuo, Genevieve Konopka, Elan D. Louis, Phyllis L. Faust
Summary: Through RNA sequencing analysis of the cerebellar cortex of essential tremor patients, we identified abnormal expression of genes and pathways related to tremor. These findings suggest that the pathogenesis of essential tremor may involve dysregulation of multiple cellular processes, and that essential tremor may be a family of disorders consisting of different types.
Article
Neuroimaging
Patrick Bedard, Pattamon Panyakaew, Hyun-Joo Cho, Mark Hallett, Silvina G. Horovitz
Summary: This study aimed to understand the differential pathophysiology of essential tremor and dystonic tremor. The results showed altered functional connectivity in the cerebellum for essential tremor patients, higher fractional anisotropy in the middle cerebellar peduncle for dystonic tremor patients, and reduced mean diffusivity in the cerebellum for both tremor groups. The findings suggest that the cerebellum is affected differently in both essential tremor and dystonic tremor.
NEUROIMAGE-CLINICAL
(2022)
Article
Neurosciences
John T. Gionco, Whitney G. Hartstone, Regina T. Martuscello, Sheng-Han Kuo, Phyllis L. Faust, Elan D. Louis
Summary: This study found no significant pathological differences in cerebellar cortex between cases of ET and ET-plus, thus not supporting the idea that ET and ET-plus represent distinct clinical-pathological entities.
Article
Clinical Neurology
Luca Angelini, Giulia Paparella, Alessandro De Biase, Annalisa Maraone, Matteo Panfili, Isabella Berardelli, Antonio Cannavacciuolo, Antonella Di Vita, Roberta Margiotta, Giovanni Fabbrini, Alfredo Berardelli, Matteo Bologna
Summary: This study investigated the progression of Essential Tremor (ET) manifestations through clinical and neurophysiological evaluation. The results showed that ET progression is characterized by the spread of tremor in multiple body segments and the emergence of soft signs. Female sex, absence of family history, and rest tremor at baseline were identified as predictive factors of worse disease progression.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Gabriela S. Gilmour, Davide Martino, Karen Hunka, Pia Lawrence, Zelma H. T. Kiss, Veronica Bruno
Summary: In this study, it was found that patients with ET-plus had similar tremor outcomes after VIM DBS compared to those with ET, without the development of new neurological issues. This suggests that patients with ET-plus can still be considered good candidates for VIM DBS treatment of tremor.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Takashi Tsuboi, Joshua K. Wong, Robert S. Eisinger, Lela Okromelidze, Mathew R. Burns, Adolfo Ramirez-Zamora, Leonardo Almeida, Aparna Wagle Shukla, Kelly D. Foote, Michael S. Okun, Sanjeet S. Grewal, Erik H. Middlebrooks
Summary: The optimal targets for deep brain stimulation in essential tremor and dystonic tremor remain unknown. This study suggests that DBS targeting the ventral intermediate nucleus/ventralis oralis posterior nucleus border and ventral intermediate nucleus region may be a reasonable treatment option for medication-refractory dystonic tremor and essential tremor patients. Our findings highlight the involvement of cerebello-thalamo-cortical and basal ganglia-thalamo-cortical networks in the pathophysiology of dystonic tremor.
Article
Clinical Neurology
Jun-Pyo Hong, Hanim Kwon, Euyhyun Park, Sun-Uk Lee, Chan-Nyoung Lee, Byung-Jo Kim, Ji-Soo Kim, Kun-Woo Park
Summary: In patients with mild-to-moderate PD, vestibular function assessed by video head-impulse tests appears relatively preserved and has minimal impact on the risk of falls. Risk of postural instability is associated with the severity of clinical symptoms in PD.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yaqin Xiang, XiuRong Huang, Qian Xu, Zhenhua Liu, Yase Chen, Qiying Sun, Junling Wang, Hong Jiang, Lu Shen, Xinxiang Yan, Beisha Tang, Jifeng Guo
Summary: Using the novel data-driven method DEBM, this study determined the sequence of several common biomarker changes in Parkinson's disease (PD). The left putamen was found to be the earliest biomarker to become abnormal, followed by the right putamen, CSF alpha-synuclein, right caudate, left caudate, and serum NfL. The estimated disease stages showed significant differences between PD and healthy controls, and achieved a high accuracy for distinguishing PD from HC.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yan Li, David J. McLernon, Carl E. Counsell, Angus D. Macleod
Summary: This study aimed to investigate the incidence and risk factors for institutionalisation in Parkinson's disease (PD) and atypical parkinsonism (AP). The study found that institutionalisation was more frequent in AP compared to PD and controls. Age, poorer cognition, and more-severe parkinsonian impairment were independent predictors of institutionalisation.
PARKINSONISM & RELATED DISORDERS
(2024)
