Review
Cell Biology
Destany K. K. Kwon, Mohit Kwatra, Jing Wang, Han Seok Ko
Summary: Levodopa is the most commonly used treatment for Parkinson's disease (PD) but comes with side effects in the advanced stages of the disease. Understanding the pathological mechanisms of levodopa-induced dyskinesia (LID) and finding alternative treatment options are crucial for improving the outcome of PD patients.
Article
Chemistry, Multidisciplinary
Angana Borbora, Yang Xu, Souradeep Dey, Xin Wang, Yuxing Yao, Biman B. Mandal, Xiaoguang Wang, Uttam Manna
Summary: A liquid-crystal-infused porous surface (LCIPS) is developed for simultaneous pulsatile and continuous release of chemicals. Two loading methods are employed, one for continuous release and the other for pulsatile release. The pulsatile and continuous release of two bioactive small molecules, tetracycline and dexamethasone, are demonstrated for potential applications in wound healing and biomedical implants.
ADVANCED MATERIALS
(2023)
Review
Biochemistry & Molecular Biology
Dominika Natalia Wojewska, Arjan Kortholt
Summary: This review provides a comprehensive overview of the current state of the art, presenting recent developments and challenges in developing LRRK2 inhibitors, and discussing extensively the potential targeting strategies from the protein perspective. As currently there are three LRRK2-targeting agents in clinical trials, more developments are predicted in the upcoming years.
Review
Biochemistry & Molecular Biology
Samaneh Mirzaei, Ketav Kulkarni, Kun Zhou, Peter J. Crack, Marie-Isabel Aguilar, David Finkelstein, John S. Forsythe
Summary: Parkinson's disease is a progressive neurological disorder that requires the development of new therapies to stop disease progression and reverse degeneration. Biomaterials play key roles in these therapies.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Clinical Neurology
Kaja Kolmancic, Nina K. Zupancic, Maja Trost, Dusan Flisar, Milica G. Kramberger, Zvezdan Pirtosek, Maja Kojovic
Summary: Switching from intermittent to continuous levodopa delivery can improve cortical maladaptive changes, reduce motor fluctuations and dyskinesias in patients with Parkinson's disease.
MOVEMENT DISORDERS
(2022)
Review
Neurosciences
Amanda L. L. Woerman, Gueltekin Tamgueney
Summary: In several neurodegenerative disorders, misfolded proteins can induce additional misfolding and propagate through the central nervous system via a self-templating mechanism. Parkinson's disease patients can be subcategorized based on the origin of misfolded alpha-synuclein, either in the brain or the gut. This review discusses the role of the gut in the pathogenesis of Parkinson's disease and other neurodegenerative disorders.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Engineering, Biomedical
Sana M. Keloth, Sridhar P. Arjunan, Sanjay Raghav, Dinesh Kant Kumar
Summary: The study found that people with early-stage PD exhibit high asymmetry, reduced modulation, and higher co-activation during walking. They have reduced muscle activity, ability to inhibit antagonist, and modulate their muscle activities, which suggests a potential for diagnosing and regularly assessing gait impairments in PD patients using wearable sensors.
JOURNAL OF NEUROENGINEERING AND REHABILITATION
(2021)
Review
Psychiatry
Jun-Fang Zhang, Xi-Xi Wang, Ya Feng, Robert Fekete, Joseph Jankovic, Yun-Cheng Wu
Summary: ICDs in PD refer to aberrant behaviors such as pathological gambling, hypersexuality, binge eating, and compulsive buying, which typically result from dopaminergic therapy. Research has focused on the broad spectrum of ICDs-related behaviors and their significant impact on patients and their families, with recent advances improving our understanding of this issue.
FRONTIERS IN PSYCHIATRY
(2021)
Review
Biochemistry & Molecular Biology
Sadegh Moradi Vastegani, Ava Nasrolahi, Shahab Ghaderi, Rafie Belali, Masome Rashno, Maryam Farzaneh, Seyed Esmaeil Khoshnam
Summary: Parkinson's disease is an age-related neurodegenerative disorder, and its pathogenesis is not completely understood. Mitochondrial dysfunction and oxidative stress are major causes and central events in the degeneration of dopaminergic neurons. This study discusses the impact of environmental, genetic, and biological factors on mitochondrial dysfunction and explores potential therapeutic targets and strategies, such as reactive oxygen species generation, calcium overload, inflammation activation, apoptosis, mitophagy, mitochondrial biogenesis, and dynamics, as well as mitochondrial transfer/transplantation, microRNAs, stem cells, photobiomodulation, diet, and exercise.
NEUROCHEMICAL RESEARCH
(2023)
Article
Neurosciences
Deborah Jacob, Lorena Guerrini, Federica Pescaglia, Simona Pierucci, Carmine Gelormini, Vincenzo Minutolo, Antonio Fratini, Giorgio Di Lorenzo, Hannes Petersen, Paolo Gargiulo
Summary: This study demonstrates the potential of using a complex postural control task to assess early-stage Parkinson's Disease patients by measuring the combined output of posturography, muscle activation, and cortical response.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Noha A. Gouda, Ahmed Elkamhawy, Jungsook Cho
Summary: Parkinson's disease (PD) is a neurodegenerative disorder characterized by degeneration of dopaminergic neurons. Current treatments for PD only aim to alleviate motor symptoms, and there is a need for disease-modifying approaches. This review provides an overview of current therapies, discusses novel therapeutic targets, immunomodulatory approaches, and stem cell research in PD, summarizes preclinical studies and clinical trials, and presents potential molecular biomarkers for early PD diagnosis.
Article
Clinical Neurology
Nurit Omer, Nir Giladi, Tanya Gurevich, Anat Bar-Shira, Mali Gana-Weisz, Tal Glinka, Orly Goldstein, Meir Kestenbaum, Jesse M. Cedarbaum, Omar S. Mabrouk, Kyle B. Fraser, Julia C. Shirvan, Avi Orr-Urtreger, Anat Mirelman, Avner Thaler
Summary: This study investigated the association between GCase activity, PD phenotype, and prodromal PD probability in carriers of GBA gene mutations, finding that low GCase activity does not explain the clinical phenotype or risk for prodromal PD in this cohort.
MOVEMENT DISORDERS
(2022)
Review
Cell Biology
Rita Caridade Silva, Helena Sofia Domingues, Antonio J. Salgado, Fabio G. Teixeira
Summary: Parkinson's disease is a common neurodegenerative disease, and the current treatment focuses on symptom relief rather than prevention of neuronal damage. Therefore, the development of neuroprotective and disease-modifying strategies is crucial. Stem cell secretome has shown promise as a potential alternative for regenerative medicine in Parkinson's disease, as it can modulate the viability and preservation of dopaminergic neurons.
NEURAL REGENERATION RESEARCH
(2022)
Review
Clinical Neurology
Mohammed Alrouji, Hayder M. Al-Kuraishy, Abdul-karim Abd Ali Al-Mahammadawy, Ali I. Al-Gareeb, Hebatallah M. Saad, Gaber El-Saber Batiha
Summary: Parkinson's disease (PD) is a neurodegenerative disease characterized by the deposition of a-synuclein and the aggregation of Lewy bodies. Cholesterol is involved in PD neuropathology in bidirectional ways that could be protective or harmful. The potential role of cholesterol in PD neuropathology was reviewed in this study.
NEUROLOGICAL SCIENCES
(2023)
Article
Health Care Sciences & Services
Tove Henriksen, Harry Staines
Summary: The study evaluated reasons for discontinuation of subcutaneous apomorphine infusion (SCAI) in Parkinson's disease patients, finding that main factors included adverse events, death, and treatment dissatisfaction. For the first 6 years of treatment, somnolence and hallucinations were the predominant side effects leading to discontinuation.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Clinical Neurology
Jun-Pyo Hong, Hanim Kwon, Euyhyun Park, Sun-Uk Lee, Chan-Nyoung Lee, Byung-Jo Kim, Ji-Soo Kim, Kun-Woo Park
Summary: In patients with mild-to-moderate PD, vestibular function assessed by video head-impulse tests appears relatively preserved and has minimal impact on the risk of falls. Risk of postural instability is associated with the severity of clinical symptoms in PD.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yaqin Xiang, XiuRong Huang, Qian Xu, Zhenhua Liu, Yase Chen, Qiying Sun, Junling Wang, Hong Jiang, Lu Shen, Xinxiang Yan, Beisha Tang, Jifeng Guo
Summary: Using the novel data-driven method DEBM, this study determined the sequence of several common biomarker changes in Parkinson's disease (PD). The left putamen was found to be the earliest biomarker to become abnormal, followed by the right putamen, CSF alpha-synuclein, right caudate, left caudate, and serum NfL. The estimated disease stages showed significant differences between PD and healthy controls, and achieved a high accuracy for distinguishing PD from HC.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yan Li, David J. McLernon, Carl E. Counsell, Angus D. Macleod
Summary: This study aimed to investigate the incidence and risk factors for institutionalisation in Parkinson's disease (PD) and atypical parkinsonism (AP). The study found that institutionalisation was more frequent in AP compared to PD and controls. Age, poorer cognition, and more-severe parkinsonian impairment were independent predictors of institutionalisation.
PARKINSONISM & RELATED DISORDERS
(2024)